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| Application No. | Application Title | Issue Date |
| 20120129765 | NOVEL SPECIFIC HCV NS3 PROTEASE INHIBITORS The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HCV in human patients or other animal hosts.... | 05/24/2012 |
| 20120129203 | Novel Peptidase Substrates The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH:
| |
| 20120107800 | CELL-TARGETING NANOPARTICLES AND USES THEREOF The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM... | 05/03/2012 |
| 20120108494 | INHIBITORS OF INTRACELLULAR UROKINASE PLASMINOGEN ACTIVATOR AND METHODS OF USE THEREOF The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the compositions for treating cancer and for delivering an amiloride conjugate into cancer cells in a subject in nee... | 05/03/2012 |
| 20120107321 | Antibodies And Epitopes Specific To Misfolded Prion Protein The present invention relates to antibodies and immunogenic peptides specific to misfolded prion protein (PrP, e g, PrPSc), and uses thereof. The immunogenic peptides comprise the amino acid sequence tyrosine-methionine-leucine (YML). The antibodies or peptid... | 05/03/2012 |
| 20120108499 | PEPTOID COMPOUNDS The invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compositions thereof.... | 05/03/2012 |
| 20120107324 | TARGETED BINDING AGENTS DIRECTED TO a5ß1 AND USES THEREOF The invention relates to targeted binding agents against α5β1 and uses of such agents. More specifically, the invention relates to fully human monoclonal antibodies directed to α5β1. The described targeted binding agents are useful in the treatment of diseases assoc... | 05/03/2012 |
| 20120052094 | Agonists of Neurotrophin Receptors and Their Use as Medicaments The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specificati... | 03/01/2012 |
| 20120045474 | Substrate peptide sequences for plague plasminogen activator and uses thereof The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla... | 02/23/2012 |
| 20120045394 | HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, incl... | 02/23/2012 |
| 20120040912 | PROTEASOME-ACTIVATING ANTI-AGING PEPTIDES AND COMPOSITIONS CONTAINING SAME The present invention relates to peptidic compounds of general formula (I):
| 02/16/2012 |
| 20120034187 | Hepatitis C Inhibitor Compounds Compounds of formula (I):
| |
| 20120028888 | APJ RECEPTOR COMPOUNDS The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor apelin, also known as the APJ receptor. The APJ recepto... | 02/02/2012 |
| 20120028880 | VEGFR-1/NRP-1 TARGETING PEPTIDES The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particu... | 02/02/2012 |
| 20120027703 | NOVEL PROTEASOME-ACTIVATING ANTI-AGING PEPTIDES AND COMPOSITIONS CONTAINING SAME The present invention relates to peptidic compounds of general formula (I):
In addition, the present i... | 02/02/2012 |
| 20120027677 | Prion-specific peptoid reagents The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a ca... | 02/02/2012 |
| 20120022371 | Compositions and methods for detecting and treating tumors containing acidic areas Improved compounds have been developed which are structured to be sequestered with very high specificity in acidic areas of tissues. When the compounds contain a radioisotope effective to report the presence of the compound the compounds are for detecting tumors contain... | 01/26/2012 |
| 20120020904 | NOVEL PROTEASOME-ACTIVATING LIGHTENING PEPTIDES AND COMPOSITIONS CONTAINING SAME The present invention relates to depigmenting, lightening and/or whitening peptidic compounds of general formula (I)
| 01/26/2012 |
| 20120022229 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.... | 01/26/2012 |
| 20120021029 | PEPTIDES USED IN THE TREATMENT AND/OR CARE OF THE SKIN AND/OR HAIR AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS Peptides of general formula (I):
its stereoisomers, mixtures thereof and/or their cosmeti... | 01/26/2012 |
| 20120021454 | RAPID FRET-BASED DIAGNOSIS OF BACTERIAL PATHOGENS The invention comprises a substrate for detection of micro-organisms, wherein said substrate comprises a set of molecular markers linked, optionally with linker molecules or moeieties, to a di-, or tripeptide consisting of amino acids X1 and X2, or X1, X2 and X3, in whi... | 01/26/2012 |
| 20120022227 | RADIOLABELLING REAGENTS AND METHODS The present invention relates to reagents and methods for [18F]-fluorination of biomolecules, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (P... | 01/26/2012 |
| 20120015866 | Prodrugs of Heteraromatic Compounds The present invention relates to prodrugs of parent drug compounds containing heteroaromatic NH groups.... | 01/19/2012 |
| 20120014925 | Self-Assembling Peptides Incorporating Modifications and Methods of Use Thereof The invention relates to a novel class of self-assembling peptides, compositions thereof, methods for the preparation thereof and methods of use thereof. The invention also encompasses methods for tissue regeneration, increasing the production of extracellular matrix pr... | 01/19/2012 |
| 20120010158 | TUMOR NECROSIS FACTOR INHIBITING PEPTIDES AND USES THEREOF The present invention relates to Tumor Necrosis Factor-alpha (TNF-alpha or TNF-α) inhibiting peptides and process for the preparation thereof. The present invention further relates to a pharmaceutical composition comprising TNF-alpha inhibiting peptides of the present ... | 01/12/2012 |
| 20120003201 | VAULT AGENTS FOR CHRONIC KIDNEY DISEASE The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a RGD-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease.... | 01/05/2012 |
| 20120004720 | G-TYPE PEPTIDES AND OTHER AGENTS TO AMELIORATE ATHEROSCLEROSIS AND OTHER PATHOLOGIES This invention provides novel peptides, and other agents, that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J.... | 01/05/2012 |
| 20120003673 | Screening method, composition containing substance selected by the screening method, and binding substance Disclosed is a screening method which can select a substance having an influence on the binding between thioredoxin and MIF. The screening method is characterized in that a test substance capable of enhancing the binding between a polypeptide belonging to the thioredoxi... | 01/05/2012 |
| 20110319347 | ANTIOXIDANT AGENT Disclosed is an antioxidant which can exhibit a higher antioxidant ability than known antioxidative peptides. The antioxidant according to the present invention comprises mimosine and/or a mimosine-containing peptide(s). The mimosine-containing peptide is a peptide whic... | 12/29/2011 |
| 20110318770 | COMPOSITIONS, KITS AND METHODS FOR DETERMINING PLASMIN ACTIVITY Compositions, kits, and methods for determining plasmin activity using a fluorogenic peptide substrate are provided.... | 12/29/2011 |
| 20110319592 | Process for the Purification of Antibodies Using Affinity Resins Comprising Specific Ligands The present invention relates to a novel process for the purification of antibodies, e.g. monoclonal antibodies. The process utilizes an affinity resin comprising a solid phase material having immobilized thereto one or more low-molecular weight synthetic ligands. The a... | 12/29/2011 |
| 20110319293 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY Synthetic protease substrates and methods which facilitate the identification of substrates of a protease, particularly ubiquitin, ubiquitin-like, or proteasome protein are provided.... | 12/29/2011 |
| 20110312875 | PEPTIDIC COMPOUNDS The present invention provides a compound of formula I, II, III and IV as defined herein and pharmaceutically acceptable derivatives thereof. The present invention further provides use of the compounds of the present invention in the treatment of bacterial infection and... | 12/22/2011 |
| 20110306560 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and use... | 12/15/2011 |
| 20110305770 | RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM The present invention relates to polymer conjugated releasable lipids and nanoparticle compositions containing the same for the delivery of nucleic acids and methods of modulating gene expression using the same. In particular, this invention relates to releasable polyme... | 12/15/2011 |
| 20110301087 | CRF1 RECEPTOR COMPOUNDS The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor for corticotrophin releasing hormone (or factor) recept... | 12/08/2011 |
| 20110301076 | ANTIMICROBIAL COMPOUNDS The present invention relates to a compound of formula (I) AA-AA-AA-R1—R2 (I) wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27... | 12/08/2011 |
| 20110301088 | CRYSTALLINE EZATIOSTAT HYDROCHLORIDE ANSOLVATE Crystalline ezatiostat hydrochloride ansolvate form D is more stable and/or more soluble that various solvated crystalline polymorphic forms of ezatiostat hydrochloride.... | 12/08/2011 |
| 20110300199 | PEPTIDES USED IN THE TREATMENT AND/OR CARE OF THE SKIN, MUCOUS MEMBRANES AND/OR SCALP AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS Peptides of general formula (I): R1-Wp-Xn-AA1-AA2-AA3-AA4-Ym-R2 their stereoisomers, mixtures thereof, and/or their cosmetically or pharmaceutically acceptable salts, a method of pre... | 12/08/2011 |
| 20110275784 | ASYMMETRIC SYNTHESIS OF PEPTIDES The present invention provides a process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S or NR8, where R8 is C1-6 alkyl, C6-12 aryl or hydrogen, with a nucleophile, wherein the ... | 11/10/2011 |
