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| Application No. | Application Title | Issue Date |
| 20120071659 | Process for the Preparation of Sufentanil Base and Related Compounds The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously ... | 03/22/2012 |
| 20120029188 | Substituted Aniline Derivatives The present invention relates to novel aniline derivatives and their use in therapy, in particular their use in the treatment of fungal infections.... | 02/02/2012 |
| 20120029021 | Nitroxide Free Radical Synergized Antineoplastic Agents Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives... | 02/02/2012 |
| 20110311583 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are ... | 12/22/2011 |
| 20110275797 | N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl group or the like; R2... | 11/10/2011 |
| 20110224337 | PROCESS FOR PREPARING AN N-ALKYLLACTAM WITH IMPROVED COLOR QUALITY The present invention relates to a process for purifying an N-alkyllactam which comprises contacting N-alkyllactams with carbon. The present invention also relates to mixtures comprising poly(vinylidene fluodride) (PVDF) and N-alkyllactams, in which the N-alkyllactams h... | 09/15/2011 |
| 20110207926 | NOVEL DIHYDROTRIAZINE DERIVATIVE A compound represented by formula (1), a tautomer thereof, or a salt of the compound or tautomer, which is useful as a bactericide/disinfectant. In the formula, R1 represents a hydrogen atom, an op... | 08/25/2011 |
| 20110129419 | IN VIVO IMAGING AGENTS The present invention relates to the field of medical imaging, and in particular to imaging of disease states associated with the upregulation of the chemokine receptor 5 (CCR5). Imaging agents, precursors and methods are provided which are useful in imaging such diseas... | 06/02/2011 |
| 20110104162 | Compounds which can be used for the Treatment of Cancers The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and especially to a racemic mixture. The ... | 05/05/2011 |
| 20110021780 | MANUFACTURING METHOD FOR A PIPERIDINE-3-YLCARBAMATE COMPOUND AND OPTICAL RESOLUTION METHOD THEREFOR Provided is a manufacturing method for a piperidine-3-ylcarbamate compound in which a pyridine-3-ylcarbamate compound and hydrogen are brought into contact in the presence of a palladium catalyst.... | 01/27/2011 |
| 20110003855 | ANTIVIRAL COMPOUNDS FOR THE TREATMENT OF HCV INFECTION Disclosed are compounds and methods of synthesis of Formula I for the development of antiviral drugs for the treatment of HCV infection.... | 01/06/2011 |
| 20100331546 | METHOD FOR OPTICAL RESOLUTION OF ALKYL PIPERIDIN-3-YL CARBAMATE AND INTERMEDIATE THEREFOR Disclosed is a method for optical resolution of an alkylpiperidin-3-yl carbamate, the method including bringing an RS mixture of an alkylpiperidin-3-yl carbamate into contact with an optically active tartaric acid in the presence of a solvent.... | 12/30/2010 |
| 20100311791 | N-HALOGENATED AMINO COMPOUNDS AND DERIVATIVES The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods ... | 12/09/2010 |
| 20100267697 | ION CHANNEL MODULATORS The present teachings provide compounds of Formula (I) and pharmaceutically acceptable salts, hydrates, and esters thereof, wherein Ar, R1, R2, R3, p, and X are defined herein... | 10/21/2010 |
| 20100267669 | HETEROCYCLIC CETP INHIBITORS Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.... | 10/21/2010 |
| 20100234353 | SULFONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y, Z and 09/16/2010 | |
| 20100197928 | METHOD FOR PREPARING DISUBSTITUTED PIPERIDINE AND INTERMEDIATES The disclosure relates to a method for preparing a compound of formula (I), wherein P1 and P2 are groups protecting the carboxylic acid and oxyamine functions, starting from pyroglutamic acid (S). The disclosure also relates to novel intermediates.... | 08/05/2010 |
| 20100152452 | STEREOSELECTIVE SYNTHESIS OF PIPERIDINE DERIVATIVES This invention relates to dialdehyde or dinitrile compounds, which are useful for stereoselective synthesis of piperidine, pyrrolidine, and azepane derivatives.... | 06/17/2010 |
| 20100152439 | PRODUCTION METHOD The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the ... | 06/17/2010 |
| 20100105894 | Cyclopropane compounds and pharmaceutical use thereof The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): | 04/29/2010 |
| 20100105917 | METHOD FOR PRODUCING OPTICALLY ACTIVE 3-AMINOPIPERIDINE OR SALT THEREOF The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the ... | 04/29/2010 |
| 20100099880 | Alternate Process for Remifentanil Preparation An alternate process for synthesizing opiate or opioid analgesics and anesthetics, and intermediates thereof is provided. In particular, a process of synthesizing synthetic opiate or opioid compounds such as, for example, remifentanil, carfentanil, sufentanil, fentanyl,... | 04/22/2010 |
| 20100069630 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.... | 03/18/2010 |
| 20100069413 | Pyrimidine and Quinazoline Derivatives This invention is concerned with compounds of the formula wherein A, R1 to R5 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The inven... | 03/18/2010 |
| 20100016600 | N- and O-Substituted 4-[2-(Diphenylmethoxy)-Ethyl]-1-[(Phenyl)Methyl]Piperdine Analogs and Methods of Treating CNS Disorders Therewith N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SERT a... | 01/21/2010 |
| 20100016601 | PROCESS FOR PREPARING REMIFENTANIL, INTERMEDIATES THEREOF, USE OF SAID INTERMEDIATES AND PROCESSES FOR THE PREPARATION THEREOF A process for preparing remifentanil by conversion of the nitrile group of a cyanopiperidinyl propanoate derivative to an ester group. Advantageously, with this process the number of steps for preparing remifentanil from commercial products is significantly reduced, com... | 01/21/2010 |
| 20090306382 | CATIONIC ALKOXYAMINES The instant invention relates to cationic alkoxyamines, which are useful as polymerization initiators/regulators in a controlled stable free radical polymerization process to produce intercalated and/or exfoliated nanoparticles from natural or synthetic clays, The inven... | 12/10/2009 |
| 20090298878 | OXIME COMPOUNDS AND THE USE THEREOF The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R... | 12/03/2009 |
| 20090258061 | ONCE-A-DAY REPLACEMENT TRANSDERMAL ADMINISTRATION OF FENTANYL A method and a daily replacement patch for transdermally administering an opioid for analgesic effect. The patch is applied to a subject to deliver the opioid through the skin. The patch may be replaced daily and over an extended period of time.... | 10/15/2009 |
| 20090239910 | Benzenesulfonamide Compounds and Their Use The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1-R3 and Z are defined as set forth in the specification. Th... | 09/24/2009 |
| 20090227566 | AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for it... | 09/10/2009 |
| 20090215765 | Neuroprotective compounds for treating optic neuropathies Neuroprotective compounds for treating optic neuropathies and screening methods for identifying neuroprotective compounds.... | 08/27/2009 |
| 20090208413 | Registry Method and Control System for Dea Schedule II-V Medicines The present invention provides compositions and methods for synthesizing labeled drugs. The present invention further provides methods for preventing or stopping prescription drug abuse for all agents registered as a Drug Enforcement Agency (DEA) schedule II through sch... | 08/20/2009 |
| 20090209766 | PROCESS FOR THE PREPARATION OF 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE 4-amino-2,2,6,6-tetramethylpiperidine is prepared by reacting 2,2,6,6-tetramethylpiperidine-4-one with ammonia and hydrogen in the presence of nickel and/or cobalt catalyst and water. The main reaction is carried out at a pressure of at most 50 bar and a temperature of ... | 08/20/2009 |
| 20090131674 | POLYMIDE OLIGOMERS AND THEIR USE The present invention relates to polyamide oligomers with linear or branched chain structure with a number average molar mass of 800 to 5000 g/mol, with basic end groups which are at least partially NH2 end groups and carboxyl end groups, produced by condensa... | 05/21/2009 |
| 20090082342 | N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS Disclosed herein are isolated forms of the compounds of Formula (I), (II), (III), (IV) and (V), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, or ester thereof. Also disclosed are methods of inhibiting an activity of a serotonin receptor, m... | 03/26/2009 |
| 20090068120 | AMIDE COMPOUND OR SALT THEREOF, AND BIOFILM INHIBITOR, BIOFILM REMOVER AND DISINFECTANT CONTAINING THE SAME The present invention provides a new amide compound and salt thereof that is capable of inhibiting biofilm formation or removing deposited biofilms. The present invention also provides a biofilm formation inhibitor or a biofilm remover containing the amide compound or s... | 03/12/2009 |
| 20090062530 | Substituted arylalkanoic acid derivatives and use thereof A compound represented by the formula (I): [In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic rin... | 03/05/2009 |
| 20090042899 | Piperazinyl-or piperidinylamine-sulfamic acid amides as inhibitors of steroid sulfatase Piperazinyl- or piperidinylamine-sulfamic acid amides and their use for the manufacture of a medicament in diseases mediated by the action of steroid sulfatase.... | 02/12/2009 |
| 20080318907 | Nitroxide Free Radical Synergized Antineoplastic Agents Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives... | 12/25/2008 |
