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| Application No. | Application Title | Issue Date |
| 20120129888 | LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR DRUG DISCOVERY Novel compounds are continually sought after to treat and prevent disorders. The invention relates to N-(2-oxo-1-phenylpiperidin-3-yl)sulfonamides useful for contributing to the search and identification of new lead compounds which can modulate the functional activity o... | 05/24/2012 |
| 20120108814 | PROCESS 738 Processes for the preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline, salts thereof, and the intermediates used in the process are described.... | 05/03/2012 |
| 20120046247 | 1,5-DIPHENYL-PENTA-1,4-DIEN-3-ONE COMPOUNDS This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.... | 02/23/2012 |
| 20120004310 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.... | 01/05/2012 |
| 20110319378 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER The present invention provides MDM2 inhibitor compounds of Formula I,
| 12/29/2011 |
| 20110301200 | THYROID RECEPTOR LIGANDS The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta (TR-Beta). Further, the present invention relates to processes of preparing such compounds, thei... | 12/08/2011 |
| 20110207709 | MODULATORS OF SEROTONIN RECEPTOR Certain biphenyl compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.... | 08/25/2011 |
| 20110207714 | SEROTONIN RECEPTOR MODULATORS The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases. ... | 08/25/2011 |
| 20110172431 | PROCESS FOR PRODUCING 1-SUBSTITUTED TRANS-4-(SUBSTITUTED AMINO) PIPERIDIN-3-OL A process is provided for producing a 1-substituted trans-4-(substituted amino)piperidin-3-ol represented by formula (III-1): The process includes a step of reacting a 1-substituted-3,4-epoxypiperidine repres... | 07/14/2011 |
| 20110172297 | Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of Formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of Formula ... | 07/14/2011 |
| 20110105562 | ALKYNYL DERIVATIVES USEFUL AS DPP-1 INHIBITORS The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.... | 05/05/2011 |
| 20110098468 | NK1 ANTAGONISTS A NK1 antagonist having the formula (I), wherein Ar1 and Ar2 are optionally substituted phenyl or heteroaryl, X1 is an ether, thio or imino linkage, R4 a... | 04/28/2011 |
| 20110098320 | Lactam Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 This invention relates to novel compounds of the Formula (I), (I*), (Ia), (Ib), (Ic), (Id), (Ie), (If), (If*), (Ig), (Ih), (Ij), (Ik), (ll1-3), (Im1-3), (In1-3), (lo1-2), (Ip1-9), (Iq1-9), (Ir1-9) and (Is1-3) pharmaceutically acceptable salts thereof, and pharmaceutical... | 04/28/2011 |
| 20110071139 | Cycloalkyl Lactame Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 This invention relates to novel compounds of the Formula (I), any of the formulas I1-I26 Ia1-3-Ij1-3 or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic t... | 03/24/2011 |
| 20110053984 | NOVEL 4-BENZHYDRYLOXY-TETRAALKYL-PIPERIDINE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS This invention relates to novel 4-benzhydryloxy-tetraalkyl-piperidine derivatives of Formula (I), any of its stereoisomers or any mixture of its stereoisomers, or an N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein Ra represents hydroge... | 03/03/2011 |
| 20110009622 | LONG-CHAIN FATTY ACYL ELONGASE INHIBITOR COMPRISING ARYLSULFONYL DERIVATIVE AS ACTIVE INGREDIENT [Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides. 01/13/2011 | |
| 20100267945 | AMINE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY A compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, where R1 is optionally substituted lower alkyl, Y is —S(O)2—, R2 is hydrogen or optio... | 10/21/2010 |
| 20100168167 | Piperidinones Useful in the Treatment of Inflammation There is provided compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, m and n have meanings given in the description, and pharmaceutically acceptable derivatives thereof, which compou... | 07/01/2010 |
| 20100076190 | METHOD FOR SYNTHESIS OF NITROXYL RADICAL The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl ... | 03/25/2010 |
| 20100048550 | SELECTIVE TR-BETA 1 AGONIST The present invention relates to novel compounds of general formula (I) which are thyroid receptor ligands and are preferably selective for the thyroid hormone receptor beta(TR-Beta). Further, the present invention relates to processes of preparing such compounds, their... | 02/25/2010 |
| 20100035865 | Sulfonamides and Pharmaceutical Compositions Thereof The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula ... | 02/11/2010 |
| 20100035879 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.... | 02/11/2010 |
| 20100029720 | Carboxamide Derivatives As Muscarinic Receptor Antagonists The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.... | 02/04/2010 |
| 20090239829 | THIOARYL SUBSTITUTED INHIBITORS OF ZINC PROTEASES AND THEIR USE There are described compounds having the general formula (I) below and their pharmaceutically acceptable salts thereof, wherein E, X, m, q, R1, R2, n and ZBG have the meanings reported in the description useful, in therapy, as inhibitors of zinc me... | 09/24/2009 |
| 20090233969 | BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula: They are... | 09/17/2009 |
| 20090215821 | N-Substituted Azacycles N-substituted azacycle derivative compounds represented by formula (I): wherein m, q, r, t and u are independently selected from 0 or 1; and p is 0, 1, 2, or 3; and A, B, D, X, Y, R, R1, R2 | |
| 20090198052 | METHOD FOR PREPARING OPTICALLY ACTIVE PIPERIDINE COMPOUNDS The present invention relates to a method for preparing a syn-form piperidine compound represented by general formula [I]: wherein,
| 08/06/2009 |
| 20090176767 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the sp... | 07/09/2009 |
| 20090156589 | 1,2-DI(CYCLIC GROUP)SUBSTITUTED BENZENE DERIVATIVE A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action and cell infiltration inhibitory action. wherei... | 06/18/2009 |
| 20090137813 | PROCESS FOR PRODUCTION OF CAREBASTINE Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III: ... | 05/28/2009 |
| 20090093451 | IL-8 Receptor Antagonists This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 04/09/2009 |
| 20090076026 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS The invention provides compounds of formula I: wherein a, b, c, d, f, W, Q, Y, R1, R2, and R3 are as defined in the specification. The compounds of formula I are muscarinic re... | 03/19/2009 |
| 20090062344 | THERAPEUTIC SUBSTITUTED PIPERIDONE COMPOUNDS Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are also disclosed.... | 03/05/2009 |
| 20090012055 | Organic compounds Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin i... | 01/08/2009 |
| 20080318907 | Nitroxide Free Radical Synergized Antineoplastic Agents Nitroxide free radicals attached to antineoplastic agents can synergize their potencies to cancer cells. This invention relates to any antineoplastic agents and their derivatives chemically attached with nitroxide free radicals, such as TEMPO and its radical derivatives... | 12/25/2008 |
| 20080269275 | Novel Mchr1 Antagonists and Their Use for the Treatment of Mchr1 Mediated Conditions and Disorders Compounds of Formula I wherein R1, D, R2, A and R3 are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions con... | 10/30/2008 |
| 20080182991 | N- AND O-SUBSTITUED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl] piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred compounds exhibit highly differential behavior as between the DAT and SERT ... | 07/31/2008 |
| 20080166332 | Methods of Treatment of Amyloidosis Using Subsituted Ethanolcyclicamine Aspartyl Protease Inhibitors The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein... | 07/10/2008 |
| 20080161354 | STABLE S-NITROSOTHIOLS, METHOD OF SYNTHESIS AND USE The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparat... | 07/03/2008 |
| 20080146588 | Piperidinyl Piperidine Tachykinin Receptor Antagonists The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these ... | 06/19/2008 |
