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| Application No. | Application Title | Issue Date |
| 20120046484 | Monomers and Macromers for Forming Hydrogels Disclosed are new compounds having utility in applications, including as reactants and intermediates in for the formation of polymers and polymeric materials especially useful as hydrogels for ophthalmic lenses.... | 02/23/2012 |
| 20120046478 | LIPID CONTAINING FORMULATIONS Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.... | 02/23/2012 |
| 20120046293 | RENIN INHIBITORS The present invention relates to renin inhibitor compounds having the structure and their use in treating cardiovascular events and renal insufficiency.... | 02/23/2012 |
| 20120040993 | NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotect... | 02/16/2012 |
| 20110313177 | 2-Oxo-1, 3-dioxolane-4-carboxylic Acid and Derivatives Thereof, Their Preparation and Use 2-Oxo-1,3-dioxolane-4-carboxylic acid and derivatives thereof, according to the following formula, in which R1 represents a negative charge, hydrogen or may be methyl or ethyl or an n-valent radica... | 12/22/2011 |
| 20110306600 | NOVEL THERAPEUTIC COMPOUNDS The invention discloses a number of therapeutic compounds and a method of treating a disorder in mammal.... | 12/15/2011 |
| 20110269722 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable c... | 11/03/2011 |
| 20110237814 | NOVEL RUTHENIUM CARBONYL COMPLEX HAVING TRIDENTATE LIGAND, ITS PRODUCTION METHOD AND USE The present invention relates to a ruthenium carbonyl complex that is represented by the following Formula (1):
| |
| 20110223105 | NEW 5-AMINOLEVULINIC ACID PRODRUGS FOR USE IN PHOTODYNAMIC THERAPY AND PHOTODYNAMIC DIAGNOSIS There is provided a compound of Formula and salts thereof wherein
| 09/15/2011 |
| 20110223535 | PHOTORESIST COMPRISING NITROGEN-CONTAINING COMPOUND New nitrogen-containing compounds are provided that comprise multiple hydroxyl moieties and photoresist compositions that comprise such nitrogen-containing compounds. Preferred nitrogen-containing compounds comprise 1) multiple hydroxyl substituents (i.e. 2 or more) and... | 09/15/2011 |
| 20110218238 | COMPOUNDS, COMPOSITIONS, FORMULATIONS AND THEIR USES THEREOF A compound, composition, method of synthesizing and using the compound of formula 1 are disclosed. The compound of formula I also comprises of salts, polymorphs, solvates, and hydrates thereof. The compound may be formulated as pharmaceutical compositions. The pharmaceu... | 09/08/2011 |
| 20110200582 | LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided are compositions and uses for cationic lipid compounds of formula (I).... | 08/18/2011 |
| 20110160228 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, inde... | 06/30/2011 |
| 20110143622 | FLUORINATED ACRYLATE COMPOSITIONS Disclosed are fluorinated acrylate compounds. The compounds are useful as monomers in the preparation of polymeric surfactants and additives for coating compositions or as treatment agents to impart various surface properties to substrates... | 06/16/2011 |
| 20110130454 | PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ... | 06/02/2011 |
| 20110124705 | PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ... | 05/26/2011 |
| 20110118451 | COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a ... | 05/19/2011 |
| 20110104057 | Novel [F-18]-labelled L-glutamic acid and L-glutamine derivatives (II), their use and processes for their preparation What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.... | 05/05/2011 |
| 20110021761 | Segmented Polymers and Their Conjugates Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful... | 01/27/2011 |
| 20110014715 | Synthesis of Peptide Nucleic Acids Conjugated with Amino Acids and Their Application This invention relates to a peptide nucleic acid (PNA) oligomer which is conjugated with one or more linear-type amino acid containing a plurality of alkyleneglycols and to a synthesis method thereof. In addition, this invention related to a linear amino acid spacer in ... | 01/20/2011 |
| 20100290991 | NOVEL [F-18]-LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), THEIR USE AND PROCESSES FOR THEIR PREPARATION What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.... | 11/18/2010 |
| 20100196826 | Photoinitiators for Energy Curing Photopolymerisable systems for coatings or photolithography comprising radically photopolimerisable oligomers and/or monomers having ethylenically unsaturated groups and, as photoinitiator, at least one compound of formula (I). ... | 08/05/2010 |
| 20100113797 | METHOD FOR PREPARING ENANTIOMERICALLY ENRICHED N-CARBOXYANHYDRIDE This disclosure relates to methods for preparing an enantiomerically enriched N-carboxyanhydride of an amino alpha acid of the formula (IIIa) or (IIIb): from a compound of the formula (IIa) or (IIb), respecti... | 05/06/2010 |
| 20100063294 | ALCOHOL PRODUCTION METHOD BY REDUCING ESTER OF LACTONE WITH HYDROGEN Provided is an alcohol production method comprising the step of reducing an ester or a lactone with hydrogen to produce a corresponding alcohol without addition of a base compound by using, as a catalyst, a ruthenium complex represented by the following general formula ... | 03/11/2010 |
| 20090234138 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs th... | 09/17/2009 |
| 20090186832 | AMINO ACID PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF Prodrugs of meptazinol and other phenolic analgesics exhibiting low oral bioavailability with amino acids or lower peptides, pharmaceutical compositions containing such prodrugs and a method for providing pain relief with such prodrugs are provided. In addition, the pre... | 07/23/2009 |
| 20090170917 | Acid Mimic Compounds for the Inhibition of Isoprenyl-S-Cysteinyl Methyltransferase Among other things, the present invention provides novel compounds capable of effectively inhibiting inflammatory responses that are mediated by G-proteins or GPCRs in neutrophils, macrophages and platelets. In particular, compounds of the present invention act as inhib... | 07/02/2009 |
| 20090018233 | Crosslink Agents and Dual Radical Cure Polymer A synthetic route to polymers comprised of at least two monomers each with a very different reactivity ratio by using a corresponding crosslink agent for each monomer. Novel crosslink agents are described that provide for the copolymerization of at least one hydrophilic... | 01/15/2009 |
| 20080312467 | NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO-PENTAN-1,5-DIOL The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-k... | 12/18/2008 |
| 20080306281 | NOVEL COMPOUNDS COMPRISING A THIOCARBONYL-SULFANYL GROUP WHICH CAN BE USED FOR THE RADICAL SYNTHESIS OF ALPHA-PERFLUOROALKYLAMINE COMPOUNDS The invention relates to compounds having the general formula (I), the method of preparation thereof and the use thereof in organic radical synthesis. The invention also relates to compounds having the formula (II), the method of preparation thereof and a method for pre... | 12/11/2008 |
| 20080207913 | Poly(ethylene glycol) containing chemically disparate endgroups The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of usin... | 08/28/2008 |
| 20080167489 | Process for producing carbamoyloxy (meth) acrylates and new carbamoyloxy (meth) acrylates The invention relates to a process for producing carbamoyloxy(meth)acrylates which comprises transesterification of hydroxyalkyl carbamates with an (meth)acrylate of formula CH2═CR29—COOR30 wherein R29 is hydrogen or methy... | 07/10/2008 |
| 20060217570 | Novel Tertiary Amine Compounds Having An Ester Structure And Processes For Preparing The Same The present invention provides ester group-containing tertiary amine compounds of the formula (R1OCH2CH2)nN(CH2CH2CO2R2)3-n which, when used as additives in chemical ampli... | 09/28/2006 |
| 20060089473 | Diol (meth) acrylate compound having urethane bond, method for producing the same, and polymer thereof The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acryla... | 04/27/2006 |
| 20050054819 | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including... | 03/10/2005 |
