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| Application No. | Application Title | Issue Date |
| 20120070378 | LANTHANIDE ION COMPLEXES AND IMAGING METHOD A Ianthanide complex, method of forming and method of using the lanthanide complex as a near-infrared luminescent material are described. The complex includes at least one lanthanide ion and at least one polydentate ligand derived from a molecule having the general form... | 03/22/2012 |
| 20120052481 | Assays for detecting modified compounds Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications... | 03/01/2012 |
| 20120035346 | LUMINESCENT COMPOUNDS Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic... | 02/09/2012 |
| 20120022230 | IONIZABLE ISOTOPIC LABELING REAGENTS FOR RELATIVE QUANTIFICATION BY MASS SPECTROMETRY Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only i... | 01/26/2012 |
| 20120022231 | Method for Manufacturing Cubic Diamond Nanocrystals A method for manufacturing cubic diamond nanocrystals (10) comprising the following successive steps: (a) providing crystalline diamond powder where the maximum particle size of the powder is equal or more than 2 um and equal or less than 1 mm; (b) milling said c... | 01/26/2012 |
| 20120010124 | Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell The invention provides cell penetrating peptide-nucleic acid conjugates having the formula P-L-N, wherein P is a cell penetrating peptide, N is a nucleic acid, preferably an oligonucleotide and more preferably a siRNA, and L is a hydrophilic polymer, preferably a polyet... | 01/12/2012 |
| 20110306125 | Protein Expression Methods The present invention relates to compositions and methods for obtaining (e.g., expressing, isolating and/or purifying) polypeptides capable of binding to and/or activating the guanylate cyclase C receptor.... | 12/15/2011 |
| 20110301327 | EPITOPE ANALOGS Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, mo... | 12/08/2011 |
| 20110293644 | COMPOSITIONS AND METHODS FOR TREATMENT OF CELIAC DISEASE The invention provides agents and vaccines for treating and diagnosing celiac disease. In particular, the present invention provides a combination of three peptides that are useful for treating and diagnosing celiac disease in a large proportion of patients.... | 12/01/2011 |
| 20110294869 | SELF DELIVERING BIO-LABILE PHOSPHATE PROTECTED PRO-OLIGOS FOR OLIGONUCLEOTIDE BASED THERAPEUTICS AND MEDIATING RNA INTERFERENCE Disclosed herein are compositions and methods for generating ribo-nucleic neutral (RNN) or deoxyribo-nucleic-neutral (DNN) polynucleotides with reduced anionic charge, for improved intracellular delivery. Also disclosed herein are methods of using RNN and DNN compositio... | 12/01/2011 |
| 20110294189 | BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from defined sites on the biomolecule. The conjugates may have desirable pharm... | 12/01/2011 |
| 20110274618 | DIAGNOSTIC AND/OR THERAPEUTIC AGENT, METHOD FOR THE MANUFACTURE THEREOF AND USE THEREOF The invention relates to the fields of materials sciences and medicine and relates to an agent, which can be used, for example, as a contrast medium for the localization of cancer cells. The object of the present invention is to disclose an agent which sensitively and s... | 11/10/2011 |
| 20110256552 | METHOD FOR PREPARING A SUBSTRATE FOR IMMOBILIZING A CELL, SAID SUBSTRATE AND USES THEREOF The present invention relates to a method of preparation of a solid substrate capable of immobilizing at least one cell and/or at least one part of a cell, said method comprising a step consisting of fixing, to said solid substrate, a fusogenic compound capable of being... | 10/20/2011 |
| 20110245462 | Non-Fluorescent Quencher Compounds and Biomolecular Assays Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo ring systems, are useful as labels when attached to biomolecules such as po... | 10/06/2011 |
| 20110237774 | METHOD FOR INTRODUCING DOTA The invention provides a method for introducing 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid (DOTA) into a compound such as a peptide. The method comprises a first step for preparing a mixed liquid of DOTA having no protecting group and dimethylsu... | 09/29/2011 |
| 20110226620 | Highly Homogeneous Molecular Markers for Electrophoresis The invention relates to marker molecules for identifying physical properties of molecular species separated by the use of electrophoretic systems. The invention further relates to methods for preparing and using marker molecules.... | 09/22/2011 |
| 20110213124 | METHODS AND SYSTEMS FOR SYNTHESIS OF A D-AMINOLUCIFERIN PRECURSOR AND RELATED COMPOUNDS Methods and systems to generate 6-amino-6-deoxy- | 09/01/2011 |
| 20110213046 | NANOPARTICLES Nanoparticles can include a core linked to a polymerizable moiety that can be polymerized, cross-linked or cured. The polymerizable nanoparticles can be included in a composition for a polymerization, cross-linking or curing reaction in an amount and disposition suffici... | 09/01/2011 |
| 20110212127 | Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine The invention relates to the preservation of an active agent, such as a polypeptide, by contacting the active agent with a preservation mixture including a sugar and polyethyleneimine.... | 09/01/2011 |
| 20110201781 | CYSTEINE LABELING SYSTEM AND METHOD OF USE THEREOF A method of use of a cysteine labeling system includes: providing a 2-cyano benzothial core with a covalently-linked biomolecule X in a reaction environment; and reacting the 2-cyano benzothial core to an N-terminal cystenine.... | 08/18/2011 |
| 20110189095 | CRKL TARGETING PEPTIDES Provided are methods and compositions for selectively targeting CRKL through the use of targeting peptides. Selective targeting of secreted CRKL through the use of a targeting peptide may be used, for example, in the treatment of cancer to deliver a chemotherapeutic com... | 08/04/2011 |
| 20110183889 | SALICYLANILIDE MODIFIED PEPTIDES FOR USE AS ORAL THERAPEUTICS This invention pertains to the surprising discovery that salicylanilides, e.g., niclosamide and/or niclosamide analogues can be reacted with a therapeutically active peptide to produce a modified peptide complex that shows increased resistance to proteolysis and that sh... | 07/28/2011 |
| 20110165606 | METHODS FOR MODIFYING, ISOLATING, DETECTING, VISUALIZING, AND QUANTIFYING CITRULLINATED AND/OR HOMOCITRULLINATED PEPTIDES, POLYPEPTIDES AND PROTEINS The present invention relates to methods and compositions for modifying, isolating, detecting, visualizing, and quantifying citrulline and/or homocitrulline-containing peptides, polypeptides, and proteins using mono- and disubstituted glyoxal derivatives. The invention ... | 07/07/2011 |
| 20110159566 | Methods and Reagents for Preparing Multifunctional Probes Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes using the methods of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low... | 06/30/2011 |
| 20110151538 | AFFINITY PURIFICATION BY COHESIN-DOCKERIN INTERACTION The present invention is directed to truncated dockerin polypeptides, recombinant polypeptides and affinity systems comprising the truncated dockerin polypeptide, methods of generating same, and methods of use thereof to purify, isolate, and detect molecules of interest... | 06/23/2011 |
| 20110150837 | Amphiphilic polymer functionalized by methionine The present invention relates to new amphiphilic polymers comprising hydrophobic groups and methionine groups. It also relates to compositions with a controlled release profile comprising such polymers, non-covalently combined with an activ... | 06/23/2011 |
| 20110143384 | METHODS OF PEPTIDE MODIFICATION The present invention relates to a method of improving the resistance of a peptide or peptidomimetic to degradation by trypsin which comprises incorporating into said peptide or peptidomimetic a C-terminal capping group of formula (I): X—Y—Z (I) wherein X is a N ato... | 06/16/2011 |
| 20110144303 | Biologically Active Peptidomimetic Macrocycles The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applicati... | 06/16/2011 |
| 20110142792 | Compositions for Increasing Polypeptide Stability and Activity, and Related Methods This disclosure provides peptides, polypeptides, fusion polypeptides, compositions, and methods for enhancing or increasing the stability of a polypeptide (e.g., Taq polymerase). Such peptides, polypeptides, fusion polypeptides, or compositions include polypeptides link... | 06/16/2011 |
| 20110144304 | Chemical Modification of Proteins The invention relates to methods for selectively converting a cysteine residue in a peptide or protein to the dehydroalanine (Dha) residue. The method also works on selenocysteine and substituted cysteine and selenocysteine residues, resulting in the Dha residue which m... | 06/16/2011 |
| 20110136201 | HETEROCYCLE-SUBSTITUTED XANTHENE DYES The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also ... | 06/09/2011 |
| 20110136723 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES A compound of the general formula X-[Q-W—(CH═CH)n—(CH2)2-L]m (I) in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing group; n represents 0 or an integer of from 1 to 4; L r... | 06/09/2011 |
| 20110135733 | ALDEHYDE CONJUGATED FLAVONOID PREPARATIONS There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form ... | 06/09/2011 |
| 20110124841 | Polypeptides Modified by Protein Trans-Splicing Technology The present invention relates to a method of preparing modified polypeptides, by linking a target polypeptide to a carrier molecule that is designed to bear one or more water-soluble polymer molecules, via protein trans-splicing. The polymer molecules can be attached to... | 05/26/2011 |
| 20110118441 | Synthesis of Highly Fluorescent Peptide-Metallic Nanoclusters as Bio-probes A method of one reaction step for synthesis of peptide template fluorescent metal nanoclusters as bioprobes. Specific targeting peptide containing a metal reactive group is synthesized and used to react with a metal salt solution under a sufficient pH condition at room ... | 05/19/2011 |
| 20110110854 | Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules The present application discloses compositions and methods of synthesis and use of 68Ga, 18F or 19F labeled molecules of use in PET or MRI imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by... | 05/12/2011 |
| 20110104783 | STEREOISOMER PEPTIDES, LIGAND-TARGETED MULTI- STEREOISOMER PEPTIDE POLYMER CONJUGATES, AND USES THEREOF The invention provides compounds of the formula Poly-([SP-LI]n-PL-L2) including a collection of 152 peptides useful to create the compounds, and their uses thereof for the treatment of a variety of mammalian diseases. The compound, a novel ligand-targeted multi-stereois... | 05/05/2011 |
| 20110098446 | Use of a tetraphenylborate (TPB) salt for the separation of biomolecules Process for the separation of a biomolecule containing at least one cationic group from a liquid medium containing said biomolecule, which comprises the use of a tetraphenylborate (TPB) salt.... | 04/28/2011 |
| 20110097758 | Peptide Conjugates and Fluorescence Detection Methods for Intracellular Caspase Assay Polypeptides labelled with a donor and acceptor pair of dyes selected from a dibenzorhodamine dye and a diamino-benzophenoxazine dye are peptide conjugates which are useful for intracellular and bead-based assays with fluorescence detection. Peptide conjugates with a ca... | 04/28/2011 |
| 20110098445 | COVALENT ATTACHMENT OF PEPTIDES AND BIOLOGICAL MOLECULES TO LUMINESCENT SEMICONDUCTOR NANOCRYSTALS A method for covalent attachment of peptides to luminescent quantum dots or other inorganic nanoparticles. The first step in the method involves functionalizing at least a portion of a surface of the quantum dot or nanoparticle with one or more materials having at least... | 04/28/2011 |
