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| Application No. | Application Title | Issue Date |
| 20120022254 | SIRTUIN MODULATING COMPOUNDS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 01/26/2012 |
| 20110263662 | 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists. 10/27/2011 | |
| 20110150827 | 5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS Provided herein are 5,5-fused heteroarylene hepatitis C virus inhibitor compounds, for example, of Formula I, IA, or IB, pharmaceutical compositions comprising the compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment ... | 06/23/2011 |
| 20110065728 | LIPOPROTEIN LIPASE-ACTIVATING COMPOSITIONS COMPRISING BENZENE DERIVATIVES The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the li... | 03/17/2011 |
| 20110009461 | 2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as... | 01/13/2011 |
| 20110003806 | Heteroaryls and uses thereof This invention provides compounds of formula IA or IB: wherein R1, R2, G1 and HY are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and ar... | 01/06/2011 |
| 20100292206 | HETEROCYCLIC COMPOUND The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophy... | 11/18/2010 |
| 20100261758 | HETEROCYCLIC AMIDES FOR USE AS PHARMACEUTICALS Compounds of Formula (I) wherein R1 is aryl, cyclohexyl or heterocyclyl, or (C1-4)alkyl substituted by aryl, cyclohexyl or heterocyclyl, R2 is defined heterocyclyl, R3 is alkyl, aryl, cyclohexyl or heterocyclyl, or (C1-4<... | 10/14/2010 |
| 20100152192 | FUSED IMIDAZOLE CARBOXAMIDES AS TRPV3 MODULATORS The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are pro... | 06/17/2010 |
| 20100076036 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS The present invention relates to heterocyclyl-substituted sulfonamides with 5-HT6 receptor affinity, and compositions thereof, and the use of said compounds for the treatment or prophylaxis of various disorders.... | 03/25/2010 |
| 20100069378 | SUBSTITUTED INDANYL SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals composition which they are made up of. The new compounds of formula (I) show aff... | 03/18/2010 |
| 20100004299 | Imidazo[2,1-b]thiazoles and their use as pharmaceuticals The present invention relates to derivatives of imidazo[2,1-b]thiazoles of formula I, in which R, R1 to R3 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitr... | 01/07/2010 |
| 20090312310 | Imidazothiazole derivatives There is provided a novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity. The present invention provides an imidazothiazole derivative represented by the following formula (1) having vari... | 12/17/2009 |
| 20090291948 | SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula 11/26/2009 | |
| 20090142347 | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification This invention relates generally to the field of mineralization, and specifically to the role of TNAP in regulating the levels of extracellular inorganic pyrophosphate. The invention provides methods for modulating the activity of TNAP activity; methods for screening fo... | 06/04/2009 |
| 20090011975 | TARGETED BONE MARROW PROTECTION AGENTS The invention provides a method of inhibiting cell death in a mammal. The method comprises administering to a mammal an effective amount of a composition comprising a cell protection factor covalently linked to a bone targeting agent via a linkage that is cleaved under ... | 01/08/2009 |
| 20090005399 | Substituted Imidazo[2,1-b]thiazole Compounds and Uses Thereof Substituted imidazo[2,1-b]thiazole compounds corresponding to formula I, a method for producing them, pharmaceutical compositions containing them, and the use thereof for regularing mGluR5 receptors, or for t... | 01/01/2009 |
| 20080287511 | Anthelmintic Imidazol-Thiazole Derivates The present invention relates to the novel anthelmintic compound tetrahydro-furan-2-carboxylic acid-[3-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide and the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, ... | 11/20/2008 |
| 20080167475 | Intermediates of 2-substituted carbapenem derivatives and process for production thereof The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe a... | 07/10/2008 |
| 20080161341 | Novel imidazothiazoles and imidazoxazoles The present invention is directed to novel compounds of formula (I) wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in tre... | 07/03/2008 |
| 20070241670 | Organic materials with phosphine sulfide moieties having tunable electric and electroluminescent properties A material comprising one or more phosphine sulfide moieties, the phosphorus atom of each of said phosphine moieties bonded by single bonds to at least two outer groups. The material is substantially purified and configured as part of a circuit. The material is preferab... | 10/18/2007 |
| 20060079520 | Sulfonamide peri-substituted bicyclics for occlusive artery disease Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is: ... | 04/13/2006 |
