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| Application No. | Application Title | Issue Date |
| 20120129833 | CYCLIC KETOENOLS FOR THERAPY The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of diabetes, obesity, hyperlipidaemia, fatty livers and of disorders o... | 05/24/2012 |
| 20120083500 | OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X 2/3 ANTAGONISTS Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, R1, R2, R3, R4, R5, R6 and R7 are as defi... | 04/05/2012 |
| 20120041212 | PROCESS FOR THE PREPARATION OF PREGABALIN The present invention provides a new enantioselective method of preparing (S)-3-(aminomethyl)-5-methylhexanoic acid, commonly known as pregabalin. The invention also provides new chiral intermediates useful in the production of pregabalin.... | 02/16/2012 |
| 20110290418 | HYDROGEN PEROXIDE COMPLEXES AND THEIR USE IN THE CURE SYSTEM OF ANAEROBIC ADHESIVES Provided is a complex of hydrogen peroxide and at least one compound represented by Formula I: wherein X is: —C(R3)3, —C... | 12/01/2011 |
| 20110245223 | HETEROCYCLIC COMPOUNDS The present invention provides a compound represented by the following formula [1′] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, an... | 10/06/2011 |
| 20110245444 | TRANSFORMATION OF BIOMASS A method for processing biomass comprising heating an aqueous slurry comprising biomass, water and a phosphate catalyst in a pressure vessel at a temperature of about 150° C. to about 500° C. to produce a mixture comprising a dispersion of an organic phase and an aque... | 10/06/2011 |
| 20110218214 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insul... | 09/08/2011 |
| 20110213146 | Transition Metal-Catalyzed C-H Amination Using Unactivated Amines One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a reactive N—H bond, in the presence of an oxidizing agent and a metal-containi... | 09/01/2011 |
| 20110098302 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of P... | 04/28/2011 |
| 20110021779 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relat... | 01/27/2011 |
| 20100311794 | CYCLOALKYLCARBAMATE BENZAMIDE ANILINE HDAC INHIBITOR COMPOUNDS The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound. ... | 12/09/2010 |
| 20100286204 | COMPOUND CAPABLE OF INHIBITING 17-BETA HYDROXYSTERIOD DEHYDROGENASE There is provided a compound having Formula I wherein
| 11/11/2010 |
| 20100234365 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).... | 09/16/2010 |
| 20100222581 | NOVEL ISOPHTHALATES AS BETA-SECRETASE INHIBITORS There is provided a series of substituted isophthalates of formula (I) or a stereoisomer thereof; or a pharmaceutically acceptable salt thereof, wherein W, R3, R5 and R6 as de... | 09/02/2010 |
| 20100222326 | New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders The present invention relates to new compounds, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.... | 09/02/2010 |
| 20100184764 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as we... | 07/22/2010 |
| 20100168189 | THERAPEUTIC SUBSTITUTED LACTAMS Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.... | 07/01/2010 |
| 20100113460 | Organic Compounds Disclosed are compounds having the ability to inhibit cytochrome P450 2A6, 2A13, and/or 2B6 and tobacco products comprising them. Also disclosed are pharmaceutical compositions comprising them.... | 05/06/2010 |
| 20100113801 | Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the pre... | 05/06/2010 |
| 20100087506 | CYCLIC AMINE COMPOUND Provision of a compound having a superior androgen receptor regulating action. A compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom,... | 04/08/2010 |
| 20100069630 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.... | 03/18/2010 |
| 20100035948 | Furanone compounds and lactam analogues thereof The present invention provides a compound of formula I and a compound of formula II, methods of use and formulations thereof. ... | 02/11/2010 |
| 20090326240 | Iron-Copper Co-Catalyzed Process for Carbon-Carbon or Carbon-Heteroatom Bonding The present invention relates to a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the... | 12/31/2009 |
| 20090318708 | 2-Oxo-1-Pyrrolidine Derivatives, Processes For Preparing Them And Their Uses The present invention relates to optically enriched or substantially optically pure 4-substituted-pyrrolidin-2-ones of formula (III), and their uses for the synthesis of 2-oxo-pyrrolidin-1-yl derivatives. ... | 12/24/2009 |
| 20090264650 | Prophylactic/Therapeutic Agent for Diabetes The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, | 10/22/2009 |
| 20090239911 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as we... | 09/24/2009 |
| 20090215736 | CASPASE INHIBITORS AND USES THEREOF This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; | |
| 20090176799 | PHOSPHODIESTERASE 4 INHIBITORS Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the... | 07/09/2009 |
| 20090099182 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharma... | 04/16/2009 |
| 20090088579 | Production Method of N-Vinyl-2-Pyrrolidone High-purity NVP can be produced by comprising at least two crystallization processes and supplying the mother liquor from the first crystallization process to the second crystallization process. Further, high-purity NVP can be obtained cont... | 04/02/2009 |
| 20090012144 | Optically active 2,5-bisaryl-delta¹ -pyrrolines and their use as pest control agents Novel optically active Δ1-pyrrolines of the formula (I) in which
| 01/08/2009 |
| 20080312432 | Stabilizers for Use in Nvp Synthesis A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasi... | 12/18/2008 |
| 20080287522 | BENZYLATED PDE4 INHIBITORS The present invention is directed to a method for reducing the emetogenic effects of PDE inhibitors, and more particularly is directed to compounds having PDE4 inhibition activity with little or no emetogenic side-effects, and chemical methods including benzylation for ... | 11/20/2008 |
| 20080287516 | Phenyl-Substituted Pyrrolidones The present invention relates to phenyl-substituted pyrrolidones and compounds related to phenyl-substituted pyrrolidones. One use of these compounds is for the inhibition of viruses, e.g., HIV. The invention further relates to methods of malting these compounds, method... | 11/20/2008 |
| 20080275043 | Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as we... | 11/06/2008 |
| 20080255136 | PYRROLIDONES WITH ANTI-HIV ACTIVITY The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a ce... | 10/16/2008 |
| 20080214836 | Process for the synthesis of lauryllactam (L12) by gas phase catalytic rearrangement of cyclododecanone oxime The present invention relates to a process for the preparation of lauryllactam in which a Beckmann rearrangement of cyclododecanone oxime is carried out. Said process is carried out in the gas phase at a temperature of between 180 and 450° C. in the presence of a micro... | 09/04/2008 |
| 20080214621 | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmace... | 09/04/2008 |
| 20080207686 | Peptide Deformylase (Pdf) Inhibitors 4 The present invention relates to compounds of formula (I). These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new antibiotics.... | 08/28/2008 |
| 20080188520 | Substituted heterocycles, their use as medicament, and pharmaceutical preparations comprising them The invention relates to compounds of formula I in which A, R1, R2, R3, R4, R5, R6, R7 and n have the meanings stated in the claims. The compounds are particularly suitable as antiarrhythmic active ingredient... | 08/07/2008 |
