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| Application No. | Application Title | Issue Date |
| 20110318359 | METHOD FOR REDUCING BLOOD PRESSURE USING INHIBITORS OF PLASMA KALLIKREIN The present invention relates to methods of reducing blood pressure in a subject by administering a plasma kallikrein inhibitor.... | 12/29/2011 |
| 20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the ... | 12/15/2011 |
| 20110275835 | PROCESS FOR PREPARING (S)-(+)-N-METHYL-3-(1-NAPHTHYLOXY)-3-(2-THIENYL)PROPYLAMINE BY USING OPTICALLY ACTIVE METHYLHYDROXYLAMINOPROPANOL COMPOUND AS INTERMEDIATE The present invention provides (S)-methylhydroxylaminopropanol compound as an intermediate in preparation of (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine. The present invention also provides a process for preparing (S)-(+)-N-methyl-3-(1-naphthyloxy)-3-(2-... | 11/10/2011 |
| 20110275663 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway The present invention relates to the use of acylthiourea or acylurea derivatives for the treatment of pathologies involving a tissue dysfunction associated with a deregulation of the Hedgehog protein signalling pathway, and also to novel acylthiourea or acylurea derivat... | 11/10/2011 |
| 20110263556 | New Compounds This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medi... | 10/27/2011 |
| 20110257196 | COMPOUNDS FOR TREATMENT OF CANCER The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant ... | 10/20/2011 |
| 20110257182 | Novel amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—s... | 10/20/2011 |
| 20110218221 | NOVEL HISTONE DEACETYLASE INHIBITORS, PROCESS FOR PREPARATION AND USES THEREOF The present invention relates to compounds represented by formula (I) or composition comprising at least one of such compounds, which are inhibitors of histone deacetylase. The detailed description of these compounds is disclosed in the Description. These compounds and ... | 09/08/2011 |
| 20110213003 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF This invention provides compounds of formula (I):
| 09/01/2011 |
| 20110213156 | 5-MEMBERED HETEROCYCLIC COMPOUND A compound represented by the following general formula (I): [wherein R1 and R2 represent an alkyl group, X represents —S—, —O— or —NH—, Y represents C or N, R3 re... | 09/01/2011 |
| 20110207945 | Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols Provided is a process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols, particularly of (S)-(−)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol, by asymmetrically hydrogenating salts of a carboxylic acids with an aminoketone of formula ... | 08/25/2011 |
| 20110207739 | Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof A series of novel 1,2-disubstituted amido-anthraquinone derivatives, and the preparation method and application of said derivatives. Said application includes said derivatives with therapeutically effective amount being prepared into pharmaceutical compositions for inhi... | 08/25/2011 |
| 20110178101 | DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt ... | 07/21/2011 |
| 20110160207 | HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating ... | 06/30/2011 |
| 20110144189 | GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING The present invention relates to compounds having the formula:
| 06/16/2011 |
| 20110118303 | NOVEL COMPOUNDS DERIVED FROM TAURINE, PROCESS OF THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE The present invention relates to compounds derived from taurine with non-steroidal anti inflammatory activity. In a first embodiment, the present invention relates to compounds derived from taurine, in which taurine is bound directly by mea... | 05/19/2011 |
| 20110092496 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 04/21/2011 | |
| 20110021528 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase act... | 01/27/2011 |
| 20110021771 | INHIBITORS OF HISTONE DEACETYLASE This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof... | 01/27/2011 |
| 20110009457 | Aminobenzamide Derivatives as Useful Agents for Controlling Animal Parasistes The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases... | 01/13/2011 |
| 20100297542 | SULPHONIUM SALT INITIATORS Compounds of the formula (I), wherein X is a single bond, CRaRb O, S, NRC, NCORC, CO, SO or SO2; L, L1, L2, L3, L4, L5, L6, L7 and L8... | 11/25/2010 |
| 20100280036 | Modulation of Pathogenicity The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I),
| |
| 20100273835 | NOVEL COMPOUNDS The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are des... | 10/28/2010 |
| 20100260778 | SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.... | 10/14/2010 |
| 20100261675 | FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upo... | 10/14/2010 |
| 20100261760 | EP2 Receptor Agonists The disclosure provides EP2 receptor agonist compounds and methods for using the compounds for treating conditions which can be alleviated by agonism of an EP2 receptor.... | 10/14/2010 |
| 20100240717 | NOVEL THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS The invention relates to thiophene derivatives of formula (I)/their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents wherein: A represents *—CO—CH═CH—, *—CO—CH2CH2 09/23/2010 | |
| 20100240911 | Process for the preparation of N-monosubstituted beta-amino alcohols A process for the preparation of a compound of formula: and/or an addition salt of a proton acid, which process comprises the following steps: | 09/23/2010 |
| 20100216849 | BIPHENYLCARBOXAMIDES This invention relates to novel biphenylcarboxamides of the formula (I)
| 08/26/2010 |
| 20100217008 | PROCESS FOR THE PREPARATION OF VALSARTAN AND INTERMEDIATE PRODUCTS The present invention relates to a new method for the production of valsartan, a valine derivative having the chemical N name is (S)—N-(1-carboxy-2-methylprop-1-yl)-N-pentanoyl-N-[2′-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]amine, and pharmacologically acceptable salt... | 08/26/2010 |
| 20100204487 | PROCESS FOR MAKING THIOPHENE CARBOXAMIDE DERIVATIVES The invention encompasses a process for making a thiophene carboxamide derivative, which is an EP4 antagonist useful for treating pain and inflammation.... | 08/12/2010 |
| 20100190779 | VIRAL POLYMERASE INHIBITORS Compounds of formula I: wherein X, R2, R3, R5 and R6 are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.... | 07/29/2010 |
| 20100173981 | THERAPEUTIC COMPOUNDS Disclosed herein is a compound according to one of the formulas or a pharmaceutically acceptable salt thereof, medicaments for the treatment of glaucoma or ocular hypertension and compositions related thereto, as further elaborated herein. ... | 07/08/2010 |
| 20100144785 | FUNGICIDE N-6-MEMBERED FUSED (HETERO) ARYL-METHYLENE-N-CYCLOALKYL CARBOXAMIDE DERIVATIVES The present invention relates N-(aromatic, 6-membered, fused, (hetero)aryl-methylene)-N-cycloalkyl carboxamide derivatives, their thiocarboxamide or N-substituted carboximidamide analogues, all of formula (I) wherein A represents a carbo-linked 5-membered heterocyclyl g... | 06/10/2010 |
| 20100137347 | SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS Disclosed herein is a compound of the formula (I). Therapeutic methods, compositions, and medicaments, related thereto are also disclosed. ... | 06/03/2010 |
| 20100137417 | Glucagon Receptor Antagonists, Preparation and Therapeutic Uses The present invention discloses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof which have glucagon receptor antagonist or inverse agonist activity, as well as methods of using these compounds and intermediates and methods for preparing such ... | 06/03/2010 |
| 20100137336 | NOVEL AMIDO DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—s... | 06/03/2010 |
| 20100137599 | PROCESS FOR PREPARING 1,4-BUTANDIOL MONITRATE The present invention relates to a process for the preparation of 1,4-butanediol mononitrate as intermediate for large scale preparation of high purity nitrooxybutyl ester of pharmaceutically active compounds.... | 06/03/2010 |
| 20100137291 | NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releas... | 06/03/2010 |
| 20100113477 | Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof The present invention provides aryl- or heteroaryl-diketo acid compounds effective to inhibit an activity of a Mycobacterial malate synthase enzyme or to inhibit a malate synthase activity in other bacteria having the enzyme. The compounds may be phenyl-naphthyl-, or th... | 05/06/2010 |
