|Application No.||Application Title||Issue Date|
|20140051708||PYRAZOLYL-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS|
The present invention relates to pyrazolyl-pyrimidine derivatives which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity. The present invention also provides methods for preparing these...
|20140051675||MODULATORS OF CELLULAR ADHESION|
The present invention provides compounds having formula (I):
|20140045870||7-(Heteroaryl-Amino)-6,7,8,9-Tetrahydropyrido[1,2-A]Indol Acetic Acid Derivatives and Their Use as Prostaglandin D2 Receptor Modulators|
The present invention relates to 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives of the formula (I),
wherein R1, R2, R3 and R4 are...
|20140045840||COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR|
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives ...
|20140042420||TRIAZOLE DERIVATIVE, AND LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE WITH THE USE OF TRIAZOLE DERIVATIVE|
It is an object of the present invention to provide a novel triazole derivative. Further, it is another object of the present invention to provide a light-emitting element having high luminous efficiency with the use of the novel triazole derivative. Moreover, it is sti...
|20140045814||PYRAZINE DERIVATIVES AS FGFR INHIBITORS|
The present invention relates to pyrazine derivatives, and pharmaceutical compositions including the same, that are inhibitors of one or more FGFR enzymes and are useful in the treatment of FGFR-associated diseases such as cancer....
|20140045823||N-CYCLOPROPYL-N-PIPERIDINYL-AMIDES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF|
The present invention relates to compounds of general formula I,
wherein R1, LP, HetAr1, (Het)Ar2 and n are as defined in the application, which have valuable pharm...
|20140034916||CONDENSED-CYCLIC COMPOUNDS AND ORGANIC LIGHT-EMITTING DIODES COMPRISING THE SAME|
Condensed-cyclic organic compounds, synthetic methods for preparing the same and an organic light-emitting diode including the same are presented. The subject polycyclic triarylamines are prepared via a series of substitution and cyclization reactions....
|20140038995||Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4 receptor|
Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis....
|20140034879||COMPOUNDS FOR ELECTRONIC DEVICES|
The present invention relates to a compound of a formula (I) or (II), to the use of this compound in an electronic device, and to an electronic device comprising one or more compounds of the formula (I) or (II). The invention furthermore relates to the preparation of th...
|20140031369||N-CYCLOPROPYL-N-PIPERIDINYL-AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF|
The present invention relates to compounds of general formula I,
wherein R1, LP, (Het)Ar1, (Het)Ar2 and n are as defined in the application, which have valuable pha...
|20140031360||BICYCLIC COMPOUNDS AS PIM INHIBITORS|
The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the inv...
|20140031336||Tetrahydroquinoline Derivatives Useful As Bromodomain Inhibitors|
Tetrahydroquinoline compounds, pharmaceutical compositions containing such compounds and their use in therapy....
|20140031354||Protein Kinase Inhibitors|
The present invention relates to compounds of Formula I:
as well as pharmaceutically acceptable salts, hydrates, isomers, or solvates thereof, wherein the variables are described herein. The present invention...
|20140027750||COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE, ORGANIC LIGHT EMITTING DIODE INCLUDING THE SAME AND DISPLAY INCLUDING THE ORGANIC LIGHT EMITTING DIODE|
A compound for an organic optoelectronic device, an organic light emitting diode including the same, and a display device including the organic light emitting diode, the compound being represented by the following Chemical Formula 1:
|20140024830||HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS|
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active....
|20140024646||OCTAHYDRO-CYCLOPENTAPYRROLYL ANTAGONISTS OF CCR2|
The present invention comprises compounds of Formula (I).
wherein: R1, R2, R3, R4, R5, Z1 and Z2 are as defined in the specificatio...
|20140018371||Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto|
The present invention relates to compounds of Formula (Ia) and pharmaceutically acceptable salts, solvates, and hydrates thereof, that are useful as a single agent or in combination with one or more pharmaceutical agents, such as, an inhibitor of DPP-IV, a biguanide, or...
A cyclic amine derivative represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes.
|20140018380||BICYCLIC HETEROARYL COMPOUNDS AS GPR119 RECEPTOR AGONISTS|
The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula I, pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications th...
|20140011803||PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF|
The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases...
|20140011825||Compounds and Compositions as Protein Kinase Inhibitors|
The present invention provides compounds of Formula I or II:
wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined here...
|20140011988||Dibenzo[B,F][1,4]Oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors|
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I)
|20140005165||SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES USEFUL AS CCR2 ANTAGONISTS|
Disclosed are CCR2 antagonists of Formula (I) or pharmaceutically acceptable thereof, wherein R1, L1 and A are defined herein. Also disclosed are pharmaceutical compositions containing the compounds, methods of treatment using the compounds, and compositions to treat di...
|20140005188||PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS|
A compound of formula (I):
or a salt thereof;
|20140005382||NITROGEN-CONTAINING CONDENSED HETEROCYCLIC COMPOUND|
There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action:
|20140001451||MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE, AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME|
A material for an organic electroluminescence device represented by the following formula (I):
Pyrandione, thiopyrandione and cyclohexanetrione compounds, which are suitable for use as herbicides....
|20140005392||METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES|
This disclosure relates to a novel process for obtaining a compound of formula I:
wherein the values of R1, R2, and R3 and P are as described in the specification, and intermediates thereof....
|20140005150||3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS|
3,4-diarylpyrazole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in th...
The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), ...
The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]...
|20130345181||PYRROLOPYRIDINEAMINO DERIVATIVES AS MPS1 INHIBITORS|
The present invention relates to the use of certain pyrrolopyridineamino derivatives (hereinafter referred to as “PPA derivatives”), particularly 1H-pyrrolo[3,2-c]pyridine-6-amino derivatives, to inhibit the spindle checkpoint function of Monospindle 1 (Mps1—also ...
|20130345197||AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES|
The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders....
The invention relates to compounds of formula
wherein R1, R2, R3, R4, X, Ar, and
are defined herein
|20130345218||INHIBITORS OF INFLUENZA VIRUSES REPLICATION|
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or pati...
|20130345208||ION CHANNEL MODULATORS AND METHODS OF USE|
In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium chann...
|20130331384||FIRMOCIDIN, AN ANTIMICROBIAL MOLECULE PRODUCED BY STAPHYLOCOCCUS EPIDERMIDIS|
The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof....
|20130331349||COMPOSITIONS AND METHODS FOR MODULATING FXR|
The present invention relates to compounds of Formula (I), a stereoisomer, enantiomer, a pharmaceutically acceptable salt or an amino acid conjugate thereof; wherein variables are as defined herein; and their pharmaceutical compositions, which are useful as modulators o...
|20130331571||GLYCINE TRANSPORTER-INHIBITING SUBSTANCES|
The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof:
The compounds of the present invention are useful in the prevention or treatment of diseases such ...