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Class 548/321.1 - Benzene ring bonded directly to the diazole ring


Subclass of Class 548 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the diazole ring is bonded directly to
No. of applications: 20
Last issue date: 04/05/2012


Application No.Application TitleIssue Date
20120082646Antiviral Compounds And Uses Thereof
This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compou...
04/05/2012
20110263664Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer
The disclosure relates to inhibitors of Pim-1 and/or Pim-2 protein kinase, to compositions comprising one or more inhibitors of Pim-1 and/or Pim-2 protein kinase, and to methods for treating cancer....
10/27/2011
20110251165DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE BETA2 ADRENERGIC RECEPTOR
The present invention provides a compound of formula (I) wherein: R1 is a group selected from —CH2OH, —NHC(O)H and R2 is a hydrogen atom; or R1 together with R2 form the group —NH—C(O)—CH═CH— wherein t...
10/13/2011
20110178134Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof
The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome....
07/21/2011
20110130391UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions....
06/02/2011
20110112097Substituted imidazoline-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof
The invention relates to compounds of formula (I) wherein the groups R and R′, A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

05/12/2011
20110086818METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS
The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while minimizing effects on non-pain-sensing neurons or other types of cells....
04/14/2011
20110046185Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof
The invention relates to compounds of formula (I) wherein the groups R and R′ A, D, E, G, L, p and R1 to R10 have the stated meanings and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs.

02/24/2011
20110039109ACTIVATOR FOR EPOXY RESIN COMPOSITIONS
Activators for heat-curing epoxy resin compositions, as well as use thereof in heat-curing epoxy resin compositions. These activators are distinguished by a good activation effect as well as good storage stability....
02/17/2011
20110021573ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of P...
01/27/2011
20100330032HETEROCYCLIC ANTIVIRAL COMPOUNDS
Compounds having the formula I wherein R1, R2, R3, R4, and R5 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inh...
12/30/2010
20100210699IMIDAZOLIDINE DERIVATIVES, USES THEREFOR, PREPARATION THEREOF AND COMPOSITIONS COMPRISING SUCH
Compounds of formula (I):

wherein

  • X is O or S,
  • R1 is acyl, aldehyde, cycloalkyl, an o...
08/19/2010
20100203135Skin Equivalent Culture
Methods of forming soft connective tissue compositions such as skin equivalents, compositions made by the methods and their uses. In particular, a method of forming a connective tissue equivalent, comprising the steps of: (i) incubating collagen-producing cells in or on...
08/12/2010
20100068786METHODS AND COMPOSITIONS FOR REVERSING P-GLYCOPROTEIN MEDICATED DRUG RESISTANCE
A method for inhibiting therapeutic drug resistance within a cell over-expressing a membrane protein is provided. The method comprises synthesizing a dimeric prodrug inhibitor of a monomeric therapeutic agent; administering the dimeric prodrug inhibitor to the membrane ...
03/18/2010
20100063120Imidazolidine Derivatives, Uses Therefor, Preparation Thereof and Compositions Comprising Such
Compounds of formula (I): wherein X is O or S, R1 is acyl, aldehyde, cycloalkyl, an optionally substituted alkyl, alkenyl or alkynyl, R2 is H. alkyl, hydroxyalkyl, haloalkyl, alkenyl, or alkynyl; substituted alkyl; alkylcarbonyl; R3 and ...
03/11/2010
20090215728Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
This invention relates to arylaminoaryl-alkyl-substituted imidazolidone-2,4-diones of formula (I) and also to their physiologically tolerated salts:

Wherein R, R′, R1 to R10, A, D, E, G, L and p are as defi...

08/27/2009
20090111864DIARYLHYDANTOIN COMPOUNDS
The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer....
04/30/2009
20090030056NOVEL SODIUM CHANNEL BLOCKERS
The present invention is directed to novel phenyloin derivative compounds and the use of such compounds as sodium channel blockers. Such compositions have utility as anti-cancer agents and can be used to limit or prevent PCa growth and/or metastasis....
01/29/2009
20080275233UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE
The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions....
11/06/2008
20080176862New Compounds 617
This invention relates to novel compounds having the structural formula I below:

and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or pr...

07/24/2008
 
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