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| Application No. | Application Title | Issue Date |
| 20120108541 | ACYLATED 1,6-ANHYDRO DECASACCHARIDE AND ITS USE AS AN ANTITHROMBOTIC AGENT The instant invention relates to the decasaccharide of formula (I), wherein Ac represents an acetyl group: in its acid form or in the form of any one of its pharmaceutically acceptable salts, and to its proce... | 05/03/2012 |
| 20120108802 | PRODUCTION OF DEFINED MONODISPERSE HEPAROSAN POLYMERS AND UNNATURAL POLYMERS WITH POLYSACCHARIDE SYNTHASES A methodology for polymer grafting by a polysaccharide synthase allows the creation of a variety of glycosaminoglycan oligosaccharides that have a natural, chimeric, hybrid and/or unnatural sugar structure and/or a targeted size (i.e., substantially monodisperse in size... | 05/03/2012 |
| 20120108542 | SULFATED OCTASACCHARIDE AND ITS USE AS ANTITHROMBOTIC AGENT The instant invention relates to the octasaccharide of formula (I): in its acid form or in the form of any one of its pharmaceutically acceptable salts, and to its process of preparation. The oligosaccharide ... | 05/03/2012 |
| 20120108543 | SULFATED HEPTASACCHARIDE AND ITS USE AS AN ANTITHROMBOTIC AGENT The instant invention relates to the heptasaccharide of formula (I):
| 05/03/2012 |
| 20120108544 | ACYLATED DECASACCHARIDES AND THEIR USE AS ANTITHROMBOTIC AGENTS The instant invention relates to decasaccharides of formula (I):
| 05/03/2012 |
| 20120083594 | Process for the Preparation of disaccharides Applied to Heparin Pentasaccharides The invention provides an intermediate and the process for making the same. This intermediate is useful in the process for making polysaccharides, and more particularly fondaparinux.... | 04/05/2012 |
| 20120046241 | DOSE OF AVE5026 FOR THE TREATMENT OF VENOUS THROMBOEMBOLISM IN PATIENTS WITH SEVERE RENAL IMPAIRMENT This invention relates to a dose of 10 mg of AVE5026 for the treatment of venous thromboembolism in patients with severe renal impairment.... | 02/23/2012 |
| 20120035107 | COMPOSITIONS FOR ACHIEVING A THERAPEUTIC EFFECT IN AN ANATOMICAL STRUCTURE Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.... | 02/09/2012 |
| 20120014874 | PHOTOSENSITIZER-METAL NANOPARTICLE CHARGE COMPLEX AND COMPOSITION CONTAINING THE COMPLEX FOR PHOTODYNAMIC THERAPY OR DIAGNOSIS Provided are a photosensitizer-metal nanoparticle charge complex and a composition for photodynamic therapy or diagnosis containing the same. The complex includes a metal nanoparticle, a photosensitizer charged with a first charge, and a linker bound to the metal nanopa... | 01/19/2012 |
| 20120010391 | Bonding Products of Aminated Polysaccharides The invention relates to a bonding product comprising at least the polysaccharides T1 and T2, characterized in that a) the monosaccharides from which the polysaccharides T1 and T2 are constructed are partially or completely bonded to each other alpha-1,4-glycosidically ... | 01/12/2012 |
| 20110288046 | ANALYSIS OF SULFATED POLYSACCHRIDES The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitori... | 11/24/2011 |
| 20110288283 | PROCESS FOR PRODUCING GLYCOSAMINOGLYCANS The invention provides a process for the production of a composition comprising a glycosaminoglycan, said process comprising subjecting a homogenate of glycosaminoglycan-containing animal material to chromatography using a chromatographic matrix in the form of a membran... | 11/24/2011 |
| 20110288047 | PROCESS FOR THE PURIFICATION OF HEPARAN SULFATE AND USE THEREOF IN COSMETOLOGICAL AND DERMATOLOGICAL PREPARATIONS The present invention relates to cosmetological and dermatological compositions comprising heparan sulfate. The invention further discloses a process for the purification of heparan sulfate for dermatological and cosmetological applications, which process comprises the ... | 11/24/2011 |
| 20110281820 | GLYCOSAMINOGLYCANS DERIVED FROM K5 POLYSACCHARIDE HAVING HIGH ANTICOAGULANT AND ANTITHROMBOTIC ACTIVITIES AND PROCESS FOR THEIR PREPARATION Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activity and useful for the control of coagulation and as antithrombotic agents are obtained starting from an optionally purified K5 polysaccharide by a process comprising the... | 11/17/2011 |
| 20110280914 | HYDROGELS CROSSLINKED WITH GOLD NANOPARTICLES AND METHODS OF MAKING AND USING THEREOF Described herein are composites useful in tissue and organ engineering. In one aspect, the composite comprises the reaction product between a macromolecule comprising at least one thiol group and a gold nanoparticle. The thiolated macro-molecule crosslinks with the gold... | 11/17/2011 |
| 20110230652 | USE OF LIPID CONJUGATES IN THE TREATMENT OF DISEASES This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y ... | 09/22/2011 |
| 20110217339 | MUCOACTIVE AGENTS FOR TREATING A PULMONARY DISEASE The present invention relates to pharmaceutical compositions which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and chronic obstructive pulmonary disease. In particular, the invention relates to ... | 09/08/2011 |
| 20110212181 | COMPOSITIONS AND METHODS FOR TREATING CHRONIC RESPIRATORY INFLAMMATION Neutrophil elastase (NE) is a protease secreted by neutrophils during inflammation. Aberrant expression of NE such as in chronic respiratory inflammatory diseases, results in tissue destruction and decline in lung function. Compositions including an NE-targeting agent t... | 09/01/2011 |
| 20110207919 | EVALUATING HEPARIN PREPARATIONS Methods of evaluating heparin preparations, e.g., for suitability for use as a drug or for use in making a drug, by determining the absence, presence or amount of a structural signature that is indicative of the methods used to make the heparin preparation.... | 08/25/2011 |
| 20110200673 | OXIDIZED HEPARIN FRACTIONS AND THEIR USE IN INHIBITING ANGIOGENESIS The present invention relates to a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 4,000 daltons, wherein from about 1% to about 100% of hydroxyl residues of the constituents are oxidized. The present invention also relates... | 08/18/2011 |
| 20110201573 | MIXTURES OF POLYSACCHARIDES DERIVED FROM HEPARIN, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to mixtures of polysaccharides derived from heparin having a mean molecular weight of 1500 to 3000 Daltons and an anti-Xa/anti-IIa ratio greater than 30, their method of preparation and pharmaceutical compositions containing them.... | 08/18/2011 |
| 20110201572 | PHARMACEUTICAL COMPOSITION WITH GLYCOSAMINOGLYCANS AND USE THEREOF IN THE TREATMENT OF CHRONIC ULCERS The invention relates to a composition of glycosaminoglycans for the treatment of diabetic foot ulcer, it specifically relates to low molecular weight heparins (LMWHs) and very low molecular weight heparins (VLMWHs) in the treatment of chronic ulcers, particularly of di... | 08/18/2011 |
| 20110166078 | OLIGOSACCHARIDE COMPOUNDS FOR USE IN MOBILISING STEM CELLS A compound of the following formula or a salt, solvate or formula (I) and a pharmaceutical composition containing said compound. It concerns also its use in the treatment of cancer and/or of pathological angiogenesis and/or in promoting the mobilisation of stem cells, i... | 07/07/2011 |
| 20110165218 | Therapeutic Bone Growth and Regeneration The use of Herapan Sulphate 2 (HS-2) in therapeutic bone growth and regeneration is described. Herapan Sulphate 2 was identified as a variant of Heparan Sulphate purified from embryonic day (E10) of murine neuroepithelia.... | 07/07/2011 |
| 20110152509 | COMPOSITIONS OF POLYSACCHARIDES DERIVED FROM HEPARIN, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Alkali and alkali-earth metal salts of polysaccharides derived from heparin, their method of preparation and the pharmaceutical compositions containing them.... | 06/23/2011 |
| 20110130555 | LIPID-POLYMER CONJUGATES, THEIR PREPARATION AND USES THEREOF This invention provides low molecular weight lipid-GAG and phospholipids-GAG conjugates and methods of use thereof in suppressing, inhibiting, preventing, or treating a pathogenic effect on a cell, including, inter alia, infection with intracellular pathogens.... | 06/02/2011 |
| 20110130473 | DILUTE FILTRATION STERILIZATION PROCESS FOR VISCOELASTIC BIOPOLYMERS Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis, however, traditional sterilization techniques result in the breakdown of such high molecular weight viscoelastic ... | 06/02/2011 |
| 20110112050 | SEPARATION OF POLYSACCHARIDES BY CHARGE DENSITY GRADIENT Methods and apparatus for the separation of polysaccharides, particular heparin products, and glycosylated molecules are provided. The separation is based on the molecular weight and charge, by application of an electric field across a low-friction matrix, modified with... | 05/12/2011 |
| 20110076729 | METHODS OF MAKING LOW MOLECULAR WEIGHT HEPARIN COMPOSITIONS Methods of making LMWH compositions are provided to provide the LMWH compositions at a yield of at least about 10%.... | 03/31/2011 |
| 20110070440 | Artificial Organelle On A Digital Microfluidic Chip Used To Redesign The Biological Activities of Heparan Sulfate Using digital microfluidics, recombinant enzyme technology, and magnetic nanoparticles, a functional prototype of an artificial Golgi organelle is described. Analogous to the natural Golgi, which is responsible for the enzymatic modification of glycosaminoglycans immobi... | 03/24/2011 |
| 20110064715 | METHODS FOR DETERMINING OLIGOSACCHARIDE BINDING The invention relates to methods for detecting and characterizing enzymatic modifications of oligosaccharides, such as heparan sulfate, and their interaction with binding partners, such as proteins, using an oligosaccharide-binding partner binding assay, such as a gel m... | 03/17/2011 |
| 20110041725 | ANTICOAGULANTS AS ANTIFOULING AGENTS Methods and compositions are provided for the reduction of fouling of objects present in marine environments. The methods and compositions include anticoagulants, such as, for example, glycosaminoglycans, coumarin-type molecules, metal chelators, plasminogen activators ... | 02/24/2011 |
| 20110033448 | Inhibitors of LL-37 Mediated Immune Reactivity to Self Nucleic Acids Methods and compositions for treating disease are provided. More particularly, methods and compositions of inhibiting pathogenic interferon production are prevented, which may be useful in the treatment of various diseases. In other embodiments, therapeutic compounds an... | 02/10/2011 |
| 20110021766 | EPIMERIZED DERIVATIVES OF K5 POLYSACCHARIDE WITH A VERY HIGH DEGREE OF SULFATION A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically fr... | 01/27/2011 |
| 20100324276 | POLYSACCHARIDE COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT AND PREVENTION OF DISORDERS ASSOCIATED WITH PROGENITOR CELL MOBILIZATION Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.... | 12/23/2010 |
| 20100316640 | POLYSACCHARIDE COMPOSITIONS AND METHODS OF USE FOR THE TREATMENT AND PREVENTION OF DISORDERS ASSOCIATED WITH PROGENITOR CELL MOBILIZATION Polysaccharide preparations lacking substantial anticoagulant activity are provided herein. Methods of making and using such preparations are provided.... | 12/16/2010 |
| 20100317617 | SILVER NANOPARTICLES AS ANTI-MICROBIAL A silver nanocomposite, a formation method for forming the silver nanocomposite, and an application method utilizing the silver nanocomposite. The silver nanocomposite includes a silver nanoparticle conjugated to a glycosaminoglycan (GAG) or glucose. The formation metho... | 12/16/2010 |
| 20100311788 | Salts of Clopidogrel With Polyanions and Their Use for Manufacturing Pharmaceutical Formulations The invention relates to salts of the active ingredient clopidogrel with polyanions. The salts are predominantly in amorphous form, and the polyanions have at least 4 negative charges.... | 12/09/2010 |
| 20100310471 | ANTIOXIDANT AND PARAMAGNETIC HEPARIN-NITROXIDE DERIVATIVES The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisation of glycosaminoglycan carboxyl or amino groups. The heparin-nitrox... | 12/09/2010 |
| 20100297604 | METHODS AND REAGENTS FOR VIRUS ISOLATION AND DETECTION The present invention relates to reagents and methods used in virus isolation and analysis.... | 11/25/2010 |
