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| Application No. | Application Title | Issue Date |
| 20120128698 | DIAGNOSIS AND TREATMENT OF AUTOIMMUNE DEMYELINATING DISEASES The present invention concerns the diagnosis and treatment of autoimmune demyelinating diseases, such as multiple sclerosis (MS), by means of a CLM-I agonist.... | 05/24/2012 |
| 20120129717 | Collection and Methods For Its Use The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select ag... | 05/24/2012 |
| 20120128658 | RAGE G82S-RELATED METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY DISORDERS This invention provides methods, compositions and articles of manufacture for inhibiting the onset of and treating inflammatory disorders such as rheumatoid arthritis. The instant invention is based on the blockade of RAGE G82S function.... | 05/24/2012 |
| 20120107932 | PRRS-VIRUS RECEPTOR AND ITS INHIBITOR This invention relates to a new cell receptor of the PRRS virus, i.e. as non-muscle myosin II-A (NMHC II-A)and its inhibitor blebbistatin, which can be used as a drug for suppressing PRRS virus infection of cells. The invention provides a method of utilizing purified NM... | 05/03/2012 |
| 20120108794 | Formyl Group-Containing Porous Support, Adsorbent Using Same, Method For Producing Same, and Method For Producing The Adsorbent The present invention relates to a method for producing a formyl group-containing porous base matrix, comprising the steps of introducing a spacer in a formyl group-containing porous particle; and then oxidizing the spacer with periodic acid and/or a periodate, to trans... | 05/03/2012 |
| 20120107301 | METHOD OF TREATING AUTOIMMUNE DISEASE BY INDUCING ANTIGEN PRESENTATION BY TOLERANCE INDUCING ANTIGEN PRESENTING CELLS Antibodies to antigen presenting cells may be utilized to interfere with the interaction of the antigen presenting cell and immune cells, including T cells. Peptides may be linked to said antibodies thereby generating an immune response to such peptides. Preferably pept... | 05/03/2012 |
| 20120082715 | Stabilized products, processes and devices for preparing the same A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced storage stability, less expensive cost of processing, and extended shelf ... | 04/05/2012 |
| 20120070406 | THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the c... | 03/22/2012 |
| 20120053325 | Purification of Immunoglobulins The present invention pertains to improved methods of using dye-ligand affinity chromatography for the isolation of antibodies or proteins comprising an antibody fragment (such as Fc fusion proteins) from a mixture of undesirable contaminants. In particular, the use of ... | 03/01/2012 |
| 20120052515 | THERAPEUTIC APPLICATIONS OF NONCOVALENT DIMERIZING ANTIBODIES Compositions and methods for providing antibodies having noncovalent, self-binding properties are disclosed. Such autophilic antibodies can bind cellular receptors to promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with ... | 03/01/2012 |
| 20120045429 | Methods and Agent for Modulating the RNA Polymerase II-Histone Surface The present invention relates to the identification of an intranucleosomal DNA loop formed during transcription through a nucleosome and use of the same to identify an agent that modulates the RNA Polymerase II-histone surface.... | 02/23/2012 |
| 20120039920 | HYDROPHOBIC MONOMERS, HYDROPHOBICALLY-DERIVATIZED SUPPORTS, AND METHODS OF MAKING AND USING THE SAME A composition is disclosed comprising a hydrophobic monomer having the structure: CH2═CR4C(O)NHC(R1R1)(C(R1R1))nC(O)XR3 wherein n is an integer of 0 or 1; R1 is independ... | 02/16/2012 |
| 20120039907 | POLYPEPTIDES INCLUDING MODIFIED CONSTANT REGIONS Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an FcγR, which processes comprise modifying the polypeptides by substitution of the amino acid at position 268 of a human IgG CH2 region for a non-native... | 02/16/2012 |
| 20120039870 | BINDING MOLECULES WITH MULTIPLE BINDING SITES, COMPOSITIONS COMPRISING THE SAME AND USES THEREOF The present invention relates to binding molecules, such as amino acid sequences with multiple antigen binding sites. In particular, the binding molecules of the present invention have at least two antigen binding sites that partially or fully overlap with each other an... | 02/16/2012 |
| 20120039906 | PD-1 Antibodies and PD-L1 Antibodies and Uses Thereof The invention relates to PD-1 antibodies and PD-L1 antibodies and uses thereof.... | 02/16/2012 |
| 20120034166 | AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for... | 02/09/2012 |
| 20120035350 | POLYNUCLEOTIDE ENCODING A NOVEL HUMAN P2X7 SPLICE VARIANT, HBMYP2X7V The present invention provides novel polynucleotides encoding HBMYP2X7v polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relate... | 02/09/2012 |
| 20120027753 | MicroRNAs in Never-Smokers and Related Materials and Methods The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer in never-smokers. The invention also provides methods of identifying anti-lung cancer agents.... | 02/02/2012 |
| 20120029171 | Method of Producing a Plurality of Isolated Antibodies to a Plurality of Cognate Antigens The present invention relates to a method for producing high affinity antibodies that are antigen-specific. The method involves binding a plurality of antibody-producing B-cells from a mammal to a plurality of cognate antigens; sorting the bound antibody-producing B-cel... | 02/02/2012 |
| 20120028878 | Membrane Evaporation for Generating Highly Concentrated Protein Therapeutics The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the... | 02/02/2012 |
| 20120027772 | THERAPEUTIC PROTEIN FORMULATIONS The present invention generally concerns formulations having a pH that inhibits aspartyl isomerization at an Asp-Asp motif in a therapeutic protein contained in such a formulation.... | 02/02/2012 |
| 20120020952 | METHODS FOR PRODUCING MIXTURES OF ANTIBODIES The invention relates to a method for producing a mixture comprising two or more different antibodies in a single recombinant host cell. In one embodiment, a mixture of different monovalent antibodies is produced. In another embodiment, a mixture of monovalent and bival... | 01/26/2012 |
| 20120022239 | PRECIPITATION OF BIOMOLECULES WITH NEGATIVELY CHARGED POLYMERS The present invention relates to methods of isolating biomolecules. More particularly, the invention relates to methods for isolating antibodies (mAbs) and related proteins including antibody fragments (Fabs) under conditions where they are positive and relatively hydro... | 01/26/2012 |
| 20120014872 | Novel Method of Diagnosing, Monitoring, Staging, Imaging and Treating Various Cancers The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating selected cancers including gynecologic cancers such as breast, ovarian, uterine and endometrial cancer and lung cancer.... | 01/19/2012 |
| 20120016106 | ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also p... | 01/19/2012 |
| 20120017337 | GENES REGULATING PLANT BRANCHING, PROMOTORS, GENETIC CONSTRUCTS CONTAINING SAME AND USES THEREOF The invention relates to genes coding for TCP family transcription factors and having a biological role in the development of axillary buds and branch growth. Furthermore, the invention relates to the promoters of the transcription of said genes, to the genetic construc... | 01/19/2012 |
| 20120009178 | TWEAK BINDING ANTIBODIES Anti-Tweak antibodies are described.... | 01/12/2012 |
| 20120009196 | MONOCLONAL ANTIBODIES AGAINST HEPATITIS C VIRUS CORE PROTEIN The present disclosure relates to anti-HCV core protein monoclonal antibodies, methods of making them, and their uses in the prevention, diagnosis, and/or treatment of disease including HCV infections.... | 01/12/2012 |
| 20120009579 | MONOCYTE-DERIVED NUCLEIC ACIDS AND RELATED COMPOSITIONS AND METHODS Nucleic acids encoding various monocyte-derived proteins and related compositions, including purified proteins and specific antibodies are described. Methods of using such composition are also provided.... | 01/12/2012 |
| 20120009596 | PROTEIN MARKERS FOR DETECTING LIVER CANCER AND METHOD FOR IDENTIFYING THE MARKERS THEREOF The present invention relates to the diagnosis of liver cancer. It discloses the use of protein ERBB3 and protein IGFBP2 in the diagnosis of liver cancer. It relates to a method for diagnosis of liver cancer from a liquid sample, derived from an individual by measuring ... | 01/12/2012 |
| 20120010390 | SEPARATION METHOD USING SINGLE POLYMER PHASE SYSTEMS The present invention relates to a process of enriching one target compound from a liquid, which process comprises at least one step of isolation performed by differentially partitioning between two aqueous phases. In the present invention the phases are formed by addin... | 01/12/2012 |
| 20120009624 | PROTEIN PARTICLES The invention relates to a protein particle comprising chimeric protein having an aggregating part capable of forming or aggregating into a substantially insoluble protein particle when expressed by a cell; and a functional part capable of binding to, or being bound by,... | 01/12/2012 |
| 20120004592 | COMPOSITIONS FOR SOLUBILIZING TISSUE Tissue solubilizing compositions are provided. The compositions comprise 3-(decyl dimethyl ammonio) propane sulfonate and polyethylene glycol dodecyl ether, such as tetraethylene glycol dodecyl ether. The compositions may be useful to solubilize tissue, including skin, ... | 01/05/2012 |
| 20110319333 | METHOD AND COMPOSITIONS FOR THE TREATMENT AND DETECTION OF ENDOTHELIN-1 RELATED KIDNEY DISEASES The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A k... | 12/29/2011 |
| 20110318269 | Method For Screening Phage Display Libraries Against Each Other The present invention relates to a method for screening phage display libraries against each other. In particular, the invention relates to a method for screening at least two phage display libraries against each other to identify and/or select one or more interacting b... | 12/29/2011 |
| 20110319598 | METHODS AND MATERIALS FOR DETERMINING ISOELECTRIC POINT The present disclosure relates to methods and materials for determining an isoelectric point for a protein including, for example, a binding molecule such as an antibody. The isoelectric points may be used in methods for the preparation of proteins. Such methods may com... | 12/29/2011 |
| 20110311552 | NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF Means and methods for the diagnosis, characterization, prognosis and treatment of cancer, specifically targeting cancer stem cells are disclosed Provided is an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain ... | 12/22/2011 |
| 20110311990 | TETRANOR-PGEM/PGAM SPECIFIC IMMUNOGENS, ANTIBODIES, TRACERS, ASSAY KITS AND METHODS FOR MAKING SAME Tetranor-PGEM/tetranor-PGAM-specific antibodies, immunogens used to generate them, the processes of their manufacture, and their uses for detecting and quantifying tetranor-PGEM in biological fluids for determining biosynthesis of PGE2 in a subject or patient... | 12/22/2011 |
| 20110312505 | Rapid Isolation of Monoclonal Antibodies from Animals Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining ... | 12/22/2011 |
| 20110313066 | STIMULUS RESPONSIVE POLYMERS FOR THE PURIFICATION OF BIOMOLECULES The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.... | 12/22/2011 |
