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| Application No. | Application Title | Issue Date |
| 20120052042 | AMPHIPHILIC COMPOUNDS AND SELF-ASSEMBLING COMPOSITIONS MADE THEREFROM The present disclosure relates to amphiphilic compounds, self assembling compositions formed from the amphiphilic compounds and methods of making such compositions.... | 03/01/2012 |
| 20120040431 | Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of o... | 02/16/2012 |
| 20120035321 | COMPOUNDS AND MEDICAL DEVICES ACTIVATED WITH SOLVOPHOBIC LINKERS The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.... | 02/09/2012 |
| 20120004194 | ALDEHYDE-FUNCTIONALIZED POLYSACCHARIDES Novel aldehyde-functionalized polysaccharide compositions are described that are more stable in aqueous solution than oxidized polysaccharides or other types of polysaccharides containing pendant aldehyde groups. The aldehyde-functionalized polysaccharides may be reacte... | 01/05/2012 |
| 20110263842 | DEXTRAN FOR TREATING LUNG CANCER Dextran for preparing medicine for anti-lung cancer, has repeated structure unit and molecular weight of 1.5-2.5 million Daltons. The dextran is extracted from land slug.... | 10/27/2011 |
| 20110251265 | POLYAMINE-CONTAINING POLYMERS AND METHODS OF SYNTHESIS AND USE The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).... | 10/13/2011 |
| 20110229550 | Acid-Degradable and Bioerodible Modified Polyhydroxylated Materials Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent... | 09/22/2011 |
| 20110223633 | METHODS AND REAGENTS FOR ENRICHMENT AND CHARACTERIZATION OF PHOSPHORYLATED BIOMOLECULES An affinity matrix comprising a metal ion covalently attached thereto and methods for making and using the same are described. The matrix has affinity for various phosphorylated biomolecules, such as phosphoproteins/phosphopeptides. The matrix may be used in a variety o... | 09/15/2011 |
| 20110180760 | HOT-MELT ADHESIVE AND METHOD FOR THE MANUFACTURE THEREOF The invention relates to a hot melt adhesive, comprising at least one polysaccharide ester gained by a reaction of a polysaccharide with an imidazolide in melted imidazole. The invention relates, further, to a process for producing the hot melt adhesive, in which imidaz... | 07/28/2011 |
| 20110171716 | CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderi... | 07/14/2011 |
| 20110172166 | Anionic polysaccharides functionalized by a hydrophobic acid derivative A novel anionic polysaccharides functionalized by at least one hydrophobic acid derivative. These novel anionic polysaccharides including hydrophobic groups have good biocompatibility and their hydrophobicity can be easily adjusted without detrimentally affecting the bi... | 07/14/2011 |
| 20110143007 | NEW POLYDEXTROSE MATERIAL The present invention discloses a new type of water-soluble polydextrose. This new type of polydextrose contains at least 75% by weight of saccharide molecules having a degree of polymerisation (DP) of 5 or more and characterised in that the non-digestible fiber content... | 06/16/2011 |
| 20110136925 | GRAFT COPOLYMERS FOR ION EXCHANGE CHROMATOGRAPHY The invention relates to a modified separating material having improved properties, to the preparation thereof, and to the use thereof for the separation of charged biopolymers from liquids.... | 06/09/2011 |
| 20110130473 | DILUTE FILTRATION STERILIZATION PROCESS FOR VISCOELASTIC BIOPOLYMERS Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis, however, traditional sterilization techniques result in the breakdown of such high molecular weight viscoelastic ... | 06/02/2011 |
| 20110112039 | Polysaccharides comprising carboxyl functional groups substituted via esterification by a hydrophobic alcohol Polysaccharide including carboxyl functional groups. The polysaccharide being chosen from the group of anionic synthetic polysaccharides including 1,6 bonds obtained from neutral polysaccharides of which at least one of a carboxyl functional groups is esterified by a hy... | 05/12/2011 |
| 20110097385 | Delivery System for Drug and Cell Therapy A method of lowering blood glucose in a mammal includes administering orally or by injection or inhalation a therapeutically effective amount of crystallized dextran microparticles and insulin to the mammal to lower blood glucose of the mammal. The composition may be a ... | 04/28/2011 |
| 20110085979 | CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. Conjugates of polymers or ... | 04/14/2011 |
| 20110059859 | Molecule Detecting System The invention disclosed here has several key elements: direct probe-on-sensor detection, mesh probe, and mesh reporter. Furthermore, the mesh probe and reporter shall have some physical cross-linking between the polymer backbone(s), either covalently or non-covalently. ... | 03/10/2011 |
| 20110003941 | METHOD FOR PREPARATION OF A BIOMOLECULE ADSORBENT The present invention is relates to method for production of a biomolecule adsorbent with a pentadentate ligand with very strong chelating properties, and to methods for use thereof for, for example, protein purification, detection or binding. The biomolecule adsorbent ... | 01/06/2011 |
| 20100331279 | Inhibition of Antigen Presentation with Poorly Catabolized Polymers Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibitin... | 12/30/2010 |
| 20100324281 | BIOSENSOR AND METHOD FOR IMMOBILIZING A PHYSIOLOGICALLY ACTIVE SUBSTANCE An object of the present invention is to provide a biosensor and a method for immobilizing a physiologically active substance, by which preconcentration effects can be obtained at a pH that is equivalent to or higher than the isoelectric point of the physiologically act... | 12/23/2010 |
| 20100304387 | METHODS AND COMPOSITIONS FOR SIGNAL ENHANCEMENT USING MULTIVALENT INTERACTIONS Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for an analyte, using an amplification polymer that multivalently binds to one or more non-analyte-specific binding site of the multivalent bridge conjugate,... | 12/02/2010 |
| 20100284972 | COMPOSITIONS AND METHODS FOR MAKING ALPHA-(1,2)-BRANCHED ALPHA-(1,6) OLIGODEXTRANS Compositions for improving the health of a subject comprise alpha-(1,2)-branched alpha-(1,6) oligodextrans, preferably with an average molecular weight between about 10 kDa and 70 kDa, between about 10% and 50% alpha-(1,2)-osidic side chains, and having at least partial... | 11/11/2010 |
| 20100279952 | CROSS-LINKED HYDROGEL CONTAINING AN ACTIVE SUBSTANCE The invention relates to a biocompatible metastable intermediate material for controlling the mobility of at least one biologically active substance. An example of the invention is a hydrogel formed by cross-linked sodium hyaluronate treated with an oxidizing agent so a... | 11/04/2010 |
| 20100248218 | Conjugates, and use thereof in detection methods The invention relates to methods for the quantitative and qualitative detection of an analyte in an assay as well as appropriate reagents therefor, especially a carrier molecule to which one or several analyte-specific binding partners are bound and which is provided wi... | 09/30/2010 |
| 20100233779 | Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of o... | 09/16/2010 |
| 20100226991 | SOLID INORGANIC/ORGANIC HYBRID WITH MODIFIED SURFACE The invention relates to solid organometallic hybrids with modified surface. Said solid may be used for example for the encapsulation and vectoring of molecules of interest such as active pharmaceutical agents, compounds of interest in cosmetics and markers, for example... | 09/09/2010 |
| 20100226985 | VISCOELASTIC AQUEOUS GELS COMPRISING MICROSPHERES The present invention provides viscoelastic gel compositions comprising microparticles which are capable of interacting with each other in a non-ionic manner, thus forming a gel network. The gel compositions may incorporate active agents and provide controlled release o... | 09/09/2010 |
| 20100221301 | Method for Preparing Porous Scaffold for Tissue Engineering The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and... | 09/02/2010 |
| 20100209441 | DRUG FOR SUPPRESSING PATHOGEN OCCURRING IN VIVO To provide a drug for actively metabolizing or excreting a pathogen occurring in vivo. The present invention is directed to a compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand whic... | 08/19/2010 |
| 20100184184 | Production of Conjugates Disclosed is a method for indirectly coupling a small molecule ligand to a molecule to be labelled with the ligand, the method comprising the step of: contacting a scaffold molecule, to which is attached at least one small molecule ligand, with the molecule to be labell... | 07/22/2010 |
| 20100184054 | BINDING OF PATHOLOGICAL FORMS OF PRION PROTEINS A process for the selective binding of an aggregating abnormal form of a protein in the presence of the nonaggregating normal form of the protein, including contacting under selective binding conditions a material containing both the abnormal and normal forms with a bin... | 07/22/2010 |
| 20100167333 | Heavy Metal Binding Compounds and Their Method of Use The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of heavy metal ions in a sample. This metal chelating moiety is a —N,N,O-triacetic acid analog of BAPTA and has the following formula | 07/01/2010 |
| 20100160467 | ORGANIC-INORGANIC HYBRID SCAFFOLDS WITH SURFACE-IMMOBILIZED NANO-HYDROXYAPATITE AND PREPARATION METHOD THEREOF Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a s... | 06/24/2010 |
| 20100159012 | Conjugates of Therapeutically Active Compounds The present invention discloses modified polymer conjugates of a polymer and a drug having reduced toxicity relative to the unmodified parent compound while retaining substantially the same degree of therapeutic activity as of the unmodified parent compound.... | 06/24/2010 |
| 20100136070 | METHODS, DEVICES, AND COMPOSITIONS FOR DERMAL FILLING Provided herein are methods, devices, and compositions for dermal filling. Also described herein are dermal filler cross-linked compositions and methods for making such compositions. Such compositions comprise, for example, a cross-linked composition of hyaluronic acid,... | 06/03/2010 |
| 20100099163 | SEPARATION MATRIX FOR VIRAL PURIFICATION The present invention relates to a method of preparing a separation matrix comprising at least one insoluble carrier to which sulphate ligands have been attached via extenders, which method comprises coupling, in a first step, of the sulphate ligands to the extenders an... | 04/22/2010 |
| 20100098653 | ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to ... | 04/22/2010 |
| 20100048483 | POLYMERIC BENZYL CARBONATE-DERIVATIVES The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using thes... | 02/25/2010 |
| 20090286757 | Antiviral composition Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, dextran, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of the invention provide antiviral activity, particularly in the treatment an... | 11/19/2009 |