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| Application No. | Application Title | Issue Date |
| 20120053180 | CYCLOHEXANE ANALOGUES AS GPR119 AGONISTS This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human h... | 03/01/2012 |
| 20120022115 | HYDROXYPYRIDONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE FOR TREATING PROLIFERATIVE DISEASES Provided herein are hydroxypyridone derivatives, for example, a compound of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.<... | 01/26/2012 |
| 20120016133 | Method for Synthesizing Pirfenidone A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethy... | 01/19/2012 |
| 20110318691 | RESIST COMPOSITION FOR SEMICONDUCTOR, AND RESIST FILM AND PATTERN FORMING METHOD USING THE SAME An embodiment of the composition contains any of compounds of general formula (I) below: ... | 12/29/2011 |
| 20110182833 | Carboxamide Derivatives Having Cooling Properties Compounds of formula (I) wherein R1-R5, n and m have the same meaning as given in the description, having cooling properties are disclosed. Furthermore a process of their production and consumer pr... | 07/28/2011 |
| 20110137041 | PROCESS FOR PREPARING ATOVAQUONE AND ASSOCIATE INTERMEDIATES The invention provides novel intermediates of atovaquone and use thereof for the preparation of atovaquone... | 06/09/2011 |
| 20110104276 | PHARMACEUTICAL COMPOSITION CONTAINING AS AN ACTIVE INGREDIENT 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE A tablet characterized by comprising 5-methyl-1-phenyl-2-(1H)-pyridone as the main ingredient and, based on the main ingredient, 10 to 50 wt. % excipient, 5 to 40 wt. % disintegrator, 1 to 10 wt. % binder, 0.5 to 5 wt. % lubricant, 2 to 6 wt. % coating basis, and 0.05 t... | 05/05/2011 |
| 20110092518 | Antifouling Compounds And Use Thereof The present invention relates to the use of compounds which have the following general formula (I), wherein R1 and R2 are independently selected from optionally substituted aryl, optionally substituted C1 to C12 alkyl and H; a... | 04/21/2011 |
| 20110092549 | Treatment of Sepsis with 5-Ethyl-1-Phenyl-2(1H)-Pyridone A pharmaceutical composition comprising 5-ethyl-1-phenyl-2-(1H)-pyridone (5-EPP) and its use for the treatment of sepsis are disclosed.... | 04/21/2011 |
| 20110003863 | METHOD FOR SYNTHESIZING PIRFENIDONE A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenzene is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of et... | 01/06/2011 |
| 20110003864 | CRYSTALLINE 1-(3-FLUOROPHENYL)-5-METHYL-2-(1H)PYRIDONE, THE PREPARATION METHODS, COMPOSITIONS AND APPLICATIONS THEREOF Crystalline pyridone compound, which is the white needle crystal containing no water and other crystallization solvents. Its unit cell belongs to monoclinic system and has space group of P21/n, wherein a=3.8512(2), b=20.2535(12), c=12.1628(6) Å, β=92.850(5... | 01/06/2011 |
| 20100261764 | SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF The present invention relates to novel therapeutic compounds of formula (I) wherein R1 is selected from the group consisting of C2-8alkyl, R2 is a methyl group, R3 is independently selected from the group consisting of H and C... | 10/14/2010 |
| 20100256383 | Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacti... | 10/07/2010 |
| 20100240704 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of at least one p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentrat... | 09/23/2010 |
| 20100222592 | Pyridone Derivative and Herbicide A pyridone derivative represented by Formula [1] or an agriculturally acceptable salt thereof: wherein R1 is a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkyny... | 09/02/2010 |
| 20100215574 | PROCESS FOR PRODUCING AN INJECTABLE MEDICAMENT PREPARATION The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a spacer molecule and of at least one protein-binding molecule. After bein... | 08/26/2010 |
| 20100174089 | HETEROARYL ARYL ETHERS The present invention relates to a process for the preparation of optionally substituted heteroaryl aryl ethers, in particular of phenoxypyridines.... | 07/08/2010 |
| 20100160385 | FUNGICIDAL TRIPHENYL-SUBSTITUTED PYRIDONES Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein
| |
| 20100160390 | COMPOUNDS CAPABLE OF ACTIVATING CHOLINERGIC RECEPTORS Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5-(3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-pyrimidinyl)-4-penten-2-amine, (4E)-N-methyl-5-(5-methoxy-3-pyridyl)-4-penten-2-amine, (4E)-N-methyl-5-(6-... | 06/24/2010 |
| 20100145060 | Schwartz Reagents: Methods of In Situ Generation and Use Embodiments of the invention provide a method of using Schwartz Reagent, Cp2Zr(H)Cl, without accumulating or isolating it. Methods provide mixtures of Cp2ZrCl2, reductants that selectively reduce Cp2ZrCl2, and subst... | 06/10/2010 |
| 20100121083 | ANTI-VIRAL AGENT Provided is an antiviral agent with high antiviral activities and low side effects (cytotoxicity). Specifically provided is an antiviral agent comprising as an effective component at least one member selected from the group consisting of 5,7,4′-trihydroxy-3′,5′-di... | 05/13/2010 |
| 20100105725 | ANTIDIABETIC BICYCLIC COMPOUNDS Diaryl ethers in which one of the aryl groups is a phenyl fused to a cycloalkyl or heterocyclic ring, to which is attached an acetic acid group, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment ... | 04/29/2010 |
| 20100105740 | O-SUBSTITUTED-DIBENZYL UREA-DERIVATIVES AS TRPV1 RECEPTOR ANTAGONISTS The invention relates to compounds of formula (I) in which R is selected from halogen, alkyl, alkoxy, aryl and heteroaryl; R1 is selected from 2-hydroxyethyl, 2,3-dihydroxypropyl, 3-hydroxypropyl, 2,2-dihydroxyethyl, 3,3-dihydroxypropyl, 1,3-dioxolane-ethyl, ... | 04/29/2010 |
| 20100087428 | Novel Potassium Channel Blockers The present invention provides a compound of formula (I)
| |
| 20100063044 | SUBSTITUTED ANILINE DERIVATIVES The present invention relates to aniline derivatives of formula I: wherein R1, R2, R3, R4, Z and q are as defined herein; or salts thereof and their use.... | 03/11/2010 |
| 20100056582 | Modulators of LXR Compounds of the invention, such as compounds of formula (I):
| 03/04/2010 |
| 20100035936 | HETEROCYCLYL SUBSTITUTED TETRAHYDRONAPHTHALENE DERIVATIVES AS 5-HT7 RECEPTOR LIGANDS The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in hum... | 02/11/2010 |
| 20100021423 | Heterocyclic antiviral compounds Compounds having the formula I wherein R1, R2, R3, R4a, R4b, R4c, R5, R6, R9 and n are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed a... | 01/28/2010 |
| 20090318455 | COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK... | 12/24/2009 |
| 20090286987 | METALLOPROTEIN INHIBITORS The present invention relates to metalloprotein inhibitors comprising:
| 11/19/2009 |
| 20090270360 | DICARBOXAMIDE DERIVATIVES The invention is concerned with novel dicarboxamide derivatives of formula (I) wherein A, B, Rc, D and E are as defined in the description and in the claims, as well as physiologically acceptable s... | 10/29/2009 |
| 20090258911 | COMPOSITION AND METHOD FOR TREATING FIBROTIC DISEASES The present invention discloses 5-methyl-1-(substituted phenyl)-2(1H)-pyridones have enhanced anti-fibrotic activities than 5-methyl-1-(non-substituted phenyl)-2(1H)-pyridones. An representative example of 5-methyl-(1-substituted phenyl)-2(1H)-pyridones is 1-(3′-fluor... | 10/15/2009 |
| 20090227591 | Cyclopentene compounds Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, R8, R9, and Rx are as defined in ... | 09/10/2009 |
| 20090198068 | SUBSTANCE HAVING ANTIOXIDANT, GEROPROTECTIVE AND ANTI-ISCHEMIC ACTIVITY AND METHOD FOR THE PREPARATION THEREOF The invention relates to the field of medicine, namely to new biologically active compounds, particularly to 2,4,6-trimethyl-3-hydroxypyridine derivatives and salts thereof (compound 1) having antioxidant, geroprotective and anti-ischemic action. The salts of compound (... | 08/06/2009 |
| 20090192125 | Local anti-infective agent for treatment of nail fungal infections A topical composition for treating nail fungal infections that utilizes an acidic antifungal agent with a molecular weight no greater than 170 Daltons in a formulation having a pH less than or equal to the pKa of the acidic antifungal agent plus one. Possible antifungal... | 07/30/2009 |
| 20090163556 | GLYCINAMIDE DERIVATIVES AS RAF-KINASE INHBITORS The present invention relates to glycinamide derivatives of formula I,
wherein A, D, and B are as herein defined, as well as the use of the compounds of fo... | 06/25/2009 |
| 20090143594 | PROCESS FOR THE CATALYTIC SYNTHESIS OF DIARYL ETHERS Described is a process for preparing diaryl ethers of the formula (I)
| 06/04/2009 |
| 20090136473 | BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compoun... | 05/28/2009 |
| 20090131485 | Deuterated pirfenidone This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods o... | 05/21/2009 |
| 20090105291 | Phenylalanine Enamide Derivatives Phenylalanine enamide derivatives of formula (1) are described:
|
