Bizarre Patents
Decorative Jeweled Wheel Cover
An improved wheel is provided wherein decorative items such as gem stones are embedded in either the wheel surface, a special mounting section attached to the wheel surface, or to a spoke strap that wraps around each spoke and positions embedded gem stones on the outside surface of the spoke.
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| Application No. | Application Title | Issue Date |
| 20110224155 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory recep... | 09/15/2011 |
| 20110112073 | COMPOSITIONS AND METHODS RELATING TO HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATING COMPOUNDS AND TARGETS THEREOF The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiom... | 05/12/2011 |
| 20110028433 | QUINAZOLINONE DERIVATIVES AS TUBULIN POLYMERIZATION INHIBITORS The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1... | 02/03/2011 |
| 20100261741 | Quinazolinone T-Type Calcium Channel Antagonists The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to ... | 10/14/2010 |
| 20100152171 | CGRP Antagonists CGRP antagonists of the formula of which the following are exemplary:
| |
| 20100113411 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions The present invention relates to CGRP antagonists of general formula
| 05/06/2010 |
| 20100068197 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF Disclosed are compounds of Formula I effective as cytotoxic agents. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.... | 03/18/2010 |
| 20100063075 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives A compound of formula (1): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions whic... | 03/11/2010 |
| 20100016285 | HETEROCYCLIDENE-N-(ARYL) ACETAMIDE DERIVATIVE The blow-described formula (I)
| 01/21/2010 |
| 20090275574 | NOVEL COMPOUNDS-300 Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4, m, n, q, s, t, X, and Y are as defined in the specification as well as... | 11/05/2009 |
| 20090253705 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. ... | 10/08/2009 |
| 20090221567 | MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177 Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein Y, X, A, R1, R2, m, p, and q are as defined in the specification as well as salts and pharmaceutical composi... | 09/03/2009 |
| 20090186881 | CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP-antagonists of general formula I wherein R1, R2, R3, R4 and X are defined as in claim 1, the tautomers, the isomers... | 07/23/2009 |
| 20090181971 | Inhibitors of Histone Deacetylase The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditio... | 07/16/2009 |
| 20090082356 | Pyrazine Derivatives and Use as P13k Inhibitors The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney di... | 03/26/2009 |
| 20080306053 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosen... | 12/11/2008 |
| 20080280887 | Selected Cgrp-Antagonists, Processes for Preparing Them and Their Use as Pharmaceutical Compositions The invention relates to CGRP-antagonists of general formula (I), wherein R1, R2, R3, R4 and R5 are defined in claim 1, to the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures salts and salt... | 11/13/2008 |
| 20080221094 | Metalloprotease inhibitors containing a squaramide moiety The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting co... | 09/11/2008 |
| 20080176830 | Compounds, Compositions, and Methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.... | 07/24/2008 |
| 20080167329 | Quinazolinone T-Type Calcium Channel Antagonists The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to ... | 07/10/2008 |
| 20080045500 | Nerve Regeneration Stimulator A nerve regeneration stimulator comprising a compound having a cholinesterase inhibitory activity, a pharmacologically acceptable salt thereof or a solvate thereof. ... | 02/21/2008 |
| 20080032973 | 2-Quinazolinone compounds and methods of use The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B... | 02/07/2008 |
| 20070244099 | CGRP Antagonists CGRP antagonists of the formula of which the following are exemplary: (1) 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide, (2) 4-(2-oxo-1,2... | 10/18/2007 |
| 20070208044 | COMPOUNDS AND THERAPEUTICAL USE THEREOF Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal ... | 09/06/2007 |
| 20070208018 | Quinazoline Derivatives The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula(I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. ... | 09/06/2007 |
| 20070191333 | Antibacterial agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as di... | 08/16/2007 |
| 20070185142 | Process for producing substituted aminoquinazolinone derivative, intermediate therefor, and pest control agent A process for producing a substituted aminoquinazolinone derivative represented by the formula (I), characterized by reducing a substituted iminoquinazolinone derivative represented by the formula (II) with hydrogen in the presence of a catalyst and either of a halogen ... | 08/09/2007 |
| 20070185103 | Beta-secretase modulators and methods of use The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds h... | 08/09/2007 |
| 20070015774 | Quinazoline derivatives useful in cancer treatment The present invention provides compounds of Formula I (wherein R1, R2, R3, L, and X are as defined herein). or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising t... | 01/18/2007 |
| 20070015773 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine recepto... | 01/18/2007 |
| 20060270849 | Process for producing pyrimidin-4-one compound A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions. ... | 11/30/2006 |
| 20060217552 | Amino alcohol ligand and its use in preparation of chiral proparglic tertiary alkohols and tertiary amines via enantioselective addition reaction The invention disclosed a new process of asymmetric alkynylation of ketone or ketimine, involving the chiral ligand-mediated asymmetric addition of zinc or copper acetylide to a trifluoromethyl ketone or ketimine intermediate to give a chiral tertiary proparglic alcohol... | 09/28/2006 |
| 20060211717 | Quinoline and quinazoline derivatives and drugs containing the same There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmaco... | 09/21/2006 |
| 20060079685 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives A compound of formula (I): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions whi... | 04/13/2006 |
| 20060052345 | Quinazolinone compounds as calcilytics Various calcilytic compounds and pharmaceutical compositions containing these compounds are disclosed. Calcilytic compounds are compounds capable of inhibiting calcium receptor activity. Techniques which can be used to obtain calcilytic compounds and uses of calcilyitc ... | 03/09/2006 |
| 20060041130 | Syntheses of quinazolinones The present invention provides intermediates, synthetic methods and novel quinazolinone compositions of matter. ... | 02/23/2006 |
| 20060030573 | Substituted quinazolinone compounds A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure IA, IB, or IC where the values of the variable are defined... | 02/09/2006 |
| 20050267098 | Modulators of cellular adhesion The present invention provides compounds having formula (I):
| 12/01/2005 |
| 20050250152 | Reagents for labeling biomolecules having aldehyde or ketone moieties Novel fluorescent derivitization reagents are described that are suitable for coupling to biomolecules that contain aldehyde or ketone functional groups. In one embodiment is provided reagents that have the following formula: wherein Q is carbonyl, thiocarbony... | 11/10/2005 |
| 20050192297 | Quinazolinone compounds with reduced bioaccumulation A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA and IB. IA and IB have the follow... | 09/01/2005 |
