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| Application No. | Application Title | Issue Date |
| 20120128705 | C6ORF167 PEPTIDES AND VACCINES CONTAINING THE SAME Peptide vaccines against cancer are described herein. In particular, epitope peptides derived from the C6orf167 gene that elicit CTLs are provided. Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenti... | 05/24/2012 |
| 20120129916 | CELL-TARGETING NANOPARTICLES COMPRISING POLYNUCLEOTIDE AGENTS AND USES THEREOF A method of generating a particle is disclosed, the particle being for delivery of a polynucleotide to a target cell. The method comprises (a) contacting the polynucleotide with a composition comprising cationic molecules, wherein the cationic molecules condense the pol... | 05/24/2012 |
| 20120128761 | Lipophilic Polynucleotide Conjugates Disclosed are lipophilic polynucleotide conjugates including polynucleotide-cholesterol conjugates and methods of delivering therapeutic polynucleotides to a mammalian cell or patient in need of treatment using said conjugates. The disclosure further provides methods of... | 05/24/2012 |
| 20120131690 | BRASSICA GAT EVENT DP-061061-7 AND COMPOSITIONS AND METHODS FOR THE IDENTIFICATION AND/OR DETECTION THEREOF Compositions and methods related to transgenic glyphosate tolerant Brassica plants are provided. Specifically, the present invention provides Brassica plants having a DP-061061-7 event which imparts tolerance to glyphosate. The Brassica plant harbor... | 05/24/2012 |
| 20120128586 | METHOD FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA The present invention provides a method for treating a subject having chronic lymphocytic leukemia (CLL) comprising administering to the subject one or more agents that target cell surface membrane antigens expressed preferentially on cells of the proliferative compartm... | 05/24/2012 |
| 20120129764 | INFLUENZA A AND B VIRUS REPLICATION-INHIBITING PEPTIDES A synthesized or isolated influenza virus replication-inhibiting peptide that competitively inhibits protein-protein interaction of the PA and PB1 of both influenza Virus Types A and B and novel in vitro binding screen to identify peptides with antiviral activity agains... | 05/24/2012 |
| 20120129918 | MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a hi... | 05/24/2012 |
| 20120129720 | APTAMER THAT RECOGNIZES PEPTIDE An aptamer capable of binding to a histidine peptide is provided. A nucleic acid used as the aptamer capable of binding to a histidine peptide is any of the following nucleic acids (a) to (d): (a) a nucleic acid having a base sequence represented by SEQ ID NO: 17: GGUN<... | 05/24/2012 |
| 20120129254 | Inducible Expression System Transcription Modulators Comprising A Distributed Protein Transduction Domain And Methods For Using The Same Aspects of the invention include inducible expression systems in which a transcription modulator having a distributed protein transduction domain is employed. Aspects of the invention further include methods of using the systems to induce expression of a coding sequence... | 05/24/2012 |
| 20120129778 | LIGAND THAT BIND TGF-BETA RECEPTOR RII The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue f... | 05/24/2012 |
| 20120129788 | PHOSPHODIESTERASE 4D7 AS MARKER FOR MALIGNANT, HORMONE-SENSITIVE PROSTATE CANCER The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for malignant, hormone-sensitive prostate cancer, wherein the expression of the marker is increased when comparing the expression in malignant, hormone-sensitive prostate cancer tissue, ... | 05/24/2012 |
| 20120129166 | METHOD OF DETECTING FUNGI BELONG TO GENUS GEOSMITHIA A method of detecting a fungus belonging to genus Geosmithia, including identifying a fungus belonging to genus Geosmithia using a nucleic acid represented by the nucleotide sequence defined in the following (a) or (b):
| 05/24/2012 |
| 20120128699 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These TROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use ... | 05/24/2012 |
| 20120129771 | PEPTIDES AND RELATED MOLECULES THAT MODULATE NERVE GROWTH FACTOR ACTIVITY The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active... | 05/24/2012 |
| 20120130045 | BIOMOLECULE-POLYMER CONJUGATES AND METHODS OF MAKING SAME Disclosed herein are biomolecule-polymer conjugates of Formula 1, as well as methods of preparing same and kits for preparing same. ... | 05/24/2012 |
| 20120108521 | IMMUNOSTIMULATORY COMPOSITIONS AND USES THEREOF The present invention provides novel immune-stimulatory polypeptides, and methods for their use and identification.... | 05/03/2012 |
| 20120108533 | NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL AGENTS This invention provides phosphate-modified nucleosides represented by the structural formula: wherein W is O or S, and wherein B, R1; R3 and R2. are s defined herein. These compounds are useful as substrates for DNA/RNA polymerases, and ... | 05/03/2012 |
| 20120108649 | METHODS AND COMPOSITIONS TO PROTECT AQUATIC INVERTEBRATES FROM DISEASE Compositions and methods of protecting aquatic invertebrates from disease is shown. In one embodiment, dsRNA or antisense RNA to a nucleic acid molecule of the disease-causing microorganism is prepared and delivered to the animal. In another embodiment, a nucleic acid m... | 05/03/2012 |
| 20120107333 | VANGL1 PEPTIDES AND VACCINES INCLUDING THE SAME The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 35, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or ... | 05/03/2012 |
| 20120110694 | PLANT MYB TRANSCRIPTION FACTOR HOMOLOGS This invention relates to an isolated nucleic acid fragment encoding a Myb-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the Myb-related transcription factor, in sense or antisense orientatio... | 05/03/2012 |
| 20120110700 | PLANTS WITH ALTERED ROOT ARCHITECTURE, RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING LEUCINE RICH REPEAT KINASE (LLRK) POLYPEPTIDES AND HOMOLOGS THEREOF Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering root structure of plants, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs... | 05/03/2012 |
| 20120108787 | Immobilization Particles for Removal of Microorganisms and/or Chemicals An immobilization particle for immobilizing a target microorganism or target chemical found in or on a mammal that includes: immobilization molecules capable of attaching to a target microorganism or a target chemical, which immobilization molecules are attached to one ... | 05/03/2012 |
| 20120110685 | MODULAR DNA-BINDING DOMAINS AND METHODS OF USE The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specificall... | 05/03/2012 |
| 20120107902 | Processes For Forming Amide Bonds And Compositions Related Thereto The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed... | 05/03/2012 |
| 20120107939 | DOWN-REGULATION OF GENE EXPRESSION USING ARTIFICIAL MICRORNAS Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.... | 05/03/2012 |
| 20120107810 | Epigenetic Markers for the Identification of Blood Sub-Cells of Type 1 The present invention relates to a method, in particular an in vitro method, for identifying CD3CD4 positive T lymphocytes of a mammal, wherein said method comprises analysing the methylation status of at least one CpG position in the CD3a/b/c/d/g genes, in particular t... | 05/03/2012 |
| 20120108446 | 4-miRNA SIGNATURE FOR PREDICTING CLEAR CELL RENAL CELL CARCINOMA METASTASIS AND PROGNOSIS An miRNA expression signature comprising a set of one or more miRNAs associated with metastatic cancer is provided. In one embodiment, the expression signature is selected from the group consisting of miR-10b, miR-139-5p, miR-130b and miR-199b-5p. In some aspects, miR-1... | 05/03/2012 |
| 20120107272 | SYNTHETIC METHODS AND DERIVATIVES OF TRIPHOSPHATE OLIGONUCLEOTIDES The invention features a oligonucleotide of formula I, or pharmaceutically acceptable salts, or prodrugs thereof:
| |
| 20120108467 | Nucleic Acid Analysis Using Sequence Tokens The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, ... | 05/03/2012 |
| 20120107331 | GEMM RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH GEMM RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH GEMM RIBOSWITCHES Disclosed is the crystal structure of a GEMM riboswitch from V. cholerae bound to c-di-GMP. The crystal structures show that the RNA binds the ligand within a three helix junction that involves base pairing and extensive base stacking. The symmetric c-di-GMP is r... | 05/03/2012 |
| 20120108497 | COMPOSITIONS FOR CONFERRING TOLERANCE TO VIRAL DISEASE IN SOCIAL INSECTS, AND THE USE THEREOF Compositions and methods for reducing susceptibility to infectious disease in bees using RNA interference technology, and more particularly, prevention and treatment of viral infections in honeybees such as Israel acute paralysis virus (IAPV) by feeding of pathogen-spec... | 05/03/2012 |
| 20120107824 | mPCR Methods for Analyzing Repeat Sequences Methods are provided for determining the methylation status of GC-rich templates. The methods include use of GC reference standards that allow simultaneous characterization of methylation status and CGG repeat length. The methods are useful for detecting genotypes assoc... | 05/03/2012 |
| 20120083477 | PROTEASOME INHIBITORS AND USES THEREOF A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bou... | 04/05/2012 |
| 20120083520 | Ghrelin binding nucleic acids The present invention is related to a nucleic acid antagonist of ghrelin.... | 04/05/2012 |
| 20120083521 | Aptamers as agonists Nucleic acid aptamers are described herein which can transduce a signal into cells by crosslinking a cell surface molecule, thereby inducing of one or more biological activities by the cells; in serving as agonists.... | 04/05/2012 |
| 20120082692 | Identification, Optimization and Use of Cryptic HLA-A24 Epitopes for Immunotherapy The present invention pertains to methods for identifying a HLA-A*2402-restricted cryptic epitope in an antigen, and for increasing its immunogenicity, in order to obtain HLA-A*2402-restricted epitopes able to trigger an immune response against HLA-A*2402-restricted cry... | 04/05/2012 |
| 20120083013 | GLUCOSYLTRANSFERASE SPECIFIC TO POSITION-4 OF FUROFURAN-TYPE LIGNAN, AND POLYNUCLEOTIDE ENCODING SAME The invention provides a polynucleotide encoding a furofuran lignan 4-O-glucosyltransferase, and others. The polynucleotide in accordance with the present invention comprises a polynucleotide consisting of the nucleotide sequence represented by SEQ ID NO: 3 or SEQ ID NO... | 04/05/2012 |
| 20120083033 | PRODUCTION OF TRANSGENIC AVIANS USING IMPROVED RETROVIRAL VECTORS A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.... | 04/05/2012 |
| 20120082715 | Stabilized products, processes and devices for preparing the same A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced storage stability, less expensive cost of processing, and extended shelf ... | 04/05/2012 |
| 20120084889 | Novel Fatty Acid Elongation Components and Uses Thereof The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and method... | 04/05/2012 |
