Comic actor Danny Kaye received patent D166,807 for the co-design of "Blowout Toy or the Like". It's similar to one of those toys that unravels when you blow into at a birthday party except Kaye's has three blowouts going in different directions, not just one.
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| Application No. | Application Title | Issue Date |
| 20120021984 | Glycoprotein Hormone Analogs This invention relates to the field of glycoprotein hormone analogs and their uses as agonists, antagonists, targeting vectors, and immunogens. In particular, this invention describes a method for stabilizing a heterodimer that permits the preparation of functional glyc... | 01/26/2012 |
| 20110319590 | Tumour Cell Lines and Uses Thereof The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b)... | 12/29/2011 |
| 20110263500 | Curcumin Conjugates for Treating and Preventing Cancers Conjugating LHRH to curcumin (LHRH-Curcumin) substantially enhances the bioavailability of curcumin, targets it to cells expressing LHRH receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin. The conjugate may be used agai... | 10/27/2011 |
| 20110105398 | RECOMBINANT FSH INCLUDING ALPHA 2,3- AND ALPHA 2,6-SAILYLATIO Preparations including recombinant FSH (rFSH).... | 05/05/2011 |
| 20110105379 | SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates... | 05/05/2011 |
| 20100221840 | METHODS FOR TESTING FOR AND INHIBITING THE DEVELOPMENT OF HUNTINGTON'S DISEASE This invention relates to Huntington's disease and more specifically to methods for testing and inhibiting the development of Huntington's disease.... | 09/02/2010 |
| 20100184641 | Novel Plasma Protein Affinity Tags Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives.... | 07/22/2010 |
| 20100174054 | Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also pro... | 07/08/2010 |
| 20100113755 | ISOLATED MODIFIED HUMAN CHORIONIC GONADOTROPIN PROTEINS Compositions and methods based on mutant Cystine Knot Growth Factors (CKGFs) comprising amino acid substitutions relative to the wild type hormone/growth factor. Mutated glycoprotein hormones, including thyroid stimulating hormone (TSH) and chorionic gonadotropin (CG) a... | 05/06/2010 |
| 20090312254 | LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cy... | 12/17/2009 |
| 20090209454 | METHOD FOR PURIFYING FSH OR A FSH MUTANT The invention relates to a method for purifying a glycoprotein, preferably FSH or a FSH mutant comprising the steps of subjecting a liquid containing said FSH or a FSH mutant to: (1) a dye affinity chromatography; (2) a weak anion exchange chromatography; (3) a hydropho... | 08/20/2009 |
| 20080280832 | Novel Fsh Glycosylation Variant D3n FSH mutant with increased glycosylation and longer half-life is described. The use of this FSH mutant for inducing folliculogenesis in human patients is also described.... | 11/13/2008 |
| 20080280818 | GLYCOSYLATION OF PEPTIDES VIA O-LINKED GLYCOSYLATION SEQUENCES The present invention provides sequon polypeptides with an amino acid sequence including one or more exogenous O-linked glycosylation sequence of the invention. In addition, the present invention provides methods of making polypeptide conjugates as well as methods of us... | 11/13/2008 |
| 20080227205 | Incorporation on Non-Naturally Encoded Amino Acids Into Proteins The invention provides methods and compositions for in vivo incorporation of non-naturally encoded amino acids into polypeptides by Pseudomonas species and strains derived therefrom. Also provided are compositions including proteins with non-naturally encoded ami... | 09/18/2008 |
| 20080070832 | Method for Purifying Fsh The invention relates to a method for purifying recombinant human FSH or an FSH variant starting from crude FSH, comprising the following steps: 1. dye-affinity chromatography; 2. hydrophobic interaction chromatography; and 3. reverse phase chromatography. ... | 03/20/2008 |
| 20080039372 | Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation The present invention is directed to a human chorionic gonadotropin (hCG) antagonist comprising deglycosylated hCG. Methods of recombinantly producing the hCG antagonist in a glycosylation-deficient host cell are also provided. Methods of treating hCG related conditions... | 02/14/2008 |
| 20080015142 | Glycopegylated Follicle Stimulating Hormone The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are ... | 01/17/2008 |
| 20070161779 | Estrogen Extraction From Pregnant Animal Urine A method of extracting oestrogens, conjugated estrogens, equine gonadotropin and equine follicle stimulant from pregnant mares urine which includes the steps of contacting the urine with dispersed particles of adsorber materials of a particle size above 200 microns and ... | 07/12/2007 |
| 20070129295 | Method for purifying fsh The invention provides a method for purifying recombinant FSH. ... | 06/07/2007 |
| 20070072303 | Method of chromatographic analysis of a protein solution An improved method of chromatographic analysis of protein samples is disclosed in which a Pluronic surfactant is used. ... | 03/29/2007 |
| 20060234352 | Homogeneity and secretion of recombinant proteins in mammalian systems The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH.... | 10/19/2006 |
| 20060073571 | Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin B-subunit and uses thereof The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the isolated human lutropin hormone-receptor/human chorionic gonadotropin-β... | 04/06/2006 |
| 20060040855 | Low efficacy gonadotropin agonists and antagonists The present invention provides glycoprotein hormone analogs having partial agonist/antagonist activity comprising an α-subunit polypeptide and a β-subunit polypeptide. The analog lacks a naturally occurring oligosaccharide on α-subunit loop 2 and is cross-linked to t... | 02/23/2006 |
| 20050256049 | Chimeric toxins for targeted therapy The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin r... | 11/17/2005 |
| 20050250185 | OGH fusion polypeptides and therapeutic uses thereof A fusion polypeptide comprising an orphan glyprotein hormone (OGH), OGH-family member, or a fragment thereof; a glycoprotein hormone subunit α1 or α2, or a fragment thereof, and optionally a peptide (P), and a fusion component (F). In one embodiment, the fusion protei... | 11/10/2005 |
| 20050233951 | Novel two gonadotropin releasing hormones and a method to isolate the same The present invention relates to two novel Gonadotropin releasing hormones muGnRH I and muGnRH II of amino acid SEQ ID 1 as QHWSAWRLPG, and SEQ ID 2 QHWSWGILPG respectively, useful for induced breeding in fish both in combination and alone, by activating production of G... | 10/20/2005 |
| 20050143567 | Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and the a... | 06/30/2005 |
| 20050112721 | Chimeric peptide immunogens Chimeric peptide epitopes can serve as effective immunogens against hormones and other small peptides or proteins. Thus, immunogenic peptides are selected from promiscuous Th epitopes and synthesized together with self antigenic peptide sequences fused with or without e... | 05/26/2005 |