Class 549/480 - Nitrogen bonded directly to the hetero ring

Subclass of Class 549 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein nitrogen is bonded directly to the hetero
No. of applications: 26
Last issue date: 01/26/2012

Application No.	Application Title	Issue Date
20120022116	COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysi...	01/26/2012
20120022100	ORGANIC COMPOUNDS Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising thes...	01/26/2012
20110178102	SIR2 REGULATION Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for...	07/21/2011
20110144321	SYNTHETIC INTERMEDIATES AND PROCESSES The invention provides novel synthetic intermediates and processes that can be used to prepare compounds of formula (I), wherein R¹has any of the values described herein and R²is a nucleoside sugar group. ...	06/16/2011
20110092564	CYCLIC AMINO ACIDS FOR THE TREATMENT OF PAIN Compositions comprising cyclic amino acids or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier. Said composition are for use in the treatment of pain. Pain includes both acute and chronic forms of pain. The preferred cyclic amino acid ...	04/21/2011
20100324046	4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing t...	12/23/2010
20100286415	SLEEP-IMPROVING AGENT The invention provides a sleep-improving agent and a sedative agent containing, as an active ingredient, oxypinnatanine or its derivative represented by the following chemical formula (I): ...	11/11/2010
20100280034	Modulation of pathogenicity The present invention relates to the use of compounds of the general Formula (XIII): whe...	11/04/2010
20100137401	2-METHYLPROP ANAMIDES AND THEIR USE AS PHARMACEUTICALS The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases ass...	06/03/2010
20100069484	SIGMA(s)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION The present invention involves new and original sigma receptors ligands : (Mono- or di-alkylaminoalkyl)-γ-butyrolactones, their analogues aminotetrahydrofuranes, the (1-adamantyl)phenyl(s) alkylamines, the N,N Dialkyl α-[(adamantyl-1)benzyloxy-2] alkylamines and the 3...	03/18/2010
20100063088	Raf Kinase Inhibitors Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se....	03/11/2010
20090170902	COMPOUNDS WHICH POTENTIATE GLUTAMATE RECEPTOR AND USES THEREOF IN MEDICINE Compounds of formula (I), salts and solvates thereof are provided: wherein Ar is selected from phenyl, pyridyl, furanyl and thienyl, each optionally substituted with one or more groups Y; and each Y group is ...	07/02/2009
20080261952	Aryl Urea Derivatives for Treating Obesity A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment....	10/23/2008
20080255377	Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives....	10/16/2008
20080108840	Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation ...	05/08/2008
20070238710	N-ARYL-N'ALKYL SULFAMIDES AS MEK INHIBITORS This invention concerns N-(ortho phenylaminoaryl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases....	10/11/2007
20070196340	Modulation of Pathogenicity The present invention relates to the use of compounds of the general Formula (XIII): wherein A⁷is C═...	08/23/2007
20070099959	O-Aminophenol derivatives and colorants containing these compounds The object of the present invention is novel o-aminophenol derivatives of Formula (I), or physiologically compatible water-soluble salts thereof, as well as an agent for the coloring of keratin fibers, especially of hair, which contains at least one o-aminophenol de...	05/03/2007
20070021427	Novel tricyclic derivatives and their use The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-inf...	01/25/2007
20060293328	Linear dicationic terphenyls and their aza analogues as antiparasitic agents Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues. ...	12/28/2006
20060276493	alpha- and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as-inhibitors of HIV protease. ...	12/07/2006
20060241301	Urea derivatives and their use as tyrosinkinase inhibitors The invention relates to novel urea derivatives which inhibit tyrosinkinases, especially TIE-2, and Raf kinases and which are used in the treatment of tumors. ...	10/26/2006
20060235035	Novel methoxybenzamibe compounds for use in mch receptor related disorders Novel compounds of Formula (I) which modulate MCH activity are disclosed, in which A is a linker; Ar₁is an aryl or heteroaryl group; R1 is a lower alkoxy group; R2 is an R1 group or hydrogen, an OH or an NH₂group, Q together with the carbonyl for...	10/19/2006
20060116377	Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses Novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups are disclosed. The novel compounds are used as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen species and/or excess Zn ions...	06/01/2006
20060041006	PDE4B inhibitors and uses therefor Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof. ...	02/23/2006
20050203135	Antagonists for treatment of CD/11CD18 adhesion receptor mediated disorders Compounds of the general structure D-L-B-(AA), for example (A), that are useful for treating Mac-1 or LFA-1-mediated disorders such as inflammatory disorders, allergies, and autoimmune diseases are provided. ...	09/15/2005

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Class 549/480 - Nitrogen bonded directly to the hetero ring