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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Application No. | Application Title | Issue Date |
| 20120129166 | METHOD OF DETECTING FUNGI BELONG TO GENUS GEOSMITHIA A method of detecting a fungus belonging to genus Geosmithia, including identifying a fungus belonging to genus Geosmithia using a nucleic acid represented by the nucleotide sequence defined in the following (a) or (b):
| 05/24/2012 |
| 20120131688 | Reverse Breeding A method for efficiently producing homozygous organisms from a heterozygous non-human starting organism, comprising providing of a heterozygous starting organism; allowing the starting organism to produce haploid cells; creating homozygous organisms from the haploid cel... | 05/24/2012 |
| 20120108662 | COMPOSITIONS AND METHODS FOR TREATING SKIN DISORDERS The present application relates to compositions and the treatment of skin disorders, dry skin, protection of skin in inflammatory events and neurological disorders. The present application more particularly discloses the identification of new genes and metabolic pathway... | 05/03/2012 |
| 20120107816 | Primer Set for Detecting EGFR Exon 21 Polymorphism and Application Thereof The invention provides a primer set for detecting a polymorphism in EGFR exon 21 L858R. The primer set has a P1 oligonucleotide and a P2 oligonucleotide and can performing amplification by using a region including the 172792nd base of SEQ ID NO: 1 as a template. As a ba... | 05/03/2012 |
| 20120107817 | Probe for Detection of Polymorphism in EGFR Gene, Amplification Primer, and Use Thereof A polymorphism-detecting probe, an amplification primer and the use thereof are provided to enable simple and highly reliable determination of different polymorphisms in an EGFR gene.... | 05/03/2012 |
| 20120107814 | Method for Determining the Predisposition of a Patient to Changed Biotransformation and to the Development of Undesired Drug Effects in a Treatment of the Patient with Atrovastatin A method for determining a predisposition of a patient to the development of muscular diseases and/or to changed biotransformation in a treatment of the patient with atorvastatin is disclosed. The presence of at least one single nucleotide polymorphism (SNP) in the UGT1... | 05/03/2012 |
| 20120107879 | METHODS FOR PRODUCTION AND PURIFICATION OF NUCLEIC ACID MOLECULES The present invention is directed to methods for the production and isolation of nucleic acid molecules. In particular, the invention concerns isolation of mRNA molecules and the production and isolation of nucleic acid molecules (e.g., cDNA molecules or libraries), whi... | 05/03/2012 |
| 20120110688 | AAD-12 EVENT 1606 AND RELATED TRANSGENIC SOYBEAN LINES This invention relates to soybean event pDAB4472-1606 (Event 1606). This invention includes a novel aad-12 transformation event in soybean plants comprising a polynucleotide sequence, as described herein, inserted into a specific site within the genome of a soybean cell... | 05/03/2012 |
| 20120108651 | GENETIC POLYMORPHISMS ASSOCIATED WITH VENOUS THROMBOSIS AND STATIN RESPONSE, METHODS OF DETECTION AND USES THEREOF The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment (particularly for reducing the risk of venous thrombosis). For example, the present invention relates to nucleic acid molecules c... | 05/03/2012 |
| 20120082678 | GENETIC POLYMORPHISMS ASSOCIATED WITH PSORIASIS, METHODS OF DETECTION AND USES THEREOF The present invention is based on the discovery of genetic polymorphisms that are associated with psoriasis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid mol... | 04/05/2012 |
| 20120082989 | USES FOR LONG POLAR FIMBRIAE GENES OF PATHOGENIC ESCHERICHIA COLI STRAINS Provided are methods for identifying lpf genes in pathogenic serotypes of the Enterobacteriaceae family and for differentiating Escherichia coli (E. coli) O157:H7 strains in an isolate using primer pairs specific to lpf gene variants, particularly IpfA1 an... | 04/05/2012 |
| 20120083595 | RICE BLAST SUSCEPTIBILITY GENE Pi21, RESISTANCE GENE pi21, AND USES THEREOF The present inventors succeeded in isolating the rice field resistance gene pi21 by linkage analysis, and found that field resistance to blast in plants could be modified by introducing or controlling the expression of the gene. Thus, it became possible to efficiently c... | 04/05/2012 |
| 20120082684 | DIAGNOSIS AND TREATMENT OF CELL PROLIFERATION AND DIFFERENTIATION DISORDERS BASED ON THE FMN2 GENE The present invention provides methods for diagnosing cell proliferation and/or differentiation disorders, compounds and methods for treating the same and methods for identifying agents potentially useful in the treatment of cell proliferation and/or differentiation dis... | 04/05/2012 |
| 20120082984 | NUCLEIC ACIDS FOR DETECTION AND DISCRIMINATION OF GENOTYPES OF CHLAMYDOPHILA PSITTACI Methods of detecting Chlamydophila, including differentiating between species of Chlamydophila and/or strains of Chlamydophila psittaci are disclosed, for example to detect and genotype a Chlamydophila psittaci infection. A sample suspected o... | 04/05/2012 |
| 20120070832 | SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) withi... | 03/22/2012 |
| 20120070831 | Amplification of Distant Nucleic Acid Targets Using Engineered Primers The invention is a method of amplifying nucleic acids by synthesizing an engineered amplicon containing the sequence of interest, but omitting intervening sequences present in the template molecule. The method utilizes an “amplicon bridge” incorporated into the ampl... | 03/22/2012 |
| 20120070838 | Polymerase Assay with a FRET Substrate This specification generally relates to non-radioactive methods of detecting nucleic acid polymerase activity and methods of detecting compounds that modulate nucleic acid polymerase activity. The activity may be measured in real-time using a real-time PCR instrument.... | 03/22/2012 |
| 20120071332 | Method for Quantification of Small RNA Species The present invention relates to a method for amplification and quantification of microRNA molecules using quantitative reverse transcription polymerase chain reaction (qRT-PCR) technology. The method comprise the steps of (a) producing cDNA molecules complementary to m... | 03/22/2012 |
| 20120053232 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 (TSSC4) Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human and tumor suppressing subtransferable candidate 4 (TSSC4) and methods of use.... | 03/01/2012 |
| 20120054907 | DELAYED FRUIT DETERIORATION ALLELE IN PLANTS AND METHODS OF DETECTION Disclosed is an isolated nucleic acid molecule comprising a nucleotide sequence that is at least 90% identical to a nucleotide sequence encoding a protein having the amino acid sequence of SEQ ID NO 4, wherein the protein has an aspartic acid (Asp) at amino acid positio... | 03/01/2012 |
| 20120052501 | KIT FOR DETECTING HTLV STRAINS AND USE THEREOF Methods and kits are described for the rapid and quantitative real-time PCR detection of HTLV nucleic acid sequences in biological samples. The procedure promises to facilitate the high throughput detection of HTLV in a cost effective and reliable manner.... | 03/01/2012 |
| 20120045753 | SEQUENCES DIAGNOSTIC FOR SHRIMP PATHOGENS Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... | 02/23/2012 |
| 20120046190 | HP1ALPHA AS A PROGNOSTIC MARKER IN HUMAN CANCER The present invention provides a prognostic marker in human cancer, HP1α, a high expression thereof being associated with a poor prognosis. The present invention further provides a method for diagnosing a cancer in a subject, HP1α a being specifically overexpressed in... | 02/23/2012 |
| 20120046339 | Novel chorismate mutase gene from the potato cyst nematode globodera rostochiensis The nucleotide sequence of a 992 bp region of cDNA and the nucleotide sequence of a 1973 bp (or a 1913 bp) of genomic DNA of the Gr-cm-1 gene were determined for G. rostochiensis. PCR primers and probes specific for G. rostochiensis and G. pallida w... | 02/23/2012 |
| 20120039889 | METHODS OF DIAGNOSING AND TREATING PROSTATE CANCER CHARACTERIZED BY NDRG1-ERG FUSION An in depth analysis of prostate cancer prostatectomy samples which over-express the ERG oncogene led to the discovery of a novel gene translocation in prostate cancer, between the NDRG1 gene (N-myc downstream regulated gene 1) on chromosome 8 and the ERG oncogene on ch... | 02/16/2012 |
| 20120039993 | Detection of Gene Expression An oligonucleotide, primer or probe comprises the nucleotide sequence of any of SEQ ID NO. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 61, 62 or 63. Th... | 02/16/2012 |
| 20120040360 | COMPOSITIONS, METHODS AND KITS TO DETECT DICER GENE MUTATIONS In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... | 02/16/2012 |
| 20120040341 | Method for the Detection and Diagnosis of Cancer Involving Primers and Probes for the Specific Detection of the MAGE-A3-Marker The present invention relates to MAGE-3 specific primers and probes for use new diagnostic kits and methods. The invention further relates to immunotherapeutic treatment of specific populations of cancer patients, suffering from MAGE-3 expressing tumours.... | 02/16/2012 |
| 20120040352 | Primers, probes and methods for nucleic acid amplification Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non... | 02/16/2012 |
| 20120040884 | Methods and Reagents for Treatment and Diagnosis of Vascular Disorders and Age-Related Macular Degeneration Disclosed are screening methods for determining a human subject's propensity to develop a vascular disorder and/or age-related macular degeneration (AMD), therapeutic or prophylactic compounds for treating disease or inhibiting its development, and methods of treating p... | 02/16/2012 |
| 20120040357 | COMPOSITIONS, METHODS AND KITS TO DETECT DICER GENE MUTATIONS In one aspect, the disclosure provides isolated nucleic acids, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... | 02/16/2012 |
| 20120035065 | Aptamer Regulated Nucleic Acids and Uses Thereof The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a primer sequence domain and an aptamer domain that is responsive to a l... | 02/09/2012 |
| 20120036589 | VACCINE The present invention is concerned with the development of a vaccine against Aeromonas hydrophila for use especially in fish. The invention provides an immunogenic S-layer protein of approximately 50 kDa of A. hydrophila for use in the development of a vac... | 02/09/2012 |
| 20120034263 | SEQUENCES DIAGNOSTIC FOR SHRIMP PATHOGENS Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... | 02/09/2012 |
| 20120028243 | AMPLIFICATION GENIQUE STATISTIQUE POUR L'IDENTIFICATION SANS A PRIORI DE MICRO-ORGANISMES PAR SEQUENCAGE SANS ETAPE DE CLONAGE A pair of hexamers and a pair of primers specifically for identifying, without preconceptions, microorganisms in a sample, and a method for identifying one or more microorganisms, and a microorganism identification kit that uses the abovementioned hexamers and primers.... | 02/02/2012 |
| 20120027777 | LJUNGAN VIRUS WITH IMPROVED REPLICATION CHARACTERISTICS The present invention relates to a Ljungan virus with improved replication characteristic and the use of this Ljungan virus, amongst other thing, in the production of a vaccine.... | 02/02/2012 |
| 20120028252 | HUMAN MENA ISOFORMS SERVE AS MARKERS OF EPITHELIAL TO MESENCHYMAL TRANSITION AND SENSITIVITY TO EGFR INHIBITION IN HUMAN CANCER CELLS The present invention discloses a method for discriminating between sensitive and resistant tumours to a treatment with EGFR inhibitor drugs comprising: in vitro testing whether tumour material expresses the hMena+11a splicing variant of hMe-na, the tumour po... | 02/02/2012 |
| 20120020990 | ISOLATED MAMMALIAN MONOCYTE CELL GENES; RELATED REAGENTS Nucleic acids encoding various monocyte cell proteins from a primate, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.... | 01/26/2012 |
| 20120021427 | Methods For Rapid Forensic DNA Analysis The present invention provides methods and primer pairs for rapid, high-resolution forensic analysis of DNA and STR-typing by using amplification and mass spectrometry, determining the molecular masses and calculating base compositions of amplification products and comp... | 01/26/2012 |
| 20120021429 | Compositions, Products, Methods And Systems to Monitor Water And Other Ecosystems Disclosed are compositions, products, methods and systems for monitoring ecosystems, such as bodies of water, for a parameter of the ecosystems, such as the presence or absence of mercury. In one embodiment, the product may include a plurality of oligonucleotides immobi... | 01/26/2012 |
