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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Application No. | Application Title | Issue Date |
| 20120129915 | ORGANIC COMPOSITIONS TO TREAT HSF1-RELATED DISEASES The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.... | 05/24/2012 |
| 20120107874 | Modified Host Cells and Uses Thereof The present disclosure provides compositions and methods comprising cells producing glycoproteins with variant glycosylation patterns. The methods and compositions may be used in producing antibodies and proteins of therapeutic value.... | 05/03/2012 |
| 20120107798 | SINGLE MOLECULE SENSITIVE PROBES FOR DETECTING RNA The various embodiments of the present disclosure relate generally to single molecule sensitive probes for detecting RNA, and more particularly to multivalent fluorescent probes for detecting a single molecule of RNA in a cell. The present invention includes a RNA imagi... | 05/03/2012 |
| 20120070456 | POLYPEPTIDE CARRIER PROTEIN The invention relates to polypeptide carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are useful as components of vaccines that can elicit a T-cell dependent immune response. These vacci... | 03/22/2012 |
| 20120070897 | Method For Enucleating Nucleated Erythrocyte, And Enucleation Inducer Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time... | 03/22/2012 |
| 20120071632 | Lenalidomide and Thalidomide Immunoassays Novel conjugates and immunogens derived from lenalidomide and antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of thalidomide and lenalidomide in biological fluids.... | 03/22/2012 |
| 20120070452 | IMMUNOADJUVANT COMPOSITION AND USE THEREOF Disclosed is a composition comprising, as an active ingredient, at least one selected from the group consisting of a Zc3h12a gene inhibitor and a Zc3h12a protein inhibitor. This composition can be used as an immunoadjuvant.... | 03/22/2012 |
| 20120071443 | NANOPARTICLES Materials and methods for studying and modulating the interaction of carbohydrate-containing moieties with other species are described, in particular, small particles, e.g. clusters of metal or semiconductor atoms, which can be employed as a substrate for immobilising a... | 03/22/2012 |
| 20120052507 | PHOSPHOLINKED DYE ANALOGS WITH AN AMINO ACID LINKER In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an amino acid or peptide linker. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an amino acid or peptide linker. The... | 03/01/2012 |
| 20120052071 | TUMOR MARKERS AND METHODS OF USE THEREOF The invention provides newly identified proteins as markers for the detection of tumors, or as targets for their treatment, particularly of tumors affecting lung, colon, breast, ovary; affinity ligands capable of selectively interacting with the newly identified markers... | 03/01/2012 |
| 20120052574 | NOVEL REAGENTS FOR TRANSFECTION OF EUKARYOTIC CELLS Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as catio... | 03/01/2012 |
| 20120053080 | PROTEIN MARKERS IDENTIFICATION FOR GASTRIC CANCER DIAGNOSIS Methods for detecting cancer as well as methods of diagnosis of cancer by detecting proteins secreted into biological fluids are disclosed The invention was first applied to detecting proteins secreted into serum and urine However, it is understood that the methods have... | 03/01/2012 |
| 20120052550 | TEMPERATURE-RESPONSIVE POLYMER PARTICLES IN PROTEIN SEPARATION APPLICATIONS The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The present invention also relates to crosslinked hydroxylic polymer particle... | 03/01/2012 |
| 20120045785 | Hybrid Prokaryotic-Eukaryotic Tubulins and Use Thereof The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.... | 02/23/2012 |
| 20120045566 | OLIGOSACCHARIDE INGREDIENT An oligosaccharide ingredient comprising glycosylated amino acids and peptides of the general formula RnSacm where R is an amino acid residue, Sac is a monosaccharide selected from the group comprising N-acetyl-neuraminic acid, N-acetyl galactosamine and galactose, n ha... | 02/23/2012 |
| 20120046235 | Conjugates of hydroxyalkyl starch and a protein, prepared by native chemical ligation Conjugates of an active substance and hydroxyalkyl starch (HAS) are provided herein. The active substance and the HAS are linked by a chemical moiety having a structure according to formula (I) wherein Y is O or S, and X is SH or (F). The conjugate has a structure accor... | 02/23/2012 |
| 20120045816 | Novel Glycosylated Polypeptides Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human ... | 02/23/2012 |
| 20120039921 | POULTRY VIRAL MATERIALS AND METHODS RELATED THERETO The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis diseas... | 02/16/2012 |
| 20120040363 | METHOD FOR ENRICHING A PROKARYOTIC DNA A method is described for enriching procaryotic DNA, said method including the steps of contacting at least one procaryotic DNA with at least one protein or polypeptide which is capable of specifically binding to non-methylated CpG motifs, and separating the protein/pol... | 02/16/2012 |
| 20120040900 | COMPOSITIONS OF AND METHODS OF USING LIGAND DIMERS Provided herein are ligand dimers, compositions thereof, as well as methods of their use. The ligand dimers provided can comprise at least one ligand to a Her receptor and can be used to force dimerization of specific receptor pairs. The forced dimerization of specific ... | 02/16/2012 |
| 20120040374 | METHOD FOR DETECTING RENAL DISEASE COMPRISING MEASURING HUMAN MEGALIN IN URINE This invention provides a diagnostic kit and a diagnostic marker used for diagnosing a renal disease. This invention also provides a method for detecting a renal disease comprising measuring at least one type of human megalin existing in urine selected from among full-l... | 02/16/2012 |
| 20120041182 | Water Soluble Cholesterol Derivatives Four novel water soluble cholesterol derivative compounds are disclosed. These compounds have various applications in studies of membrane proteins, including drug screening and studies of receptor stability and folding. In one aspect the water soluble cholesterol deriva... | 02/16/2012 |
| 20120040345 | 2-Nitrobenzyl-Modified Ribonucleotides This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.... | 02/16/2012 |
| 20120034255 | CONFORMATIONALLY STABILIZED HIV ENVELOPE IMMUNOGENS Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including ... | 02/09/2012 |
| 20120035344 | NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow c... | 02/09/2012 |
| 20120034254 | ANTIGENIC CLOAKING AND ITS USE Disclosed are antigens that include a target epitope that is defined by atomic coordinates of those amino acids of the antigen that contact an antibody of interest that specifically binds the antigen. The disclosed antigens have between about 10% and about 90% of surfac... | 02/09/2012 |
| 20120036600 | METHOD FOR GENERATING HYPOALLERGENIC GLYCOPROTEINS IN MUTATED OR TRANSGENIC PLANTS OR PLANT CELLS, AND MUTATED OR TRANSGENIC PLANTS AND PLANT CELLS FOR GENERATING HYPOALLERGENIC GLYCOPROTEINS Method for providing a hypoallergenic glycoprotein includes growing at least one of a mutated plant, a part of the mutated plant, plant cells produced from the mutated plant, a transgenic plant, a part of the transgenic plant and plant cells produced from the transgenic... | 02/09/2012 |
| 20120029174 | METHODS FOR PRODUCING SUBSTANTIALLY HOMOGENEOUS HYBRID OR COMPLEX N-GLYCANS IN METHYLOTROPHIC YEASTS The present invention provides methods for effectively and efficiently converting methylotrophic yeast's heterogeneous high mannose-type N-glycosylation to mammalian-type N-glycosylation by disruption of an endogenous glycosyltransferase gene (OCH1) and step-wise introd... | 02/02/2012 |
| 20120029173 | ATTENUATED SALMONELLA ENTERICA SEROVAR PARATYPHI A AND USES THEREOF The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccine, and methods of using these strains and conjuga... | 02/02/2012 |
| 20120028911 | Mucin Derived Polypeptides The present technology relates to isolated MUC17, Muc3 or MUC3 derived polypeptides and polynucleotides encoding the same. The MUC17, Muc3 or MUC3 derived polypeptides and polynucleotides can be used to treat gastrointestinal tract diseases and disorders. Also described... | 02/02/2012 |
| 20120029167 | AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND A drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. T... | 02/02/2012 |
| 20120021987 | Mucin 3 EGF-Like Domains The invention provides for a mucin3 polypeptide, a polypeptide including a mucin3 EGFlike domain, and nucleic acids encoding such polypeptides. The invention also provides for methods of treating an individual that has or is at risk of developing a disease or condition ... | 01/26/2012 |
| 20120021437 | TETRANOR-PGDM/PGJM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME Tetranor-PGDM/tetranor-PGJM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses in assay kits for detecting and quantifying tetranor-PGDM and tetranor-PGJM in biological fluids for determining biosynthesis of PGD 01/26/2012 | |
| 20120014964 | ALPHA SYNUCLEIN TOXICITY Present inventions demonstrates that alpha synuclein toxicity such as α-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of... | 01/19/2012 |
| 20120016110 | METHOD OF IMMOBILIZING AND STRETCHING A NUCLEIC ACID ON A SUBSTRATE The present invention relates to a method of immobilizing and stretching a nucleic acid on a silicon substrate, to nucleic acids and substrates prepared according to this method, to uses of the method and to uses of the nucleic acid and the substrate.... | 01/19/2012 |
| 20120015877 | USE OF GDF TRAPS TO INCREASE RED BLOOD CELL LEVELS In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.... | 01/19/2012 |
| 20120011600 | OPTIMIZING GLYCAN PROCESSING IN PLANTS The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylo... | 01/12/2012 |
| 20120010155 | GNTIII EXPRESSION IN PLANTS The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The inv... | 01/12/2012 |
| 20120009212 | CONJUGATES UTILIZING PLATFORM TECHNOLOGY FOR STIMULATING IMMUNE RESPONSE Templated conjugates created from naturally-occurring protein sequences found in pathogens, such as viruses, are disclosed. The sequences are “templated” into a consensus coiled-coil sequence in order to form a two-stranded antigen suitable for immunization of a sub... | 01/12/2012 |
| 20120009624 | PROTEIN PARTICLES The invention relates to a protein particle comprising chimeric protein having an aggregating part capable of forming or aggregating into a substantially insoluble protein particle when expressed by a cell; and a functional part capable of binding to, or being bound by,... | 01/12/2012 |
