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| Application No. | Application Title | Issue Date |
| 20120130045 | BIOMOLECULE-POLYMER CONJUGATES AND METHODS OF MAKING SAME Disclosed herein are biomolecule-polymer conjugates of Formula 1, as well as methods of preparing same and kits for preparing same. ... | 05/24/2012 |
| 20120082715 | Stabilized products, processes and devices for preparing the same A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced storage stability, less expensive cost of processing, and extended shelf ... | 04/05/2012 |
| 20120052136 | NOVEL HEAMOGLOBIN AND USES THEREOF The present invention relates to isolated haemoglobin from worms belonging to the Nereididae family and its use in cell culture medium, in preservation solutions and as artificial oxygen carrier for transfusion.... | 03/01/2012 |
| 20120028899 | COMPOSITION AND PROCESS FOR SYNTHESIZING TENSE AND RELAXED STATE POLYMERIZED HEMOGLOBIN Described herein is a composition and process for synthesizing a hemoglobin-based oxygen carrier (HBOC) composition that includes a polymerized hemoglobin locked in at least one of the tense or relaxed quaternary state and has a molecular weight of at least about 500 kD... | 02/02/2012 |
| 20120004396 | COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such compositions. Such compositions according to the present invention have bette... | 01/05/2012 |
| 20110318765 | METHOD FOR PRE-TREATING SAMPLE CONTAINING GLYCATED HEMOGLOBIN There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time... | 12/29/2011 |
| 20110250670 | LIGHT ENERGY-INDUCED STABILITY OF BIOMATERIALS Disclosed are methods and apparatuses for stabilizing labile biomolecules in an aqueous solution without the use of chemicals. For example, some embodiments involve exposing an aqueous solution of a labile biomolecule, such as a protein, to light energy to stabilize the... | 10/13/2011 |
| 20110250641 | ZWITTERIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE A compound of the formula: wherein R1 is independently selected from C1-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of â€... | 10/13/2011 |
| 20110243849 | HEME-BINDING PHOTOACTIVE POLYPEPTIDES AND METHODS OF USE THEREOF The present disclosure provides photoactive polypeptides. A subject photoactive polypeptide is useful in a variety of applications, which are also provided.... | 10/06/2011 |
| 20110195478 | BLADDER CANCER BIOMARKER AND TEST METHOD USING THE SAME The present invention discloses a bladder cancer biomarker and a test method using the same. The biomarker contains at least one of the mentioned 69 compounds, such as apolipoprotein A1 (APOA1), apolipoprotein A2 (APOA2), peroxiredoxin 2 (PRDX2), heparin cofactor 2 prec... | 08/11/2011 |
| 20110172390 | Protein-Proteophore Complexes The application relates to a composition comprising a hyperbranched polymer attached to a core and a biologically active moiety. The biologically active moiety is attached to the core by means of a substantially non-enzymatically cleavable linker L. The composition can ... | 07/14/2011 |
| 20110117626 | Hydrophobic Interaction Chromatography Membranes, and Methods of Use Thereof Described herein are composite materials and methods of using them for hydrophobic interaction chromatography (HIC). In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a ma... | 05/19/2011 |
| 20110071275 | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine The present invention describes novel neuroprotective and multifunctional intra- and inter-molecular redox coupled polynitroxylated pegylated carboxy hemoglobins as high therapeutic index agents for un-met medical needs or diseases, which require acute or chronic allevi... | 03/24/2011 |
| 20110070658 | SYSTEMS AND METHODS FOR DETERMINING THE PERCENTAGE OF GLYCATED HEMOGLOBIN Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.... | 03/24/2011 |
| 20100261248 | Pharmaceutical Composition Comprising An Immunoglobulin FC Region as a Carrier Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends ... | 10/14/2010 |
| 20100261885 | PEGylation by the Dock and Lock (DNL) Technique The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a target agent to a DDD sequence and at... | 10/14/2010 |
| 20100247681 | NITRITE AND NITRITE-METHEME THERAPY TO DETOXIFY STROMA-FREE HEMOGLOBIN BASED BLOOD SUBSTITUTES This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to trea... | 09/30/2010 |
| 20100216695 | SECOND GENERATION LOW OXYGEN AFFINITY PEGYLATED HEMOGLOBINS AS OXYGEN-CARRYING PLASMA EXPANDERS Provided are hemoglobins having at least two chemical modifications that lower oxygen affinity, hemoglobins chemically modified by the addition of glyceraldehyde-3-phosphate, and hemoglobins having at least two specific chemical modifications. PEGylated versions of thes... | 08/26/2010 |
| 20100190194 | POSTPRANDIAL HYPERGLYCEMIA MARKER, METHOD OF MEASURING THE SAME, AND USAGE THEREOF A new method of diagnosing postprandial hyperglycemia by indirectly measuring a blood glucose level is provided. Postprandial hyperglycemia is detected by measuring a glycation degree of lysine in hemoglobin, in which a side chain amino group of lysine is glycated (GHbL... | 07/29/2010 |
| 20100183589 | HUMAN BLOOD PROTEINS EXPRESSED IN MONOCOT SEEDS The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.... | 07/22/2010 |
| 20100167374 | ULTRA-FAST CHROMATOGRAPHY The present invention relates to a chromatographic method of separating biological material comprising, providing chromatographic media comprising inorganic oxide particles having an average diameter of about 2 microns or less and an average pore diameter of 300 â„« or ... | 07/01/2010 |
| 20100137189 | MODIFIED GLOBIN PROTEINS WITH ALTERED ELECTRON TRANSPORT PATHWAY The present invention relates to a modified porphyrin-based oxygen-carrying protein, such as haemoglobin, which has been found, in its unmodified state to have a low affinity site of electron transfer and a high affinity electron transfer between a reductant and ferryl ... | 06/03/2010 |
| 20100062416 | Immobilisation and application of antigenic carbohydrates to detect infective micro-organisms The invention relates to the field of chemistry and diagnosis, more in particular to diagnosis of current and/or past and/or symptomless infections or of a history of exposure to a gram-negative-bacterium (such as an enterobacteriaceae or a legionella). Even more... | 03/11/2010 |
| 20090298746 | Pegylated hemoglobin and albumin and uses thereof The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin, wherein the PEG is a maleimide PEG, an alkylamide PEG, an iodoacetamide PEG, a p-nitro thio-phenyl PEG, a vinyl sulfo... | 12/03/2009 |
| 20090258004 | HUMAN BLOOD PROTEINS EXPRESSED IN MONOCOT SEEDS The invention is directed to blood proteins produced in monocot seeds and isolated therefrom for use in therapeutic compositions, and to methods of making these isolated blood proteins and to therapeutic compositions comprising them.... | 10/15/2009 |
| 20090232909 | Method for determining physiological effects of hemoglobin NO preferentially binds to the minor population of the hemoglobin's vacant hemes in a cooperative manner, nitrosylates hemoglobin thiols, or reacts with liberated superoxide in solution. The distribution of minor forms of hemoglobin can be tested and the results can be ... | 09/17/2009 |
| 20090215670 | Site specific pegylated hemoglobin, method of preparing same, and uses thereof The present invention provides pegylated hemoglobins comprising a maleimide polyethylene glycol (PEG) conjugated to a thiol moiety of a cysteine residue of hemoglobin, methods of preparing the pegylated hemoglobins, compositions and blood substitutes comprising the pegy... | 08/27/2009 |
| 20090185998 | NEW ACTIVATED POLY(ETHYLENE GLYCOLS) AND RELATED POLYMERS AND THEIR APPLICATIONS There are disclosed chemically active poly(ethylene glycols) and other hydrophilic polymers that are suitable for coupling to pharmaceutically or diagnostically active agents such as peptides, oligonucleotides, proteins or non-peptide molecules. The compounds are repres... | 07/23/2009 |
| 20090137762 | METHOD OF FORMING A POLYMERIZED HEMOGLOBIN SOLUTION FROM STABILIZED HEMOGLOBIN A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereb... | 05/28/2009 |
| 20090088370 | Method for Improved Isolation of Recombinantly Produced Proteins The present invention provides a method for increasing the yield of a protein produced by cultivating eukaryotic cells and adding an ionic substance to the culture medium prior to harvest of the protein. Suitable ionic substances are the salts of the Hofmeister series, ... | 04/02/2009 |
| 20090082257 | MalPEG-Hb conjugate- containing compositions for delivering carbon monoxide (CO) to cells The present invention relates to compositions for delivering carbon monoxide (CO) to cells using heme proteins as carriers. In one embodiment, the present invention relates to the use of MalPEG surface modified hemoglobin to deliver CO to cells.... | 03/26/2009 |
| 20090060862 | PEGylation by the Dock and Lock (DNL) Technique The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a target agent to a DDD sequence and at... | 03/05/2009 |
| 20090023632 | Hemoglobin-haptoglobin complexes Construct-complexes of a hemoglobin, a hepatocyte modifying substance bound to the hemoglobin, and a haptoglobin bound to the hemoglobin, are provided, for administration to mammalian patients. The construct-complex may be formed ex vivo, or a hemoglobin-hepatocyte modi... | 01/22/2009 |
| 20080313823 | Support-Colouring Means The invention relates to catalytic systems which are used to generate colours on a support. The inventive means are characterised in that they comprise one or more deactivated oxidation catalysts. The invention can be used to colour organic or inorganic supports.... | 12/25/2008 |
| 20080247949 | Biological Tissue Examination Agent Comprising Hemoglobin Labeled With Oxygen Isotope And Method For Producing The Same The present invention relates to a biological tissue examination agent comprising hemoglobin labeled with 15O2 and a method for producing the same. More specifically, the present invention relates to a biological tissue examination agent for diagno... | 10/09/2008 |
| 20080227205 | Incorporation on Non-Naturally Encoded Amino Acids Into Proteins The invention provides methods and compositions for in vivo incorporation of non-naturally encoded amino acids into polypeptides by Pseudomonas species and strains derived therefrom. Also provided are compositions including proteins with non-naturally encoded ami... | 09/18/2008 |
| 20080193996 | METHODS FOR SEPARATING MOLECULES The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modified so... | 08/14/2008 |
| 20080146493 | Use of Haptoglobin and Hemoglobin to Modulate Na Ion Transport in a Vertebrate The invention provides methods and compositions for increasing Na ion transport and/or epithelial fluid transport in a vertebrate by administering an effective amount of haptoglobin or haptoglobin and hemoglobin. The invention also provides a new therapeutic approach fo... | 06/19/2008 |
| 20080108555 | Method and Apparatus for Preparing an Acellular Red Blood Cell Substitute A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable... | 05/08/2008 |
| 20080096805 | Nitric oxide-blocked cross-linked tetrameric hemoglobin The present invention includes compositions containing carboxamidomethylated cross-linked hemoglobin where the cysteine moiety of the hemoglobin includes a thiol protecting group and where the hemoglobin has a reduced ability to bind with nitric oxide. Preferably, the h... | 04/24/2008 |
