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| Application No. | Application Title | Issue Date |
| 20120128649 | MODIFIED NON-CYTOTOXIC PROTEASES The present invention relates to a modified polypeptide comprising a non-cytotoxic protease, a translocation domain, a destructive protease cleavage site and a Targeting Moiety that binds to a Binding Site on a nerve cell, wherein after cleavage of the destructive cleav... | 05/24/2012 |
| 20120129227 | THERMOSTABLE CELLULASES, AND MUTANTS THEREOF, CAPABLE OF HYDROLYZING CELLULOSE IN IONIC LIQUID The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introduci... | 05/24/2012 |
| 20120131692 | BRASSICA GAT EVENT DP-073496-4 AND COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND/OR DETECTION THEREOF Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-073496-4 event which imparts tolerance to glyphosate. The Brassica plant harbor... | 05/24/2012 |
| 20120128652 | ENDOLYSIN PLYP40 The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO:1. The present invention further relates to the nucleic acid molecules comprising a nucleotide sequence coding for the polypeptide, vectors comprising the nucleic acid mole... | 05/24/2012 |
| 20120131695 | Chalcone synthase dihyrdoflavonol 4-reductase and leucoanthocyanidine reductase from clover, medic ryegrass or fescue The present invention relates to nucleic acid fragments encoding amino acid sequences for flavonoid biosynthetic enzymes in plants, and the use thereof for the modification of, for example, flavonoid biosynthesis in plants, and more specifically the modification of the ... | 05/24/2012 |
| 20120129222 | MUTANT FORMATE DEHYDROGENASE, GENE ENCODING THE SAME, AND METHOD FOR PRODUCING NADH Durability of formate dehydrogenase is improved with the use of formate dehydrogenase exhibiting high specific activity that is unpredictable from conventional findings. A specific amino acid substitution is introduced into Gibberella zeae-derived formate dehydro... | 05/24/2012 |
| 20120128727 | BACTERIAL EXPRESSION OF AN ARTIFICIAL GENE FOR THE PRODUCTION OF CRM197 AND ITS DERIVATIVES The present invention relates to polynucleotide sequences comprising the SEQ ID N° 1 encoding CRM197 and optimised for its expression in E. coli. The invention consequently concerns a method for the production of CRM197 in E. coli via a fusion protein CRM... | 05/24/2012 |
| 20120128631 | COMPOSITIONS AND METHODS FOR KINASE-MEDIATED CYTOPROTECTION AND ENHANCED CELLULAR ENGRAFTMENT AND PERSISTENCE Disclosed are methods of protecting cells, especially non-vascular system, non-hematopoietic cells and tissues, from apoptosis and enhancing their engraftment, survival, and/or persistence by providing enhanced levels of PIM activity for the cell, including PIM-1 activi... | 05/24/2012 |
| 20120128635 | METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA B Disclosed herein are methods and compositions for insertion of Factor IX (FIX) sequences into the genome of a cell for treating hemophilia B.... | 05/24/2012 |
| 20120129788 | PHOSPHODIESTERASE 4D7 AS MARKER FOR MALIGNANT, HORMONE-SENSITIVE PROSTATE CANCER The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for malignant, hormone-sensitive prostate cancer, wherein the expression of the marker is increased when comparing the expression in malignant, hormone-sensitive prostate cancer tissue, ... | 05/24/2012 |
| 20120131699 | METHODS AND COMPOSITIONS FOR OBTAINING MARKER-FREE TRANSGENIC PLANTS The invention provides methods and compositions for identifying transgenic seed that contain a transgene of interest, but lack a marker gene. Use of an identification sequence that results in a detectable phenotype increases the efficiency of screening for seed and plan... | 05/24/2012 |
| 20120107899 | Heat-Stable Carbonic Anhydrases and Their Use The present invention relates to use of Caminibacter carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas, biogas or ambient air. The Caminibacter carbonic anhydrases are especially well suited for these purpose due to their ex... | 05/03/2012 |
| 20120107904 | CARBOXY TERMINAL RESIDUES AS PREDICTORS AND REGULATORS OF PROTEIN STABILITY Compositions and methods are provided that are useful for predicting and controlling the stability of expressed polypeptides. The compositions and methods may be used to predict and as desired, increase or decrease the stability of proteins recombinantly expressed in my... | 05/03/2012 |
| 20120107906 | NOVEL LIPOLYTIC ENZYME LIP1 The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at le... | 05/03/2012 |
| 20120110703 | PROTEIN HAVING NOVEL PRENYLTRANSFERASE ACTIVITY AND GENE ENCODING THE SAME This invention provides DNAs of a prenyltransferase derived from a hop (Humulus) plant. The invention also provides protein having the prenyltransferase activity of a hop plant and a method for producing and detecting a novel organism using a gene encoding such p... | 05/03/2012 |
| 20120107342 | Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method Described is an ex vivo animal or challenge model used as a method to identify protective (e.g., recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. Further d... | 05/03/2012 |
| 20120107903 | Mutant Glucose Dehydrogenase A mutant glucose dehydrogenase having an amino acid sequence at least 80% identical to SEQ ID NO:3 and having glucose dehydrogenase activity, wherein amino acid residues corresponding to positions 326, 365 and 472 of said amino acid sequence are replaced with glutamine,... | 05/03/2012 |
| 20120107889 | ENDOPHYTIC YEAST STRAINS, METHODS FOR ETHANOL AND XYLITOL PRODUCTION, METHODS FOR BIOLOGICAL NITROGEN FIXATION, AND A GENETIC SOURCE FOR IMPROVEMENT OF INDUSTRIAL STRAINS The present invention provides novel endophytic yeast strains capable of metabolizing both pentose and hexose sugars. Methods of producing ethanol and xylitol using the novel endophytic yeast are provided herein. Also provided are methods of fixing nitrogen and fertiliz... | 05/03/2012 |
| 20120110688 | AAD-12 EVENT 1606 AND RELATED TRANSGENIC SOYBEAN LINES This invention relates to soybean event pDAB4472-1606 (Event 1606). This invention includes a novel aad-12 transformation event in soybean plants comprising a polynucleotide sequence, as described herein, inserted into a specific site within the genome of a soybean cell... | 05/03/2012 |
| 20120107299 | PHOSPHORYLATION-INHIBITING AGENT OR DEPHOSPHORYLATING AGENT FOR PTEN Provided is a preventive, progression inhibitor or remedy for a disease one of the causes of which is the activation of the P13K/AKT signaling pathway or vice versa. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting the phosp... | 05/03/2012 |
| 20120107265 | METHOD FOR PRODUCING MONOTERPENE AND MONOTERPINOID COMPOUNDS AND USE THEREOF In various embodiments, the present disclosure provides a method and enzyme for forming various compounds, such as monoterpenes and monoterpenoid compounds. In a specific example, the present disclosure provides a method for producing one or more of (−)-ipsdienol, (âˆ... | 05/03/2012 |
| 20120108493 | Polypeptide Fragments Comprising Endonuclease Activity and Their Use The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyx... | 05/03/2012 |
| 20120107905 | Variants of Fungal Serine Protease The present invention relates to fungal serine protease variants, which comprise an amino acid substitution of valine at position 208 of the parent Fusarium equiseti Fe_RF6318 serine protease, wherein the position of the substitution corresponds to the amino acid... | 05/03/2012 |
| 20120107314 | CAB MOLECULES The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.... | 05/03/2012 |
| 20120110694 | PLANT MYB TRANSCRIPTION FACTOR HOMOLOGS This invention relates to an isolated nucleic acid fragment encoding a Myb-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the Myb-related transcription factor, in sense or antisense orientatio... | 05/03/2012 |
| 20120107907 | THERMOSTABLE NEUTRAL METALLOPROTEASES The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly prefer... | 05/03/2012 |
| 20120084890 | REGULATORY SEQUENCES FOR EXPRESSING GENE PRODUCTS IN PLANT REPRODUCTIVE TISSUE Expression cassettes causing specific regulatory control of transgene expression in plants, wherein the expression cassettes include regulatory sequences from the MADS gene family for expression of recombinant gene products in the reproductive tissue of plants for the p... | 04/05/2012 |
| 20120083590 | POLYPEPTIDES HAVING DNA POLYMERASE ACTIVITY A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.... | 04/05/2012 |
| 20120084889 | Novel Fatty Acid Elongation Components and Uses Thereof The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and method... | 04/05/2012 |
| 20120083013 | GLUCOSYLTRANSFERASE SPECIFIC TO POSITION-4 OF FUROFURAN-TYPE LIGNAN, AND POLYNUCLEOTIDE ENCODING SAME The invention provides a polynucleotide encoding a furofuran lignan 4-O-glucosyltransferase, and others. The polynucleotide in accordance with the present invention comprises a polynucleotide consisting of the nucleotide sequence represented by SEQ ID NO: 3 or SEQ ID NO... | 04/05/2012 |
| 20120082976 | METHOD OF SCREENING FOR INSULIN SECRETION-POTENTIATING AGENTS Disclosed are a novel method of screening for insulin secretion-potentiating agents as well as means for performing such screening. The means include a DNA encoding fluorescent-labeled Epac2 comprising two different DNAs encoding two different fluorescent proteins which... | 04/05/2012 |
| 20120083024 | Materials and Methods for Synthesis of a Flavor and Aroma Volatile in Plants The subject invention concerns polynucleotides encoding a plant 2-phenylethanol dehydrogenase enzyme. In one embodiment, the polynucleotide encodes a tomato 2-phenylethanol dehydrogenase. The subject invention also concerns polynucleotides encoding a plant phenylalanine... | 04/05/2012 |
| 20120082983 | Microbial Reductive Dehalogenation of Vinyl Chloride Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabol... | 04/05/2012 |
| 20120070863 | NOVEL BETA-GALACTOSIDE-ALPHA2,3-SIALYLTRANSFERASE, A GENE ENCODING THEREOF, AND A METHOD FOR PRODUCING THEREOF The present invention provides a novel β-galactoside-α2,3-sialyltransferase and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase, as well as a method for producing the sialyltransferase ... | 03/22/2012 |
| 20120070871 | POLYPEPTIDE HAVING D-LACTATE DEHYDROGENASE ACTIVITY, POLYNUCLEOTIDE ENCODING THE POLYPEPTIDE, AND PROCESS FOR PRODUCTION OF D-LACTIC ACID Highly productive D-lactic acid fermentation uses a transformant obtained by introducing into a host cell a polynucleotide encoding a polypeptide according to any one of the following (A) to (C) in such a manner that the polypeptide is expressed, which polypeptide has a... | 03/22/2012 |
| 20120070876 | VARIANT FORM OF URATE OXIDASE AND USE THEREOF The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxid... | 03/22/2012 |
| 20120070826 | LAFORA'S DISEASE GENE A novel gene (EPM2B) that is mutated in humans and dogs with Lafora's disease is described.... | 03/22/2012 |
| 20120070881 | Bacillus licheniformis chromosome The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances a... | 03/22/2012 |
| 20120073019 | Yield Enhancement in Plants by Modulation of a ZM-CIPK1 Protein Compositions and methods for modulating plant development and for increasing yield in a plant are provided. The compositions include a ZM-CIPK1 sequence. Compositions of the disclosure comprise amino acid sequences and nucleotide sequences selected from SEQ ID NOS: 1 an... | 03/22/2012 |
| 20120071546 | Novel Glutamic Acid Decarboxylase (GAD) Chimera And Methods Of Use The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinso... | 03/22/2012 |
