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"I watched his countenance closely, to see if he was not deranged ... and I was assured by other senators after he left the room that they had no confidence in it."
U.S. Senator Smith of Indiana ; After seeing Samuel Morse demonstrate the telegraph.
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| Application No. | Application Title | Issue Date |
| 20120108602 | Carbamoyl Compounds as DGAT1 Inhibitors 190 DGAT-1 inhibitor compounds of formula (1), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity
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| 20120107273 | NEW PIPERAZINE COMPOUND AND USE THEREOF AS A HCV POLYMERASE INHIBITOR The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof... | 05/03/2012 |
| 20120053149 | THIAZOLE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS The present invention relates to thiazole derivatives of formula I and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular disea... | 03/01/2012 |
| 20120045470 | IMATINIB IMMUNOASSAY Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.... | 02/23/2012 |
| 20120040992 | OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed.... | 02/16/2012 |
| 20120040020 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein... | 02/16/2012 |
| 20120040977 | INHIBITORS OF HCV NS5A Provided herein are compounds, pharmaceutical compositions and combination therapies for inhibition of hepatitis C.... | 02/16/2012 |
| 20120040993 | NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotect... | 02/16/2012 |
| 20120040968 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND Provided is a compound useful as an inhibitor against the kinase activity of EML4-ALK fusion protein. As a result of intensive and extensive studies on compounds having inhibitory activity against the kinase activity of EML4-ALK fusion prot... | 02/16/2012 |
| 20120035407 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and condit... | 02/09/2012 |
| 20120035408 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorder... | 02/09/2012 |
| 20120028954 | Substituted Pyridine, Pyridazine, Pyrazine And Pyrimidine Compounds And Methods For Using The Same Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T... | 02/02/2012 |
| 20120028979 | 2-(PIPERIDIN-1-YL)-4-HETEROCYCLYL-THIAZOLE-5-CARBOXYLIC ACID DERIVATIVES AGAINST BACTERIAL INFECTIONS Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described. | 02/02/2012 |
| 20120022254 | SIRTUIN MODULATING COMPOUNDS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 01/26/2012 |
| 20120022075 | NOVEL PHENYLPYRROLE DERIVATIVE The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: ... | 01/26/2012 |
| 20120010410 | (2R)-1-(3-CHLORO-2-PYRAZINYL)-2-METHYLPIPERAZINE AND SALTS THEREOF The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general fo... | 01/12/2012 |
| 20120004221 | Antibacterial Compositions Compounds of formula (I) have antibacterial activity: wherein: m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is an optionally substituted, divalent C1-C6 alkylene, alkenylene or alkynyl... | 01/05/2012 |
| 20120004207 | THERAPEUTIC USES OF DERIVATIVES OF PIPERIDINYL-AND PIPERIDINYL-ALKYL CARBAMATES Compound corresponding to the general formula (I):
| 01/05/2012 |
| 20120004241 | SUCCINATE SALT OF (2R)-METHYL-1-PIPERAZINE The present invention relates to a process for the preparation of compounds which are therapeutically active in the central nervous system. In one aspect, the invention relates to a process for the preparation of compounds of the general fo... | 01/05/2012 |
| 20110319393 | ANTHELMINTIC AGENTS AND THEIR USE This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositio... | 12/29/2011 |
| 20110313151 | ANELLATED PYRIDINE COMPOUNDS The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein X, Y, A, R1, R2, and R3 are as descri... | 12/22/2011 |
| 20110306587 | UNSATURATED NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS Unsaturated nitrogen heterocyclic compounds of formula (I): as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treat... | 12/15/2011 |
| 20110306590 | ARYL- AND HETEROARYL- NITROGEN-HETEROCYCLIC COMPOUNDS AS PDE10 INHIBITORS Aryl- and heteroaryl-nitrogen heterocyclic compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependen... | 12/15/2011 |
| 20110306589 | NITROGEN CONTAINING HETEROARYL COMPOUNDS The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1,... | 12/15/2011 |
| 20110301143 | HETEROCYCLIC DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR 12/08/2011 | |
| 20110294819 | Hepatitis C Virus Inhibitors The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the... | 12/01/2011 |
| 20110295006 | CYCLIC DIPEPTIDES AS FEED ADDITIVES Feed additives containing essential amino acids which are diketopiperazines of formulas (IV) or (V) or salts thereof are provided: In formulas (IV) and (V), R1 and R2 may be an amino aci... | 12/01/2011 |
| 20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compou... | 12/01/2011 |
| 20110294809 | TROPANE UREA DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS MODULATORS OF THE ACTIVITY OF 11BETAHSD1 The invention relates to tropane urea derivatives of general formula (I) and to the application thereof as modulators of the activity of 11β-hydroxysteroid dehydrogenose type 1 (11βHSD1).... | 12/01/2011 |
| 20110288091 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, a... | 11/24/2011 |
| 20110281861 | THIAZOPYRIMIDINONES AND USES THEREOF The present invention provides a compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof. The present invention further provides a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said ... | 11/17/2011 |
| 20110275803 | PROCESS FOR SYNTHESIZING OXIDIZED LACTAM COMPOUNDS The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I: ... | 11/10/2011 |
| 20110269760 | TUBULIN INHIBITORS Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also descr... | 11/03/2011 |
| 20110269737 | 7-(Piperazine-1-Ymethyl)-1H-Indole-2-Carboxylic Acid (Phenyl)-Amide Derivatives and Allied Compounds as P38 Map Kinase Inhibitors for the Treatment of Respiratory Diseases The present invention provides compounds according to general formula (I) which are proposed for the treatment of respiratory complaints, particularly asthma and COPD.... | 11/03/2011 |
| 20110269756 | BENZOTHIAZOLONE DERIVATIVES Compounds of the formula I, in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, an... | 11/03/2011 |
| 20110263571 | NOVEL AMIDE DERIVATIVE AND USE THEREOF AS MEDICINE Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide deri... | 10/27/2011 |
| 20110257398 | Compositions and Methods Including Cell Death Inducers and Procaspase Activation Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction ... | 10/20/2011 |
| 20110256064 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compou... | 10/20/2011 |
| 20110251194 | ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF The disclosure concerns heterobicyclic compounds of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as enantiomers, diastereoisomers and mixtures thereof. Methods for preparing the compounds, pharmaceutical compositions, and methods o... | 10/13/2011 |
| 20110251209 | COMPOUNDS FOR TREATING PARASITIC DISEASE A compound, particularly an antimalarial compound, according to formula I:
| 10/13/2011 |
