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| Application No. | Application Title | Issue Date |
| 20120046272 | Novel Therapeutic Compounds The present invention describes a series of therapeutically active compounds of formula I,
that are useful for treating a disorder in a mammal. In the f... | 02/23/2012 |
| 20120004206 | INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insul... | 01/05/2012 |
| 20110313158 | Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines The invention describes the development of highly efficient, recyclable two component system, CuAl-hydrotalcite/rac 1,1′-Binaphthalene-2,2′-diol catalytic system for the N-alkylation of electron deficient aryl chlorides in presence of potassium carbonate as a base a... | 12/22/2011 |
| 20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the ... | 12/15/2011 |
| 20110306600 | NOVEL THERAPEUTIC COMPOUNDS The invention discloses a number of therapeutic compounds and a method of treating a disorder in mammal.... | 12/15/2011 |
| 20110275784 | ASYMMETRIC SYNTHESIS OF PEPTIDES The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the ... | 11/10/2011 |
| 20110230428 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Certain chemical entities are provided herein. Pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibitio... | 09/22/2011 |
| 20110207926 | NOVEL DIHYDROTRIAZINE DERIVATIVE A compound represented by formula (1), a tautomer thereof, or a salt of the compound or tautomer, which is useful as a bactericide/disinfectant. In the formula, R1 represents a hydrogen atom, an op... | 08/25/2011 |
| 20110046129 | 2-Phenylethylamino Derivatives as Calcium and/or Sodium Channel Modulators 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.... | 02/24/2011 |
| 20110046128 | NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment of other central nervous system (“CNS”) diseases and disorders, such ... | 02/24/2011 |
| 20110039852 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are meth... | 02/17/2011 |
| 20100331234 | AMINOALCOHOL LIPIDOIDS AND USES THEREOF Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic ... | 12/30/2010 |
| 20100317582 | NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to meth... | 12/16/2010 |
| 20100304966 | Fungicidal Compounds, Method For the Production Thereof, And Use Thereof To Combat Damaging Fungi, And Agents Comprising The Same Compounds of the formula I in which the substituents have the meaning given in the description, processes for preparing these compounds, compositions comprising them and their use for controlling harmful fung... | 12/02/2010 |
| 20100279997 | ANALGESIC THAT BINDS FILAMIN A A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within. | 11/04/2010 |
| 20100280024 | RENIN INHIBITORS The present invention relates to renin inhibitors of formula (I), their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (I), their tautomeric for... | 11/04/2010 |
| 20100179109 | RENIN INHIBITORS Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases a... | 07/15/2010 |
| 20100144588 | PROTON ACCEPTOR IMINIUM/CARBOCATION-TYPE COUPLING AGENTS Novel iminium-type coupling agents containing proton acceptors in their iminium moiety, which can be used beneficially as coupling agents in various chemical polypeptide and/or polynucleotide syntheses, and are particularly useful as yield enhancing and racemization sup... | 06/10/2010 |
| 20100113778 | PROCESS FOR PREPARING O-CHLOROMETHYLPHENYLGLYOXYLIC ESTERS, IMPROVED PROCESS FOR PREPARING (E)-2-(2-CHLOROMETHYLPHENYL)-2-ALKOXIMINOACETIC ESTERS, AND NOVEL INTERMEDIATES FOR THEIR PREPARATION An improved process for preparing o-chloromethylphenylglyoxylic esters of the formula which comprises converting a compound of the formula by reac... | 05/06/2010 |
| 20100105686 | PHENYLSULFAMOYL BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS The present invention relates to new sulfonamide derivatives of formula (I) wherein
| |
| 20100069630 | NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation.... | 03/18/2010 |
| 20100036119 | FLUORINATING REAGENTS AND THEIR PREPARATION The present invention relates to α,α-difluoroamines, fluorinating reagents comprising α,α-difluoroamines and also processes for preparing α,α-difluoroamines and fluorinating reagents comprising α,α-difluoroamines.... | 02/11/2010 |
| 20090286775 | Bicyclic Derivatives as P38 Kinase Inhibitors New bicyclic derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors. ... | 11/19/2009 |
| 20090275583 | ANTIVIRAL COMPOUNDS AND USE THEREOF The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.... | 11/05/2009 |
| 20090216015 | Base Stable Ionic Liquids The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.... | 08/27/2009 |
| 20090181943 | Inhibitors of Histone Deacetylase This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates,... | 07/16/2009 |
| 20090163496 | ANTIBACTERIAL AGENTS Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of ... | 06/25/2009 |
| 20090062530 | Substituted arylalkanoic acid derivatives and use thereof A compound represented by the formula (I): [In the formula, Link represents a saturated or unsaturated straight hydrocarbon chain having 1 to 3 carbon atoms, C2 to C6 in the aromatic rin... | 03/05/2009 |
| 20090042730 | Substituted Arylketones The invention relates to novel aryl ketones of the formula (I) in which | 02/12/2009 |
| 20090029999 | Synephrine derivatives useful as anti-inflammatory agents This invention provides compounds having the structural formula: wherein:
| |
| 20090023734 | INHIBITORS OF HISTONE DEACETYLASE The invention provides compounds and methods for treating cell proliferative diseases. The invention provides new inhibitors of histone deacetylase enzymatic activity, compositions of the compounds comprising the inhibitors and a pharmaceutically acceptable carrier, exc... | 01/22/2009 |
| 20090023736 | Compounds for treating proliferative disorders Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceut... | 01/22/2009 |
| 20080261981 | NOVEL DERIVATIVES OF AMINO ACIDS FOR TREATMENT OF OBESITY AND RELATED DISORDERS Novel amino acid derivatives are provided that are useful for management of disorders such as obesity and immunological diseases. The derivatives are also useful in lowering blood glucose levels in hyperglycemic disorders and for treating related disorders such as body ... | 10/23/2008 |
| 20080234274 | Novel Compounds The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S.... | 09/25/2008 |
| 20080200461 | MODULATORS OF ACETYL-COENZYME A CARBOXYLASE AND METHODS OF USE THEREOF The present invention provides compounds of formula I: along with methods of use thereof for the control of agricultural pests, particularly fungal pests, weedy pests and insect pests, as well as use as pharm... | 08/21/2008 |
| 20080200467 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS Disclosed are alpha keto amide and alpha hydroxy amide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, c... | 08/21/2008 |
| 20080194536 | Cyanoarylamines The present invention relates to a compound represented by the following formula: (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a combination thereof,... | 08/14/2008 |
| 20080139564 | SUBSTITUTED PHENYL PROPYL AMINES AS HISTAMINE H3 RECEPTOR AND SEROTONIN TRANSPORTER MODULATORS Certain substituted phenyl propyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.... | 06/12/2008 |
| 20080096848 | Substituted N-Aryl-9-Oxo-9H-Fluorene-1-Carboxamides and Analogs as Activators of Caspases and Inducers of Apoptosis The present invention is directed to substituted N-aryl-9-oxo-9H-fluorene-1-carboxamides and analogs thereof, represented by the general Formula I: (I) wherein R1-R8, X and Ar are defined herein. The present invention also relates to the discovery ... | 04/24/2008 |
| 20080045470 | Ceramides and Apoptosis-Signaling Ligand The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods for making the compounds of form... | 02/21/2008 |
