Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Application No. | Application Title | Issue Date |
| 20120039920 | HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME A composition is disclosed comprising a hydrophobic monomer having the structure: CH2═CR4C(O)NHC(R1R1)(C(R1R1))nC(O)XR3 wherein n is an integer of 0 or 1; R1 is independ... | 02/16/2012 |
| 20120041063 | ANTITUMORAL COMPOUNDS A compound of general formula (I) wherein, R11, R12, R13, R14, R15, W, Y, R1, R2, R3, R4, R5, and R6 take various meanings for use in the t... | 02/16/2012 |
| 20120029067 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in metho... | 02/02/2012 |
| 20120027844 | COMPOUNDS, THEIR SYNTHESES, COMPOSITIONS, AND METHODS TO TREAT CANCER Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes. Methods for the treatment of cancer in animals comprising administering a compo... | 02/02/2012 |
| 20120004243 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy, halogeno and (1-6C)alkyl, or a ... | 01/05/2012 |
| 20110313057 | DIFUNCTIONALIZED AROMATIC COMPOUNDS AND POLYMERS THEREFROM The present invention relates to compounds of formula I, which are difunctionalized aromatic compounds, and polymers formed from the same.
| 12/22/2011 |
| 20110312092 | DUAL-TERMINAL AMIDE HYDROGELLING AGENT Disclosed is a benzamide derivative represented by formula (1). In the formula, k1 represents an integer from 0-4, m1 represents an integer from 1-100, and n1 represents an integer from 1-6. In addition, R1 represents a hydrocarbon group with 8-22 carbon atom... | 12/22/2011 |
| 20110306668 | CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID A process for synthesizing and screening solution phase derived libraries of fenbufen and ethacrynic acid is provided in the present invention. Compounds in the present invention having cytotoxicities are useful for a variety of therapeutic applications.... | 12/15/2011 |
| 20110294892 | Use of histone deacetylase inhibitors for the care of Philadephia-negative myeloproliferative syndromes The use of substances capable of inhibiting one or more enzymes of the histone deacetylase family (histone deacetylase inhibitors) for the therapeutic treatment of Philadelphia-negative myeloproliferative syndromes (polycythemia vera, essential thrombocythemia or idiopa... | 12/01/2011 |
| 20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compou... | 12/01/2011 |
| 20110288076 | Sphingosine-1-Phosphate Receptor Antagonists This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1-pho... | 11/24/2011 |
| 20110263626 | NOVEL BRADYKININ B1-ANTAGONISTS The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined... | 10/27/2011 |
| 20110263899 | Novel Process for the Preparation of Amino Acid Derivatives The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, whi... | 10/27/2011 |
| 20110257374 | Novel Reagents for Directed Biomarker Signal Amplification Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. ... | 10/20/2011 |
| 20110251131 | DEUTERATED 2-AMINO-3-HYDROXYPROPANOIC ACID DERIVATIVES This invention relates to novel 2-amino-3-hydroxypropanoic acid derivatives and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases ... | 10/13/2011 |
| 20110251248 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.... | 10/13/2011 |
| 20110178092 | HIV-1 Protease Inhibitors Described are novel protease inhibitors and methods for using said protease inhibitors in the treatment of human immunodeficiency virus (HIV) infection.... | 07/21/2011 |
| 20110172303 | DEACETYLASE INHIBITORS AND USES THEREOF The present invention provides novel compounds of formula (I) and pharmaceutical compositions thereof. The inventive compounds are useful as deacetylase inhibitors (e.g., histone deacetylase inhibitors) and may be useful in the treatment of proliferative diseases such a... | 07/14/2011 |
| 20110172239 | Compounds, Compositions and Methods for the Treatment of Amyloid Diseases and Synucleinopathies such as Alzheimer's Disease, Type 2 Diabetes and Parkinson's Disease Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed ... | 07/14/2011 |
| 20110137047 | Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-arylocta... | 06/09/2011 |
| 20110136878 | AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromat... | 06/09/2011 |
| 20110130350 | SYNTHESIS SCHEME FOR LACOSAMIDE The present invention is concerned with an improved method of producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide) comprising the 0-methylation of a compound of formula (I) to produce a compound of formula (II) in a single step reaction.... | 06/02/2011 |
| 20110131029 | CRYSTAL STRUCTURE OF THE INFLUENZA VIRUS POLYMERASE PAC-PB1N COMPLEX AND USES THEREOF Provided are the expression method of influenza virus polymerase PAc-PB1N complex, the co-crystallization method of the complex and the three-dimendional structure of the crystal of PAc-PB1N complex. Also provided are the compounds binding to the i... | 06/02/2011 |
| 20110117055 | Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds Provided herein are hepatitis C virus entry inhibitor oxoacetamide compounds, pharmaceutical compositions thereof, and methods for their use in treatment or prevention of hepatitis C virus infection in a subject in need thereof.... | 05/19/2011 |
| 20110039851 | CCR10 ANTAGONISTS The invention relates to a compound of formula (I): or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The i... | 02/17/2011 |
| 20110034731 | Solid Forms Of An N-(Phenylmethyl)Propanamide Derivative And Processes Of Preparation The invention relates to solid forms of the anti-epileptic agent lacosamide (I). The invention also relates to mixtures of solid forms of lacosamide. The invention further relates to mixtures of lacosamide enantiomers crystallized in a conglomerate Form and the use ther... | 02/10/2011 |
| 20110021528 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase act... | 01/27/2011 |
| 20110021815 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation. 01/27/2011 | |
| 20110021482 | Novel N-Benzylamide Substituted Derivatives of 2-(Acylamido)acetic Acid and 2-(Acylamido)propionic Acids: Potent Neurological Agents A first aspect of the invention is a compound (sometimes also referred to herein as an “active agent” or “active compound”) of Formula I or Ia: or a pharmaceutically acceptable salt or prodrug thereof... | 01/27/2011 |
| 20100331410 | Biaryl Amides A compound of formula: for treating ocular hypertension.... | 12/30/2010 |
| 20100298308 | Compositions and methods for bone formation and remodeling The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domai... | 11/25/2010 |
| 20100280108 | Antitumoral Compounds A compound of general formula (I) wherein, R11, R12, R13, R14, R15, W, Y, R1, R2, R3, R4, R5, and ... | 11/04/2010 |
| 20100240712 | INSECTICIDAL COMPOUNDS Novel aromatic compounds of formula (I): wherein A1, A2, A3, A4, R1, R2, R5, G1, G2, Q1, Q2, Y1, Y2, Y3 and Y4 ... | 09/23/2010 |
| 20100203650 | BIOMOLECULE BINDING LIGANDS The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an affinity for a substance. The ligand is a compound of formula (III) or... | 08/12/2010 |
| 20100173985 | Polyphenol proteasome inhibitors, synthesis, and methods of use The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in metho... | 07/08/2010 |
| 20100137194 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metaboli... | 06/03/2010 |
| 20100120872 | ORGANIC COMPOUNDS AND THEIR USES The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.... | 05/13/2010 |
| 20100113504 | AMIDE COMPOUNDS AND THEIR USE AS ANTITUMOR AGENTS The present invention relates to a compound of Formula (I), its geometrical isomers, in an optically active form as enantiomers, diastereomers, as well as in the form of racemate, as well as pharmaceutically acceptable salts thereof, wherein R is selected from CONHOH, C... | 05/06/2010 |
| 20100069630 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.... | 03/18/2010 |
| 20100062465 | Detection of Histone Deacetylase Inhibition Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylas... | 03/11/2010 |
