Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Application No. | Application Title | Issue Date |
| 20120022254 | SIRTUIN MODULATING COMPOUNDS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 01/26/2012 |
| 20120015941 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.... | 01/19/2012 |
| 20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the ... | 12/15/2011 |
| 20110288293 | ISOQUINOLINE DERIVATIVE A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.... | 11/24/2011 |
| 20110218201 | NOVEL PYRAZOLONE-DERIVATIVES AND THEIR USE AS PDE-4 INHIBITORS The compounds of Formula (I), are novel effective inhibitors of the type 4 phosphodiesterase.... | 09/08/2011 |
| 20110212969 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF This invention provides compounds of formula (I):
| 09/01/2011 |
| 20110212970 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other co... | 09/01/2011 |
| 20110195969 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention fur... | 08/11/2011 |
| 20110105513 | AMINO-QUINOXALINE AND AMINO-QUINOLINE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS Compounds of the Formula (I), where W represents CH or N; and Q represents —CN, —C(═NOH)NH2, —CONHR1 or various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof. Car... | 05/05/2011 |
| 20110105491 | THIAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS The invention relates to thiazolidine derivatives of the formula (I) wherein A, B, and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to their use as medicaments, especially as orexin rece... | 05/05/2011 |
| 20110070317 | PYRROLOPYRIDINES AS KINASE INHIBITORS Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in ... | 03/24/2011 |
| 20110065713 | Benzazole Derivatives, Compositions, and Methods of Use as B-Secretase Inhibitors The present invention is directed to benzazole compounds that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment or prevention of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also... | 03/17/2011 |
| 20110044899 | LABELLED ANALOGUES OF HALOBENZAMIDES AS MULTIMODAL RADIOPHARMACEUTICALS AND THEIR PRECURSORS A compound of formula (I): in which R1 represents a hydrogen atom, an optionally labelled halogen, a radionuclide or a Sn[(C1-C4)alkyl]3 group, Ar represents an aryl group or a heteroaryl group, R9 represents a hydr... | 02/24/2011 |
| 20110046110 | QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 02/24/2011 |
| 20110021528 | NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase act... | 01/27/2011 |
| 20110015192 | SIRTUIN MODULATING COMPOUNDS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 01/20/2011 |
| 20110009401 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceut... | 01/13/2011 |
| 20100280036 | Modulation of Pathogenicity The present invention relates to the use of compounds of the general Formula (I): wherein in Formula (I),
| |
| 20100261725 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other co... | 10/14/2010 |
| 20100216803 | ORNITHINE DERIVATIVE Provided is a compound which is useful as a therapeutic agent for chronic renal insufficiency and a therapeutic agent for diabetic nephropathy. The present inventors have made extensive studies on an ornithine derivative having an antagonis... | 08/26/2010 |
| 20100210620 | Substituted Aryl Sulfone Derivatives as Calcium Channel Blockers A series of substituted aryl sulfone derivatives represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutic... | 08/19/2010 |
| 20100197681 | Triazolopyridine Compounds and Their Use as Ask Inhibitors The present invention relates to triazolopyridine compounds according to Formula (I), their use as medicament, for treating autoimmune disorders, inflammatory diseases, cardiovascular diseases and/or neurodegenerative diseases and a process for their preparation.... | 08/05/2010 |
| 20100183712 | ACYLATED INDANYL AMINES AND THEIR USE AS PHARMACEUTICALS The present invention relates to acylated indanyl amines according to the general formula (I)
| |
| 20100120775 | Farnesoid X Receptor Agonists The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.... | 05/13/2010 |
| 20100113462 | SUBSTITUTED BENZOYLAMINO-INDAN-2-CARBOXYLIC ACIDS AND RELATED COMPOUNDS The present invention relates to novel compounds of the formula I: wherein in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, w... | 05/06/2010 |
| 20100105667 | Quinoxaline- and Quinoline-Carboxamide Derivatives The invention relates to compounds of formula (I) wherein the substituents are as defined in the specification, in free form or in the form of a pharmaceutically acceptable salt, solvate, ester, N-oxide there... | 04/29/2010 |
| 20100081657 | QUINOXALINES USEFUL AS INHIBITORS OF PROTEIN KINASES The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or d... | 04/01/2010 |
| 20100061928 | LABELLED ANALOGUES OF HALOBENZAMIDES AS RADIOPHARMACEUTICALS The present invention relates to the use of a compound of formula (I):
| 03/11/2010 |
| 20100029598 | Extended Benzamide Derivatives as Modulators of the EP2 Receptor The present invention relates to extended benzamide derivatives of the general formula I, to processes for preparation thereof and to use thereof for production of pharmaceutical compositions for treatment of disorders and indications associated with the EP2 ... | 02/04/2010 |
| 20090286791 | Amide Compounds The present invention provides compounds represented by the formula (Ia): the formula (Ib): the formula (Ic): ... | 11/19/2009 |
| 20090281086 | 2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS A compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein: HetA is a C5 arylene group, wherein the two substituent groups are on adjacent ring atoms, and where the group is further optionally substituted by one halo, amino or C 11/12/2009 | |
| 20090192175 | INSECTICIDAL COMPOUNDS Novel heteroaromatic compounds of formula (I): wherein A1, A2, A3, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof. Furthermore, t... | 07/30/2009 |
| 20090176775 | DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE The present invention is related to a compound of formula (I): wherein i, j, n, o, p, q, r, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R | |
| 20090029986 | N-AROYL CYCLIC AMINES Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.... | 01/29/2009 |
| 20090023730 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Cert... | 01/22/2009 |
| 20080293727 | Novel sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This ... | 11/27/2008 |
| 20080167307 | Carboxylic Acid Derivative Containing Thiazole Ring and Pharmaceutical Use Thereof According to the present invention, a compound represented by the following formula (I) having a superior PPARα agonist action and concurrently showing a hypolipidemic action can be provided, and further, a compound useful as a synthetic intermediate for the... | 07/10/2008 |
| 20080045483 | Phenylcarboxylic Acid Derivatives and Use Thereof for the Treatment of Diabetes The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1, and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of patholog... | 02/21/2008 |
| 20080027059 | SUBSTITUTED ISOXAZOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, METHODS OF PREPARING SAME, AND USES OF SAME The invention relates to substituted isoxazolines according to the general formula (I): in which A, R1, R2, R3, R4, Z, X, m, n, and p, are given in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted isoxazolines, to methods of ... | 01/31/2008 |
| 20050026923 | Quinoxaline derivatives having antiviral activity The invention relates to substituted quinoxalines which have antiviral and immunomodulatory activity. The compounds of the invention are useful for treating infectious diseases, particularly viral diseases. ... | 02/03/2005 |
