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| Application No. | Application Title | Issue Date |
| 20120035409 | BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-M... | 02/09/2012 |
| 20120010402 | CGRP Receptor Antagonists The disclosure generally relates to the novel compounds of formula I, including their salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders in... | 01/12/2012 |
| 20110313163 | Methods for One-Pot N-Demethylation/N-Functionalization of Morphine and Tropane Alkaloids The present invention provides a method for the N-demethylation and N-functionalization of an N-methylated heterocycle such as a morphine alkaloid or tropane alkaloid. The method comprises reacting the heterocycle with an functionalization agent in the presence of a tra... | 12/22/2011 |
| 20110306633 | SELECTIVE M4 RECEPTOR ANTAGONIST AND ITS MEDICAL USE The present invention provides a selective M4 receptor antagonist, levorotatory demethylated phencynonate or its nontoxic pharmaceutically acceptable salt, a pharmaceutical composition comprising this compound, and a use thereof in the manufacture of a medicament for th... | 12/15/2011 |
| 20110301133 | COMPOSITIONS OF PROTEIN RECEPTOR TYROSINE KINASE INHIBITORS The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particula... | 12/08/2011 |
| 20110281845 | ORGANIC COMPOUNDS The present disclosure relates to XIAP inhibitor compounds of the formula I. ... | 11/17/2011 |
| 20110275627 | INDOLIZINE INHIBITORS OF LEUKOTRIENE PRODUCTION The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein X1 to X4, R1 to R4, A, B, D and m are as defined he... | 11/10/2011 |
| 20110230497 | BIOLOGICALLY ACTIVE AMIDES The present invention is directed to biologically active amides which are ligands at the NPY Y5 receptor. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acce... | 09/22/2011 |
| 20110207704 | Novel Oxadiazole Compounds Novel oxadiazole compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions as agonists or antagonists of the S1P family of G protein-coupled receptors for treating diseases associated with modulation of S1P family re... | 08/25/2011 |
| 20110195929 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.... | 08/11/2011 |
| 20110178119 | Bridged N-Bicyclic Sulfonamido Inhibitors of Gamma Secretase The invention provides N-bicyclic sulfonamido compounds of Formula (I) wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system. Compounds of Formula I are useful in treating or preventing cogn... | 07/21/2011 |
| 20110136854 | NOVEL 9-AZA-BICYCLO[3.3.1]NON-3-YLOXY CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS This invention relates to novel 9-aza-bicyclo[3.3.1]non-3-yloxy chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compos... | 06/09/2011 |
| 20110130418 | SUBSTITUTED PHENYLENEDIAMINES AS INHIBITORS OF THE INTERACTION BETWEEN MDM2 AND P53 The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I). ... | 06/02/2011 |
| 20110124858 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PEST CONTROL AGENT The present invention relates to a nitrogen-containing heterocyclic compound or salt thereof, represented by the following formula (I), and a pest control agent containing the compound or salt thereof, as an active ingredient of the pest control agent: 05/26/2011 | |
| 20110065915 | CATALYSTS FOR METATHESIS REACTIONS INCLUDING ENANTIOSELECTIVE OLEFIN METATHESIS, AND RELATED METHODS The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced a... | 03/17/2011 |
| 20110008288 | HEPATITIS C VIRUS INHIBITORS The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus (HCV). Conse... | 01/13/2011 |
| 20100324088 | Fused Pyridone M1 Receptor Positive Allosteric Modulators The present invention is directed to fused pyridone compounds of formula (I) (I) that are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain o... | 12/23/2010 |
| 20100317690 | TREATMENT OF PROTEIN FOLDING DISORDERS Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and wh... | 12/16/2010 |
| 20100286398 | METHOD FOR PRODUCING CIS-3-SUBSTITUTED-3-AZABICYCLO[3.2.1]OCTAN-8-OL DERIVATIVE There are provided, according to the present invention, a method for producing a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative, the method characterized in that a trans-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative or a mixture of the trans- and ci... | 11/11/2010 |
| 20100240637 | Inhibitors of the Interaction Between MDM2 and P53 The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, m, p, s, t, R1 | |
| 20100233279 | Compositions And Methods Comprising Analogues Of Radicicol A Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or preve... | 09/16/2010 |
| 20100174084 | 2-Alkoxy-6-alkyl-phenyl-substituted Spirocyclic Tetramic Acid Derivatives The invention relates to novel 2-alkoxy-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives of the formula (I) in which A, B, D, G, X, Y and Z are as defined above, to a plurality of processes and... | 07/08/2010 |
| 20100152158 | Substituted Disulfonamide Compounds Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a | |
| 20100137300 | Indolizine Acetic Acid Derivatives as CRTH2 Antagonists The specific compounds of this list: {7-cyano-2-methyl-1-[4-(morpholine-4-sutfonyl)benzyl]indolizin-3-yl}acetic acid, {1-(3-chloro-4-ethanesulfonylbenzyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro4-(morpholine-4-sulfonyl)benzyl]-7-cyano-2-methylindolizin-... | 06/03/2010 |
| 20100130738 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT It is to provide a novel pyrazolone derivative represented by the following general formula (1), which is useful as a pharmaceutical and has a phosphodiesterase inhibitory action: wherein R1,R... | 05/27/2010 |
| 20100081680 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described ... | 04/01/2010 |
| 20100040548 | HIGH PENETRATION PRODRUG COMPOSITIONS OF ANTIMICROBIALS AND ANTIMICROBIAL-RELATED COMPOUNDS The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of antimicrobials and antimicrobial-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are ca... | 02/18/2010 |
| 20100004455 | Method for producing piperidin-4-one derivative Provided is a method for producing a piperidin-4-one derivative useful as an intermediate for agricultural chemicals or pharmaceutical products. A piperidin-4-one derivative represented by formula (III-a) or formula (III-b) is produced by reacting a cyclic bis(aminol)et... | 01/07/2010 |
| 20090318694 | Cross-Linked Amine Compounds and Agents for Pest Control Cyclic amine compounds represented by formula (1) or salts thereof or N-oxides thereof, wherein Cy1 represents an unsubstituted or substituted aromatic ring; X represents oxygen, sulfur, unsubstitu... | 12/24/2009 |
| 20090312364 | NOVEL CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS This invention relates to novel chromen-2-one derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical composit... | 12/17/2009 |
| 20090286777 | 5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists The present invention is directed to certain 5,6-fused pyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations compri... | 11/19/2009 |
| 20090275606 | Heterocyclic Compounds as MEK Inhibitors The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer ... | 11/05/2009 |
| 20090259045 | Process for production of azabicycloalkanol derivative The object is to produce an azabicycloalkanol derivative, particularly a cis-3-substituted-3-azabicyclo[3.2.1]octan-8-ol derivative which is a useful intermediate for agricultural chemicals or pharmaceutical agents, with a good yield and at an industrially low cost. A d... | 10/15/2009 |
| 20090235467 | NEW AMINOINDOLIZINES, DYEING COMPOSITION COMPRISING AT LEAST ONE AMINOINDOLIZINE, METHODS AND USES THEREOF A new class of chemical entities chosen from aminoindolizines of formula (I), acid addition salts thereof, and solvates thereof: their use for dyeing keratin fibers, including human keratin fibers such as the... | 09/24/2009 |
| 20090181945 | TWO CYCLIC CINNAMIDE COMPOUND The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by the general formula (I): 07/16/2009 | |
| 20090163497 | Compounds Useful as Antagonists of CCR2 The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R1 are defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful f... | 06/25/2009 |
| 20090124595 | MAPK/ERK KINASE INHIBITORS Compounds of the following formula are provided for use with MEK: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such c... | 05/14/2009 |
| 20090111815 | Carboxamide Compound and Use of the Same A carboxamide compound represented by the formula (I): [wherein Q represents a nitrogen-containing 6-membered aromatic heterocyclic group optionally fused with a benzene ring, two or more ring constitutional ... | 04/30/2009 |
| 20090105230 | Anti-inflammatory medicaments Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compoun... | 04/23/2009 |
| 20090082389 | PESTICIDAL SUBSTITUTED PIPERIDINES The invention relates to the use of piperidine derivatives encompassed from the general formula (I) for the control of pests, including arthropods and helminths, and a method for the control of pests. ... | 03/26/2009 |
