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| Application No. | Application Title | Issue Date |
| 20120128592 | SURFACE ENHANCED RAMAN SPECTROSCOPY (SERS) COMPOUNDS AND METHODS OF THEIR PREPARATION A compound for detecting an analyte using Surface Enhanced Raman Spectroscopy (SERS) and a method of forming the compound is provided. The compound has Formula I: wherein W is selected from the group consisti... | 05/24/2012 |
| 20120107324 | TARGETED BINDING AGENTS DIRECTED TO a5ß1 AND USES THEREOF The invention relates to targeted binding agents against α5β1 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to α5β1. The described targeted binding agents are useful in the treatment of diseases assoc... | 05/03/2012 |
| 20120070406 | THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the c... | 03/22/2012 |
| 20120052566 | ANTI-VEGF-C ANTIBODIES AND METHODS USING SAME The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.... | 03/01/2012 |
| 20120052110 | METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds.... | 03/01/2012 |
| 20120045816 | Novel Glycosylated Polypeptides Provided herein are glycosylated polypeptide compositions with substantially reduced Neu5Gc content. The glycosylated polypeptides compositions with substantially reduced Neu5Gc content can be obtained from cell sources cultured with Neu5Gc competitor or from non-human ... | 02/23/2012 |
| 20120039911 | CD93 OR USE OF SOLUBLE FRAGMENT THEREOF The present invention relates to an anti-inflammatory composition using the antibody specifically binding to CD93 or its soluble fragment, and a diagnostic method and a diagnostic kit for inflammatory disease using CD93 or its soluble fragment specific antibody or aptam... | 02/16/2012 |
| 20120034161 | PRETARGETING KIT, METHOD AND AGENTS USED THEREIN Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse ele... | 02/09/2012 |
| 20120028878 | Membrane Evaporation for Generating Highly Concentrated Protein Therapeutics The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the... | 02/02/2012 |
| 20120027768 | MONOCLONAL ANTIBODY PRODUCTION BY EBV TRANSFORMATION OF B CELLS A method for producing a clone of an immortalised human B memory lymphocyte, comprising the step of transforming human B memory lymphocytes using Epstein Barr virus (EBV) in the presence of a polyclonal B cell activator. The method is particularly useful in a method for... | 02/02/2012 |
| 20120027755 | PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE The invention relates to a purified antibody or fragment thereof that specifically binds an Aβ protofibril. The invention further relates to a composition that includes such antibodies. The invention also relates to using such antibodies and compositions for treating a... | 02/02/2012 |
| 20120027761 | Treatment of Inflammatory Diseases by Inhibiting Cold-Inducible RNA-Binding Protein (CIRP) Disclosed are pharmaceutical compositions comprising a CIRP inhibitor. A method of treating a subject suffering from an inflammatory condition comprising administering to said subject a CIRP inhibitor is also described herein.... | 02/02/2012 |
| 20120020983 | EMP2 ANTIBODIES AND THEIR THERAPEUTIC USES The present invention provides methods and compositions useful in the treatment or prevention of Chlamydia infections and cancer. The methods and compositions inhibit the entry of Chlamydia into a host cell expressing EMP2 by interfering with the interacti... | 01/26/2012 |
| 20120020972 | ANTIBODIES RELATING TO PIVKA-II AND USES THEREOF The present disclosure relates to antibodies and immunoassay methods for use in the diagnosis, treatment and prevention of hepatocellular carcinoma (HCC), liver cancer and related conditions.... | 01/26/2012 |
| 20120022239 | PRECIPITATION OF BIOMOLECULES WITH NEGATIVELY CHARGED POLYMERS The present invention relates to methods of isolating biomolecules. More particularly, the invention relates to methods for isolating antibodies (mAbs) and related proteins including antibody fragments (Fabs) under conditions where they are positive and relatively hydro... | 01/26/2012 |
| 20120021534 | MARKERS FOR BRAIN DAMAGE Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.... | 01/26/2012 |
| 20120015364 | METHOD FOR THE SELECTION OF ENDOTHELIAL CELLS DEATH INDUCERS VIA NETRIN-1 AND ITS APPLICATIONS The present invention relates to an in vitro method for selecting a compound capable to induce the death of endothelial cells, preferably endothelial cells from vessels or neovessels. The invention further comprises the use of netrin-1 function inhibitors as compounds c... | 01/19/2012 |
| 20120015387 | MARKER PEPTIDES FOR DETERMINING THE OCCURRENCE OF AN INFLAMMATORY STATE IN A SUBJECT An enzyme proteolysis-resistant peptide that binds to antibodies directed against the amino acid region 1-116 of the endocan's polypeptide sequence, which peptide possesses an apparent molecular weight of 14 kDa.... | 01/19/2012 |
| 20120010390 | SEPARATION METHOD USING SINGLE POLYMER PHASE SYSTEMS The present invention relates to a process of enriching one target compound from a liquid, which process comprises at least one step of isolation performed by differentially partitioning between two aqueous phases. In the present invention the phases are formed by addin... | 01/12/2012 |
| 20120009602 | Reagents and Methods for Assessment of Human Tumor Malignancy and for Targeting Malignant Tumor Cells The disclosure relates to a monoclonal antibody, designated MAbH11B2C2, that binds specifically with a human hyaluronan-binding protein, designated H11B2C2. This protein can occur in two forms, one (apparently expressed by all malignant cells) having an apparent molecul... | 01/12/2012 |
| 20110318301 | IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those n... | 12/29/2011 |
| 20110313066 | STIMULUS RESPONSIVE POLYMERS FOR THE PURIFICATION OF BIOMOLECULES The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.... | 12/22/2011 |
| 20110311443 | PHARMACEUTICAL COMPOSITION AND METHOD FOR IDENTIFYING A CANCEROUS AND/OR AN INFLAMMATORY DISEASE IN A PATIENT The invention relates to a method for treating a cancerous and/or an inflammatory disease in a patient, comprising internally administering to the patient an effective amount of a pharmaceutical preparation blocking the biological activity of at least one protein cluste... | 12/22/2011 |
| 20110311517 | Antibodies and methods for treating estrogen receptor-associated diseases Provided herein in certain embodiments are antibodies, antibody fragments, pharmaceutical compositions, methods for modulating the functions of estrogen receptor alpha 36, and methods for preventing and/or treating diseases mediated by estrogen receptor alpha 36.... | 12/22/2011 |
| 20110311516 | Chemically Programmed Vaccination Provided herein is a method for chemically programmed vaccination. Methods include inducing a covalent-binding polyclonal antibody response in a subject and programming the polyclonal response with a targeting compound.... | 12/22/2011 |
| 20110311544 | Anti-cd71 Monoclonal Antibodies and Uses Thereof for Treating Malignant Tumor Cells The present invention provides novel anti-CD71 monoclonal antibodies, in particular mouse-human chimeric anti-CD71 monoclonal antibodies, advantageously associated to effector cells for triggering ADCC mechanisms. Anti-CD71 antibodies, as well as pharmaceutical composit... | 12/22/2011 |
| 20110311990 | TETRANOR-PGEM/PGAM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME Tetranor-PGEM/tetranor-PGAM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses for detecting and quantifying tetranor-PGEM in biological fluids for determining biosynthesis of PGE2 in a subject or patient... | 12/22/2011 |
| 20110301333 | REMOVAL OF PROTEIN AGGREGATES FROM BIOPHARMACEUTICAL PREPARATIONS USING CALCIUM PHOSPHATE SALTS The present invention provides novel and improved compositions containing calcium phosphate and methods of using the same for the removal of protein aggregates from biopharmaceutical compositions containing a product of interest, e.g., a therapeutic antibody or protein.... | 12/08/2011 |
| 20110287960 | Method For Producing Monoclonal Antibodies The present invention relates to methods for producing monoclonal antibodies. In particular, the invention relates to high throughput methods for producing and screening monoclonal antibodies more rapidly than conventional methods.... | 11/24/2011 |
| 20110287458 | METHOD AND COMPOSITION FOR THE DIAGNOSIS AND MONITORING OF INFLAMMATORY DISEASES The present invention provides a canine S100 calcium binding protein useful in diagnosing an inflammatory disease. Also provided are methods of diagnosing an inflammatory disease by assaying a biological sample for the canine S100 calcium binding protein. The invention ... | 11/24/2011 |
| 20110288277 | Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell prot... | 11/24/2011 |
| 20110286958 | HPMA POLYMER PLATINUM CHELATES Polymeric platinum amidomalonate complexes, where the platinum is in +2 or +4 oxidation state, and where the complexes optionally contain tumor seeking groups, are useful in the treatment of cancer.... | 11/24/2011 |
| 20110280800 | IL-1 BINDING PROTEINS Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.... | 11/17/2011 |
| 20110280877 | Inhibition of B7-H1/CD80 interaction and uses thereof The present invention provides a composition comprising an agent which specifically blocks interaction between B7-H1 and CD80 but not interaction between B7-H1 and PD-1 and a vaccine, optionally in a pharmaceutically acceptable carrier. Further provided is a method of t... | 11/17/2011 |
| 20110280930 | PRODUCTS AND METHODS FOR STIMULATING AN IMMUNE RESPONSE The present invention provides products which comprise (i) a support and (ii) a BCR-binding antigen attached to the support. The products are capable of BCR-mediated internalization. The products are useful in the induction or augmentation of immune responses, and metho... | 11/17/2011 |
| 20110274702 | NEUTRALIZING ANTI-INFLUENZA A VIRUS ANTIBODIES AND USES THEREOF The invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to an epitope in the stem region of an influenza A hemagglutinin trimer and neutralize a group 1 subtype and a group 2 subtype of influenza A virus. The invention also rel... | 11/10/2011 |
| 20110268727 | ANTI-INTERFERON-ALPHA ANTIBODIES The present invention relates generally to the generation and characterization of neutralizing anti-IFN-α monoclonal antibodies with broad reactivity against various IFN-α subtypes. The invention further relates to the use of such anti-IFN-α antibodies in the diagnos... | 11/03/2011 |
| 20110268741 | Immunotherapy for Contact Dermatitis Using Co-Signal Regulation Compounds, compositions and methods for immunotherapy in contact dermatitis. Compounds and compositions (e.g. monoclonal antibodies) that stimulate the LAIR-1 expression pathway in LAIR-1 expressing immune cells and are useful for preventing or treating contact dermatit... | 11/03/2011 |
| 20110263826 | ANTIBODIES WHICH BIND SELECTIVELY TO HAIR OF ANIMALS AND AN ANTIBODY BASED DRUG DELIVERY SYSTEM FOR ANIMALS The present invention provides antibodies which bind selectively to hair of animals and an antibody based drug delivery system in which a particular formulation can be directed to animal hair. This is driven by the need of increasing the effective period of therapeutics... | 10/27/2011 |
| 20110250204 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING DISEASES Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases... | 10/13/2011 |
