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| Application No. | Application Title | Issue Date |
| 20120129840 | NOVEL VIRAL REPLICATION INHIBITORS The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to nov... | 05/24/2012 |
| 20120083474 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 Certain heterocyclic amide compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPA1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowe... | 04/05/2012 |
| 20120083471 | Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same The present invention relates to novel pharmaceutical compositions containing the same, and methods of use for a variety of therapeutically valuable uses including, but not limited to, treating obesity by inhibiting the activity of Glycerol 3-phosphate acyltransferase (... | 04/05/2012 |
| 20120053053 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES The present invention relates to substituted pyrimidine derivatives, as well as N-oxides thereof and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal co... | 03/01/2012 |
| 20120053346 | Pyrimidine Carboxamide Derivatives The invention relates to a compound of the formula wherein the substituents are as defined herein, and a pharmaceutically acceptable salt of the compound of formula (1). The compounds of formula (1) and their... | 03/01/2012 |
| 20120040826 | NOVEL HERBICIDES Bicyclic dione compounds, and derivatives thereof, which are suitable for use as herbicides. ... | 02/16/2012 |
| 20120035139 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.... | 02/09/2012 |
| 20120029194 | LIQUID CRYSTAL COMPOUND HAVING DIFLUOROPROPENYLENEOXY BONDING GROUP The invention provides a liquid crystal compound having general physical properties necessary for the compound, namely stability to heat, light and so forth, a wide temperature range of a liquid crystal phase, a high clearing point, a good compatibility with other compo... | 02/02/2012 |
| 20120028995 | NOVEL COMPOUNDS FOR MEDICAL USE AS PEPTIDASE EFFECTORS The invention relates to compounds of general formula (I) as set forth in the claims as well as to the use of the compounds of the general formula (1) in the medical field, specifically for use in the suppression of DNA synthesis and inflammatory cytokine production as ... | 02/02/2012 |
| 20120018672 | LIQUID CRYSTAL COMPOUND, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE The invention provides a liquid crystal compound having a high stability to heat, light or the like, a wide temperature range of a nematic phase, a small viscosity, a large optical anisotropy and a suitable elastic constant K33, and further having a suitable ... | 01/26/2012 |
| 20120014997 | ARYL SULFONAMIDES Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in ... | 01/19/2012 |
| 20120004243 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy, halogeno and (1-6C)alkyl, or a ... | 01/05/2012 |
| 20110319411 | ISOINDOLINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 12/29/2011 |
| 20110319429 | SUBSTITUTED 1,1,3,1-TETRAOXIDOBENZO[D][1,3,2]DITHIAZOLES AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and methods of using the compounds.... | 12/29/2011 |
| 20110318807 | Small Molecule Inhibitors of Ghrelin O-Acyltransferase Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.... | 12/29/2011 |
| 20110306493 | Sulfoximinamide Compounds for Combating Animal Pests The invention relates to sulfoximinamid compounds of formula (I), to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to the use of the sulfoximinamid compounds, of their salts or of compositions ... | 12/15/2011 |
| 20110306621 | ACYLGUANIDINE DERIVATIVES An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT5A receptor modulating action. It was confirmed that acylguanidine derivatives, which... | 12/15/2011 |
| 20110294830 | NITROGEN-CONTAINING COMPOUNDS AND HARMFUL ORGANISM CONTROL AGENTS The present invention provides a nitrogen-containing compound represented by formula (I1) (in formula (I1), R0 represents a nitro group or the like, Z represents an optionally substituted aryl group or the like, R3 represents ... | 12/01/2011 |
| 20110281879 | SULFONYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositi... | 11/17/2011 |
| 20110281870 | NOVEL SUBSTITUTED OCTAHYDROCYCLOPENTA[C]PYRROL-4-AMINES AS CALCIUM CHANNEL BLOCKERS The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L1, L2, R1, R2, and R3 are as defined in the sp... | 11/17/2011 |
| 20110275797 | N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R1 represents a carboxyl group or the like; R2... | 11/10/2011 |
| 20110275813 | Bicylic 1,3-diones and Their Use as Insecticides, Acaricides and/or Fungicides The present invention relates to the use of compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, Y, X, and G have the meanings given above as insecticides and/or acaricides and/or fungicides. | 11/10/2011 |
| 20110269756 | BENZOTHIAZOLONE DERIVATIVES Compounds of the formula I, in which R1, R2, R3, R3′, R4, R4′, E, E′, E″ and E′″ have the meanings indicated in Claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, an... | 11/03/2011 |
| 20110269761 | ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS The invention relates to substituted aryl-sulphonylglycine derivatives of general formula (I) wherein the groups Ra to Rf, A and Z are defined as in the specification and claims, which are suitable for preparing a pharmaceutical composition for the... | 11/03/2011 |
| 20110269784 | USE OF TETRAHYDROPYRIMIDINES Tetrahydropyrimidines of the formula where R is a hydrogen atom or a hydrocarbon radical comprising up to eight carbon atoms, R′ is hydrogen, OH or OR″ and R″ is R or COR, with R having the above descri... | 11/03/2011 |
| 20110263626 | NOVEL BRADYKININ B1-ANTAGONISTS The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined... | 10/27/2011 |
| 20110257196 | COMPOUNDS FOR TREATMENT OF CANCER The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant ... | 10/20/2011 |
| 20110251168 | 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8 | |
| 20110233463 | CHIRAL COMPOUNDS, CHOLESTERIC AND FERROELECTRIC LIQUID CRYSTAL COMPOSITIONS COMPRISING THESE CHIRAL COMPOUNDS, AND LIQUID CRYSTAL DISPLAYS COMPRISING THESE LIQUID CRYSTAL COMPOSITIONS Chiral liquid crystal compounds of the general formula (1): in which at least one of R1 and R2 is a chiral substituent, K may be a single bond or the same a... | 09/29/2011 |
| 20110237578 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF Compounds are provided according to formula (I), where A, B, W, X′, L, R1, R3, R4b, and m′ are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of ... | 09/29/2011 |
| 20110230488 | HYBRID-IONONE AND CURCUMIN MOLECULES AS ANTICANCER AGENTS The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifu... | 09/22/2011 |
| 20110224209 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) The present invention is directed to 4,4-di-substituted piperidine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.... | 09/15/2011 |
| 20110223093 | IONIC LIQUID SYSTEMS FOR CARBON DIOXIDE AND SULFUR DIOXIDE REMOVAL This invention relates to sulfur functionalized ionic liquid compounds that are useful in methods of carbon dioxide or sulfur dioxide removal to which they may be applied.... | 09/15/2011 |
| 20110212969 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF This invention provides compounds of formula (I):
| 09/01/2011 |
| 20110207749 | Glycine Chroman-6-Sulfonamides for Use as Inhibitors of Diacylglycerol Lipase The present disclosure is generally directed to compounds that can inhibit DAGLα and/or β activity, compositions comprising such compounds, and methods for inhibiting DAGLα and/or β activity.... | 08/25/2011 |
| 20110207748 | Tri-Aryl/Heteroaromatic Cannabinoids and Use Thereof Cannabinoid derivatives according to formula (I) are disclosed wherein, X, Y, R1, R2, and W can have the definitions provided herein. Without limitation, use of such compounds, their sal... | 08/25/2011 |
| 20110193022 | FIVE-RING LIQUID CRYSTAL COMPOUND HAVING A NITROGEN-CONTAINING HETEROCYCLIC RING, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE Provided is a liquid crystal compound having general physical properties necessary for a compound, stability to heat, light or the like, a wide liquid crystal phase temperature range, a high clearing point, an excellent compatibility with other liquid crystal compounds,... | 08/11/2011 |
| 20110190262 | Aryl-and Heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity.... | 08/04/2011 |
| 20110183957 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsiv... | 07/28/2011 |
| 20110178042 | Hydroxamic Acid Derivatives Useful as Antibacterial Agents The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 ... | 07/21/2011 |
