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| Application No. | Application Title | Issue Date |
| 20120130046 | TROPOELASTIN DERIVATIVES The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of the invention. The invention further provides methods for the production of... | 05/24/2012 |
| 20120129255 | FUNCTIONALIZATION OF SILK MATERIAL BY AVIDIN-BIOTIN INTERACTION The present invention provides for compositions and methods of linking silk fibroin to active agents through the specific interaction between avidin and biotin, providing for functionalization of silk-based protein biomaterials. An avidin- or biotin-modified silk is a b... | 05/24/2012 |
| 20120128721 | SCHISTOSOMA VACCINE The method for large scale production of a full length Schistosomal paramyosin coiled coil dimer composition is carried out by providing a composition comprising recombinant paramyosin, contacting the composition with a strand separation agent to remove paramyosin fragm... | 05/24/2012 |
| 20120041177 | METHOD OF PRODUCING POLYMERS OF SPIDER SILK PROTEINS A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and/or an ion composition that prevents polymerisation of the spider silk protein. The properties of the li... | 02/16/2012 |
| 20120027814 | Polymeric Fibers Having Tissue Reactive Members A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a specific binding pair, and contacting the polymeric fiber to biological tissue, t... | 02/02/2012 |
| 20120022005 | Synthetic Dragline Spider Silk-Like Proteins The present application relates to isolated amino acid sequence comprising multiple repeats of a semi-synthetic spider silk protein domain, or any functional homolog, variant, derivative, fragment or mutant thereof. The amino acid sequence of the invention further compr... | 01/26/2012 |
| 20110297904 | HUMIDITY RESPONSIVE MATERIALS AND SYSTEMS AND METHODS USING HUMIDITY RESPONSIVE MATERIALS The invention relates to silk or other materials formed to have predetermined contraction/relaxation characteristics, wherein the contraction/relaxation characteristics are initiated by exposure thereof to predetermined humidity characteristics in the adjacent atmospher... | 12/08/2011 |
| 20110288273 | HIGH YIELD DIALYSIS-FREE PROCESS FOR PRODUCING ORGANOSOLUBLE REGENERATED SILK FIBROIN The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing ... | 11/24/2011 |
| 20110275788 | FIBROUS PROTEIN FUSIONS AND USE THEREOF IN THE FORMATION OF ADVANCED ORGANIC/INORGANIC COMPOSITE MATERIALS The claimed invention provides a fusion polypeptide comprising a fibrous protein domain and a mineralization domain. The fusion is used to form an organic-inorganic composite. These organic-inorganic composites can be constructed from the nano- to the macro-scale depend... | 11/10/2011 |
| 20110253984 | ELECTRONIC GRADE SILK SOLUTION, OTFT AND MIM CAPACITOR WITH SILK PROTEIN AS INSULATING MATERIAL AND METHODS FOR MANUFACTURING THE SAME An electronic grade silk solution, an organic thin film transistor (OTFT) and a metal-insulator-metal capacitor with silk protein as the insulating material manufactured by use of the silk solution, and methods for manufacturing the same are disclosed. The OTFT of the p... | 10/20/2011 |
| 20110217750 | Dendrimers and Dendrimer Applications An activatable functionalised Nth generation dendrimer having: a core comprising a first monomer having at least two carboxylic acid functional groups; and N successive generations, where N=0 to 10, wherein each generation comprises: a second monomer having a... | 09/08/2011 |
| 20110201783 | Apparatus for the Preparation of a Thread From Silk Proteins The present invention relates to a thread preparation process from silk proteins including an apparatus which is appropriate for performing the method. Furthermore, the invention is directed to the threads obtained therewith as well as the use thereof. The invention use... | 08/18/2011 |
| 20110189773 | SILK FIBROIN FIBER BUNDLES FOR MATRICES IN TISSUE ENGINEERING The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides th... | 08/04/2011 |
| 20110177997 | Cross-Beta Silk Genes The present invention relates to silk proteins which can be used to produce silk with a cross-beta structure, as well as nucleic acids encoding such proteins. The present invention also relates to recombinant cells and/or organisms which synthesize silk proteins. Silk p... | 07/21/2011 |
| 20110177151 | IMPLANTABLE MATERIAL AND A METHOD FOR THE PREPARATION THEREOF A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at le... | 07/21/2011 |
| 20110172394 | IMPLANTABLE MATERIAL FOR THE REPAIR, AUGMENTATION, OR REPLACEMENT OF BONE AND A METHOD FOR THE PREPARATION THEREOF A method for the preparation of an implantable material for the repair, augmentation or replacement of bone from a fibroin solution, the method comprising the steps of: preparing a gel from the fibroin solution; preparing a material by subjecting the gel to one or more ... | 07/14/2011 |
| 20110171239 | pH INDUCED SILK GELS AND USES THEREOF This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid f... | 07/14/2011 |
| 20110117168 | METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platele... | 05/19/2011 |
| 20110117167 | METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platele... | 05/19/2011 |
| 20110021752 | Tropoelastin Derivatives The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of the invention. The invention further provides methods for the production of... | 01/27/2011 |
| 20100323421 | METHOD FOR CHEMICALLY MODIFYING BIOPOLYMER AND POLYPEPTIDE It is an object of the present invention to provide a method for chemically modifying biopolymer and polypeptide with a hydrophobic compound or a compound which causes degradation or reaction under basic condition. The present invention provides a method for producing a... | 12/23/2010 |
| 20100298877 | Recombinant Spider Silk Proteins The present invention is directed to recombinant spider silk proteins, nucleic acids, coding for these recombinant spider silk proteins, as well as hosts suitable for expressing those nucleic acids. Furthermore, the present invention is directed to a method of aggregati... | 11/25/2010 |
| 20100294716 | Templated Native Silk Smectic Gels One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible... | 11/25/2010 |
| 20100255056 | Fibronectin Type III Domain Based Scaffold Compositions, Methods And Uses A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in dia... | 10/07/2010 |
| 20100256042 | METHODS OF USING CHIMERIC COILED-COIL MOLECULE The present application discloses a method of treating a disease that is treatable by therapeutic angiogenesis comprising administering to a needy subject an effective amount of a chimeric coiled coil molecule comprising a coiled-coil domain linked to a receptor binding... | 10/07/2010 |
| 20100230339 | Particulate chiral separation material A chiral particulate material and method of making the same are provided. The material includes a fibrous protein or chiral synthetic polymer, optionally crosslinked, organized into a multilayered chiral structure including nanoscale chiral pores or channels. The partic... | 09/16/2010 |
| 20100222553 | SPIDER SILK DRAGLINE POLYNUCLEOTIDES, POLYPEPTIDES AND METHODS OF USE THEREOF The disclosure provides spider silk dragline polypeptides and polynucleotides encoding the same. Methods of using such polypeptides and polynucleotides and designing novel biomaterials using repeat units of the polypeptides and polynucleotides.... | 09/02/2010 |
| 20100209405 | SERICIN EXTRACTED SILKWORM FIBROIN FIBERS The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides th... | 08/19/2010 |
| 20100196432 | BIOPOLYMER STRUCTURES The invention described herein relates to biopolymer structures. The biopolymer structures are spatially organized from the nanometer to centimeter length scales and incorporate functionally active cells. Applications of the biopolymer structures include use with stem c... | 08/05/2010 |
| 20100178304 | METHOD FOR SILK FIBROIN GELATION USING SONICATION This invention provides for a process of rapidly forming silk fibroin gelation through ultrasonication. Under the appropriate conditions, gelation can be controlled to occur within two hours after the ultrasonication treatment. Biological materials, including viable cel... | 07/15/2010 |
| 20100100975 | SILK PROTEINS The present invention provides silk proteins, as well as nucleic acids encoding these proteins. The present invention also provides recombinant cells and/or organisms which synthesize silk proteins. Silk proteins of the invention can be used for a variety of purposes su... | 04/22/2010 |
| 20100068517 | ENHANCED SILK PROTEIN MATERIAL HAVING IMPROVED MECHANICAL PERFORMANCE AND METHOD OF FORMING THE SAME The invention provides an enhanced silk fiber rivaling spider silk in mechanical performance, in combination with a very low-cost method for producing it from the usual silkworms. The method provides for the simple application of an electric field which results in an en... | 03/18/2010 |
| 20100055184 | HYDROGELS FOR VOCAL CORD AND SOFT TISSUE AUGMENTATION AND REPAIR The present invention provides hydrogels and compositions thereof for vocal cord repair or augmentation, as well as other soft tissue repair or augmentation (e.g., bladder neck augmentation, dermal fillers, breast implants, intervertebral disks, muscle-mass). The hydrog... | 03/04/2010 |
| 20100055438 | CONCENTRATED AQUEOUS SILK FIBROIN SOLUTION AND USE THEREOF The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides... | 03/04/2010 |
| 20100029553 | Microfluidic Device for Controlled Aggregation of Spider Silk The present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly of the said silk protein(s) to defined morphologies, such as spheres, n... | 02/04/2010 |
| 20100021440 | USE OF TROPOELASTIN FOR REPAIR OR RESTORATION OF TISSUE The present invention relates to tropoelastin and to tissue repair and restoration using elastic materials. Disclosed is a process for producing an elastic material from tropoelastin including heating a solution of tropoelastin having an alkaline pH to form an elastic m... | 01/28/2010 |
| 20090286959 | High Molecular Weight Fibroin Having Improved Antioxidant Activity, Tyrosinase Inhibitory Ability and/or Cytotoxicity to Cancer Cells by Irradiation, and Methods of Making and Using the Same Disclosed are a fibroin with increased molecular weight and improved antioxidant activity, tyrosinase inhibitory ability and cytotoxicity to cancer cells, which has a molecular structure modified by irradiation, a method for production thereof, use of the irradiated fib... | 11/19/2009 |
| 20090281044 | ELASTIN DIGEST COMPOSITIONS AND METHODS UTILIZING SAME The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticit... | 11/12/2009 |
| 20090246283 | Repeat Sequence Protein Polymer Nanoparticles Optionally Containing Active Agents and Their Preparation A nanocomposite of a repeat sequence protein polymer, such as a copolymer of silk and elastin, is produced by Supercritical Antisolvent Precipitation with Enhanced Mass Transfer (SAS-EM). The nanocomposite may include an active agent, such as a protein or hormone, that ... | 10/01/2009 |
| 20090232963 | DIAZONIUM SALT MODIFICATION OF SILK POLYMER A method for modifying silk polymer by coupling a chemical moiety to a tyrosine residue of a silk polymer is described herein for the purpose of altering the physical properties of the silk protein. Thus, silk proteins with desired physical properties can be produced by... | 09/17/2009 |
