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Vehicular Impact Signaling Device
An apparatus for the deployment of a visible plume to alert other motorists that a proximate motor vehicle has been involved in a collision.
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| Application No. | Application Title | Issue Date |
| 20120128756 | Skin Permeating And Cell Entering (SPACE) Peptides and Methods of Use Thereof The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells.... | 05/24/2012 |
| 20120070416 | Macrocyclic Proline Derived HCV Serine Protease Inhibitors The present invention discloses compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus... | 03/22/2012 |
| 20120070854 | HNRNP A3 Related Peptides and Use Thereof for Diagnosis of Rheumatoid Arthritis The invention relates to a peptide and retro or retro-inverso peptide thereof, with a length of ≦25 amino acid residues, characterized in that the peptide comprises at least one citrulline residue, and exhibits a sequence identity over the whole sequence of the peptid... | 03/22/2012 |
| 20120046219 | MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDES The invention relates to melanocortin receptor-specific cyclic peptides of Formula (I) or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4a, R4... | 02/23/2012 |
| 20120040894 | Mini-Hepcidin Peptides and Methods of Using thereof Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.... | 02/16/2012 |
| 20120020893 | Intravascular Imaging Device and Uses Thereof The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging agents.... | 01/26/2012 |
| 20120021973 | Peptides for Treatment of Obesity The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, an... | 01/26/2012 |
| 20120014873 | PEPTIDES WHOSE UPTAKE BY CELLS IS CONTROLLABLE A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantl... | 01/19/2012 |
| 20120003201 | VAULT AGENTS FOR CHRONIC KIDNEY DISEASE The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a RGD-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease.... | 01/05/2012 |
| 20110319316 | Method for Preventing and Treating Hyperpermeability A peptide is described, which consists of 7-17 adjacent amino acids and comprises the hexamer TX EX X E, wherein X, X and X can be any natural or non-natural amino acid, wherein the peptide has no TNF receptor binding activity and is cyclized, for the prevention and tre... | 12/29/2011 |
| 20110311564 | Method for Producing Intermediates for the Production of Novel Macrocycles that are Inhibitors of the Proteasomic Degradation of p27, such as Argyrin and Derivatives Thereof, and Uses of Said Macrocycles The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular argyrin and derivatives thereof, for a treatment in a variety of conditions, such as the induction of immunotolerance, autoimmune ... | 12/22/2011 |
| 20110312879 | TEMPLATE-FIXED BETA-HAIRPIN PEPTIDOMIMETICS WITH CXCR4 ANTAGONIZING ACTIVITY Template-fixed peptidomimetics formula (Ia) formula (Ib) wherein Z is a template-fixed chain of 14 α-amino and/or α-hydroxy acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid), are Pro, Gly, a glycolic acid ... | 12/22/2011 |
| 20110313130 | BIFUNCTIONAL CHELATING AGENTS A bifunctional chelating agent of the formula (I): wherein the variables R1, R1′, Q1, Q2 and M are as defined in the description of the present application. Also ... | 12/22/2011 |
| 20110312878 | PHARMACOLOGICALLY ACTIVE PEPTIDE CONJUGATES HAVING A REDUCED TENDENCY TOWARDS ENZYMATIC HYDROLYSIS The invention is directed to a pharmacologically active peptide conjugate having a reduced tendency towards enzymatic cleavage comprising a pharmacologically active peptide sequence (X) and a stabilising peptide sequence (Z) of 4-20 amino acid residues covalently bound ... | 12/22/2011 |
| 20110297820 | PSEUDACYCLIN AND METHOD OF INDICATION OF A FUNGUS PSEUDALLESCHERIA BOYDII Pseudacyclin and method of indication of a fungus Pseudallescheria boydii Pseudacyclins are secondary metabolites isolated from a filamentous fungus Pseudallescheria boydii. They reveal a cyclic-like structure which is represented by a cyclopeptide backbon... | 12/08/2011 |
| 20110300141 | Novel Alphabeta-Binding protein and its peptide derivatives and uses thereof A protein kinase C inhibitor that binds B-amyloid and its peptide derivatives with the same function are disclosed. These may be useful in the treatment of Alzheimer's disease, for example as pseudo vaccines comprising antibodies, or as part of fusion proteins which are... | 12/08/2011 |
| 20110294743 | METASTASIS-SPECIFIC PEPTIDES AND THEIR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS The present invention concerns peptide sequences that specifically recognize cells of human hepatic metastases. The invention comprises also the use of nucleic acids coding for such peptides, as well as conjugates and formulations of such peptides for diagnostic and the... | 12/01/2011 |
| 20110280802 | Linkers For Radiopharmaceutical Compounds A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting ... | 11/17/2011 |
| 20110269671 | NISIN DERIVATIVES AND THE USE THEREOF The present invention relates to a nisin derivative comprising amino acid substitutions in the peptide sequence encoding the hinge region of the protein, wherein the derivative exhibits an increased anti-microbial activity.... | 11/03/2011 |
| 20110269698 | Novel Cyclic Pentadepsipeptide Derivative and Fusarium Strain Producing The Same Disclosed is a Fusarium strain producing novel cyclic pentadepsipeptides which are of excellent multidrug resistance-reversing activity and inhibitory activity against cancer cells. Also, novel cyclic pentadepsipeptides are provided as active ingredients of the c... | 11/03/2011 |
| 20110263042 | ASSAY METHOD FOR ANTIBODIES AGAINST CYCLIC CITRULLINATED PEPTIDE The present invention relates to method for assaying anti-cyclic citrullinated peptide antibodies in a clinical sample, said method comprising contacting said sample with at least one homogeneous reagent comprising at least one specific binder for anti-CCP antibodies, w... | 10/27/2011 |
| 20110263815 | TRIAZOLE MACROCYCLE SYSTEMS The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.... | 10/27/2011 |
| 20110256172 | EPITOPE-TARGETED ANTHRAX VACCINE Anthrax vaccine compositions comprise a segment of a PA toxin protein that stimulates a B cell immune response specific for a defined epitope on the protective antigen of B. anthracis, a pharmaceutical excipient and optionally, one or more other protein segments ... | 10/20/2011 |
| 20110257364 | PROCESS FOR PURIFYING GLYCOPEPTIDE PHOSPHONATE DERIVATIVES Disclosed are methods of purifying glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups that are useful as antibacterial agents. The methods include contacting a solution of the glycopeptide derivatives with a pol... | 10/20/2011 |
| 20110245459 | Processes for Intermediates for Macrocyclic Compounds The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4<... | 10/06/2011 |
| 20110236484 | Genus-Wide Chlamydial Peptide Vaccine Antigens Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for a... | 09/29/2011 |
| 20110236316 | PEPTIDE TARGETING IMAGING AGENTS AND METHODS OF USE THEREOF Described herein are peptide targeting imaging agents. The peptides are covalently attached to the imaging agent and have a specific peptide sequence that enables the imaging agent to accumulate specifically in tumor tissues. Additionally, the imaging agents are readily... | 09/29/2011 |
| 20110230416 | PEPTIDE DERIVATIVES AND USE THEREOF AS CARRIERS FOR MOLECULES IN THE FORM OF CONJUGATES The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and ... | 09/22/2011 |
| 20110229472 | Peptides and Related Compounds Having Thrombopoietic Activity The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.... | 09/22/2011 |
| 20110229510 | GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic peptide scaffolds that display c... | 09/22/2011 |
| 20110212057 | CYCLOUNDECADEPSIPEPTIDE COMPOUNDS AND USE OF SAID COMPOUNDS AS A MEDICAMENT At least one embodiment of the present invention relates to new cycloundecadepsipeptide compounds and to the use of said compounds as a medicament, in particular as antiviral agents, more particularly for preventing or treating Hepatitis C infections or HCV induced diso... | 09/01/2011 |
| 20110212891 | AZEPINONE DERIVATIVES The present invention relates to a compound represented by formula (I): wherein R1 represents a hydrogen atom or the like; R2 and R3 represent a hydrogen atom or the like; R4 is a group represented by (II) R5 repres... | 09/01/2011 |
| 20110207674 | ANTITUMORAL COMPOUNDS Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof useful as antitumour agents. ... | 08/25/2011 |
| 20110207658 | High Purity Lipopeptides The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatogra... | 08/25/2011 |
| 20110195083 | CYCLIC V3 PEPTIDES FOR ANTI HIV-1 VACCINE Isolated cyclic polypeptides useful as vaccinations for the treatment/prevention of HIV are disclosed. An exemplary peptide comprises at least 18 consecutive amino acids of a V3 domain of gp120, starting at position 303 and ending at position 322, the positioning being ... | 08/11/2011 |
| 20110189095 | CRKL TARGETING PEPTIDES Provided are methods and compositions for selectively targeting CRKL through the use of targeting peptides. Selective targeting of secreted CRKL through the use of a targeting peptide may be used, for example, in the treatment of cancer to deliver a chemotherapeutic com... | 08/04/2011 |
| 20110190210 | PROMININ-1 PEPTIDE FRAGMENTS AND USES THEREOF Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell... | 08/04/2011 |
| 20110191867 | PEPTIDE VACCINE FOR INFLUENZA VIRUS The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an an... | 08/04/2011 |
| 20110182922 | PEPTIDES OF IL1 BETA AND TNF ALPHA AND METHOD OF TREATMENT USING SAME The present invention relates to peptides derived from the proinflammatory cytokines, interleukin-1β (IL1β) and tumor necrosis factor α (TNFα), and their use in human or veterinary therapy, such as to generally treat diseases linked to the overproduction of IL1β or... | 07/28/2011 |
| 20110183891 | Methods and Compositions for Inhibiting Fungal Infection and Disease The present invention describes a previously unknown interaction between secreted aspartic proteases (SAPs), including SAPs 4-6 of Candida albicans, and integrins on host cells. The SAPs secure entry into the host cell through RGD-like binding motifs and subseque... | 07/28/2011 |
