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| Application No. | Application Title | Issue Date |
| 20120004381 | RAFT POLYMERISATION A method of preparing polymer, the method comprising polymerising one or more ethylenically unsaturated monomers of formula (I)
| 01/05/2012 |
| 20110312974 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone... | 12/22/2011 |
| 20110312875 | PEPTIDIC COMPOUNDS The present invention provides a compound of formula I, II, III and IV as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and... | 12/22/2011 |
| 20110305729 | Scriptaid Isosteres and Their Use in Therapy Compounds of the invention are of the formula (I); wherein: | |
| 20110275674 | Small Molecules Modulator of Epigenetic Regulation and Their Therapeutic Applications Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not... | 11/10/2011 |
| 20110269966 | SEMICONDUCTING ARTICLES An amic acid or amic ester precursor can be applied to a substrate and thermally converted into a thin organic semiconducting layer of the corresponding arylene diimide. This semiconducting layer can be used in various semiconductive articles such as organic light emitt... | 11/03/2011 |
| 20110269967 | AROMATIC AMIC ACIDS OR AMIC ESTERS AND COMPOSITIONS Novel amic acids and amic esters can be thermally converted into corresponding arylene diimides. These amic acids and amic ester can be used as precursors to prepare semiconducting thin films that can be used in various articles including thin-film transistor devices th... | 11/03/2011 |
| 20110237578 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF Compounds are provided according to formula (I), where A, B, W, X′, L, R1, R3, R4b, and m′ are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of ... | 09/29/2011 |
| 20110237573 | N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings. ... | 09/29/2011 |
| 20110224225 | Inhibitors of protein kinases Compounds of general Formula (I): wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dep... | 09/15/2011 |
| 20110166132 | Gamma Secretase Modulators The present invention provides compounds that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containing such comp... | 07/07/2011 |
| 20110152323 | Histone deacetylase inhibitors and uses thereof The present invention discloses a group of histone deacetylase inhibitors and use thereof. The histone deacetylase inhibitors are useful in the treatment of malignant tumors and the diseases associated with differentiation and proliferation. The histone deacetylase inhi... | 06/23/2011 |
| 20110118234 | Urea Compounds as Gamma Secretase Modulators The present invention provides compounds Formula (I) that are gamma secretase modulators and are therefore useful for the treatment of diseases treatable by modulation of gamma secretase such as Alzheimer's disease. Also provided are pharmaceutical compositions containi... | 05/19/2011 |
| 20110077160 | PESTICIDES Compounds having the following generic formula are disclosed. ... | 03/31/2011 |
| 20110064657 | LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), BIOLOGICAL EVALUATION, AND USE AS IMAGING AGENTS The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or wi... | 03/17/2011 |
| 20110003859 | N- (6-AMINOPYRIDIN-3-YL) -3- (SULFONAMIDO) BENZAMIDE DERIVATIVES AS B-RAF INHIBITORS FOR THE TREATMENT OF CANCER Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammali... | 01/06/2011 |
| 20100331549 | Novel compounds useful for modulating abnormal cell proliferation There is described compounds of Formulæ I, II, III, IV and V. The compounds of Formulæ I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.... | 12/30/2010 |
| 20100324092 | PYRIDYL AND PYRIMIDINYL DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS The present invention relates to a novel class of pyridyl and pyrimidinyl derivatives. The pyridyl and pyrimidinyl compounds can be used to treat cancer. The pyridyl and pyrimidinyl compounds can also inhibit histone deacetylase and are suitable for use in selectively i... | 12/23/2010 |
| 20100324046 | 4-CARBOXYBENZYLAMINO DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS The present invention relates to a novel class of 4-carboxybenzylamino derivatives. The 4-carboxybenzylamino compounds can be used to treat cancer. The 4-carboxybenzylamino compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing t... | 12/23/2010 |
| 20100266714 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 rec... | 10/21/2010 |
| 20100267697 | ION CHANNEL MODULATORS The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein... | 10/21/2010 |
| 20100190788 | Amide derivatives as kinase inhitors The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R 07/29/2010 | |
| 20100178247 | CA-IX SPECIFIC RADIOPHARMACEUTICALS FOR THE TREATMENT AND IMAGING OF CANCER A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of ... | 07/15/2010 |
| 20100178246 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: complexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, par... | 07/15/2010 |
| 20100168070 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and in the claims. The inve... | 07/01/2010 |
| 20100099881 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound. The novel sphingosine compound or a salt thereof according to t... | 04/22/2010 |
| 20100081673 | HETEROARYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with... | 04/01/2010 |
| 20100062937 | BENZANILIDES WITH INSECTICIDAL ACTIVITY Benzanilides of the formula: in which X represents hydrogen, halogen, nitro, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl or C1-6 alkylsulfonyloxy; Y repr... | 03/11/2010 |
| 20100000028 | Styryl sulfide dyes Disclosed are styryl sulfide dyes of formula (1), wherein R1, R′1, R2, R′2, R3 and R′3, independently from each other are hydrogen; C1-C20alkyl or C1-C20a... | 01/07/2010 |
| 20090312314 | HETEROAROMATIC MONOAMIDES AS OREXININ RECEPTOR ANTAGONISTS The present invention is concerned with novel sulfonamides of formula wherein R1, R2, R3, R4, R5, Ar, Ar1, Ar2, n, o and p are as d... | 12/17/2009 |
| 20090275550 | Pyridyl Amide T-Type Calcium Channel Antagonists The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to ... | 11/05/2009 |
| 20090172897 | STYRYL THIOL/DISULFIDE COMPOUND WITH A HYDROXY(CYCLO)ALKYLAMINO UNIT, PROCESS FOR LIGHTENING KERATIN MATERIALS USING SAME The disclosure relates to the dyeing of keratin materials using styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dyes. Disclosed herein is a dye composition comprising a styryl hydroxy(cyclo)alkylamino thiol/disulfide fluorescent dye and a dyeing process with... | 07/09/2009 |
| 20090042867 | COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1 to R13, A, B, L, and i are defined as indicated in the description and the claim... | 02/12/2009 |
| 20090030042 | Amide Addition Reaction A method of making a compound of formula II comprising the reaction of a compound of formula RCONH2 with a compound of formula III R be... | 01/29/2009 |
| 20090018141 | KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH Provided herein are Compounds having the following structure:
| 01/15/2009 |
| 20080242702 | Paclitaxel enhancer compound One embodiment of the present invention is a compound represented by the Structural Formula (I):
| |
| 20080090794 | Potassium Channel Inhibitors The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like. ... | 04/17/2008 |
| 20080039490 | PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord, in one embodiment, the compounds, composition... | 02/14/2008 |
| 20070293501 | Thioalkeneamides as Transketolase Inhibitors The present invention provides thioalkeneamides of formula (I) which are useful as transketolase inhibitors: wherein R1, R2, R3, R4, R5, R6, Ra-Rd, n and ring A are as defined herein... | 12/20/2007 |
| 20070219244 | Histone deacetylase inhibitors as therapeutics for neurological diseases The invention provides HDAC inhibitors that may be used as therapeutics for the treatment of a neurodegenerative or neuromuscular condition. The invention provides compounds of formula I: The invention also provides pharmaceutical compositions and articles of manufa... | 09/20/2007 |
