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| Application No. | Application Title | Issue Date |
| 20120108632 | PRENYLTRANSFERASE INHIBITORS FOR OCULAR HYPERTENSION CONTROL AND THE TREATMENT OF GLAUCOMA The invention concerns in one embodiment a method of treating glaucoma or elevated intraocular pressure comprising administering a pharmaceutically effective amount of a composition comprising at least one prenyltransferase inhibitor. In another embodiment, the inventio... | 05/03/2012 |
| 20120053243 | PARAKERATOSIS INHIBITOR AND SKIN PREPARATION FOR EXTERNAL USE To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing/ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention/amelioration, etc., and further provide a skin preparation for ext... | 03/01/2012 |
| 20120016151 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors.... | 01/19/2012 |
| 20110288239 | POLYMERIC POLYAMINES AND METHOD FOR PRODUCING THE SAME The present invention discloses a polymeric polyamine which can be produced by polymerizing polyoxyalkylene-amine and a linker. The linker can be anhydride, carboxylic acid, epoxy, isocyanate or poly(styrene-co-maleic anhydride) copolymers (SMA). The present invention a... | 11/24/2011 |
| 20110251418 | CASR AGONISTS By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More... | 10/13/2011 |
| 20110229940 | METHOD FOR PRODUCING L-AMINO ACID The present invention relates to a method for producing an L-amino acid by reacting an enantiomeric mixture of an N-succinyl amino acid with L-succinylase in the presence of N-acylamino acid racemase to specifically hydrolyze the L-form. In particular, the present inven... | 09/22/2011 |
| 20110213157 | TRICYCLIC AMIDE COMPOUND A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH... | 09/01/2011 |
| 20110130587 | PROCESS FOR PREPARING R-BETA-AMINO PHENYLBUTYRIC ACID DERIVATIVES Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthes... | 06/02/2011 |
| 20110118482 | BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in... | 05/19/2011 |
| 20110092733 | NATEGLINIDE CRYSTALS Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble.... | 04/21/2011 |
| 20110064673 | New L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them The present invention relates to fluorinated glutamic acid (glutamate) and glutamine derivatives wherein the fluorine atom is 19F. The glutamic acid (glutamate) and glutamine derivatives are compound(s) of general Formula I, which encompasses all possible diastereoisome... | 03/17/2011 |
| 20110065681 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF Compounds are provided according to formula 1: where A, B, W, X′, L, R1, R3, R4b, and m′ are as defined herein. Provided compounds and pharmaceutical compositions thereof ... | 03/17/2011 |
| 20110046397 | NEW PROCESSES The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are... | 02/24/2011 |
| 20110039933 | S1P-1 RECEPTOR AGONISTS The invention provides compounds formula (I), their preparation, and their use as pharmaceutically active immuno-suppressive agents for the treatment of autoimmune disorders, organ transplant rejection, disorders associated with an activated immune system, as well as ot... | 02/17/2011 |
| 20100331552 | ACID SALT OF TOLTERODINE HAVING EFFECTIVE STABILITY FOR TRANSDERMAL DRUG DELIVERY SYSTEM The present invention relates to an acid salt of tolterodine with superior stabililty and useful as a transdermal drug delivery system. More specifically, the present invention relates to a novel acid salt of tolterodine with superior stabililty to the conventional acid... | 12/30/2010 |
| 20100324140 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention disclos... | 12/23/2010 |
| 20100305131 | Substituted Aminopropionic Derivatives as Neprilysin inhibitors The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined... | 12/02/2010 |
| 20100286427 | RETINOID PRODRUG COMPOUND A compound represented by the following general formula (I): [R1 to R5 represent hydrogen atom, an alkyl group, or a trialkylsilyl group, X represents —NH—CO—, —CO—NH—, —N(... | 11/11/2010 |
| 20100273725 | Novel compounds useful in therapeutic and cosmetic methods The present invention relates to photosensitizer compounds for use in cosmetic and therapeutic applications of photodynamic therapy. The compounds of the present invention are designed for topical application and are characterized by a low permeability to the stratum co... | 10/28/2010 |
| 20100256414 | PROCESS FOR THE PREPARATION OF CHIRALLY PURE NATEGLINIDE The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester the... | 10/07/2010 |
| 20100234307 | PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.... | 09/16/2010 |
| 20100216886 | POLYMORPHS OF N2-(1,1'-BIPHENYL-4-YLCARBONYL)-N1-[2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHYL]-L-ALPHA-GLUTAMINE Disclosed are novel polymorphic forms of N2-(1,1′-biphenyl-4-ylcarbonyl)-N1-[2-(4-fluorophenyl)-1,1-dimethylethyl]-L-α-glutamine, methods of preparing the polymorphic forms, compositions containing the polymorphic forms, and methods of treatment... | 08/26/2010 |
| 20100172844 | ALBUMIN BINDING MOLECULES AND USES THEREOF The invention relates to portable albumin binders, which are useful for improving the pharmacokinetic properties of diagnostic or therapeutic agents, in particular increasing the blood circulations time and/or the tissue penetration capacity of such agents.... | 07/08/2010 |
| 20100168079 | Biaryl Benzylamine Derivatives The present invention relates to biaryl-benzylamine compounds, to processes for their production, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.... | 07/01/2010 |
| 20100152460 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.... | 06/17/2010 |
| 20100145090 | PROCESS FOR THE PREPARATION OF PROTECTED L ALANINE DERIVATIVES The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.... | 06/10/2010 |
| 20100129311 | PHENYLALANINE AMIDE INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS The present invention relates to new phenylalanine amide inhibitors of ATP-sensitive potassium channels, pharmaceutical compositions thereof, and methods of use thereof. ... | 05/27/2010 |
| 20100093536 | CONTROL OF GRASSY WEEDS WITH VINYLGLYCINES AND VINYLGLYCINE-PRODUCING ORGANISMS The present disclosure concerns specific herbicide molecules, herbicidal compositions comprising the molecules and the bacterial strains that produce certain of these molecules, and methods of using these molecules and bacterial strains to control grassy weeds and other... | 04/15/2010 |
| 20090324540 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.... | 12/31/2009 |
| 20090305891 | CYCLOALKYLPHENYL SUBSTITUTED CYCLIC KETOENOLS The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which
| 12/10/2009 |
| 20090291978 | Enzyme Inhibitors Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxyest... | 11/26/2009 |
| 20090281160 | Angiotensin I-converting enzyme (ace) inhibitors This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an α,β-unsaturated keto intermediate. A key feature of the p... | 11/12/2009 |
| 20090253933 | NATEGLINIDE CRYSTALS Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble.... | 10/08/2009 |
| 20090252676 | N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or moni... | 10/08/2009 |
| 20090143469 | SALTS OF NATEGLINIDE The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preven... | 06/04/2009 |
| 20090131384 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS The invention provides novel compounds, methods for treating or preventing a condition related to ER-stress, e.g. hypercholesterolemia, atherosclerosis and related conditions, and pharmaceutical compositions related thereto.... | 05/21/2009 |
| 20090131441 | Metabolites Of 2-Arylpropionic Acid Derivatives And Pharmaceutical Compositions Containing Them Metabolites of 2-(R)-4-isobutylarylpropionamides and pharmaceutical compositions containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membran... | 05/21/2009 |
| 20090124669 | Structural Analogues of Avenanthramides, Their Use in Compositions Useful in the Treatment of Dermatological Disorders Novel compounds for the prevention and treatment of dermatological disorders with an immunoallergic, hyperproliferative and inflammatory component, and a method of producing such compounds. The compounds are bioisosteres of substances with avenanthramide structures.... | 05/14/2009 |
| 20090111874 | Phenyl-containing n-acyl amine and aminoacid derivatives, methods for the production thereof, a pharmaceutical composition and the use thereof The present invention relates to novel phenyl-N-acyl derivatives of biogenic amines and amino acids of general formula (I) as cyclooxynease inhibitors, possessing analgetic and anti-inflammatory properties and devoid of side effects in particular ulcerogeneity and pro-s... | 04/30/2009 |
| 20090076301 | METHODS FOR PRODUCING NATEGLINIDE CRYSTALS There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with... | 03/19/2009 |
