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| Application No. | Application Title | Issue Date |
| 20120131693 | SOYBEAN MARKERS LINKED TO SCN RESISTANCE This disclosure concerns compositions and methods for identifying the SCN resistant phenotype in soybean. In some embodiments, the disclosure concerns methods for performing marker-assisted breeding and selection of plants carrying one or more determinants of SCN resist... | 05/24/2012 |
| 20120131690 | BRASSICA GAT EVENT DP-061061-7 AND COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND/OR DETECTION THEREOF Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-061061-7 event which imparts tolerance to glyphosate. The Brassica plant harbor... | 05/24/2012 |
| 20120126175 | OLIGONUCLEOTIDE DERIVATIVE, LABELING AGENT AND USE FOR LABELING AGENT The disclosures of the Specification provide an oligonucleotide derivative suited to practical use, as well as a fluorescent dye cluster and use therefor. The disclosures of the Specification use a labeling agent comprising a plurality of nucleotide derivative units rep... | 05/24/2012 |
| 20120131692 | BRASSICA GAT EVENT DP-073496-4 AND COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND/OR DETECTION THEREOF Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-073496-4 event which imparts tolerance to glyphosate. The Brassica plant harbor... | 05/24/2012 |
| 20120107812 | Means and methods for investigating nucleic acid sequences The invention provides improved methods for investigating nucleic acid sequences, wherein at least one additional probe is used which is specific for a (pseudo)gene variant of a target nucleic acid. The invention further provides improved calibrators which are particula... | 05/03/2012 |
| 20120107820 | Multiplexed Quantitative PCR End Point Analysis of Nucleic Acid Targets Certain embodiments of the present invention are directed to one pot multiplexed quantitative PCR methods for end point analysis of a plurality of nucleic acid targets in a complex sample without user intervention, and to various encoded particles on which are immobiliz... | 05/03/2012 |
| 20120107815 | Polymorphism Detection Probe, Polymorphism Detection Method, Evaluation of Drug Efficacy, and Polymorphism Detection Kit The invention provides a probe which detects a polymorphism in the MDR1 gene. The probe has a P1 and/or a P2 oligonucleotide. The P1 oligonucleotide has a sequence that is complementary to a first base sequence, in which the first base sequence is a partial sequence of ... | 05/03/2012 |
| 20120107798 | SINGLE MOLECULE SENSITIVE PROBES FOR DETECTING RNA The various embodiments of the present disclosure relate generally to single molecule sensitive probes for detecting RNA, and more particularly to multivalent fluorescent probes for detecting a single molecule of RNA in a cell. The present invention includes a RNA imagi... | 05/03/2012 |
| 20120053079 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF CANCER The present invention relates to methods and compositions for diagnosing and treating cancer, such as breast cancer and skin cancer.... | 03/01/2012 |
| 20120052079 | Compositions, Kits, and Methods for Predicting Anti-Cancer Response to Anthracyclines The present invention is based, in part, on the discovery that amplification of human chromosome 8q22-23 regions and over-expression of 8q22-23 genes (e.g., LAPTM4B and YWHAZ) is associated with and predictive of resistance to anthracycline-type chemotherapy. Accordingl... | 03/01/2012 |
| 20120052502 | REAL-TIME PCR DETECTION USING STABILIZED PROBES A probe protector oligonucleotide is described for the improved CATACLEAVE™ probe detection of nucleic acid sequences in a test sample. The probe protector oligonucleotide is designed to be substantially complementary to the FRET pair labeled CATACLEAVE™ oligonucleo... | 03/01/2012 |
| 20120040357 | COMPOSITIONS, METHODS AND KITS TO DETECT DICER GENE MUTATIONS In one aspect, the disclosure provides isolated nucleic acids, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... | 02/16/2012 |
| 20120039887 | COMPOSITIONS AND METHODS FOR DIAGNOSING PROSTATE CANCER BASED ON DETECTION OF SLC45A3-ELK4 FUSION TRANSCRIPT RNA transcripts representing a fusion of a human SLC45A3 nucleic acid and a human ELK4 nucleic acid that are associated with prostate cancer are described. Compositions and methods useful for detection of fusion transcripts of human SLC45A3 and ELK4 genetic sequences as... | 02/16/2012 |
| 20120039993 | Detection of Gene Expression An oligonucleotide, primer or probe comprises the nucleotide sequence of any of SEQ ID NO. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 44, 61, 62 or 63. Th... | 02/16/2012 |
| 20120040352 | Primers, probes and methods for nucleic acid amplification Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following non... | 02/16/2012 |
| 20120040341 | Method for the Detection and Diagnosis of Cancer Involving Primers and Probes for the Specific Detection of the MAGE-A3-Marker The present invention relates to MAGE-3 specific primers and probes for use new diagnostic kits and methods. The invention further relates to immunotherapeutic treatment of specific populations of cancer patients, suffering from MAGE-3 expressing tumours.... | 02/16/2012 |
| 20120039893 | MUTANT SMOOTHENED AND METHODS OF USING THE SAME The emergence of mutations in tyrosine kinases following treatment of cancer patients with molecular-targeted therapy represents a major mechanism of acquired drug resistance. Here, we describe a mutation in the serpentine receptor, Smoothened (SMO), which results in re... | 02/16/2012 |
| 20120040360 | COMPOSITIONS, METHODS AND KITS TO DETECT DICER GENE MUTATIONS In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... | 02/16/2012 |
| 20120036599 | NOVEL FUNGAL ENZYMES This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and me... | 02/09/2012 |
| 20120030838 | NOVEL FUNGAL ENZYMES This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and me... | 02/02/2012 |
| 20120021930 | Multiplex Nucleic Acid Detection The present invention relates to a novel multiplex detection of nucleic acid targets in a sample. This is accomplished by using novel padlock probes which contain a unique cleavage site for linearization and a first member of a binding pair for isolation of the padlock ... | 01/26/2012 |
| 20120020977 | PANCREATIC CANCER GENES The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplas... | 01/26/2012 |
| 20120021410 | TRIGGERED MOLECULAR GEOMETRY BASED BIOIMAGING PROBES The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable molecular shape with prescribed geometry. In some embodiments the prescrib... | 01/26/2012 |
| 20120015049 | MICRORNA BIOMARKER IN CANCER This invention provides compositions and methods for predicting and improving a chemotherapy response to treat an ovarian cancer. In one embodiment, the invention provides compositions and methods for detecting the expression level of Let-7i microRNA to predict a chemot... | 01/19/2012 |
| 20120015358 | ORTHOGONAL NUCLEIC ACID AFFINITY PAIRS The invention provides methods to identify pRNA- and pDNA oligomer affinity pairs. Affinity pairs comprised of nucleic acid oligomers which demonstrate no cross-reactivity (“orthogonal”) are designed using software and empirically verified by thermodynamic study and... | 01/19/2012 |
| 20120015827 | METHOD FOR THERAPY PREDICTION IN TUMORS HAVING IRREGULARITIES IN THE EXPRESSION OF AT LEAST ONE VEGF LIGAND AND/OR AT LEAST ONE ERBB-RECEPTOR The present invention is related to a method for predicting a clinical response of a patient suffering from or at risk of developing a neoplastic disease towards a given mode of treatment, said method comprising the steps of: a) obtaining a biological sample from said p... | 01/19/2012 |
| 20120010275 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 Provided herein are isolated genomic polynucleotide fragments from the p15 arm of chromosome 11 and methods of use.... | 01/12/2012 |
| 20120010395 | COMPOSITIONS, PROBES, AND CONJUGATES AND USES THEREOF The present invention relates to compositions useful as probes and in other applications and methods of their use. In some embodiments, nucleotides are prepared and functionalized with dyes. In some embodiments a first molecule is functionalized with an alkynyl group, a... | 01/12/2012 |
| 20120003638 | KIT FOR HIGH THROUGHPUT MUTATION SCREENING METHODS One example embodiment includes a kit to execute a method of simultaneously screening for genetic mutations in different genes in a multitude of samples. The kit includes an antisense deoxyribonucleic acid (DNA) probe, where the antisense DNA probe will be mixed with a ... | 01/05/2012 |
| 20110319283 | OLIGONUCLEOTIDES CAPABLE OF DISCRIMINATING BETWEEN NUCLEIC ACID SEQUENCES THAT COMPRISE A CONSERVED SEQUENCE The invention provides inter alia an oligonucleotide (or “probe”) able to discriminate between a nucleic acid target and a nucleic acid variant thereof (for example, mRNA splice variants, or chimeric gene and corresponding parent gene mRNAs) in which the target and ... | 12/29/2011 |
| 20110319333 | METHOD AND COMPOSITIONS FOR THE TREATMENT AND DETECTION OF ENDOTHELIN-1 RELATED KIDNEY DISEASES The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A k... | 12/29/2011 |
| 20110318746 | RAPID OLIGO PROBES Disclosed are methods, rapid probes, and kits for general purpose nucleic acid detection.... | 12/29/2011 |
| 20110311968 | Allele-Specific Amplification of Nucleic Acids The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, having an internally-placed selective nucleotide complementary to on... | 12/22/2011 |
| 20110314569 | Combination of Two Genetic Elements for Controlling the Floral Development of a Dicotyledonous Plant, and Use in Detection and Selection Methods The present invention relates to a combination of two genetic elements for controlling the development of the floral type of a dicotyledonous plant, said combination comprising, respectively:
| 12/22/2011 |
| 20110306510 | OPTIMIZED PPROBES AND PRIMERS AND METHODS OF USING SAME FOR THE DETECTION, SCREENING, ISOLATING AND SEQUENCING OF MRSA, MSSA STAPHYLOCOCCUS MARKERS, AND THE ANTIBIOTIC RESISTANCE GENE MEC A Described herein are primers and probes useful for the detection, screening, isolation and sequencing of MRSA, MSSA, Staphylococci markers, and the antibiotic resistance gene mecA.... | 12/15/2011 |
| 20110302667 | TRANSGENIC BRASSICA EVENT MON 88302 AND METHODS OF USE THEREOF The invention provides plants comprising transgenic event MON 88302 that exhibit tolerance to glyphosate herbicide. The invention also provides seeds, plant parts, cells, commodity products, and methods related to the event. The invention also provides DNA molecules tha... | 12/08/2011 |
| 20110294123 | METHODS FOR DIAGNOSING OR TREATING PROSTATE CANCER The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods ... | 12/01/2011 |
| 20110294118 | WATER SOLUBLE FLUORESCENT COMPOUNDS The invention provides a novel class of fluorescent compounds. Also provided are conjugates of the fluorescent compounds, methods of using the fluorescent compounds and their conjugates as well as kits including the fluorescent compounds and their conjugates.... | 12/01/2011 |
| 20110288148 | TRIGGERED COVALENT PROBES FOR IMAGING AND SILENCING GENETIC EXPRESSION The present invention relates to the use of cross-linking probes to covalently bind probes to nucleic acid targets. In some embodiments, the probe comprises an initiator region that is able to bind to a first portion of a target nucleic acid, a probe region linked too t... | 11/24/2011 |
| 20110287421 | Probes for Detection of NAT2 Gene, Reagent Containing the Same, and The Uses Thereof Primer sets for amplifying target regions containing sites to be detected in the NAT2 gene by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward primers consisting... | 11/24/2011 |
