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| Application No. | Application Title | Issue Date |
| 20120108602 | Carbamoyl Compounds as DGAT1 Inhibitors 190 DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity
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| 20120107902 | Processes For Forming Amide Bonds And Compositions Related Thereto The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed... | 05/03/2012 |
| 20120053300 | FUNCTIONALIZED POLYSULFIDE SILICA COUPLING AGENTS AND SILICA REINFORCED RUBBER COMPOSITION FOR TIRE COMPONENTS The invention relates to functionalized polysulfide silica coupling agents and silica reinforced rubber compositions. Such rubber composition may be used, for example, for tire components such as, for example, tire treads.... | 03/01/2012 |
| 20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the ... | 12/15/2011 |
| 20110306597 | Nicotinamide Derivatives The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the treatment of allerg... | 12/15/2011 |
| 20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compou... | 12/01/2011 |
| 20110294858 | SUBSTITUTED 6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the c... | 12/01/2011 |
| 20110288076 | Sphingosine-1-Phosphate Receptor Antagonists This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1-pho... | 11/24/2011 |
| 20110275797 | N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl group or the like; R2... | 11/10/2011 |
| 20110275603 | NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS The present invention provides dihydroorotate dehydrogenase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders wherein the inhibition of Dihydroorotate dehy... | 11/10/2011 |
| 20110275615 | NOVEL SUBSTITUTED AMIDES, THEIR PREPARATION AND USE An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meani... | 11/10/2011 |
| 20110269709 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable c... | 11/03/2011 |
| 20110269722 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable c... | 11/03/2011 |
| 20110263659 | Analogs of 1-Methylnicotinamide The present invention is directed to derivatives and analogs of 1-methyl-nicotinamide useful for elevating the blood levels of 1-methylnicotinamide or deuterated species in a subject.... | 10/27/2011 |
| 20110262025 | Cosmetic Compositions and Methods for Maintaining and Improving Barrier Function of the Stratum Corneum and to Reduce the Visible Signs of Aging in Skin Gene panels, biomarker panels and microarrays relating to lipid formation in stratum corneum of human skin as a function of extrinsic and/or intrinsic aging conditions, and methods for assessing the age status of human skin, methods for identifying or evaluating an agen... | 10/27/2011 |
| 20110263626 | NOVEL BRADYKININ B1-ANTAGONISTS The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined... | 10/27/2011 |
| 20110224156 | Propionic Acids, Propionic Acid Esters, and Related Compounds The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, including but not limited to disease... | 09/15/2011 |
| 20110201603 | Novel Acylaminobenzamide Derivatives The present invention relates to novel Acylaminobenzamide derivatives represented by the following formula (I) and use thereof as pesticides: wherein V represents an aromatic ring group of V1 to V5 described in the detailed description, Q represents an aromatic ring gro... | 08/18/2011 |
| 20110178102 | SIR2 REGULATION Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for... | 07/21/2011 |
| 20110178104 | Anti-Heparin Compounds The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a ... | 07/21/2011 |
| 20110158947 | SULFONYLUREA RECEPTOR AND MEANS FOR TREATING ISCHAEMIA We disclose agents useful in the treatment of diseases or conditions that would benefit from improved muscle function and including pharmaceutical compositions and diagnostic tests for determining the predisposition of a subject, in particular a male subject, to cardiov... | 06/30/2011 |
| 20110144052 | NIACIN PRODRUGS AND DEUTERATED VERSIONS THEREOF The invention relates to prodrugs of niacin and their use in pharmaceutical composition and therapeutic treatment of disease.... | 06/16/2011 |
| 20110136831 | N-2-(Hetero)Arylethylcarboxamide Derivative, and Pest-Controlling Agent Comprising the Same An N-2-(hetero)arylethylcarboxamide derivative represented by the formula (I) wherein R1 and R2 are each independently a hydrogen atom etc., R3 and R4 are each inde... | 06/09/2011 |
| 20110136877 | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS The present invention provides novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. The compounds are of the general formula (I): ... | 06/09/2011 |
| 20110136792 | NOVEL CARBOXYLIC ACID ANALOGS AS GLYCOGEN SYNTHASE ACTIVATORS Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceu... | 06/09/2011 |
| 20110105760 | Method for Producing Aminobiphenylene The present invention relates to a process for preparing substituted 2-aminobiphenyls and to a process for preparing (Het)arylamides of such 2-aminobiphenyls.... | 05/05/2011 |
| 20110105532 | Haloalkyl-substituted amides as insecticides and acaricides The present invention relates to halogen-substituted amide derivatives of the general formula (I) in which R1 to R6, Q1 to Q8, A, V, W, X, Y, n and m are each defin... | 05/05/2011 |
| 20110092536 | NOVEL ANTI-INFECTIOUS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES OF SAID DERIVATIVES IN TREATMENT The invention relates to bi-substrate inhibitor molecules associating (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also relates to the me... | 04/21/2011 |
| 20110092695 | CELL CULTURE MODEL FOR ACQUIRED CHEMORESISTANCE OF CHRONIC MYELOGENOUS LEUKEMIA AND RELATED METHODS FOR IDENTIFYING AGENTS TO OVERCOME RESISTANCE A method of generating a chronic myelogenic leukemia (CML) acquired chemoresistant culture model is provided. Such a method may comprise providing a naïve blast crisis CML cell line; administering/contacting the cell line with a mutation-inducing dose of imatinib; main... | 04/21/2011 |
| 20110082177 | N'-NITROXYALKYLNICOTINAMIDES FOR THE TREATMENT OF CARDIOVASCULAR DISEASES The invention relates to the novel N′-nitroxyalkylnicotinamide derivatives represented by the general formula I wherein R1 is C1-C4 alkyl; R2 is hydrogen. C1-C4 alkyl, CH2OH or CH2... | 04/07/2011 |
| 20110077395 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenas... | 03/31/2011 |
| 20110071197 | BIS-ARYL COMPOUNDS FOR USE AS MEDICAMENTS There is provided compounds of formula I, wherein ring A, D1, D2a, D2b, D3, L1, Y1, L3 and Y3 have meanings given in the description, and pharmaceutically-acceptable salts thereof, w... | 03/24/2011 |
| 20110059950 | ANILINE DERIVATIVE HAVING ANTI-RNA VIRAL ACTIVITY Viruses, and particularly RNA viruses, have high mutation rates. Hence, antiviral agents that have been developed to date targeting protease or reverse transcriptase of viruses have quickly lost their effectiveness and resistant viruses have emerged. Also, in recent yea... | 03/10/2011 |
| 20110053990 | FATTY ACID NIACIN CONJUGATES AND THEIR USES The invention relates to fatty acid niacin conjugates; compositions comprising an effective amount of a fatty acid niacin conjugate; and methods for treating or preventing an metabolic disease comprising the administration of an effective amount of a fatty acid niacin c... | 03/03/2011 |
| 20110054183 | Method For Manufacturing Aryl Carboxamides A process for preparing arylcarboxamides of the formula (I) where Ar =a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from haloge... | 03/03/2011 |
| 20110034378 | Pharmaceutical Combinations Comprising Specified Age Breaker and Further Drugs, I.A. Antihypertensive Drugs, Antidiabetic Drugs Etc. The present invention relates to a combination, such as a combined preparation or pharmaceutical composition comprising: (a) compound of formula (I), and/or (II) or a pharmaceutically acceptable salt thereof; (b) at least one therapeutic agent selected from the group co... | 02/10/2011 |
| 20110021528 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase act... | 01/27/2011 |
| 20110009457 | Aminobenzamide Derivatives as Useful Agents for Controlling Animal Parasistes The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases... | 01/13/2011 |
| 20110009622 | LONG-CHAIN FATTY ACYL ELONGASE INHIBITOR COMPRISING ARYLSULFONYL DERIVATIVE AS ACTIVE INGREDIENT [Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides. 01/13/2011 | |
| 20110009631 | Phenethanolamine Derivatives for Treatment of Respiratory Diseases Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases.... | 01/13/2011 |
