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| Application No. | Application Title | Issue Date |
| 20120128741 | MODIFIED HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and ... | 05/24/2012 |
| 20120129919 | POLYCATIONIC AMPHIPHILIC CYCLOOLIGOSACCHARIDES AND THE USE THEREOF AS MOLECULAR TRANSPORTERS The present invention relates to a group of polycationic amphiphilic cyclooligosaccharides which, due to their molecular structure, may be used as molecular transporters to the interior of cells. Furthermore, the present invention also relates to the use of said compoun... | 05/24/2012 |
| 20120107942 | COMPOUNDS AND METHODS FOR RAPID LABELING OF N-GLYCANS The present invention provides compounds and methods for rapid labeling of N-glycans, for example, rapid fluorescent labeling of N-glycans. In one aspect, the present invention provides fluorescent carbamate or thiocarbamate compounds. Upon contacting with N-glycans, th... | 05/03/2012 |
| 20120107874 | Modified Host Cells and Uses Thereof The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.... | 05/03/2012 |
| 20120082717 | COMPLEX, MULTILAYER USING THE SAME, AND DEVICE COATED WITH THE MULTILAYER Disclosed herein is a complex, wherein micelles and/or liposomes dispersed in hyaluronic acids and/or hyaluronic acid derivatives, with a drug and/or functional material loaded in the micelles and/or the liposomes. The complex can release the drug and/or functional mate... | 04/05/2012 |
| 20120083006 | METHODS FOR THE IDENTIFICATION OF KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF KINASE PROTEINS The present invention relates to immobilization compounds (I), immobilization products and preparations thereof as well as methods and uses for the identification of kinase interacting compounds or for the purification or identification of kinase proteins. 04/05/2012 | |
| 20120046435 | Water-Soluble Carbohydrate Polyethers The present invention relates to novel carbohydrate polyether compositions that are soluble in aqueous media and particularly to carbohydrate polyether compositions exhibiting reverse thermogelation properties in aqueous media. Also, since the carbohydrate polyethers of... | 02/23/2012 |
| 20120034462 | HAIR-LIKE SHAPED HYDROGELS FOR SOFT TISSUE AUGMENTATION Hair-like shaped crosslinked hydrogels and methods for preparing such crosslinked hydrogels and are provided.... | 02/09/2012 |
| 20120035321 | COMPOUNDS AND MEDICAL DEVICES ACTIVATED WITH SOLVOPHOBIC LINKERS The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.... | 02/09/2012 |
| 20120035128 | POLYSACCHARIDE DERIVATIVE AND HYDROGEL THEREOF Disclosed are a polysaccharide derivative obtained by substituting some of the carboxyl groups of a carboxy polysaccharide with —NH—X—CO—Y—Z; and a hydrogel thereof. Here, X is a C1-10 hydrocarbon group, Y is a polyalkylene oxide having oxygen atoms... | 02/09/2012 |
| 20120022016 | Compounds and methods for selectively targeting tumor-associated mucins The present invention relates to pharmaceutical compositions containing tumor-selective targeted inhibitor glycoconjugates. These bioconjugates are ALK5 inhibitors covalently bound to biocompatible carrier molecules which selectively target and specifically bind to Muc4... | 01/26/2012 |
| 20110319357 | Hyaluronic Acid Derivatives The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and ... | 12/29/2011 |
| 20110305744 | PREPARATION FOR VAGINAL AND RECTAL USE AND RELATIVE PRODUCTION METHOD A preparation for vaginal and rectal use comprising hyaluronic acid, with an average particle size comprised between about 50 micrometers and about 200 micrometers and a molecular weight comprised between about 1,000,000 Da and about 1,800,000 Da.... | 12/15/2011 |
| 20110288283 | PROCESS FOR PRODUCING GLYCOSAMINOGLYCANS The invention provides a process for the production of a composition comprising a glycosaminoglycan, said process comprising subjecting a homogenate of glycosaminoglycan-containing animal material to chromatography using a chromatographic matrix in the form of a membran... | 11/24/2011 |
| 20110287067 | REINFORCED ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex... | 11/24/2011 |
| 20110263724 | THREADS OF HYALURONIC ACID AND/OR DERIVATIVES, THEREOF, METHODS OF MAKING THEREOF AND USES THEREOF The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.... | 10/27/2011 |
| 20110245196 | NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobia... | 10/06/2011 |
| 20110244520 | Compositions and Methods for Bacterial Production of Chondroitin The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial fermentation and post-fermentation sulfation.... | 10/06/2011 |
| 20110230652 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y ... | 09/22/2011 |
| 20110224423 | INOSITOL AND TREHALOSE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES COMPRISING THE SAME The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for... | 09/15/2011 |
| 20110217750 | Dendrimers and Dendrimer Applications An activatable functionalised Nth generation dendrimer having: a core comprising a first monomer having at least two carboxylic acid functional groups; and N successive generations, where N=0 to 10, wherein each generation comprises: a second monomer having a... | 09/08/2011 |
| 20110212901 | HYALURONIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF The present invention provides a hydrophobic group-introduced hyaluronic acid derivative comprising at least one repeating unit represented by the formula (I): wherein R1, R2, R3 | |
| 20110206772 | POLYSACCHARIDE COMPOSITION AND METHODS OF ISOLATION OF THE EMULSION STABILIZING CATIONIC POLYELECTROLYTIC POLYSACCHARIDE The present invention relates to purification and use of a novel emulsion stabilizing polysaccharide. In particular, a polyelectrolyte exopolysaccharide with high molecular weight comprising a high molecular weight polymer with a tri-saccharide repeating unit is disclos... | 08/25/2011 |
| 20110166339 | CRYSTALLINE CARBOHYDRATE DERIVATIVE α-Lactosamine hydrochloride, substantially free of β-lactosamine hydrochloride; a method of preparing α-lactosamine hydrochloride monohydrate from an anomeric mixture of lactosamine hydrochloride, including: preparing a solution including the anomeric mixture of lact... | 07/07/2011 |
| 20110142876 | CONJUGATED VI SACCHARIDES Two Vi conjugates have been prepared by carbodiimide-mediated synthesis, using adipic acid dihydrazide derivatized CRM197 (a non-toxic variant of diphtheria toxin) and tetanus toxoid, as carrier proteins.... | 06/16/2011 |
| 20110136722 | Drug Delivery Carrier The present disclosure relates to a method for the sustained release of a drug, comprising the steps of: (a) preparing a biocompatible polymer having a hydrophobic group conjugated to the biocompatible polymer; and (b) contacting the biocompatible polymer to the drug fo... | 06/09/2011 |
| 20110071274 | IMMOBILISATION OF CHELATING GROUPS FOR IMMOBILISED METAL ION CHROMATOGRAPHY (IMAC) The present invention refers to a method for binding a polycarboxylic acid to a solid phase. Further, the invention refers to a solid phase having a polycarboxylic acid immobilized thereto and methods of using the solid phase, e.g. for purifying His-tagged recombinant p... | 03/24/2011 |
| 20110070595 | METHODS FOR THE IDENTIFICATION OF PARP INTERACTING MOLECULES AND FOR PURIFICATION OF PARP PROTEINS The present invention relates to immobilization compounds and methods useful for the identification of PARP interacting compounds or for the purification or identification of PARP proteins.... | 03/24/2011 |
| 20110065910 | CARBOHYDRATES Carbohydrates having functional groups, such as carboxylic acid groups and methods of making such carbohydrates.... | 03/17/2011 |
| 20110060139 | CARBOHYDRATE DERIVATIVES A 1,2-dideoxy-1,2-diamino oligosaccharide or polysaccharide in its free base, salt or metal-complex form as shown in General Formula 1 and derivative thereof is described. R1, R2 and R | |
| 20110053887 | SOCS3 EXPRESSION PROMOTER, DRUG AND FOOD CONTAINING THE SAME AND METHOD OF PROMOTING THE EXPRESSION OF SOCS3 A SOCS3 expression promoter includes hyaluronic acid having an average molecular weight of 500,000 or more and/or a salt thereof as an active ingredient.... | 03/03/2011 |
| 20110024292 | COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, includin... | 02/03/2011 |
| 20100317617 | SILVER NANOPARTICLES AS ANTI-MICROBIAL A silver nanocomposite, a formation method for forming the silver nanocomposite, and an application method utilizing the silver nanocomposite. The silver nanocomposite includes a silver nanoparticle conjugated to a glycosaminoglycan (GAG) or glucose. The formation metho... | 12/16/2010 |
| 20100311687 | POLYSACCHARIDES DERIVATISED WITH CITRIC ACID Non-crosslinked derivatives of oligo/polysaccharides of formula I, wherein: X is OH, OM, NH—R1, O—R1; M is an alkaline or alkaline-earth metal, transition metal, or cation containing a quaternary nitrogen atom; Y is H or R2; R1: the ... | 12/09/2010 |
| 20100255097 | POLYSACCHARIDE DERIVATIVES OF LIPOIC ACID, AND THEIR PREPARATION AND USE AS SKIN COSMETICS AND MEDICAL DEVICES Disclosed are polysaccharides containing residues of glucosamine or galactosamine in the repetitive unit, characterised by the presence of esters on the hydroxyls or amides on the amine functions, with lipoic acid or with mixtures of lipoic acid and formic acid.... | 10/07/2010 |
| 20100210587 | Swellable Crosslinked Hyaluronan Powder And Method For Producing The Same The present invention is provides a crosslinked hyaluronan powder excellent in swellability in water and a method for simply producing the same. A method for producing the swellable crosslinked hyaluronan powder is characterized by comprising mixing a crosslinking agent... | 08/19/2010 |
| 20100196510 | COMPOSITION AND TREATMENT Disclosed are compositions for the treatment of neuropathy and in particular peripheral neuropathy. The compounds include low molecular weight glycosaminoglycans. The peripheral neuropathy may be due to cancer treatment drugs.... | 08/05/2010 |
| 20100184965 | Complex consisted of a polysaccharide and an HBP The invention relates to a complex consisted of a polysaccharide and an HBP, said polysaccharide being consisted from glycoside bonds of (1,6) and/or (1,4) and/or (1,3) and/or (1,2) type and functionalized with at least one salifiable or salified tryptophan derivative. ... | 07/22/2010 |
| 20100178346 | DISC AUGMENTATION WITH HYALURONIC ACID The present invention relates to materials comprising hyaluronic acid for replacement or augmentation of the nucleus pulposus The materials have a Poisson's ratio of 0.40 to 0.80 based on that of the human nucleus pulposus.... | 07/15/2010 |
| 20100173865 | Anti-Cancer Agent-Hyaluronic Acid Conjugate Compositions and Methods Methods of making conjugates comprising an anti-cancer agent and hyaluronic acid, together with mixtures of reaction products comprising such conjugates and methods of using such conjugates in therapeutic and research applications are disclosed.... | 07/08/2010 |
