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Class 530/398 - Gonadatropins


Subclass of Class 530 - Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Definition: Proteins having the structure of gonadatropins and compounds
No. of applications: 28
Last issue date: 01/26/2012


Application No.Application TitleIssue Date
20120021984Glycoprotein Hormone Analogs
This invention relates to the field of glycoprotein hormone analogs and their uses as agonists, antagonists, targeting vectors, and immunogens. In particular, this invention describes a method for stabilizing a heterodimer that permits the preparation of functional glyc...
01/26/2012
20110319590Tumour Cell Lines and Uses Thereof
The present invention relates to a cell line selected from the group consisting of (a) a cell line denominated NM-F9 having the DSMZ accession number DSM ACC2606; (b) a cell line denominated NM-D4 having the DSMZ accession number DSM ACC2605; and subclones of (a) or (b)...
12/29/2011
20110263500Curcumin Conjugates for Treating and Preventing Cancers
Conjugating LHRH to curcumin (LHRH-Curcumin) substantially enhances the bioavailability of curcumin, targets it to cells expressing LHRH receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin. The conjugate may be used agai...
10/27/2011
20110105398RECOMBINANT FSH INCLUDING ALPHA 2,3- AND ALPHA 2,6-SAILYLATIO
Preparations including recombinant FSH (rFSH)....
05/05/2011
20110105379SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF
Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates...
05/05/2011
20100221840METHODS FOR TESTING FOR AND INHIBITING THE DEVELOPMENT OF HUNTINGTON'S DISEASE
This invention relates to Huntington's disease and more specifically to methods for testing and inhibiting the development of Huntington's disease....
09/02/2010
20100184641Novel Plasma Protein Affinity Tags
Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives....
07/22/2010
20100174054Compositions of Aminoacyl-tRNA Synthetase and Uses Thereof
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also pro...
07/08/2010
20100113755ISOLATED MODIFIED HUMAN CHORIONIC GONADOTROPIN PROTEINS
Compositions and methods based on mutant Cystine Knot Growth Factors (CKGFs) comprising amino acid substitutions relative to the wild type hormone/growth factor. Mutated glycoprotein hormones, including thyroid stimulating hormone (TSH) and chorionic gonadotropin (CG) a...
05/06/2010
20090312254LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING SAME
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cy...
12/17/2009
20090209454METHOD FOR PURIFYING FSH OR A FSH MUTANT
The invention relates to a method for purifying a glycoprotein, preferably FSH or a FSH mutant comprising the steps of subjecting a liquid containing said FSH or a FSH mutant to: (1) a dye affinity chromatography; (2) a weak anion exchange chromatography; (3) a hydropho...
08/20/2009
20080280832Novel Fsh Glycosylation Variant D3n
FSH mutant with increased glycosylation and longer half-life is described. The use of this FSH mutant for inducing folliculogenesis in human patients is also described....
11/13/2008
20080280818GLYCOSYLATION OF PEPTIDES VIA O-LINKED GLYCOSYLATION SEQUENCES
The present invention provides sequon polypeptides with an amino acid sequence including one or more exogenous O-linked glycosylation sequence of the invention. In addition, the present invention provides methods of making polypeptide conjugates as well as methods of us...
11/13/2008
20080227205Incorporation on Non-Naturally Encoded Amino Acids Into Proteins
The invention provides methods and compositions for in vivo incorporation of non-naturally encoded amino acids into polypeptides by Pseudomonas species and strains derived therefrom. Also provided are compositions including proteins with non-naturally encoded ami...
09/18/2008
20080070832Method for Purifying Fsh
The invention relates to a method for purifying recombinant human FSH or an FSH variant starting from crude FSH, comprising the following steps: 1. dye-affinity chromatography; 2. hydrophobic interaction chromatography; and 3. reverse phase chromatography. ...
03/20/2008
20080039372Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation
The present invention is directed to a human chorionic gonadotropin (hCG) antagonist comprising deglycosylated hCG. Methods of recombinantly producing the hCG antagonist in a glycosylation-deficient host cell are also provided. Methods of treating hCG related conditions...
02/14/2008
20080015142Glycopegylated Follicle Stimulating Hormone
The present invention provides conjugates between follicle stimulating hormone and PEG moieties. The conjugates are linked via an intact glycosyl linking group that is interposed between and covalently attached to the peptide and the modifying group. The conjugates are ...
01/17/2008
20070161779Estrogen Extraction From Pregnant Animal Urine
A method of extracting oestrogens, conjugated estrogens, equine gonadotropin and equine follicle stimulant from pregnant mares urine which includes the steps of contacting the urine with dispersed particles of adsorber materials of a particle size above 200 microns and ...
07/12/2007
20070129295Method for purifying fsh
The invention provides a method for purifying recombinant FSH. ...
06/07/2007
20070072303Method of chromatographic analysis of a protein solution
An improved method of chromatographic analysis of protein samples is disclosed in which a Pluronic surfactant is used. ...
03/29/2007
20060234352Homogeneity and secretion of recombinant proteins in mammalian systems
The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH....
10/19/2006
20060073571Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin B-subunit and uses thereof
The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the isolated human lutropin hormone-receptor/human chorionic gonadotropin-β...
04/06/2006
20060040855Low efficacy gonadotropin agonists and antagonists
The present invention provides glycoprotein hormone analogs having partial agonist/antagonist activity comprising an α-subunit polypeptide and a β-subunit polypeptide. The analog lacks a naturally occurring oligosaccharide on α-subunit loop 2 and is cross-linked to t...
02/23/2006
20050256049Chimeric toxins for targeted therapy
The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting moieties consist of gonadotropin r...
11/17/2005
20050250185OGH fusion polypeptides and therapeutic uses thereof
A fusion polypeptide comprising an orphan glyprotein hormone (OGH), OGH-family member, or a fragment thereof; a glycoprotein hormone subunit α1 or α2, or a fragment thereof, and optionally a peptide (P), and a fusion component (F). In one embodiment, the fusion protei...
11/10/2005
20050233951Novel two gonadotropin releasing hormones and a method to isolate the same
The present invention relates to two novel Gonadotropin releasing hormones muGnRH I and muGnRH II of amino acid SEQ ID 1 as QHWSAWRLPG, and SEQ ID 2 QHWSWGILPG respectively, useful for induced breeding in fish both in combination and alone, by activating production of G...
10/20/2005
20050143567Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same
A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and the a...
06/30/2005
20050112721Chimeric peptide immunogens
Chimeric peptide epitopes can serve as effective immunogens against hormones and other small peptides or proteins. Thus, immunogenic peptides are selected from promiscuous Th epitopes and synthesized together with self antigenic peptide sequences fused with or without e...
05/26/2005
 
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