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...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Application No. | Application Title | Issue Date |
| 20120108513 | PURIFICATION METHOD FOR DIVALENT CATION BINDING PROTEINS ON ANION EXCHANGE RESIN The present invention relates to a method for the purification of divalent cation binding proteins with high purity on an anion exchange resin material, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said me... | 05/03/2012 |
| 20120052550 | TEMPERATURE-RESPONSIVE POLYMER PARTICLES IN PROTEIN SEPARATION APPLICATIONS The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particle... | 03/01/2012 |
| 20120029176 | Chromatography Media And Method Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when com... | 02/02/2012 |
| 20120022228 | PURIFICATION OF AMPHOTERIC PRODUCTS, OR OF PRODUCTS LIABLE TO BE CONVERTED INTO AMPHOTERIC PRODUCTS A process for purifying at least one product from a substrate containing at least one product, includes subjecting the substrate to centrifugal partition chromatography in an ion exchange displacement mode to purify the at least one product from the substrate, the at le... | 01/26/2012 |
| 20120018380 | PREPARATIVE CHROMATOGRAPHY COLUMN AND METHODS A chromatography column that captures components in a process liquid in a free flow state and allows elution in steps is described.... | 01/26/2012 |
| 20120010390 | SEPARATION METHOD USING SINGLE POLYMER PHASE SYSTEMS The present invention relates to a process of enriching one target compound from a liquid, which process comprises at least one step of isolation performed by differentially partitioning between two aqueous phases. In the present invention the phases are formed by addin... | 01/12/2012 |
| 20110301342 | APPARATUS AND PROCESS FOR PURIFICATION OF PROTEINS The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth... | 12/08/2011 |
| 20110294990 | Refolding of Recombinant Proteins Processes are provided for recovering and purifying refolded recombinant proteins produced in heterologous host cells, which includes the step of refolding the protein in a high pH buffer.... | 12/01/2011 |
| 20110287518 | Polypeptide Purification The invention relates to the purification of different gamma carboxylated forms of a polypeptide using ion exchange chromatography. In particular, the invention provides a method for purifying a polypeptide having a desired content of gamma-carboxyglutamic acid from a s... | 11/24/2011 |
| 20110269947 | APO-2 LIGAND/TRAIL FORMULATIONS The present invention relates generally to Apo2L/TRAIL purification involving crystallization.... | 11/03/2011 |
| 20110206692 | CONFORMERS OF BACTERIAL ADHESINS The invention relates to isolated or purified bacterial adhesin conformers, preferably with improved stability and/or immunogenicity. In a preferred aspect, the invention comprises an isolated bacterial adhesin conformer F. Also provided are methods of isolation and/or ... | 08/25/2011 |
| 20110166332 | ENHANCED ANTIBODY AGGREGATE REMOVAL WITH CAPTO ADHERE IN THE PRESENCE OF PROTEIN-EXCLUDED ZWITTERIONS The invention relates to a method for separating at least one non-aggregated protein from a liquid protein preparation by contacting said preparation with a multimodal anion exchanger in the presence of protein-excluded zwitterions at a concentration of 0.25 to 2.5 M.... | 07/07/2011 |
| 20110150911 | Methods and reagents for treating, preventing and diagnosing bunyavirus infection Immunogenic compositions for use in treating, preventing and diagnosing infection caused by the California (CAL) serotype of the genus Bunyavirus, such as La Crosse virus (LACV), are disclosed. Also described are reagents for use in diagnostic assays.... | 06/23/2011 |
| 20110129895 | Method For Purifying Protein A method is provided for purifying protein having steps of loading a sample containing proteins into a column containing an ion exchanger in a first direction to allow the ion exchanger to absorb proteins; and passing a salt solution through the column in a second direc... | 06/02/2011 |
| 20110118453 | PROTEIN SEPARATION VIA ION-EXCHANGE CHROMATOGRAPHY AND ASSOCIATED METHODS, SYSTEMS, AND DEVICES The present invention provides methods for separating proteins from a protein mixture. In one aspect, a method for separating a high concentration protein mixture into a bound protein fraction and a flow-through protein fraction can include delivering a protein mixture ... | 05/19/2011 |
| 20110092681 | Purification of VWF for Increased Removal of Non-Lipid Enveloped Viruses The present invention provides methods for purifying Von Willebrand factor (VWF) for increased removal of non-lipid enveloped viruses.... | 04/21/2011 |
| 20110092682 | Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin Methods and systems for chromatographically purifying a botulinum neurotoxin are provided. These methods and systems allow for efficient purification of a non-complexed form of the botulinum neurotoxin in high purity and yield that can be used as an active... | 04/21/2011 |
| 20110065900 | SEPARATION METHOD UTILIZING POLYALLYLAMINE LIGANDS The present invention relates to a method for removing at least one negatively charged substance from an aqueous liquid by contacting the liquid with a separation matrix comprising a plurality of polyallylamine ligands, comprising binding said negatively charged substan... | 03/17/2011 |
| 20110054153 | METHOD OF PURIFYING APO-2 LIGAND/TRAIL USIN CRYSTALLISATION THE COLD The present invention relates generally to Apo2L/TRAIL purification involving crystallization.... | 03/03/2011 |
| 20110034672 | PURIFICATION OF NOT-GLYCOSYLATED POLYPEPTIDES The current invention reports a method for the purification of a not-glycosylated, heterologous polypeptide, which has been recombinantly produced in a prokaryotic cell, wherein the method comprises three chromatography steps of which the first chromatography step selec... | 02/10/2011 |
| 20110015374 | Method for Commercial Isolation of Egg Yolk IgY, Its Product, and Uses of the Product A method for extraction and purification of IgY from immune avian egg yolk comprising diluting a mixture of liquid egg yolk and liquid egg white in treated water; stirring the diluted mixture to obtain an egg mixture; separating the egg mixture into a first water solubl... | 01/20/2011 |
| 20100324269 | REFOLDING PROTEINS USING A CHEMICALLY CONTROLLED REDOX STATE A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying the thiol pair ratio and the redox buffer strength to achieve conditions under which efficient folding at concen... | 12/23/2010 |
| 20100292447 | METHOD AND AGENT FOR REFOLDING PROTEINS This invention relates to the use of ionic liquids comprising a cation with at least one electron donor region and one positively charged electrostatic region which are spatially distinct from each other for protein refolding and a method for refolding proteins using sa... | 11/18/2010 |
| 20100261886 | PROTEIN PURIFICATION BY CITRATE PRECIPITATION The invention provides methods for isolating proteins in purified form from mixtures by precipitation with citrate. The methods are advantageous in that they effectively separate a protein from lower molecular weight contaminants, including fragments or portions of the ... | 10/14/2010 |
| 20100261275 | Production of Recombinant Interferon Proteins A method of purifying a recombinant interferon protein involves providing an aqueous mixture of the recombinant protein and contaminating proteins; precipitating the contaminating proteins from the aqueous mixture at a pH in a range of from 0.5 to 6; separating the aque... | 10/14/2010 |
| 20100228010 | METHOD FOR PURIFYING PROTEIN The present invention provides a method for purifying a protein to remove impurities from a mixture liquid containing a desired protein and the impurities, comprising the step of performing filtration using a porous membrane having a graft chain on a pore surface and an... | 09/09/2010 |
| 20100190210 | Protein Purification The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity ion exchange chromatography process without the use of an in-process tangential flow filtration step.... | 07/29/2010 |
| 20100172894 | METHODS FOR PURIFICATION OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES Processes and methods of purifying or separating Single Domain Antigen Binding (SDAB) molecules that include one or more single binding domains (e.g., one or more nanobody molecules), substantially devoid of a complementary antibody domain and an immunoglobulin constant... | 07/08/2010 |
| 20100144596 | An Apo-Ferredoxin Preparation, A Process For Producing Same And Uses Thereof A process for obtaining a pure preparation of an apo- form of an [Fe2S2] ferredoxin is provided. The process comprising, applying a solution comprising a holo- form of the [Fe2S2] ferredoxin on an anion exchange column; and el... | 06/10/2010 |
| 20100144622 | METHODS FOR PRODUCTION OF RECOMBINANT PLASMINOGEN AND PLASMIN POLYPEPTIDES Methods of producing properly refolded recombinant plasminogen and plasmin polypeptide are provided. Denatured recombinant plasminogen polypeptide is refolded by first solubilizing the polypeptide with a chaotroph and reducing and oxidizing agents at high pH, followed b... | 06/10/2010 |
| 20100144028 | Method And Device For Continuous Membrane Adsorption A method and system is provided for yielding biopharmaceutical products involving a chromatographic separation process. The method comprises: providing a plurality of membrane adsorber cartridges; providing a plurality of valves, communicatively coupled to said pluralit... | 06/10/2010 |
| 20100111853 | ANTIBODIES THAT BIND TO IL-12 AND METHODS OF PURIFYING THE SAME Anti-IL-12 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-12 antibodies from a sample matrix is presented. These isolated anti-IL-12 antibodies can be used in a clinical setting as wel... | 05/06/2010 |
| 20100112664 | METHOD OF MAKING MACROPOROUS CATION EXCHANGE RESINS Methods of making macroporous cation exchange resins are described. The macroporous cation exchange resins are in the form of particles such as beads that contain a hydrophilic, crosslinked, (meth)acrylic-type polymeric material. Additionally, methods of purifying a pos... | 05/06/2010 |
| 20100113751 | PURIFICATION OF ACIDIC PROTEINS USING CERAMIC HYDROXYAPATITE CHROMATOGRAPHY The present invention provides a method of removing product-related inactive or partially active species, high molecular weight aggregates, as well as other process-related impurities from preparations of acidic proteins by using ceramic hydroxyapatite chromatography.... | 05/06/2010 |
| 20100028952 | FERMENTATION AND PURIFICATION OF ACTINOMADURA CHROMOPROTEIN AND RELATED SPECIES The present invention provides methods for production and purification of active chromoproteins produced by Actinomadura sp. 21G792. The chromoproteins are useful for developing pharmaceutical compositions and treating diseases such as cancer or bacterial infecti... | 02/04/2010 |
| 20100021935 | Goodpasture Antigen Binding Protein and Its Detection The present invention provides native Goodpasture antigen binding protein isoforms, monoclonal antibodies directed against such proteins, and methods for their use.... | 01/28/2010 |
| 20090324650 | Method for The Production of Hydrolyzed Allergen A method for the production of a purified extract of natural allergens comprising the steps of
| 12/31/2009 |
| 20090318674 | PROCESS FOR PURIFICATION OF ANTIBODIES The disclosed embodiments are directed to methods and compositions for purification of proteins, in particular, to methods and compositions for an antibody purification process that includes aggregate removal and the use of solubility enhancing additives such as zwitter... | 12/24/2009 |
| 20090306346 | METHOD FOR SEPARATING PROTEINS FROM LIQUID MEDIA The invention relates to a method for separating proteins from liquid media, comprising
| 12/10/2009 |
| 20090306352 | Basic Protein Purification Tags from Thermophilic Bacteria The invention is related to a method for purification of recombinant proteins using highly basic proteins from thermophilic bacteria as purification tags for use in a cation-exchange chromatography purification step. The basic proteins may be ribosomal proteins. The rec... | 12/10/2009 |
