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| Application No. | Application Title | Issue Date |
| 20120070434 | ANTIBODIES CONTAINING THERAPEUTIC TPO/EPO MIMETIC PEPTIDES The present disclosure features therapeutic antibodies (e.g., TPO mimetic antibodies) and therapeutically-active fragments thereof as well as methods for preparing and using the antibodies and fragments. For example, the therapeutic antibodies and their fragments are us... | 03/22/2012 |
| 20120046229 | MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES Modified relaxin polypeptides and their uses thereof are provided... | 02/23/2012 |
| 20120034655 | FSH PRODUCING CELL CLONE The present invention relates to nucleic acid molecules comprising a nucleic acid sequence coding for the α- and the β-chain of the human follicle stimulating hormone (FSH), respectively, which has been modified with respect to the codon usage in CHO cells. The presen... | 02/09/2012 |
| 20120021984 | Glycoprotein Hormone Analogs This invention relates to the field of glycoprotein hormone analogs and their uses as agonists, antagonists, targeting vectors, and immunogens. In particular, this invention describes a method for stabilizing a heterodimer that permits the preparation of functional glyc... | 01/26/2012 |
| 20110305710 | NOVEL COMPOUNDS FOR THE TREATMENT OF GLAUCOMA OR OCULAR HYPERTENSION This invention relates to compositions and methods for the treatment or prophylaxis of glaucoma and ocular hypertension, and for lowering of intraocular pressure. The invention provide VEGFR-1 agonists and combinations of vascular endothelial growth factor B (VEGF-B) wi... | 12/15/2011 |
| 20110293587 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such meth... | 12/01/2011 |
| 20110293586 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such metho... | 12/01/2011 |
| 20110294733 | MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND MANUFACTURING METHOD THEREOF The invention concerns human thrombopoietin and in particular modified forms of thrombopoietin (TPO) with improved properties. The improved proteins contain amino acid substitutions at specific positions within the TPO molecule. The invention provides modified TPO molec... | 12/01/2011 |
| 20110286981 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such meth... | 11/24/2011 |
| 20110237651 | TREATMENT OF ERYTHROPOIETIN (EPO) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO EPO Oligonucleotide compounds modulate expression and/or function of Erythropoietin (EPO) polynucleotides and encoded products thereof. Methods for treating diseases associated with Erythropoietin (EPO) comprise administering one or more oligonucleotide compounds designed t... | 09/29/2011 |
| 20110207221 | Targeted genomic modification with partially single-stranded donor molecules Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or compositions comprising these molecules can be used in methods for targeted integration of an exogenous sequence ... | 08/25/2011 |
| 20110195896 | ISOFORM-SPECIFIC INSULIN ANALOGUES A method treating a mammal by administering a physiologically effective amount of an insulin analogue or a physiologically acceptable salt thereof where the insulin analogue displays more than twofold greater binding affinity to insulin receptor isoform A (IR-A) than in... | 08/11/2011 |
| 20110177029 | O-LINKED GLYCOSYLATION USING N-ACETYLGLUCOSAMINYL TRANSFERASES The present invention provides covalent conjugates between a polypeptide and a modifying group, such as a water-soluble polymer (e.g., PEG). The amino acid sequence of the polypeptide includes one or more O-linked glycosylation sequence, each being a substrate for a GIc... | 07/21/2011 |
| 20110173722 | NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and... | 07/14/2011 |
| 20110166064 | HALOGEN-STABILIZED INSULIN An insulin analogue comprises a B-chain polypeptide incorporating a halogenated phenylalanine at position B24, B25 or B26. The halogenated phenylalanine may be ortho-monofluoro-phenylalanine, ortho-monobromo-phenylalanine, ortho-monochloro-phenylalanine, or para-monochl... | 07/07/2011 |
| 20110135614 | MODIFIED GROWTH HORMONE The invention provides, a nucleic acid molecule encoding a growth hormone (GH) in which the RSP sorting signal has been mutated, such that the GH can be constitutively secreted by the nonregulated secretory pathway (NRSP) in a mammalian cell. The invention also provides... | 06/09/2011 |
| 20110117072 | HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) in... | 05/19/2011 |
| 20110117600 | PROCESS FOR OBTAINING ASPART INSULIN USING A PICHIA PASTORIS YEAST STRAIN The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a ... | 05/19/2011 |
| 20110111460 | Method for Making Mature Insulin Polypeptides The invention is related to a method for making human insulin analogues by culturing an fungi cell comprising a DNA vector encoding a precursor for human insulin analogue, wherein the said precursor comprises a connecting peptide flanked with cleavage sites at both junc... | 05/12/2011 |
| 20110105396 | TGF-BETA3 MUTANTS The invention provides TGF-β3s, or fragments or derivatives thereof, wherein the alpha-helix-forming domain between amino acid residues (58) and (67) of full-length wild type TGF-β3 comprises at least one alpha-helix-stabilising substitution. The invention also provid... | 05/05/2011 |
| 20110077196 | NON-STANDARD INSULIN ANALOGUES An insulin analogue comprises a B-chain polypeptide containing at least one alteration selected from a methylated phenylalanine substitution at position B24 and an addition of two amino acids to the carboxyl end of the B-chain polypeptide. A first amino acid at position... | 03/31/2011 |
| 20110076257 | Modified Nucleotide Sequence Encoding Glucagon-Like Peptide-1 (GLP-1), Nucleic Acid Construct Comprising Same for Production of Glucagon-Like Peptide-1 (GLP-1), Human Cells Comprising Said Construct and Insulin-Producing Constructs, and Method of Use Thereof An isolated chimeric GLP-1 nucleic acid sequence encoding a human pro-insulin leader, a glucagon-like peptide-1 (GLP-1), and a furin cleavable site between the human pro-insulin leader sequence and the GLP-1 is provided. Also provided is an isolated modified chimeric GL... | 03/31/2011 |
| 20110065638 | NOVEL CRUSTACEAN ANDROGENIC GLAND HORMONE The present invention relates to a novel crustacean androgenic gland hormone. More specifically, the invention relates to an androgenic gland hormone derived from Penaeus monodon. The invention relates further to the use of the hormone to influence the sex ratio ... | 03/17/2011 |
| 20110059855 | Use of adiponectin for the diagnosis and/or treatment of presbycusis The present invention relates to mutations located within the gene coding for adiponectin, said mutations being associated with presbycusis. The present invention further relates to adiponectin polynucleotides comprising such mutations, to adiponectin polypeptides encod... | 03/10/2011 |
| 20110004947 | COMPOSITIONS AND METHODS FOR OSTEOGENIC GENE THERAPY The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides rec... | 01/06/2011 |
| 20100330676 | EXPRESSION OF SURROGATE LIGHT CHAINS The present invention concerns surrogate light chain (SURROBODY™) constructs comprising surrogate light chain sequences with heterologous signal sequences.... | 12/30/2010 |
| 20100323954 | CHIMERIC POLYPEPTIDES AND USES THEREOF The disclosure provides nucleic acid molecules encoding chimeric polypeptides, chimeric polypeptides, pharmaceutical compositions comprising chimeric polypeptides, and methods for treating metabolic disorders such as diabetes and obesity using such nucleic acids, polype... | 12/23/2010 |
| 20100317585 | LONG-ACTING COAGULATION FACTORS AND METHODS OF PRODUCING SAME Polypeptides and polynucleotides encoding same comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a coagulation factor and not to an amino terminus are disclosed. Pharmaceutical compositions comprising the... | 12/16/2010 |
| 20100305034 | GROWTH FACTOR ISOFORM An isolated VEGF polypeptide having anti-angiogenic activity, said polypeptide including the amino acid sequence of SEQ.ID NO.1, or variants thereof.... | 12/02/2010 |
| 20100298220 | FIBROBLAST GROWTH FACTOR MUTANTS HAVING IMPROVED FUNCTIONAL HALF-LIFE AND METHODS OF THEIR USE Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine a... | 11/25/2010 |
| 20100273215 | Secretion Yield of a Protein of Interest by in vivo Proteolytic Processing of a Multimeric Precursor The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The invention further relates to a cell comprising this nucleic acid molecule and... | 10/28/2010 |
| 20100256226 | EG-VEGF NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USE The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules compri... | 10/07/2010 |
| 20100222274 | GLYCOSYLATION-DEFICIENT HEPATOCYTE GROWTH FACTOR The invention provides a modified glycosylation-deficient HGF and a production method thereof. The glycosylation-deficient HGF is produced by introducing amino acid mutation(s) so that no glycosylation take place at at least one glycosylation site of hepatocyte growth f... | 09/02/2010 |
| 20100216710 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on... | 08/26/2010 |
| 20100203627 | LONG-TERM IN VIVO TRANSGENE EXPRESSION Efficient and prolonged hCFTR expression is one of the major obstacles for cystic fibrosis lung therapy. hCFTR mRNA expression levels depend on eukaryotic expression cassette components, prokaryotic backbone elements, and the gene transfer method may also influence tran... | 08/12/2010 |
| 20100189682 | Biologically active proteins having increased In Vivo and/or In Vitro stability The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these enti... | 07/29/2010 |
| 20100174054 | Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also pro... | 07/08/2010 |
| 20100150909 | PTHrP-DERIVED MODULATORS OF SMOOTH MUSCLE PROLIFERATION The present invention relates to the use of mutants of parathyroid hormone-related protein, to treat disorders associated with smooth muscle cells, and to inhibit the cellular activation and proliferation thereof. The method can be employed in diverse tissues to effect ... | 06/17/2010 |
| 20100143288 | HUMAN GRANULOCYTE-COLONY STIMULATING FACTOR ISOFORMS Disclosed is a novel physiologically active protein, which is a human granulocyte colony stimulating factor isoform, constructed in order to increase the in vivo lifetime of human granulocyte colony sedtimulating factor. The human granulocyte colony stimulating factor i... | 06/10/2010 |
| 20100120677 | ACTIVITY OF RECOMBINANT EQUINE FOLLICLE STIMULATING HORMONE The present invention provides methods of producing biologically active recombinant eFSH analogs and methods of increasing reproduction in mammals, particularly equine, using recombinant eFSH analogs. Also provided are methods of producing biologically active single cha... | 05/13/2010 |
