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A vest or belt is integrally formed with tubular, pet receiving passageways which extend around the wearer's body and terminate in pocket-like chambers for feeding and retrieval.
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| Application No. | Application Title | Issue Date |
| 20120129771 | PEPTIDES AND RELATED MOLECULES THAT MODULATE NERVE GROWTH FACTOR ACTIVITY The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active... | 05/24/2012 |
| 20120128684 | Conserved Hemagglutinin Epitope, Antibodies to the Epitope and Methods of Use Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes in the stem region, and methods of making and using both.... | 05/24/2012 |
| 20120129759 | PROTEIN SURFACE REMODELING Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic amino acid residues on the surface of a protein, suitable for mutating to... | 05/24/2012 |
| 20120107855 | CROSSLINKING REAGENT FOR ANALYSIS OF PROTEIN-PROTEIN INTERACTION Crosslinking reagents and methods for using the same for analysis of protein-protein interactions, are provided. The crosslinking reagents include a trifunctional scaffold that links two protein linking groups to each other and branches to link an affinity tag, where th... | 05/03/2012 |
| 20120083542 | METHOD FOR TREATING WASTES The present invention relates to a process for the treatment of waste in a reactor (3) comprising the steps of combining the waste to be processed and an aqueous, alkaline solution to form a reaction mixture, heating the reaction mixture to a temperature range be... | 04/05/2012 |
| 20120083591 | METHOD OF PRODUCING A SET OF MHC MOLECULES The present invention relates to a method of producing a set of MHC molecules, and more precisely to a method of producing a set of MHC molecules which differ in their peptide bound in the binding groove. The method allows for parallel and rapid synthesis of different M... | 04/05/2012 |
| 20120052090 | PEPTIDIC ANTIGEN THAT INDUCES ANTIBODY RECOGNIZING THREE-DIMENSIONAL STRUCTURE OF HIV AND METHOD FOR SYNTHESIZING SAME An object of the present invention is to provide an HIV antibody-inducing peptide antigen that can be used without problems for HIV, which is highly prone to mutation, and is effective in developing an antibody or a vaccine having excellent specificity and binding activ... | 03/01/2012 |
| 20120046453 | PROTEIN CHARGE REGULATOR AND PROTEIN-ENCAPSULATING POLYMER MICELLE COMPLEX The present invention provides a protein delivery means (e.g., a polyion complex) which allows efficient introduction into cells (particularly into the cytoplasm), is highly stable in serum, and is also widely applicable. The polyion complex of the present invention com... | 02/23/2012 |
| 20120039813 | INTRINSICALLY COLORED, LUMINESCENT SILK FIBROIN AND A METHOD OF PRODUCING THE SAME This present invention proposes a method of producing intrinsically colored, luminescent silk fibroin by feeding silkworms with feed comprising the luminescent dyes as well as the appropriate degumming process to remove sericin while retaining the dyes in silk fibroin a... | 02/16/2012 |
| 20120039902 | Method for the treatment of t cell mediated conditions by depletion of icos-positive cells in vivo The present invention relates generally to binding agents useful in the selective depletion of T cells in vivo. More specifically, the invention relates to ICOS-binding agents which once bound to ICOS expressed on the surface of cells, in particular ICOS-bearing activat... | 02/16/2012 |
| 20120034671 | Protein Matrix For Light-Initiated Electron Transfer The present invention provides selective modification of polypeptide sequences with electron transfer moieties. The resulting polypeptide assemblies represent a novel class of electron transfer complexes that are capable of transferring electrons over very long distance... | 02/09/2012 |
| 20120034166 | AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for... | 02/09/2012 |
| 20120035114 | INHIBITORS OF STAT3 AND USES THEREOF Compounds which inhibit the activity of signal transducer and activator of transcription 3 (STAT3) are provided together with methods of making and using the same. The compounds are designed to bind to the SH2 domain of STAT3, preventing STAT3 from binding to receptors ... | 02/09/2012 |
| 20120027683 | DIABETES T CELL RECEPTORS T cell receptors (TCRs) having the property of binding to a murine insulin-derived peptide, LYLVCGERG (SEQ ID NO:62), presented by the murine H-2Kd complex (LYLVCGERG-H-2Kd). The TCRs comprise at least one TCR α chain variable domain and/or at lea... | 02/02/2012 |
| 20120021002 | GENETICALLY ENGINEERED CLOSTRIDIAL GENES, PROTEINS ENCODED BY THE ENGINEERED GENES, AND USES THEREOF The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regi... | 01/26/2012 |
| 20120022231 | Method for Manufacturing Cubic Diamond Nanocrystals A method for manufacturing cubic diamond nanocrystals (10) comprising the following successive steps: (a) providing crystalline diamond powder where the maximum particle size of the powder is equal or more than 2 um and equal or less than 1 mm; (b) milling said c... | 01/26/2012 |
| 20120016111 | Compositions for the treatment of cancer, and methods for testing and using the same A composition comprising leukotoxin proteins isolated from a bacterium is provided. In this composition, greater than 85% of the leukotoxin proteins are chemically modified at a basic amino acid residue, and the proteins induce cell death in myeloid leukocytes, while re... | 01/19/2012 |
| 20120014964 | ALPHA SYNUCLEIN TOXICITY Present inventions demonstrates that alpha synuclein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of... | 01/19/2012 |
| 20120015872 | COMPLEMENT RECEPTOR 2 TARGETED COMPLEMENT MODULATORS Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions c... | 01/19/2012 |
| 20120003710 | Isolation of Biomolecules from Biological Samples Nanoparticles for use in the collection, concentration, isolation and storage of biomolecules from biological samples are provided. More specifically, nanoparticles used to isolate biomolecules, including nucleic acids and proteins, cells, cell fragments, bacteria, and ... | 01/05/2012 |
| 20120003712 | METHOD FOR PREPARING A SITE-SPECIFIC PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be d... | 01/05/2012 |
| 20110319602 | T2R TASTE RECEPTORS AND GENES ENCODING SAME Functional assays that detect the effect of a particular compound or compounds on the activation of at least one human T2R polypeptide are provided. These assays include e.g., assays which detect the effect of said compound on intracellular calcium, second messengers su... | 12/29/2011 |
| 20110319601 | Inorganic Particle Conjugates The ionic conjugates include an inorganic particle electrostatically associated with a macromolecule which can interact specifically with predetermined chemical species or biological targets.... | 12/29/2011 |
| 20110306554 | PEPTIDE CAPABLE OF BINDING TO IMMUNOGLOBULIN The present invention provides a peptide capable of binding to an immunoglobulin, a fusion protein with the peptide, nucleic acids coding for the peptide and for the fusion protein, methods for producing the peptide and the fusion protein, and a composition and means fo... | 12/15/2011 |
| 20110306122 | Hanging Drop Plate A hanging drop plate and a method of cultivating cells or of producing molecular aggregates in at least one liquid volume that adheres to a drop contact area of such a hanging drop plate. The hanging drop plate has a body with a first surface and a second surface that i... | 12/15/2011 |
| 20110300074 | 3,6-DISUBSTITUTED XANTHYLIUM SALTS This invention pertains generally to processes, uses, methods and materials utilising particular xanthylium compounds, including compounds of formula (I) and (II), as further defined herein. These compounds are useful as drugs, for example, in the treatment of tauopathi... | 12/08/2011 |
| 20110300160 | SULFATION OF WNT PATHWAY PROTEINS Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a. Also provided is a composition comprising an isolated and purified Wnt pathway protein, where the protein is sulfated ... | 12/08/2011 |
| 20110301057 | IN SITU ORIENTED IMMOBILIZATION OF PROTEINS ON A SUPPORT The present invention relates to a method of directing in situ oriented immobilization of a protein on a support. This method involves providing a support and contacting the support with a solution. The solution comprises (a) a protein comprising a coupling moiety and (... | 12/08/2011 |
| 20110301341 | MODIFIED ORGANS AND CELLS FOR XENOTRANSPLANTATION It has been discovered that there are at least two significant antigens present on the cells of animal species such as pigs that elicit an immune or inflammatory response immediately upon implantation into humans or contact with human serum. The first is an α-galactosy... | 12/08/2011 |
| 20110294137 | Sensor The invention relates to an ADP binding molecule comprising a polypeptide, said polypeptide comprising amino acid sequence corresponding to at least amino acids 11 to 310 of SEQ ID NO:1, wherein said polypeptide comprises a substitution relative to SEQ ID NO:1 at amino ... | 12/01/2011 |
| 20110294189 | BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharm... | 12/01/2011 |
| 20110294740 | TREATMENT OF AMYLOIDOSES USING MYELIN BASIC PROTEIN AND FRAGMENTS THEREOF In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the amyloid-beta peptide associated with Alzheimer's disease (“AD”) and cerebral a... | 12/01/2011 |
| 20110289610 | HCV/GBV-B CHIMERIC VIRUS An HCV/GBV-B chimeric virus which maintains the replication function of HCV and is capable of infecting tamarin is disclosed in order to construct an HCV animal model which can be used as a development or evaluation system for therapeutic agents for HCV. The HCV/GBV-B c... | 11/24/2011 |
| 20110287047 | CROSS-BETA STRUCTURES AS CARRIER IN VACCINES The invention provides means and methods for producing and/or selecting immunogenic compositions, comprising providing said composition with at least one epitope for a B-cell receptor and/or at least one epitope for a T-cell receptor, coupled to a protein that comprises... | 11/24/2011 |
| 20110287067 | REINFORCED ADHESIVE COMPLEX COACERVATES AND METHODS OF MAKING AND USING THEREOF Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex... | 11/24/2011 |
| 20110275057 | ALLOSTERIC CONTROL OF PROTEINS BY MANIPULATING MECHANICAL TENSION A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of th... | 11/10/2011 |
| 20110275134 | Arrestin Biosensor The present invention relates to a novel biosensor. A resonance energy transfter (RET) biosensor comprising a beta(β)-arrestin tagged with a first and a second chromophore, wherein said first chromophore is a fluorophore and said second chromophore is a fluorophore or ... | 11/10/2011 |
| 20110269231 | PROTEOGLYCAN-BINDING PEPTIDES THAT MODULATE STEM CELL BEHAVIOR Biomaterials presenting synthetic peptides and methods of preparing biomaterials are disclosed. More particularly, the disclosure is directed to biomaterials including a substrate including a synthetic peptide thereon, wherein the synthetic peptide is selected from synt... | 11/03/2011 |
| 20110269945 | FLUORESCENT PROTEIN An object of the present invention is to provide a novel fluorescent protein derived from favia favus. The present invention provides a fluorescent protein derived from favia favus having the following properties: 11/03/2011 | |
| 20110269244 | LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.... | 11/03/2011 |
