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| Application No. | Application Title | Issue Date |
| 20120129879 | Compounds and Compositions for Use in Phototherapy and in Treatment of Ocular Neovascular Disease and Cancers The invention relates generally to anti-angiogenesis agents and related methods of using to anti-angiogenesis agents for biomedical applications including direct monotherapy and combination therapy for treatment of an angiogenesis related condition. In an embodiment, th... | 05/24/2012 |
| 20120029007 | MORPHINAN COMPOUNDS This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are ... | 02/02/2012 |
| 20110306603 | LARGE SUBSTITUENT, NON-PHENOLIC OPIOIDS AND METHODS OF USE THEREOF 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.... | 12/15/2011 |
| 20110257214 | MORPHINAN COMPOUNDS This invention relates to novel morphinan compounds and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are ... | 10/20/2011 |
| 20110243889 | OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are not limited to, use for the prevention and treatment of septic shock and oth... | 10/06/2011 |
| 20110230511 | CARBOXAMIDE BIOISOSTERES OF OPIATES A compound of formula I is disclosed. Compounds of formula I are useful as analgesics, anti-inflammatory agents, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.... | 09/22/2011 |
| 20110212173 | Controlled Release Treatment of Depression There is described a pharmaceutical composition for controlled release of an active compound wherein the active compound is selected from the group comprising tramadol, resveratrol, acetaminophen, xorphanol, cinfenoac, furcloprofen, bismuth subsalicylate, enofelast, tri... | 09/01/2011 |
| 20110206780 | MORPHINAN MODULATORS OF NMDA RECEPTORS, SIGMA1 RECEPTORS, SIGMA2 RECEPTORS, AND/OR A3B4 NICOTINIC RECEPTORS The present invention relates to new morphinan modulators of NMDA receptors, σ1 receptors, σ2 receptors, and/or α3β4 nicotinic receptors, pharmaceutical compositions thereof, and methods of use thereof. ... | 08/25/2011 |
| 20110190267 | PRODRUGS OF OPIOIDS AND USES THEREOF The present invention concerns prodrugs of opioid analgesics and pharmaceutical compositions containing such prodrugs. Methods for providing more consistent pain relief by increasing the bioavailability of the opioid analgesic with the aforementioned prodrugs are provid... | 08/04/2011 |
| 20110112130 | Opioid-Nornicotine Codrugs Combinations for Pain Management The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic a... | 05/12/2011 |
| 20110112131 | Opioid-Ketamine and Norketamine Codrug Combinations for Pain Management The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and ketamine or norketamine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a s... | 05/12/2011 |
| 20110071296 | Preparation of 10-Keto Morphinans by Benzylic Oxidation The present invention provides processes for the preparation of 10-keto and/or 10-hydroxy morphinans. In particular, the invention provides to processes for preparing a 10-keto morphinan by chromium-catalyzed benzylic oxidation of a morphinan with a periodic acid.... | 03/24/2011 |
| 20110065743 | KAPPA OPIOID RECEPTOR LIGANDS Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such a... | 03/17/2011 |
| 20110015219 | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as a method for identifying (+)-morphinans that may be therapeutically effective by determining whether the (+)-morphinan inhibits the activation of TLR9. A... | 01/20/2011 |
| 20100317858 | METAL COORDINATION COMPOUND AND LIGHT-EMITTING MATERIAL CONTAINING THE SAME To provide a light-emitting device that is capable of red-light-emitting with high luminance and high efficiency and that is excellent in endurance; and a metal coordination compound metal coordination compound having a partial structure represented by formula (1) that ... | 12/16/2010 |
| 20100317861 | Remove Amination of 6-Keto Normorphinans by Catalytic Hydrogen Transfer The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.... | 12/16/2010 |
| 20100210843 | Process for the Reductive Alkylation of Normorphinans The invention provides a process for the N-alkylation of normorphinan compounds to produce N-alkylated morphinan compounds. In particular, the process relates to the alkylation of a normorphinan compound by a carboxaldehyde in the presence of a reducing agent to form an... | 08/19/2010 |
| 20100190817 | LARGE SUBSTITUENT, NON-PHENOLIC AMINE OPIOIDS 8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications.... | 07/29/2010 |
| 20100120813 | PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof.... | 05/13/2010 |
| 20100113500 | ORALLY BIOAVAILABLE PRODUCTS OF (+)-3-HYDROXYMORPHINAN FOR PARKINSON'S DISEASE PREVENTION OR TREATMENT The present invention is directed to a novel prodrug of (+)-3-hydroxymorphinan compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for preparing the same, and its use for preventing or treating Parkinson's disease.... | 05/06/2010 |
| 20100099699 | PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF The present invention provides a compound of formula I: wherein X−, R1, and R2 are as defined herein, and compositions thereof, useful as a peripheral mu opioid receptor ant... | 04/22/2010 |
| 20100081819 | Processes for the synthesis of tertiary amines The invention provides processes for the preparation of morphinans having a tertiary amine. In particular, the present invention provides processes for the formation of tertiary amine alkaloids by direct N-alkylation of secondary amine alkaloids, the processes co-mediat... | 04/01/2010 |
| 20100081817 | Processes for the selective amination of ketomorphinans The present invention is generally directed to a process for the preparation of a ketomorphinan comprising maintaining a ketone group as unprotected and performing reductive amination using a hydrogen source and a catalyst.... | 04/01/2010 |
| 20100069639 | Processes for the Synthesis of Five and Six Membered Heterocyclic Rings The present invention provides processes for the synthesis of five and six membered rings. In particular, the present invention provides processes for the synthesis of five and six membered rings in alkaloids.... | 03/18/2010 |
| 20100068786 | METHODS AND COMPOSITIONS FOR REVERSING P-GLYCOPROTEIN MEDICATED DRUG RESISTANCE A method for inhibiting therapeutic drug resistance within a cell over-expressing a membrane protein is provided. The method comprises synthesizing a dimeric prodrug inhibitor of a monomeric therapeutic agent; administering the dimeric prodrug inhibitor to the membrane ... | 03/18/2010 |
| 20100048906 | Preparation of Substituted Morphinan-6-Ones and Salts and Intermediates Thereof The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.... | 02/25/2010 |
| 20100035826 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.... | 02/11/2010 |
| 20100009927 | Anti-Inflammatory and Anti-Allergy Extracts from Nettle The present invention relates in part to nettle extracts that are useful for treating or preventing seasonal allergies, allergic rhinitis, and other inflammatory conditions.... | 01/14/2010 |
| 20090270624 | PROCESS FOR PURIFYING NOROXYMORPHONE COMPOUNDS A process for purifying plant extracts which consist essentially of noroxymorphone compounds and which comprise, as impurities, α,β-unsaturated noroxymorphone compounds, by (a) converting the plant extract or the product of a subsequent stage in the synthesis of a sel... | 10/29/2009 |
| 20090197905 | QUATERNARY OPIOID CARBOXAMIDES Compounds of formulas: are disclosed. The compounds are useful for ameliorating the side effects of therapeutic opiates.... | 08/06/2009 |
| 20090176818 | Antitussive Agent An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic substituent or a pharmaceutically acceptable acid addition salt thereo... | 07/09/2009 |
| 20090156816 | Sinomenine derivatives and processes for their synthesis The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates.... | 06/18/2009 |
| 20090143417 | METHODS OF TREATING PAIN The present invention is directed to methods and compositions for inducing, promoting or otherwise facilitating pain relief. More particularly the present invention discloses the combination of a nitric oxide donor and an opioid analgesic in the therapeutic management o... | 06/04/2009 |
| 20090048447 | METHOD FOR DECREASING OPIOID METABOLISM 8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is —CH2OH, —CH2NH2, —NHSO2CH3, Q is O or S and Y is O, S or NOH are usef... | 02/19/2009 |
| 20090005563 | CONVERSION OF THEBAINE TO MORPHINE DERIVATIVES The present invention provides methods for the conversion of thebaine to a morphine derivative, such as hydrocodone. Novel ketal intermediates of the conversion are provided. A one-pot procedure for the conversion comprises treating thebaine with an acid in the presence... | 01/01/2009 |
| 20080318966 | Sinomenine Derivatives and Preparation and Uses Thereof The present invention relates to the preparation and pharmacological use of sinomenine derivatives of formula I. The approach disclosed herein is the modification of D ring by-substituting for R. Additional substitutions in the other rings are also provided herein. Seve... | 12/25/2008 |
| 20080292585 | Azonafide Derivatives, Methods for Their Production and Pharmaceutical Compositions Therefrom Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmace... | 11/27/2008 |
| 20080280936 | Morphinan Compounds This disclosure relates to novel morphinan compounds and their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods... | 11/13/2008 |
| 20080262231 | Processes for Preparing Morphinans and Intermediates Thereof The present invention is directed to processes for the synthesis of morphinans. In particular, a process for cyclizing a β,γ-bicyclic ketone compound to form a nordihydrothebainone product using the Grewe cyclization reaction is improved by forming a reaction mixture ... | 10/23/2008 |
| 20080233606 | USE OF RAMAN SPECTROSCOPY IN ENZYME ACTIVITY ASSAYS Provided herein are assays for detecting enzyme activity using Raman Spectroscopy.... | 09/25/2008 |
