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| Application No. | Application Title | Issue Date |
| 20120083488 | TETRACYCLIC COMPOUND A compound represented by the general Formula (I) below, or a salt or solvate thereof, which is useful as an ALK inhibitor, and is useful for prophylaxis or treatment of a disease accompanied by abnormality in ALK, for example, cancer, cancer metastasis, depression or c... | 04/05/2012 |
| 20120071487 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE Novel piperazine, piperidine and tetrahydropyridine derivatives comprising a dibenzofurane moiety are provided herein, as well as pharmaceutical compositions comprising same and therapeutic uses thereof.... | 03/22/2012 |
| 20120053132 | COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the... | 03/01/2012 |
| 20120053173 | HETEROCYCLIC COMPOUND Provision of a prophylactic or therapeutic agent for diabetes, which has superior efficacy. A compound represented by the formula: wherein each symbol is as described in the spec... | 03/01/2012 |
| 20120010247 | BICYCLIC COMPOUND The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer an... | 01/12/2012 |
| 20110275625 | Heteroaryl Diamide Compounds Useful as MMP-13 Inhibitors Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I). ... | 11/10/2011 |
| 20110272681 | LIGHT-EMITTING ELEMENT MATERIAL AND LIGHT-EMITTING ELEMENT A light-emitting element has high luminous efficiency and excellent durability. The light-emitting element includes at least a light-emitting layer between a positive electrode and a negative electrode, and emits light by electrical energy. The light-emitting element is... | 11/10/2011 |
| 20110230350 | ARYL-AND HETARYLSULFONAMIDES AS ACTIVE INGREDIENTS AGAINST ABIOTIC PLANT STRESS Use of substituted sulfonamides of the formula (I) or salts thereof for enhancing stress tolerance in plants to abiotic stress, especially for enhancing plant growth and/or for increasing plant yield.... | 09/22/2011 |
| 20110212940 | S1P Receptor Modulating Compounds and Use Thereof The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators,... | 09/01/2011 |
| 20110201815 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to fused heterocyclic derivatives represented by the following formula (I) ... | 08/18/2011 |
| 20110118248 | Heteroaryl sulfonamides and CCR2/CCR9 Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pha... | 05/19/2011 |
| 20110112142 | NOVEL ESTROGEN RECEPTOR LIGANDS The invention provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt: wherein R3 05/12/2011 | |
| 20110098236 | DIAMIDE INHIBITORS OF CYTOCHROME P450 Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the... | 04/28/2011 |
| 20110098237 | METHODS FOR INHIBITING DRUG DEGRADATION Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the... | 04/28/2011 |
| 20110086877 | Small Molecule Inhibitors of Botulinum Neurotoxins Disclosed herein are methods of inhibiting the activity of Botulinum neurotoxin A metalloprotease with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or preventing intoxication caused by bacteria of at least one bacterial strain in a ... | 04/14/2011 |
| 20110065631 | PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS A process for the synthesis of bisfuran intermediates of formula (0) useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed. Furthermore disclosed is a HIV protease inhibitor of formula (IV) as well as various intermediates thereof. | 03/17/2011 |
| 20110061723 | DYE SENSITISED SOLAR CELL The present invention pertains to an electrode layer comprising a porous film made of oxide semiconductor fine particles sensitized with certain methin dyes. Moreover the present invention pertains to a photoelectric conversion device comprising said electrode layer, a ... | 03/17/2011 |
| 20110046182 | EFFICIENT ASPIRIN PRODRUGS Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied as a cancer chemopreventative agent. Despite its value aspirin contin... | 02/24/2011 |
| 20110039821 | Fused Phenyl Amido Heterocyclic Compounds The present invention relates to a compound of formula (I):
| 02/17/2011 |
| 20110021540 | Bis-(Sulfonylamino) Derivatives in Therapy 066 The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptabl... | 01/27/2011 |
| 20110015185 | Benzofuran Compounds The present invention relates to compounds of formula (I): wherein | 01/20/2011 |
| 20100331370 | Novel isobenzofuran analogs of sclerophytin A Isobenzofuran analogs of sclerophytin A are prepared in a highly concise fashion via an aldol-cycloaldol sequence. The analogs exhibit IC50's as low as 1 Ī¼M in growth inhibitory studies against KB3 cells using an MTT assay. Preferred analogs have one ... | 12/30/2010 |
| 20100311582 | CHEMICAL COMPOUNDS A compound of the formula (I) where, for example, W, X and Y are each CH; R1 and R6, independently of each other, are for example, selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C3-C8-cycloalkyl, R... | 12/09/2010 |
| 20100292190 | NOVEL TUBULIN POLYMERISATION INHIBITORS The present invention relates to compounds of general formula (I) as tublin polymerisation inhibitors and methods for preparing such compounds. ... | 11/18/2010 |
| 20100267947 | EXO-SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ... | 10/21/2010 |
| 20100179137 | PYRIDONE COMPOUND [Solving Means] The present inventors have conducted extensive studies on an EP4 receptor agonist, and as a result, found that a novel pyridone compound characterized in that the 1-position in the pyridone ring is substituted with a group having an acidic group such as ... | 07/15/2010 |
| 20100137298 | Biaryl Sulfonamides and Methods for Using Same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.... | 06/03/2010 |
| 20100125073 | BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF CANCERS OF THE CENTRAL NERVOUS SYSTEM The present invention relates to benzofuran and benzothiophene derivatives and compositions containing such compounds for the production of medicaments for the treatment of cancers of the central nervous system as monotherapy or combination with other agents.... | 05/20/2010 |
| 20100123123 | ORGANIC THIN-FILM TRANSISTORS A thin-film transistor comprises a semiconducting layer comprising a semiconducting material selected from Formula (I) or (II): wherein X, R1, R2, R3, R4, R5 <... | 05/20/2010 |
| 20100120760 | BENZOFURAN-CARBOXAMIDE DERIVATIVES AS ANTIVIRAL AGENTS A compound of the formula (I): as defined herein, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing a compound of the formula (I) for use in inhibiting hepatitis C virus polymerase and/or of treating or preventing an illness due t... | 05/13/2010 |
| 20100121062 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: ... | 05/13/2010 |
| 20100093806 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING AMINOINDAZOLE AND AMINOBENZOFURAN ANALOGS PDE4 inhibition is achieved by novel compounds, e.g., aminoindazole and aminobenzofuran analogs. The compounds of the present invention are of Formulas I and II: wherein R1, R2, R3<... | 04/15/2010 |
| 20100081658 | HETEROCYCLIC ANTIVIRAL COMPOUNDS Compounds having the formula I wherein R1, R2a, R2b, R2c, R3, Y and p are as defined herein and C2-C3 is a single or double bond are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and ... | 04/01/2010 |
| 20100062937 | BENZANILIDES WITH INSECTICIDAL ACTIVITY Benzanilides of the formula: in which X represents hydrogen, halogen, nitro, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl or C1-6 alkylsulfonyloxy; Y repr... | 03/11/2010 |
| 20100056796 | Compounds Suitable As Precursors to Compounds that are Useful for Imaging Amyloid Deposits The present invention relates to novel derivatives that are suitable as precursors to compounds that are useful for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. The compounds deriving from these pr... | 03/04/2010 |
| 20100004208 | SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerisation inhibitors.... | 01/07/2010 |
| 20090306055 | PHENYLAZOLE COMPOUNDS, PRODUCTION PROCESS AND ANTIOXIDANTS The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), A represents an optionally substituted ... | 12/10/2009 |
| 20090306112 | ANTIVIRAL PROTEASE INHIBITORS The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds. | 12/10/2009 |
| 20090281138 | Bis-(Sulfonylamino) Derivatives in Therapy 066 The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, r... | 11/12/2009 |
| 20090281321 | EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exe... | 11/12/2009 |
