"Rail travel at high speeds is not possible because passengers, unable to breathe, would die of asphyxia."
Dionysius Lardner, Professor of Natural Philosophy and Astronomy at University College, London ; 1830
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| Application No. | Application Title | Issue Date |
| 20120000118 | LOW-MOLECULAR WEIGHT POLYISOBUTYL-SUBSTITUTED AMINES AS DISPERSANT BOOSTERS A fuel additive composition comprising (A) polyisobutyl-based nitrogen-containing dispersants with MN of the polyisobutyl group of from 650 to 1800 Dalton, (B) carrier oils substantially free of nitrogen and (C) polyisobutyl-based dispersant boosters with M 01/05/2012 | |
| 20110311884 | PENTACYCLIC ANION SALT AND USE THEREOF AS AN ELECTROLYTE The invention relates to a pentacyclic anion salt and to the use thereof in electrolyte compositions. The compound comprises an inorganic, organic or organometallic cation M of valency m (1≦m≦3) and m anions corresponding to the formula (I) in which Rf is... | 12/22/2011 |
| 20110295000 | PRODUCTION METHOD The present invention relates to a process for preparing compounds of general formula I wherein R1 and R2 are defined as in claim 1, the pharmaceutically acceptable salts and the ... | 12/01/2011 |
| 20110172430 | METHOD FOR THE CONTINUOUS PRODUCTION OF AN AMINE USING AN ALUMINUM-COPPER CATALYST Process for the continuous preparation of an amine by reaction of a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary and secondary amines at a temperature in the range from ... | 07/14/2011 |
| 20110160176 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR The invention relates to compounds of the formula (I) wherein n is 0, 1 or 2; G is CH2 or CHR3; R1 is H, C,-C6-alkyl, C,-C6-alkyl substituted by C3-C6-cycloalkyl, C1-C6-hy... | 06/30/2011 |
| 20110124679 | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES Methods of treating or suppressing oxidative stress diseases including mitochondrial diseases, impaired energy processing disorders, neurodegenerative diseases and diseases of aging are disclosed, as well as compounds useful in the methods of the invention, such as 2-su... | 05/26/2011 |
| 20110060144 | METHOD FOR MANUFACTURING MAGNESIUM AMIDES A method for manufacturing amidomagnesium halogenides and admixtures thereof with alkali metal salts in aparotic, organic solvents, compounds obtained according to the method and use thereof in synthesis chemistry, for example for deprotonizing enolizable systems, funct... | 03/10/2011 |
| 20110034693 | PREPARATION OF METHYLPENTAMETHYLENEDIAMINE AND METHYLPIPERIDINE Methyl-2-pentamethylenediamine and methyl-3-piperidine are prepared by hydrogenation of methylglutaronitrile in the presence of a catalyst including cobalt, chromium, and nickel, especially a catalyst based on Raney cobalt doped with nickel and chromium.... | 02/10/2011 |
| 20100292436 | METHOD FOR PRODUCING BIVALIRUDIN A method for producing bivalirudin using solid phase peptide synthesis by the following steps: a) mixing a Fmoc-amino acid resin or a Fmoc-peptide resin with a de-protective agent so as to remove Fmoc-; b) in the presence of a condensing agent, condensing a Fmoc- or Boc... | 11/18/2010 |
| 20100291299 | STRONTIUM AND BARIUM PRECURSORS FOR USE IN CHEMICAL VAPOR DEPOSITION, ATOMIC LAYER DEPOSITION AND RAPID VAPOR DEPOSITION Cyclopentadienyl and Indenyl barium/strontium metal precursors and Lewis base adducts thereof are described. Such precursors have utility for forming Ba- and/or Sr-containing films on substrates, in the manufacture of microelectronic devices or structures.... | 11/18/2010 |
| 20100282081 | ABSORBENT LIQUID, AND APPARATUS AND METHOD FOR REMOVING C02 OR H2S FROM GAS WITH USE OF ABSORBENT LIQUID An absorbent liquid according to the present invention is an absorbent liquid for absorbing CO2 or H2S or both from gas, in which the absorbent liquid includes an alkanolamine as a first compound component, and a second component including a nitrog... | 11/11/2010 |
| 20100274009 | METHOD FOR PRODUCING AN AMINE Processes for preparing an amine, the processes comprising: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting... | 10/28/2010 |
| 20100267770 | PIPERIDINE DERIVATIVES AND COSMETIC COMPOSITIONS THEREOF The present invention provides piperidine derivatives of formula (I): salts and optical isomers thereof and cosmetic compositions containing them.... | 10/21/2010 |
| 20100137600 | Photogenerated reagents This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated ... | 06/03/2010 |
| 20100069420 | SPIRO-PIPERIDINE INHIBITORS Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a compositio... | 03/18/2010 |
| 20100056567 | NOVEL ALKYL SUBSTITUTED PIPERIDINE DERIVATIVES AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising... | 03/04/2010 |
| 20090312304 | ORGANIC COMPOUNDS 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the prepa... | 12/17/2009 |
| 20090306391 | METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES The invention relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by contacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material in the presence of a... | 12/10/2009 |
| 20090239907 | METHODS AND COMPOSITIONS FOR TREATING FISH DISEASES Therapeutic and prophylactic treatments of aquatic species and aquatic diseases through the controlled introduction of a heterocyclic N-halamine into an aquatic habitat.... | 09/24/2009 |
| 20090227571 | Androgen Receptor Modulator Compounds and Methods Provided herein are compounds that bind to androgen receptors and modulate the activity and/or the amount of androgen receptors and to methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using s... | 09/10/2009 |
| 20090215764 | Antimicrobial agents Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, g... | 08/27/2009 |
| 20090176988 | Preparation and Use of Magnesium Amides The present application relates to mixed Mg/Li amides of the general formula R1R2N—Mg(NR3R4)mX,m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl conta... | 07/09/2009 |
| 20090156824 | Hydroamination of Alkenes A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group includi... | 06/18/2009 |
| 20090124806 | PROCESS FOR PRODUCING CARBOXYLIC ACID FROM PRIMARY ALCOHOL To provide an industrially-useful and environmentally-friendly novel oxidation reaction. A process for producing a carboxylic acid from a primary alcohol, which comprises using an alkali metal chlorite as a co-oxidizing agent and using, as ... | 05/14/2009 |
| 20090093493 | 1-PHENYLALCOXY-2-BETA-PHENYLETHYL DERIVATIVES AS P-GLYCOPROTEIN (P-GP) INHIBITORS USEFUL IN DRUG RESISTANCE EVENTS The invention relates to a new class of compounds, which are 1-phenylalcoxy-2-β-phenylethyl derivatives, as P-glycoprotein (P-GP) inhibitors. These compounds are useful in drug resistance events. They have been shown able to inhibit in a dose-dependent manner Glycoprot... | 04/09/2009 |
| 20090082203 | INSECTICIDAL BIS(SUBSTITUTED PHENYL)-1-{[4-(SATURATED HETEROCYCLYL-SUBSTITUTED)PHENYLMETHYL]- (4-PIPERIDYL)}METHANE DERIVATIVES It has now been found that certain novel bis(substituted phenyl)-1 {[4-(saturated heterocyclyl-substituted)phenyl-methyl](4-piperidyl)}methane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I); where R through R 03/26/2009 | |
| 20090065739 | LIQUID CRYSTAL COMPOUND HAVING CHLORONAPHTHALENE MOIETY, LIQUID CRYSTAL COMPOSITION, AND OPTICAL DEVICE A compound represented by formula (1): wherein R1 is hydrogen or alkyl having 1 to 20 carbons, in which in the alkyl, arbitrary —CH2— may be replaced by —O—, —S—, —COO—, ... | 03/12/2009 |
| 20090062261 | NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist. A compound represented by: | 03/05/2009 |
| 20090042938 | Chemical Compounds The use of a compound of formula (I), Y is a single bond, C═O, C═S or S(O)m where m is 0, 1 or 2; the ring (II) is a 6 membered aromatic ring or is a 5 or 6 membered heteroaromatic ring; Z and Z′ are ═C— or —N— provided that both are not N; R 02/12/2009 | |
| 20090012120 | Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines An ylide-based aza-Payne rearrangement of 2,3-aziridin-1-ols leads to an efficient process for the preparation of pyrrolidines. The aza-Payne rearrangement under the basic reaction conditions favors the formation of epoxy amines. Subsequent nucleophilic attack of... | 01/08/2009 |
| 20080255149 | Carboxyamine Compounds and Methods of Use Thereof The invention relates to the use of carboxyamine compounds and salts thereof in the treatment of HDAC dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases.... | 10/16/2008 |
| 20080251169 | IONIC LIQUID, A METHOD OF SYNTHESIZING AN IONIC LIQUID, A PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID, AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION An ionic liquid is disclosed A precursor composition that comprises at least one ionic liquid and at least one energetic material is also disclosed, as is a method of synthesizing an ionic liquid and a method of desensitizing an explosive composition.... | 10/16/2008 |
| 20080182875 | N-(2-Hydroxyethyl)-N-Methyl-4-(Quinolin-8-yl(1-(Thiazol-4-ylmethyl)Piperidin-4-ylidene)Methyl)Benzamide N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, pharmaceutically acceptable salts thereof, and/or mixtures thereof, as well as, pharmaceutical compositions thereof, methods of treatment therewith, and processes of... | 07/31/2008 |
| 20080161576 | METHOD OF FORMING A DRY QUATERNARY AMMONIUM SALT MIXTURE Disclosed herein is a method comprising:
| 07/03/2008 |
| 20080161281 | Amino-Substituted Tricyclic Derivatives and Methods of Use Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and... | 07/03/2008 |
| 20080103135 | PHENYLALKYNES Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ... | 05/01/2008 |
| 20080051401 | 2,4,6-Trisubstituted Pyrimidines as Phosphotidylinositol (Pi) 3-Kinase Inhibitors and Their Use in the Treatment of Cancer The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R1, R2, q, R3, r, R4, X1 and Q1 have any of the meanings defined in the description; processes for their preparation, pharma... | 02/28/2008 |
| 20080051579 | Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same The present invention provides a method of resolving piperdin-yl-alkylene-alcohols, in high yield at high enantiomeric purity, for example 2-piperidin-2-yl-ethanol. ... | 02/28/2008 |
| 20070299052 | Inhibitors of IAP The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R... | 12/27/2007 |
| 20070293391 | Novel Strong Boron-Containing Acids, The Preparation And Use Thereof The invention relates to boron-containing acids of the general formula (I) [B(RF)4-x-y(CN)xFy]− H+ (I), where x=0, 1, 2, 3 or 4, y=0, 1, 2 or 3 x+y≦4, and in which the ligands RF may be ide... | 12/20/2007 |