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| Application No. | Application Title | Issue Date |
| 20120107842 | METHOD FOR DETECTING ANTIBODY AGAINST SITH-1 IN BIOLOGICAL SAMPLE The present invention provides a method for detecting an antibody against a small protein encoded by the intermediate stage transcript of HHV-6 (SITH-1) in a biological sample. The method of the present invention comprises: 05/03/2012 | |
| 20120039924 | COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleoti... | 02/16/2012 |
| 20110311990 | TETRANOR-PGEM/PGAM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME Tetranor-PGEM/tetranor-PGAM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses for detecting and quantifying tetranor-PGEM in biological fluids for determining biosynthesis of PGE2 in a subject or patient... | 12/22/2011 |
| 20110311615 | NOVEL GP41 ANTIGENS The present invention deals with a modified polypeptide comprising three contiguous segments N, L and C represented by the formula N−L−C and comprising: a N-helix region of gp41 (N), a C-helix region of gp41 (C), and a connecting loop comprising a synthetic linker (... | 12/22/2011 |
| 20110268758 | TUBERCULOSIS ANTIGEN DETECTION ASSAYS AND VACCINES The present invention relates to isolated Tuberculosis (TB) antigens that are useful in therapeutic and vaccine compositions for stimulating a TB specific immunological response. The identified antigens are also useful in diagnostic assays to determine the presence of a... | 11/03/2011 |
| 20110263517 | Cytokines and Cytokine Receptors with Reduced Immunogenicity The present invention provides methods for the identification of CD4+ T-cell epitopes in the sequences of various proteins, namely, human cytokines and cytokine receptors, as well as the production of peptides which when incorporated into the protein sequence, are no lo... | 10/27/2011 |
| 20110229523 | MODIFICATION OF ALLERGENS FOR IMMUNOTHERAPY The present invention relates to pharmaceutical compositions for immunotherapy, for example for immunotherapy of peanut allergy. Further, the present invention relates to methods for the preparation of the present pharmaceutical compositions for immunotherapy, and their... | 09/22/2011 |
| 20110229509 | POLYPEPTIDES FOR INDUCING A PROTECTIVE IMMUNE RESPONSE AGAINST STAPHYLOCOCCUS AUREUS Disclosed are polypeptides comprising an amino acid sequence structurally related to SEQ ID NO 1 and uses of such polypeptides and compositions thereof. SEQ ID NO 1 is a full length S. aureus sequence. A derivative of SEQ ID NO 1 containing an amino terminal his-... | 09/22/2011 |
| 20110201791 | MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5,... | 08/18/2011 |
| 20110195089 | COMPOSITIONS, METHODS, AND KITS FOR ENHANCING THE IMMUNOGENICITY OF PATHOGENIC ANTIGENS The invention provides a method of enhancing the immunogenicity of pathogenic antigens by removing or disrupting intrachain disulfide bonds responsible for maintaining tertiary protein structure. Removal of one or more disulfide bonds can increase the titer of neutraliz... | 08/11/2011 |
| 20110182925 | Ehrlichia canis DIVA (Differentiate Infected from Vaccinated Animals) The invention provides Ehrlichia canis antigens that can be used to detect E. canis infected animals regardless of whether the animals have been vaccinated for E. canis. The invention also provides compositions and methods for determining the presen... | 07/28/2011 |
| 20110158977 | Immunogenic compositions for Chlamydia trachomatis The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across the Chlamydia trachomatis serovars. Such changes in LcrE genotypes across the Chlamydia trachomatis serovars are likely to correspond with changes in... | 06/30/2011 |
| 20110150921 | NOVEL FUSION PROTEINS AND USE THEREOF FOR PREPARING HEPATITIS C VACCINES An immunogenic fusion protein includes at least, on the C-terminal side, a first peptide composed of the S protein deleted of the transmembrane domain thereof located at the N-terminal end thereof, of a hepatitis B virus (HBV) isolate, and on the N-terminal side, a seco... | 06/23/2011 |
| 20110130300 | ASSAY FOR DIAGNOSING STREPTOCOCCUS PNEUMONIAE Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized... | 06/02/2011 |
| 20110126301 | Dendritic Cell Marker and Uses Thereof The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen presenting dendritic cells. In particular, the present invention relates to compounds such as antibodies that bind ... | 05/26/2011 |
| 20110104064 | CYCLIZED NON-NATIVE SYNTHETIC PEPTIDE AND COMPLEX OF PEPTIDES COMPRISING SAID CYCLIZED PEPTIDE, INTENDED TO INDUCE AND TO CHARACTERIZE THE PREVENTION OR TREATMENT OF CONDITIONS IN MAMMALS Non-native synthetic peptide cyclized by means of a disulphide bridge, characterized by the amino acid sequence (E34P) that follows (SEQ ID No. 1): E-D-E-H-K-G-K-Y-C-R-L-G-N-D-C-R-T-T-E-P-T-T-T-A-T-P-R-G-T-P-T-P-A-P and a complex of non-native synthetic peptides that is... | 05/05/2011 |
| 20110059121 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. A... | 03/10/2011 |
| 20110052496 | HOLLOW NANOPARTICLES AND USES THEREOF Aspects of the invention provide hollow nanoparticles and uses thereof. In particular, the invention provides membrane-enclosed vesicles comprising a truncated form of an HBsAg S protein lacking one or two of its amino-terminal transmembrane domains.... | 03/03/2011 |
| 20110027915 | METHOD OF PRODUCING INSOLUBLE CARRIER PARTICLES, INSOLUBLE CARRIER PARTICLES, MEASUREMENT REAGENT, SPECIMEN ANALYZING TOOL, AND IMMUNOTURBIDIMETRIC ASSAY The present invention provides a measurement reagent that is capable of suppressing nonspecific aggregation even when the amount of antibody to be carried is increased, and is capable of measuring in a wide measurement concentration range with high measurement sensitivi... | 02/03/2011 |
| 20110020352 | ENDOGENOUS RETROVIRUSES UP-REGULATED IN PROSTATE CANCER Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy.... | 01/27/2011 |
| 20110015376 | Papilloma Virus-Like Particles, Fusion Proteins as Well as Processes for Their Production The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus prote... | 01/20/2011 |
| 20110008838 | CHIMERIC VARICELLA ZOSTER VIRUS VIRUS-LIKE PARTICLES The present invention discloses novel chimeric Varicella Zoster Virus (VZV) virus-like particles (VLPs) comprising chimeric VZV glycoproteins. The invention also discloses vaccine formulations of the chimeric VZV-VLPs and methods of inducing an immune response in subjec... | 01/13/2011 |
| 20110008380 | Anaplasma Phagocytophilum (Aph) Antigens and Antibodies Specific for Anaplasma The invention provides methods and compositions for the detection and treatment of Anaplasma phagocytophilum and Anaplasma platys infection.... | 01/13/2011 |
| 20110002916 | Plasmodium falciparum antigens and their vaccine and diagnostic applications The invention concerns novel Plasmodium falciparum antigens and their vaccine and diagnostic applications. More particularly, the invention concerns immunogenic polynucleotide and polypeptide molecules, compositions comprising them, and methods for diagnosis and ... | 01/06/2011 |
| 20110002955 | ANTI-OBESE IMMUNOGENIC HYBRID POLYPEPTIDES AND ANTI-OBESE VACCINE COMPOSITION COMPRISING THE SAME Disclosed is an immunogenic hybrid polypeptide for the prevention and treatment of obesity, in which a mimetic peptide of a B cell epitope of apolipoprotein B-IOO; a rabies virus helper T cell epitope or hepatitis B virus surface antigen helper T cell epitope and a C-te... | 01/06/2011 |
| 20100280229 | POLYPEPTIDE The present invention provides a polypeptide inducing the production of an antibody in permucosal administration in the presence of no immunological adjuvant, a composition containing the polypeptide, and use thereof. The present invention solves the above object by pro... | 11/04/2010 |
| 20100261026 | Compositions comprising oriented, immobilized macromolecules and methods for their preparation The present invention provides methods and compositions that facilitate the identification of structures of a variety of macromolecules. For instance, the present invention provides methods for the selective immobilization of macromolecules in an extended or oriented st... | 10/14/2010 |
| 20100247574 | CHIMERIC NEWCASTLE DISEASE VIRUS VLPs The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines ... | 09/30/2010 |
| 20100204458 | Process for the Production of Immunogenic Compositions The present invention relates to a process for producing immunogenic polypeptides, comprising reducing disulfide bonds and blocking the resulting free thiol group with a blocking agent. The immunogenic peptides comprise a fragment of MAGE A3.... | 08/12/2010 |
| 20100151490 | Antigenic Protein Conjugates and Process for Preparing Same An improved process for the preparation of antigenic protein conjugates is provided. The conjugates preferably are formed through reaction with one or more free sulfhydryl groups in the antigenic protein. The process of the present invention preferably employs a trialky... | 06/17/2010 |
| 20100143410 | POLYPEPTIDE FRAGMENTS OF THE HEPATITIS E VIRUS, THE VACCINE COMPOSITION COMPRISING SAID FRAGMENTS AND THE DIAGNOSTIC KITS The present invention relates to polypeptide(s) comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of n-polymeric polypeptide, wherein n is an integer from 1-180; to a chimeric protein consist... | 06/10/2010 |
| 20100111992 | CYTOMEGALOVIRUS PEPTIDES AND METHODS OF USE THEREOF A method of modulating an immune response in a subject is disclosed. The invention is based on the discovery that an effective therapeutic strategy for ameliorating the symptoms of cytomegalovirus infection can be achieved by administering an effective amount of a CMV-d... | 05/06/2010 |
| 20100092508 | Molecular Antigen Arrays The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the producti... | 04/15/2010 |
| 20100069571 | Thioester-Terminated Water Soluble Polymers and Method of Modifying the N-Terminus of a Polypeptide Therewith The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specific... | 03/18/2010 |
| 20100062015 | FUSION PROTEIN VACCINE The present invention relates to the fields of microbiology and vaccine technology, and concerns the development of a vaccine capable of conferring immunity to group B Streptococcus infections. More particularly, the present invention relates to a novel fusion pr... | 03/11/2010 |
| 20100055126 | METHAMPHETAMINE-LIKE HAPTEN COMPOUNDS, LINKERS, CARRIERS AND COMPOSITIONS AND USES THEREOF The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+)... | 03/04/2010 |
| 20100055085 | HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity... | 03/04/2010 |
| 20100015173 | COILED-COIL LIPOPEPTIDE HELICAL BUNDLES AND SYNTHETIC VIRUS-LIKE PARTICLES The invention relates to lipopeptide building blocks consisting of a peptide chain comprising a coiled-coil domain, linked covalently to a lipid moiety comprising long alkyl or alkenyl chains, and optionally linked to an antigen; and to helical lipopeptide bundles and s... | 01/21/2010 |
| 20100015725 | LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diag... | 01/21/2010 |
| 20090321357 | Affinity Particle And Affinity Separation Method The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic powder and also by having ligands having specific affinity with a certain targe... | 12/31/2009 |
