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| Application No. | Application Title | Issue Date |
| 20120128586 | METHOD FOR TREATING CHRONIC LYMPHOCYTIC LEUKEMIA The present invention provides a method for treating a subject having chronic lymphocytic leukemia (CLL) comprising administering to the subject one or more agents that target cell surface membrane antigens expressed preferentially on cells of the proliferative compartm... | 05/24/2012 |
| 20120129758 | MUSCLE FUNCTION ENHANCING PEPTIDE The present invention relates to a peptide comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptide for medical use, in particular, for treating or ... | 05/24/2012 |
| 20120128684 | Conserved Hemagglutinin Epitope, Antibodies to the Epitope and Methods of Use Disclosed are antibodies that bind to the stem region of influenza hemagglutinin in the neutral pH conformation, hemagglutinin epitopes in the stem region, and methods of making and using both.... | 05/24/2012 |
| 20120128646 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE DISEASE The present invention is related to the development and treatment of autoimmune disease. Autoimmune diseases can result from tissue damage caused by the activation of autoreactive T cells by autoantigens. For example, peptide fragments of naturally occurring proteins (i... | 05/24/2012 |
| 20120128708 | DIAGNOSTIC MYCOBACTERIUM TUBERCULOSIS TEST A method of diagnosing Mycobacterium tuberculosis infection in a human, or of determining whether a human has been exposed to Mycobacterium tuberculosis, comprising (i) contacting T-cells from said human with one or more of (a) a peptide having the sequenc... | 05/24/2012 |
| 20120129776 | Bioactive peptides and method of using same Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.... | 05/24/2012 |
| 20120107829 | STABILIZING COMPOSITIONS FOR IMMOBILIZED BIOMOLECULES The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. T... | 05/03/2012 |
| 20120107916 | METHODS AND COMPOSITIONS FOR AFFECTING THE DIFFERENTIATION OF CLOSTRIDIA IN CULTURE The invention relates generally to methods and compositions for maintaining and manipulating microbial cultures of Gram-positive bacteria. Also provided are methods for identifying quorum sensing regulatory proteins and auto-inducing peptides in Gram-positive bacteria. ... | 05/03/2012 |
| 20120108493 | Polypeptide Fragments Comprising Endonuclease Activity and Their Use The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyx... | 05/03/2012 |
| 20120108492 | LIGAND-SPECIFIC NON-ANTIBODY COMPOUNDS THAT INHIBIT CR2 ACTIVATION AND METHODS OF USE THEREOF The present invention describes a novel non-antibody ligand-specific compound that selectively binds to a complement receptor type 2 (CR2) protein, a ligand thereof, or both, wherein the compound competitively inhibits CR2 ligand's binding to a CR2 protein in a standard... | 05/03/2012 |
| 20120108787 | Immobilization Particles for Removal of Microorganisms and/or Chemicals An immobilization particle for immobilizing a target microorganism or target chemical found in or on a mammal that includes: immobilization molecules capable of attaching to a target microorganism or a target chemical, which immobilization molecules are attached to one ... | 05/03/2012 |
| 20120108450 | Receptors Useful for Gas Phase Chemical Sensing The invention provides for a receptor, capable of binding to a target molecule, linked to a hygroscopic polymer or hydrogel; and the use of this receptor in a device for detecting the target molecule in a gaseous and/or liquid phase. The invention also provides for a me... | 05/03/2012 |
| 20120107902 | Processes For Forming Amide Bonds And Compositions Related Thereto The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an O-silylated thionoester and an amine under conditions such that an amide is formed... | 05/03/2012 |
| 20120107800 | CELL-TARGETING NANOPARTICLES AND USES THEREOF The invention generally refers to a cell-targeting nanoparticle, wherein the cell-targeting nanoparticle is directly conjugated to at least one cysteine-containing peptide, wherein the cysteine-containing peptide is selected from the group consisting of glutathione (GSM... | 05/03/2012 |
| 20120083427 | KINASE AND PHOSPHATASE ASSAYS Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptid... | 04/05/2012 |
| 20120083442 | MYOSTATIN BINDING AGENTS The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such ... | 04/05/2012 |
| 20120070406 | THERAPEUTIC PROTEIN COMPOSITIONS HAVING REDUCED IMMUNOGENICITY AND/OR IMPROVED EFFICACY The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the c... | 03/22/2012 |
| 20120071628 | TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE Disclosed is a topical therapeutic agent for ophthalmic diseases, which comprises a compound capable of binding specifically to a DNA sequence. More preferably disclosed is a topical therapeutic agent for ophthalmic diseases, which comprise a pyrrole-imidazole polyamide... | 03/22/2012 |
| 20120070488 | METHOD OF INDUCING NEUTRALIZING ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.... | 03/22/2012 |
| 20120070907 | METHOD TO DEPLETE MONOCLONAL ANTIBODIES IN A BIOLOGICAL SAMPLE The present invention provides methods for depleting a biological sample from a patient of a humanized or chimeric monoclonal antibody prior to cross-matching the sample for transplantation. The method comprises treating the sample with a peptide or other moiety that se... | 03/22/2012 |
| 20120071396 | Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction... | 03/22/2012 |
| 20120071400 | LIPID METABOLISM-IMPROVING REAGENT Our objective is to provide a novel lipid metabolism-improving reagent effective in preventing and treating hyperlipidemia and obesity and to provide this reagent in food, beverages, nutritional supplements, and fodders with the ability to improve lipid metabolism. The ... | 03/22/2012 |
| 20120052110 | METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or promotion of healing of, wounds.... | 03/01/2012 |
| 20120053123 | NATRIURETIC POLYPEPTIDES HAVING MUTATIONS WITHIN THEIR DISULFIDE RINGS Materials and Methods related to making and using natriuretic polypeptides having a mutation in the ring portion of their structure.... | 03/01/2012 |
| 20120052481 | Assays for detecting modified compounds Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications... | 03/01/2012 |
| 20120053129 | TARGET-ACTIVATED CELL/TISSUE-PENETRATING PEPTIDE FOR DELIVERY OF IMPERMEABLE COMPOUNDS AND USE THEREOF The present invention relates to a target-activated cell/tissue-penetrating peptide for delivery of impermeable compounds (Target Activated Cell/tissue Translocation peptide for Impermeable Compound Strategy (TACTICS)), and the use thereof, and more particularly to a ta... | 03/01/2012 |
| 20120052569 | TAG PEPTIDE HAVING A PROTEASE RECOGNITION SEQUENCE AND USE THEREOF Provided is a tag peptide in which a protease recognition sequence and an epitope of an antibody against the tag peptide are overlapped and thereby the protease recognition sequence per se is usable for detection or purification. Also provided is a purification method f... | 03/01/2012 |
| 20120053225 | AKT TYROSINE 176 PHOSPHORYLATION CANCER BIOMARKER AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. The present study uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase,... | 03/01/2012 |
| 20120054879 | HCV Coreceptor and Methods of Use Thereof The invention relates to the discovery that the Claudin-1 protein functions as a co-receptor for entry of HCV into cells. Methods of inhibiting, preventing or mitigating HCV infections by inhibiting HCV interactions with Claudin-1 are provided. Methods of identifying ag... | 03/01/2012 |
| 20120053509 | VACCINES FOR HUMAN PAPILLOMA VIRUS AND METHODS FOR USING THE SAME Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV 6, HPV 11, HPV 33 and HPV58 E6 and E7. Pharmaceutical composition, recombinant vaccines comprising and live attenuated vaccine... | 03/01/2012 |
| 20120053320 | MICROBIAL NANOWIRES AND METHODS OF MAKING AND USING SAME A nanowire comprising a purified protein filament, such as a pilus, isolated from a bacterium, such as Geobacter sulfurreducens, is provided. Such a purified pilus can contain peptide subunits capable of assembling into the protein filament and establishing an el... | 03/01/2012 |
| 20120052090 | PEPTIDIC ANTIGEN THAT INDUCES ANTIBODY RECOGNIZING THREE-DIMENSIONAL STRUCTURE OF HIV AND METHOD FOR SYNTHESIZING SAME An object of the present invention is to provide an HIV antibody-inducing peptide antigen that can be used without problems for HIV, which is highly prone to mutation, and is effective in developing an antibody or a vaccine having excellent specificity and binding activ... | 03/01/2012 |
| 20120046369 | Methods for enhancing the stability of foods, beverages, and cosmetics using natural products derived from non-allergenic proteinaceous sources The present invention relates to compositions with effective metal chelating activity and utility as natural antioxidants in food, beverages, nutritional supplements and cosmetics. The compositions of the present invention may be prepared by enzymatically hydrolyzing hy... | 02/23/2012 |
| 20120046441 | Combinatorial Synthesis of Libraries of Macrocyclic Compounds Useful in Drug Discovery A library of macrocyclic compounds of the formula (I)
| 02/23/2012 |
| 20120045390 | Composition and Methods for the Diagnosis and Treatment of Tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... | 02/23/2012 |
| 20120045394 | HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, incl... | 02/23/2012 |
| 20120045429 | Methods and Agent for Modulating the RNA Polymerase II-Histone Surface The present invention relates to the identification of an intranucleosomal DNA loop formed during transcription through a nucleosome and use of the same to identify an agent that modulates the RNA Polymerase II-histone surface.... | 02/23/2012 |
| 20120041173 | WATER SOLUBLE SOLID PHASE PEPTIDE SYNTHESIS A solid phase peptide synthesis method is disclosed. The method includes the steps of deprotecting an amino group in its protected form that is protected with a protecting group containing a Michael acceptor site composed of an α,β-unsaturated sulfone in a solvent sel... | 02/16/2012 |
| 20120040857 | ISOLATION OF FACTORS THAT ASSOCIATE DIRECTLY OR INDIRECTLY WITH CHROMATIN Methods for isolating non-coding nucleic acids that are associated with chromatin at a target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a target genomic DNA sequence and one or more non-coding nucleic acids associate... | 02/16/2012 |
| 20120041171 | PROCESS FOR THE PRODUCTION OF A RECOMBINANT POLYPEPTIDE OF INTEREST The present invention relates to a process for the production of a recombinant polypeptide of interest, a polypeptide obtained by said process, a recombinant polynucleotide, an expression vector, an expression construct and to the use of a specific signal peptide and of... | 02/16/2012 |
