Class 536/17.2 - Nitrogen containing

Subclass of Class 536 - Organic compounds -- part of the class 532-570 series
Definition: Compound which contain nitrogen.
No. of applications: 38
Last issue date: 01/05/2012

Application No.	Application Title	Issue Date
20120003260	Solid-Phase and Solution-Phase Synthesis of Glycosylphosphatidylinositol Glycans One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated...	01/05/2012
20110300177	TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adj...	12/08/2011
20110280893	SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative....	11/17/2011
20110251288	PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE AMINES The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline. ...	10/13/2011
20110245192	NEW ACTIVATORS FOR TREATING AND/OR PREVENTING DISEASES OR MEDICAL CONDITIONS WHICH BENEFIT FROM AN INCREASED TRANSPORT OF HYALURONAN ACROSS A LIPID BILAYER The present invention relates in general to a compound (activator) which is characterized by a formula selected from the following formulas A, B and/or C or a pharmaceutically acceptable salt thereof. The present invention further relates to pharmaceutical composition c...	10/06/2011
20110237657	Transport-Mediating Colloidal Pharmaceutical Compounds The invention relates to transport mediator-bonded colloids comprising pharmaceutical substances or fluorescence markers, to a method for the production thereof, and to a pharmaceutical preparation comprising said compounds....	09/29/2011
20110229409	LINKABLE LEWIS X ANALOGS Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe^X) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe^...	09/22/2011
20110201794	Disaccharides for drug discovery Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular ...	08/18/2011
20110152508	REAGENTS AND METHODS FOR PREPARING LPS ANTAGONIST B1287 AND STEREOISOMERS THEREOF The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shoc...	06/23/2011
20110137010	PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, EFFICIENT RNA SYNTHESIS AND CONVENIENT INTRODUCTION OF 3'-END LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3′ end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in 5′→3′ direction, leading to very cle...	06/09/2011
20110118199	USE OF CNS PENETRATING ANTICANCER COMPOUNDS FOR THE TREATMENT OF PROTOZOAL DISEASES The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In particular, the invention relates to the use of anticancer agents that can penetr...	05/19/2011
20110105418	PROCESS FOR PREPARING FONDAPARINUX SODIUM AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF Processes for the synthesis of the Factor Xa anticoagulent Fondaparinux, and related compounds are described. Also described are protected pentasaccharide intermediates as well as efficient and scalable processes for the industrial scale production of Fondaparinux sodiu...	05/05/2011
20110105420	AMINOSUGAR COMPOUND AND PROCESS FOR PRODUCTION THEREOF [Object] Disclosed is a compound useful as an active ingredient for a pharmaceutical composition having an α-amylase inhibitory activity, particularly a pharmaceutical composition for the treatment of diabetes. [Solution] An investigation ...	05/05/2011
20110086767	MUTANTS OF GLYCOSIDE HYDROLASES AND USES THEREOF FOR SYNTHESIZING COMPLEX OLIGOSACCHARIDES AND DISACCHARIDE INTERMEDIATES Method for preparing the disaccharide α-D-glucopyranosyl-(1→4)-2-N-acetyl-2-deoxy-α-D-glucopyranoside, comprising the step of using a mutant of a wild type glycoside hydrolase....	04/14/2011
20110046078	METHODS AND COMPOSITIONS FOR TREATING DISEASES AND DISORDERS ASSOCIATED WITH SIGLEC-8 The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and treatm...	02/24/2011
20110046003	ALPHA-SELECTIVE SIALYL PHOSPHATE DONORS FOR PREPARATION OF SIALOSIDES AND SIALOSIDE ARRAYS FOR INFLUENZA VIRUS DETECTION A novel N-acetyl-5-N,4-O-carbonyl-protected dibutyl sialyl phosphate donor for sialylation of both primary and sterically hindered secondary acceptors to prepare sialosides with high yield and α-selectivity is disclosed. Methods for making disaccharide building blocks ...	02/24/2011
20110028702	COMPOSITIONS AND PROCESSES FOR PREPARING 13-DEOXY-ANTHRACYCLINES 13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthrcyclines, and an improved method of reducing 13-benzene-sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at...	02/03/2011
20100330009	COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS The present invention relates to derivatives of the 1H-pyrano[4,3-b]benzofuran-1-one structure and their nitrogen analogues which possess powerful antioxidant properties combined with a highly effective UV absorbing functionality in one molecule. These compounds are esp...	12/30/2010
20100248272	Method for identifying Smk box riboswitch modulating compounds The invention is directed, inter alia, to a method for identifying a compound that modulates a gene expression of an mRNA molecule containing a S_MKbox riboswitch that contains a SAM binding pocket, wherein the mRNA molecule is produced by a lactic acid bacte...	09/30/2010
20100221269	SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative....	09/02/2010
20100197625	SYNTHETIC LIPOPHILIC INOSITOL GLYCANS FOR TREATMENT OF CANCER AND GLUCOSE-METABOLISM DISORDERS The present intervention related to materials and methods for the synthesis of lipophilic inositol glycan compounds, and salts, solvates and physiological functional derivatives thereof, and their use for the treatment of cancer and glucose-metabolism disorders, such as...	08/05/2010
20100184607	MONOSACCHARIDE COMPOUNDS AND METHODS THEREFOR A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I....	07/22/2010
20100144653	Fatty acid carbohydrate hybrid molecules as therapeutic agents and methods thereof Described herein are fatty acid carbohydrate hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof....	06/10/2010
20100121040	THERAPEUTIC AGENT FOR PAIN DISEASE Disclosed is an analgesic agent for a non-inflammatory pain disease, which comprises a sialic acid or a pharmaceutically acceptable salt thereof as an active ingredient. The sialic acid which is an active ingredient for the agent has an analgesic effect on a disease mod...	05/13/2010
20100009902	Glycoconjugation Using Saccharyl Fragments The present invention provides conjugates between a substrate, e.g., peptide, glycopeptide, lipid, etc., and a modified saccharyl fragment bearing a modifying group such as a water-soluble polymer, therapeutic moiety or a biomolecule. The conjugates are linked via the e...	01/14/2010
20090270598	AMPHIPHILES FOR PROTEIN SOLUBILIZATION AND STABILIZATION The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilizat...	10/29/2009
20090263867	LONG-CHAIN CHONDROITIN SUGAR CHAIN AND METHOD FOR PRODUCING THE SAME AND METHOD FOR PROMOTING SYNTHESIS OF CHONDROITIN A method for producing a chondroitin sugar chain comprises at least the following step: a step of allowing “a glucuronic acid donor”, “an N-acetyl galactosamine donor”, “a sugar receptor” and “a bacterial cell enzyme which synthesizes chondroitin” to coe...	10/22/2009
20090227544	Bone Targeted Therapeutics and Methods of Making and Using the Same The present invention provides novel bisphosphonate conjugates, pharmaceutical compositions comprising bisphosphonate conjugates and methods of using such analogs in the treatment of bone cancer, bone-related diseases, bone infection, bone inflammation, and diseases of ...	09/10/2009
20090048186	Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial...	02/19/2009
20080312165	Process for obtaining pure monosialoganglioside GM1 for medical use A process for preparing pure monosialoganglioside GM1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside GM1 comprising (a) separation of GM1 from a lipidic mixture containing the monosialoganglioside G...	12/18/2008
20080299044	Saccharide Fluorescent Substrates, Preparation Method and Uses Thereof The invention concerns saccharide type fluorescent enzymatic substrates comprising on the same saccharide unit a fluorophor F1 and an inhibitor of the fluorescence of F1, and their use for preparing a diagnostic reagent for in vivo functional imaging, as well as a diagn...	12/04/2008
20080182805	O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-Acetyl moiety An O-GlcNAcase-specific inhibitor and substrate are engineered by the extension of the N-Acetyl Moiety of O-(2-acet-amido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc). The reagent substrate includes a fluorophor and the inhibitor. This reagent substrat...	07/31/2008
20080159954	METAL CHELATES HAVING A PERFLUORINATED PEG RADICAL, PROCESSES FOR THEIR PREPARATION, AND THEIR USE The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis ...	07/03/2008
20080139485	Methods and Compositions For Treating Diseases and Disorders Associated With Siglec-8 Expressing Cells The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the invention provides methods and compositions for the prevention and treatm...	06/12/2008
20080015344	SYNTHESIS OF MONOVALENT AND POLYVALENT ARABINANS AND MANNOSE-CAPPED ARABINANS OF THE PROTECTIVE CELL-WALL COAT OF MYCOBACTERIUM TUBERCULOSIS The present application provides arabinans and mannose-capped arabinan compositions of formulas I-VIII, described herein, and methods of making the compositions. ...	01/17/2008
20080014281	Chitin Micro-Particles As An Adjuvant A composition and method for the preparation of micro-particles of chitin (a naturally occurring polymer of N-acetyl-D-glucosamine), the characterization of chitin micro-particles as an immune adjuvant and the use of chitin micro-particles to enhance protective immunity...	01/17/2008
20070282096	Sialic Acid Derivatives An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful fu...	12/06/2007
20050249829	Compounds for altering food intake in humans The present invention relates to a process of providing an extract containing at least one simmondsin compound. The extract is provided from jojoba plant, and used as a dietary supplement for use in a weight control regiment in humans. The present invention also provide...	11/10/2005

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Class 536/17.2 - Nitrogen containing