"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
|Application No.||Application Title||Issue Date|
Compounds of Formula (I)
are effective in the treatment of a microbial infection....
|20100193774||Quinoid Compounds and Their Use in Semiconducting Matrix Materials, Electronic and Optoelectronic Structural Elements|
The invention relates to quinoid compounds and their use in semiconductive matrix materials, electronic and optoelectronic structural elements....
[Solving Means] The present inventors have conducted extensive studies on an EP4 receptor agonist, and as a result, found that a novel pyridone compound characterized in that the 1-position in the pyridone ring is substituted with a group having an acidic group such as ...
The invention relates to the novel chemical compounds of the formula (I): (I) in free or salt form, its use in the treatment of NET and/or SERT mediated conditions, e.g., depression, vasomotor symptoms, e.g., hot flashes and other diseases or conditions mediated by NET ...
|20100168426||NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES|
The present application relates to a new process for the asymmetric production of 3-(pyridin-4-yl)-3-hydroxy-pentanoic acid derivatives, which are useful intermediates in the manufacture of compounds that are known to show antiproliferative activity....
The present invention relates to processes for preparing certain 2-pyridones and 2-pyridinols, to novel compounds of these two types and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection, in the medici...
|20100137376||AMIDE COMPOUND AND METHOD FOR CONTROLLING PLANT DISEASE USING THE SAME|
Disclosed is a plant disease control agent containing an amide compound represented by formula (1) below which has an excellent plant disease controlling effect as an active ingredient.
(In the formula, X
|20100089284||COLORANT COMPOUND AND INK INCLUDING THE COLORANT COMPOUND|
The invention provides a colorant compound represented by the following general formula (1):
wherein R1 and R2 represent independently from each other a species selected from at least on...
|20100076199||PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRIDONE CARBOXYLIC ACIDS|
The present invention relates to methods for the preparation of pyridone carboxylic acids for use as intermediates in the preparation of various synthetic organic compounds. The pyridone carboxylic acids can for example be used as intermediates in the production of pote...
|20100069440||PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE|
Disclosed are compounds of the formula I:
wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid r...
The present invention relates to chelating agents, in particular to chelating agents which are capable of forming complexes with paramagnetic metal ions such as iron (III) and gadolinium (III). The invention also relates to the complexes formed and their use as MRI cont...
|20100022779||Isotopically substituted proton pump inhibitors|
The invention relates to compounds of formula 1
and formula 10
and to compositions comprising these compounds and methods of treating gastrointest...
|20090298889||PHARMACEUTICAL COMPOSITIONS CONTAINING 2-PYRIDONE DERIVATIVES AS EFFECTIVE COMPONENTS|
The present invention herein provides a 2-pyridone derivative which has a cell adhesion-inhibitory activity and which is useful for preventing and/or treating pathema or disease conditions including, for instance, inflammations which relate to leukocytic infiltration. T...
|20090286818||Pyridine Non-Classical Cannabinoid Compounds and Related Methods of Use|
wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid receptors....
|20090247588||2-TRIFLUOROMETHYLNICOTINAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS|
The present invention relates to compounds formula I:
and pharmaceutically acceptable salts thereof, wherein R1 to R8 are as defined in the description and claims for use as HDL-choleste...
|20090220622||USE OF MIMOSINE OR A DERIVATIVE THEREOF FOR TREATING THE CUTANEOUS EFFECTS OF PSORIASIS AND RELATED SKIN DISORDERS, AND COSMETIC OR PHARMACEUTICAL COMPOSITION CONTAINING SAME|
The present invention relates to the use of mimosine or a derivative thereof for treating the cutaneous effects of psoriasis and related skin disorders....
|20090171095||PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND|
A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting ma...
|20090156648||Preparations containing pyridoxine and alpha-hydroxyisocaproic acid (HICA)|
The present invention relates to stable salts of pyridoxine and α-hydroxyisocaproic acid (HICA) endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited t...
|20090137640||POTENTIATOR FOR RADIATION THERAPY COMPRISING PYRIDINE DERIVATIVE AS ACTIVE INGREDIENT|
The present invention relates to a radiotherapy enhancer that can reduce the radiation dose and adverse drug reactions when used in combination with a cancer radiotherapy. There is provided a radiotherapy enhancer comprising, as an active ingredient, a pyridine derivati...
|20090048276||Inhibitors of Fatty Acid Synthase (Fas)|
The instant invention provides for compounds which comprise substituted 3-aryl-4-hydroxyquinolin-2(1H)-ones that inhibit FAS activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting FAS activity by administeri...
|20080242706||Fluorinated derivatives of deferiprone|
The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, processes for the manufac...
Iron modulator compounds of formula (I) are provided for treating amyloidoses wherein R1 is selected from H, C1-6 alkyl, C1-6 alkenyl, C1-6 hydroxyalkyl, C1-6 hydroxyalkenyl, R2 is selected from H, C...
|20080177077||PROCESSES FOR THE PREPARATION OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1(2H)-YL)-N,4-DIMETHYLBENZAMIDE|
This invention is directed generally to processes for the preparation of compounds of Formula I:
wherein R2, R3, R4, R5, X1, X2, X3...
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases. ...
|20080027224||Camptothecin analogs and methods of preparation thereof|
A compound having the formula
in racemic form, enantiomerically enriched form or enantiomerically pure form; wherein X is a radical precursor; R5 is a C1-10 alkyl group, an alkenyl group, an alkynyl group, or a benzyl group; R6
|20070275953||2-Pyridinone Derivatives, Having Hiv Inhibiting Properties|
The present invention relates to 2-Pyridinone derivatives, more specifically 5-ethyl-6-methyl-2-pyridinone derivatives, according to general formula I that inhibit human immunodeficiency virus type 1 (HIV-1) replication and are therefore of interest in the treatment of ...
Compounds of Formula (I): are effective in the treatment of a microbial infection. ...
|20070249687||Carbamoylpyridone Derivatives Having Inhibitory Activity Against Hiv Integrase|
An object of the present invention provides a novel compound having the anti-viral activity, particularly, the HIV integrase inhibitory activity, and a drug containing the same, particularly, an anti-HIV drug.
There is provided a compound represented by the formu...
|20070244165||Method for Identifying and Producing Effectors of Calmodulin-Dependent Peptidyl-Prolyl Cis/Trans Isomers|
The present invention relates to a method for identifying and producing effectors of peptidyl-prolyl cis/trans isomerases which can be activated by calmodulin. The invention also relates to the use of the identified effectors for the production of medicaments and to scr...
Compounds of Formula (I): are effective in the treatment of a microbial infection. ...
|20070208112||Use of Pyridindione Derivatives for Protecting Organic Material Against Detrimental Effects of Light|
The present invention relates to the use of pyridinedione derivatives of general formula I and if appropriate their tautomers in which
|20070191608||Process for preparing 3-aminothienopyridone derivatives|
This invention provides a class of 3-amino-7H-thieno[2,3-b]pyridin-6-one derivatives, substituted in the 7-position by an aryl, heteroaryl, cycloalkyl or heterocycloalkyl moiety, and in the 2-position by a specified range of substituent groups; also provided is a proces...
|20070135465||Fab I Inhibitor and Process for Preparing Same|
A compound which is effective for inhibiting Fab I, and a method for treating a bacterial infection. ...
|20070010563||Novel methods for the treatment of inflammatory diseases|
Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine ...
|20060293522||Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions|
The present invention provides novel urea mimics and analogues of Formula (I):
or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as defined herein. These compounds are se...
|20060173051||DERIVATIVES OF 4-DEMETHYLPENCLOMEDINE, USE THEREOF AND PREPARATION THEREOF|
Thiocarbonate and thiocarbamate derivatives of 4-demethylpenclomedine are provided along with pharmaceutical compositions containing them and use for treating cancer. A method for preparing the derivatives is also provided. ...
|20060111405||O-pyridinequinone derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives|
The present invention relates to the o-pyridinequinone disubstituted derivatives, the composition containing the derivatives, the process for preparation of the derivatives and the use of the derivatives. The o-pyridinequinone disubstituted derivatives of the present in...
|20050271736||Pyrithione compound and microcapsule using the same|
A compound represented by formula (I); a multifunctional isocyanate composition, containing an adduct formed by treating the compound represented by formula (I) with a compound represented by formula (II); and a microcapsule using the multifunctional isocyanate composi...
The present invention relates to novel compounds of the formula (I)
in which W, X, Y, Z, G, A, B, Q1, Q2 and D are each as defined in the disclosure, to a plurality of processes for their preparation and to their use as pesticides and he...
|20050245552||N-substituted pyridinone and pyrimidinone derivatives for use as lp-pla2 inhibitors in the treatment of artherosclerosis|
Compounds of formula (I):
are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis. In Formula I R1, R2, R3, R4, R5, R6, X and Y. ...