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| Application No. | Application Title | Issue Date |
| 20120083602 | BENZAMIDES AND RELATED INHIBITORS OF FACTOR XA Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compo... | 04/05/2012 |
| 20120071519 | CRYSTALLINE FORMS OF A FACTOR Xa INHIBITOR Provided herein are crystalline forms of a maleate salt of betrixaban, compositions and methods of preparation or use thereof.... | 03/22/2012 |
| 20120071662 | PREPARING AMINOARYLALKYL COMPOUNDS The invention relates to a process for preparing aminoarylalkyl compounds, more particularly 5-amino-2-isopropylpyridine.... | 03/22/2012 |
| 20120053170 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS The present invention relates to nicotinamide derivatives of formula (I), to compositions containing same, and to the therapeutic use thereof, in particular as anticancer drugs. The invention also relates to the method for preparing said compounds, as well as to some of... | 03/01/2012 |
| 20120046250 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.... | 02/23/2012 |
| 20120041201 | METHOD FOR PRODUCING FLUORINE-CONTAINING POLYETHER CARBOXYLIC ACID AMIDE A fluorine-containing polyether carboxylic acid amide represented by the general formula: CnF2n+1O(C3F6O)mRfCONHAr, wherein Rf is a fluorocarbon group having 1 to 2 carbon atoms, Ar is a nitrogen-containing heterocy... | 02/16/2012 |
| 20120041206 | PROCESS FOR PRODUCING DIAMINE DERIVATIVE The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a process for industrially producing a compound (1) represented by the following formula (1): | 02/16/2012 |
| 20120028977 | Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, e... | 02/02/2012 |
| 20120022258 | Novel Processes for the manufacture of Propane-1-sulfonic acid -amide According to the present invention there are provided novel processes for the manufacture of the compound of formula 1 as well as intermediates and novel synthesis routes for key intermediates used in those p... | 01/26/2012 |
| 20120015943 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF This invention provides compounds of formula (I):
| 01/19/2012 |
| 20120004228 | Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors There is provided compounds of formula I, wherein Y, ring A, Da, Db, D2, D3, L1, Y1, L2, Y2, L3 and Y3 <... | 01/05/2012 |
| 20110319454 | DERIVATIVES OF CYCLOALKYL- AND CYCLOALKENYL-1,2-DICARBOXYLIC ACID COMPOUNDS HAVING FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) AGONIST OR ANTAGONIST ACTIVITY The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.... | 12/29/2011 |
| 20110319627 | METHODS OF SYNTHESIZING FACTOR Xa INHIBITORS Described herein are novel methods of preparing a compound of Formula II or a pharmaceutically acceptable salt thereof. In some embodiments, the method is for preparing betrixaban or a pharmaceutically acceptable salt thereof. Also described are compositions comprising ... | 12/29/2011 |
| 20110301179 | NAPHTHAMIDES AS ANTICANCER AGENTS A compound (particularly useful for inhibiting cancer) according to formula I:
| 12/08/2011 |
| 20110295018 | PROCESS FOR THE MANUFACTURE OF AN INTERMEDIATE IN THE SYNTHESIS OF DABIGATRAN The invention relates to a process for the synthesis of the diamine of formula (1) an important intermediate in the synthesis of dabiagtran etexilate. ... | 12/01/2011 |
| 20110263556 | New Compounds This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medi... | 10/27/2011 |
| 20110224266 | 4 AMINOPYRIDINE AND A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF NEURONAL DISORDERS A composition is provided having the formula where R1 in each occurrence is independently H or a C1-C4 hydrocarbon; R3 is H, and R4 is a moiety capable o... | 09/15/2011 |
| 20110224225 | Inhibitors of protein kinases Compounds of general Formula (I): wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dep... | 09/15/2011 |
| 20110213157 | TRICYCLIC AMIDE COMPOUND A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH... | 09/01/2011 |
| 20110190282 | NOVEL VEGF-2 RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF The invention relates to compounds of general formula (I) wherein W, D, E, G, J, L, R1, R2, R3, R4, R5 and Y are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alo... | 08/04/2011 |
| 20110190256 | Amine and Ether Compounds Which Modulate The CB2 Receptor Compounds which modulate the CB2 receptor are disclosed. The compounds are useful for treating CB2 receptor-mediated diseases such as pain.... | 08/04/2011 |
| 20110184032 | Novel Phenylamino Isonicotinamide Compounds The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.... | 07/28/2011 |
| 20110178087 | Compositions and Their Use as Anti-Tumor Agents The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but ... | 07/21/2011 |
| 20110166161 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS This invention relates to novel heterocyclic carboxamide derivatives and salts thereof. More particularly, it relates to novel heterocyclic carboxamide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and t... | 07/07/2011 |
| 20110160163 | INHIBITORS OF p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to inhibitors of ZAP70. The invention also relates to methods for producing these inh... | 06/30/2011 |
| 20110160211 | CYCLOPENTYLACRYLAMIDE DERIVATIVE A compound having a hypoglycemic effect is provided. The compound and a pharmaceutically acceptable salt thereof are useful for the treatment or prevention of diabetes, obesity, and the like. The compound is represented by the general formula (1): | 06/30/2011 |
| 20110152175 | DENDRIMERIC COMPOUNDS COMPRISING AMINO ACIDS, HYPERBRANCHED CORE COMPOUND, PROCESS FOR PREPARATION OF DENDRIMERIC COMPOUNDS COMPRISING AMINO ACIDS AND HYPERBRANCHED CORE COMPOUND, AND USE THEREOF The invention provides dendrimeric compounds of the formula 1 comprising amino acids, wherein n is an integer of 1-4, T is an alkylidene —(CH2)2CONH(CH2)2- group, R2 is an —NH2 group or a moiety of a primary organic amine, and P is an amino acid and/or peptide moiet... | 06/23/2011 |
| 20110152323 | Histone deacetylase inhibitors and uses thereof The present invention discloses a group of histone deacetylase inhibitors and use thereof. The histone deacetylase inhibitors are useful in the treatment of malignant tumors and the diseases associated with differentiation and proliferation. The histone deacetylase inhi... | 06/23/2011 |
| 20110130431 | Compounds Which Modulate The CB2 Receptor Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those comp... | 06/02/2011 |
| 20110124875 | IMINOPYRIDINE DERIVATIVES AND USES THEREOF The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. | 05/26/2011 |
| 20110124874 | IMINOPYRIDINE DERIVATIVES AND USE THEREOF The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. | 05/26/2011 |
| 20110105571 | Opioid Receptor Antagonists A compound of the formula (I) wherein the variables X1, X2, B, D, R1 to R7 including R3′, p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtur... | 05/05/2011 |
| 20110105530 | ORGANIC COMPOUNDS The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also enco... | 05/05/2011 |
| 20110098325 | PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyridine benzamide and pyrazine benzamide compounds (referred to herein as PDBA and PZBA compounds) which, inter alia, inhibit protein kinase D (PKD) (e.g., ... | 04/28/2011 |
| 20110082299 | METHOD FOR THE PREPARATION OF DABIGATRAN A method for the manufacture of dabigatran of formula VIII, in which the product of a reaction of 4-ethylamino-3-nitrobenzoic acid chloride with ethyl-3-(pyridin-2-ylamino)propanoate, is converted to the hydrochloride using a hydrogen chloride solution producing the com... | 04/07/2011 |
| 20110065717 | SULFOXIMINE DERIVATIVES AS FACTOR XA INHIBITORS The present invention relates to novel substituted sulfoximine derivatives of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, methods for their preparation, use o... | 03/17/2011 |
| 20110053958 | MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO The present invention relates to amide derivatives of Formula (XIIIa) and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in th... | 03/03/2011 |
| 20110052552 | COMPOSITIONS TO EFFECT NEURONAL GROWTH Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed... | 03/03/2011 |
| 20110053939 | NOVEL AROMATIC NITRO COMPOUNDS Pharmaceutical compositions comprising at least one compound of e.g. the formulas (Ie) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents have the following meaning—X— is e.g. and Y is e.g. or the pharmaceuti... | 03/03/2011 |
| 20110039846 | IMINOPYRIDINE DERIVATIVES AND USE THEREOF The present invention aims to provide an iminopyridine derivative compound having an α1D adrenergic receptor antagonistic action, which is useful as an agent for the prophylaxis or treatment of a lower urinary tract disease and the like. The present invention provides ... | 02/17/2011 |
