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| Application No. | Application Title | Issue Date |
| 20120129795 | ANTIVIRAL COMPOUNDS Herein are disclosed novel compounds according to Formula (I) and aggregates comprising such compounds. These aggregates are useful to treat and prevent ocular infections caused by a vims, which virus binds to terminal sialic residues present on the cell surface of the ... | 05/24/2012 |
| 20120053134 | PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NEURONAL DAMAGE AND NEUROLOGICAL DISEASES The present invention relates to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases, and more particularly, to a pharmaceutical composition for preventing or treating neuronal damage and neurological diseases containing, as... | 03/01/2012 |
| 20120035115 | CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for tr... | 02/09/2012 |
| 20120034241 | IMMUNOGENIC COMPOSITIONS AND USES THEREOF The present invention relates generally to a method of eliciting or otherwise inducing an effective immune response to a micro-organism and compositions for use therein. More particularly, the present invention relates to a method of inducing an immune response to a par... | 02/09/2012 |
| 20120029167 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND A drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. T... | 02/02/2012 |
| 20120021430 | FUNCTIONAL LIPID CONSTRUCTS The invention relates to methods for effecting qualitative and quantitative changes in the functional moieties expressed at the surface of cells and multi-cellular structures, and functional lipid constructs for use in such methods. In particular, the invention relates ... | 01/26/2012 |
| 20120021046 | GLUCOSAMINE AND GLUCOSAMINE/ANTI-INFLAMMATORY MUTUAL PRODRUGS, COMPOSITIONS, AND METHODS Mutual prodrugs of glucosamine, and derivatives and analogs of glucosamine and an anti-inflammatory agent, compositions thereof, and methods for, e.g., treating disorders and conditions by administration of the compositions are provided. Topical compositions of glucosam... | 01/26/2012 |
| 20120003260 | Solid-Phase and Solution-Phase Synthesis of Glycosylphosphatidylinositol Glycans One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated... | 01/05/2012 |
| 20110300120 | OLIGOSACCHARIDE-PROTEIN CONJUGATES Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal ... | 12/08/2011 |
| 20110280893 | SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.... | 11/17/2011 |
| 20110256173 | CHEMICAL SYNTHESIS OF PHOSPHATIDYLINOSITOL MANNOSIDE GLYCANS FROM MYCOBACTERIUM TUBERCULOSIS The efficient synthesis of phosphatidylinositol mono- to hexa-mannoside (PIM1 to PIM6) is reported. The invention relates to these phosphatidylinositol mono- to hexa-mannosides carrying a linker and a reactive functional group, e.g. the sulfhydryl ... | 10/20/2011 |
| 20110257109 | USE OF DRUGS THAT ACTIVATE P2Y RECEPTORS TO ENHANCE SYNAPTOGENESIS The present invention encompasses compositions and methods that activate P2Y receptors for the increased production of new synapses in the central nervous system. The formulations of the invention may be administered to a healthy subject or to a subject in need thereof ... | 10/20/2011 |
| 20110256552 | METHOD FOR PREPARING A SUBSTRATE FOR IMMOBILIZING A CELL, SAID SUBSTRATE AND USES THEREOF The present invention relates to a method of preparation of a solid substrate capable of immobilizing at least one cell and/or at least one part of a cell, said method comprising a step consisting of fixing, to said solid substrate, a fusogenic compound capable of being... | 10/20/2011 |
| 20110237529 | Adenosine Analogs and Their Use The invention provides adenosine analog compounds that act at P2Y receptors, e.g., the P2Y2 receptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secreti... | 09/29/2011 |
| 20110237657 | Transport-Mediating Colloidal Pharmaceutical Compounds The invention relates to transport mediator-bonded colloids comprising pharmaceutical substances or fluorescence markers, to a method for the production thereof, and to a pharmaceutical preparation comprising said compounds.... | 09/29/2011 |
| 20110224162 | SYNTHETIC ANALOGUES OF PHOSPHATIDYL-MYO-INOSITOL MANNOSIDES WITH AN INHIBITORY ACTIVITY OF THE INFLAMMATORY RESPONSE The present invention relates to novel synthetic analogues of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same and to the use thereof in the pre... | 09/15/2011 |
| 20110213134 | Synthetic membrane anchors The invention relates to synthetic molecules that spontaneously and stably incorporate into lipid by-layers, including cell membranes. Particularly, although not exclusively, the invention relates to the use of these molecules as synthetic membrane anchors or synthetic ... | 09/01/2011 |
| 20110165603 | SMALL MOLECULE FLUORESCENT SENSORS FOR DETECTION OF POST-TRANSLATIONALMODIFICATIONS AND PROTEIN INTERACTIONS IN BIOASSAYS The present invention relates to novel compounds which are capable as acting as fluorescent sensors or which are precursors for these and for the use of these for the assay of biological processes such as posttranslational modifications of biological molecules such as p... | 07/07/2011 |
| 20110152508 | REAGENTS AND METHODS FOR PREPARING LPS ANTAGONIST B1287 AND STEREOISOMERS THEREOF The present invention provides methods for preparing LPS antagonist lipodisaccharide B1287 and stereoisomers thereof, which compounds are useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shoc... | 06/23/2011 |
| 20110137019 | NUCLEIC ACID COMPRISING ZWITTERIONIC NUCLEOTIDES This invention provides pH-responsive zwitterionic nucleotides and nucleic acids comprising said nucleotides, wherein said zwitterions are constituted from one or more anionic internucleoside linkages and one or more cationic moieties and said zwitterionic nucleotides f... | 06/09/2011 |
| 20110130353 | HIGHLY PURIFIED ANTIENDOTOXIN COMPOUND The invention provides compositions containing a highly purified antiendotoxin compound and methods of preparing and using such compositions.... | 06/02/2011 |
| 20110059908 | COMPOSITIONS COMPRISING LIPOTEICHOIC ACID FOR USE IN TREATING PLEURAL EFFUSION OR PNEUMOTHORAX The present invention relates to lipoteichoic acid T for use in treating pleural effusion or pneumothorax. The present invention also relates to the use of lipoteichoic acid T (LTA-T) in the manufacture of a medicament for treating pleural effusion or pneumothorax. The ... | 03/10/2011 |
| 20100316704 | PLATINUM COMPLEXES AND METHODS OF USE The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the... | 12/16/2010 |
| 20100317024 | DERIVATIVES, REAGENTS, AND IMMUNOASSAY FOR DETECTING LEVETIRACETAM Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivat... | 12/16/2010 |
| 20100310602 | SYNTHETIC GLUCOPYRANOSYL LIPID ADJUVANTS Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L<... | 12/09/2010 |
| 20100297156 | ANALOGUES OF PHOSPHATIDYLINOSITOL MANNOSIDES The invention relates to compounds which are immunomodulatory compounds and, in particular, can induce IL-12 secretion. The invention also relates to compositions containing the compounds, precursors, and prodrugs of these compounds, use of these compounds as adjuvants ... | 11/25/2010 |
| 20100286067 | GLYCOCONJUGATION OF POLYPEPTIDES USING OLIGOSACCHARYLTRANSFERASES The current invention provides polypeptides and polypeptide conjugates that include an exogenous N-linked glycosylation sequence. The N-linked glycosylation sequence is preferably a substrate for an oligosaccharyltransferase (e.g., bacterial PgIB), which can catalyze th... | 11/11/2010 |
| 20100221269 | SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.... | 09/02/2010 |
| 20100152429 | SODIUM SALT OF DISACCHARIDE COMPOUND, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME Disclosed are a sodium salt represented by the average formula (I) below, and a method for producing such a sodium salt. (In the formula, m1, n1, m2 and n2 independently represent 0 or a positive number not greater than 2, whi... | 06/17/2010 |
| 20100093654 | TETRASUBSTITUTED CLUCOPYRANOSYLATED BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE Tetrasubstituted glucopyranosylated benzene derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable f... | 04/15/2010 |
| 20100075321 | LABELED COMPOUND AND DETECTION METHOD USING THE SAME A labeled compound is so designed that an aromatic tertiary amine compound is bondable with a biomolecule. One of S1 and S2 contains a group bound with a molecular chain 10 (e.g. an oligonucleotide) capable of binding with a biomolecule or a reacti... | 03/25/2010 |
| 20100076183 | PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS A nucleoside monomer that is protected by a thionocarbamate protecting group is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotid... | 03/25/2010 |
| 20100069312 | AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS FOR TREATING AUTOIMMUNE DISEASES The invention provides prophylactic and therapeutic applications of select aminoalkyl glucosamine phosphate (AGP) compounds in autoimmune diseases.... | 03/18/2010 |
| 20100048492 | COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF DISEASES ASSOCIATED WITH TNF AND/OR IL-12 OVEREXPRESSION The present invention relates to a pharmaceutical composition comprising at least one compound of formula (I): or one of its pharmaceutically acceptable salts in which R1, R2 and R3... | 02/25/2010 |
| 20100009902 | Glycoconjugation Using Saccharyl Fragments The present invention provides conjugates between a substrate, e.g., peptide, glycopeptide, lipid, etc., and a modified saccharyl fragment bearing a modifying group such as a water-soluble polymer, therapeutic moiety or a biomolecule. The conjugates are linked via the e... | 01/14/2010 |
| 20090312531 | OLIGNUCLEOTIDES COMPRISING A LIGAND TETHERED TO A MODIFIED OR NON-NATURAL NUCLEOBASE One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In c... | 12/17/2009 |
| 20090285844 | NON-TOXIC MUTANTS OF PATHOGENIC GRAM-NEGATIVE BACTERIA A method is provided for identifying, isolating, and producing htrB mutants of gram-negative bacterial pathogens. The method comprises mutating the htrB gene of a gram-negative bacterial pathogen so that there is a lack of a functional htrB protein, resulting in a mutan... | 11/19/2009 |
| 20090270339 | Unit Dose Form of Glufosfamide A lyophilized unit dose form containing about 2 g of glufosfamide is useful in treatment of cancer and other hyper-proliferative diseases.... | 10/29/2009 |
| 20090239814 | Carbohydrate Conjugates as Delivery Agents for Oligonucleotides The present invention provides iRNA agents comprising at least one subunit of the formula (I):
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| 20090206245 | Mass analysis method using fine metal particles It is an object of the present invention to provide a novel mass spectrometry method which overcomes the conventional problems mentioned above, which can analyze at a high sensitivity and high accuracy a chemical reaction on a surface of a self-organized membrane bound ... | 08/20/2009 |
