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| Application No. | Application Title | Issue Date |
| 20100234444 | HINDERED ESTER-BASED BIODEGRADABLE LINKERS FOR OLIGONUCLEOTIDE DELIVERY The invention provides hindered ester-based biodegradable linkers for the delivery of oligonucleotides in vivo, as well as method of making and using the same.... | 09/16/2010 |
| 20100221269 | SYNTHETIC LIPID A DERIVATIVE The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivative.... | 09/02/2010 |
| 20100209384 | Sustained release formulations comprising very low molecular weight polymers The present invention relates to a parenteral, sustained and controlled release, semisolid formulation comprising an end-capped oligomer and at least one active substance without any supplementary viscosity reducing agent or excipient.... | 08/19/2010 |
| 20100209440 | Targeted Delivery of siRNA The present invention provides a method of delivering RNA interference molecules to a cell or a cell in a subject, which comprises contacting the cell with a protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double ... | 08/19/2010 |
| 20100183610 | GENETIC POLYMORPHISMS ASSOCIATED WITH ALZHEIMER'S DISEASE, METHODS OF DETECTION AND USES THEREOF The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid mole... | 07/22/2010 |
| 20100160211 | GLYCOPEPTIDE PHOSPHONATE DERIVATIVES Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agen... | 06/24/2010 |
| 20100136010 | Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55... | 06/03/2010 |
| 20100098713 | NOVEL 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 AND 65577 MOLECULES AND USES THEREFOR The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors contai... | 04/22/2010 |
| 20100061932 | PEPTIDES USEFUL AS CELL-PENETRATING PEPTIDES The present invention is related to a peptide having an amino acid sequence comprising at least 8 consecutive amino acids of the human lactoferrin protein or of the bovine lactoferrin protein, whereby the peptide is suitable to act as a cell-penetrating peptide.... | 03/11/2010 |
| 20100040714 | Asthma/Allergy Therapy that Targets T-lymphoctyes and/or Eosinophils A pharmaceutical composition for the treatment and/or prophylaxis of diseases caused by type I hypersensitivity reactions consisting essentially of Glicophosphopeptical, or pure Nigella Sativa seeds, in a concentration which stimulate Th1 lymphocytes and selectiv... | 02/18/2010 |
| 20100016215 | COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a mammalian subject are disclosed. The oligonucleotide has 8-30 bases, with at leas... | 01/21/2010 |
| 20090324495 | COMPOUNDS AND METHODS FOR ENZYME-MEDIATED TUMOR IMAGING AND THERAPY The invention provides methods and compositions, e.g., for tumor imaging and therapy.... | 12/31/2009 |
| 20090305947 | LIVESTOCK MANAGEMENT FOR IMPROVED REPRODUCTIVE EFFICIENCY The present invention relates to methods for controlling the reproductive cycles and weaning in livestock, particularly to the use of casein-derived peptides for estrus induction and reduction of anestrus intervals, enabling early weaning without negatively affecting th... | 12/10/2009 |
| 20090285838 | USE OF SOLUBLE CD164 IN INFLAMMATION AND AUTOIMMUNE DISORDERS The present invention relates to novel therapeutic uses of soluble proteins comprising the extracellular region of human CD164, in particular for treating inflammatory and/or autoimmune disorders.... | 11/19/2009 |
| 20090263362 | FERTILITY ENHANCEMENT USING LIPID CARRIERS AND BIOACTIVE MOLECULES The invention relates to a composition and method for enhancing fertilization. Fertilization enhancement is achieved by effectively delivering bioactive molecules with a lipid anchor (GPI-linked proteins) to the surface of epididymal or ejaculated sperm. The process may... | 10/22/2009 |
| 20090258820 | ECHINOCANDIN/CARBOHYDRATE COMPLEXES A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex in pharmaceutical formulations a... | 10/15/2009 |
| 20090258819 | Reagents and Methods for Smooth Muscle Therapies The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.... | 10/15/2009 |
| 20090226450 | Novel 15571, 2465, 14266, 2882, 52871, 8203 and 16852 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 15571, 2465, 14266, 2882, 52871, 8203 or 16852 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15571, 2465, 14266, 2882, 5... | 09/10/2009 |
| 20090226451 | Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636... | 09/10/2009 |
| 20090191226 | ADJUVANT FORMULATION COMPRISING A SUBMICRON OIL DROPLET EMULSION An adjuvant composition, comprising a metabolizable oil and an emulsifying agent, wherein the oil and the detergent are present in the form of an oil-in-water emulsion having oil droplets substantially all of which are less than 1 micron in diameter. In preferred embodi... | 07/30/2009 |
| 20090192076 | RECOMBINANT VWF FORMULATIONS The present invention provides long-term stable pharmaceutical formulations of recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations.... | 07/30/2009 |
| 20090186808 | Method and Compound for the Treatment of Valvular Disease A method for treating valvular stenosis The method involves the administration of a therapeutically effective amount of a reverse lipid (in particular cholesterol) transport agonist to a mammal Most preferred is an Apolipoprotein A-1 mimetic peptide/phospholipid complex... | 07/23/2009 |
| 20090176695 | Reagents and Methods for Smooth Muscle Therapies The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.... | 07/09/2009 |
| 20090176694 | Reagents and Methods for Smooth Muscle Therapies The present invention provides novel polypeptides comprising heat shock protein 20 (HSP20)-derived polypeptides to treat or inhibit smooth muscle vasospasm, as well to treat and inhibit smooth muscle cell proliferation and migration.... | 07/09/2009 |
| 20090156466 | Characterization of a MEKK binding site and uses thereof The present invention provides binding motifs, binding sites, peptides, and 14-3-3/MEKK complexes. Also provided are agents reactive with same, pharmaceutical compositions, molecules, and kits comprising same, and methods of producing same. The present invention further... | 06/18/2009 |
| 20090111735 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use to mitigate or prevent physiologically deleterious side-effects and/or modulate the intracellular balance of oxidized and reduced thioredoxin (Trx) in patients with cancer who are receiving treatment with o... | 04/30/2009 |
| 20090099066 | Tissue specific peptide conjugates and methods Cell-penetrating peptides useful for targeting a therapeutic compound to a selected mammalian tissue, methods for their identification, methods of forming conjugate compounds containing such peptides, and conjugates formed thereby are disclosed. The cell-penetrating pep... | 04/16/2009 |
| 20090069218 | PHARMACEUTICAL COMPOSITIONS COMPRISING CASEIN DERIVED PEPTIDES AND METHODS OF USE THEREOF The present invention relates to peptides derived from casein and their use in the management of lactating animals, particularly to methods for decreasing the length of the dry period of a lactating livestock animal, for increasing its milk yield and milk hygiene after ... | 03/12/2009 |
| 20090068187 | Novel 14275, 54420, 8797, 27439, 68730, 69112 and 52908 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14275, 54420, 8797, 27439... | 03/12/2009 |
| 20090069219 | DEUTERIUM-ENRICHED TELAVANCIN The present application describes deuterium-enriched telavancin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.... | 03/12/2009 |
| 20090062180 | Glycogen synthase kinase-3 inhibitors Novel conjugates that are capable of inhibiting GSK-3 activity, a process of producing same, pharmaceutical compositions including same and methods of using same in the treatment of GSK-3 mediated conditions are disclosed. Methods of treating affective disorders using G... | 03/05/2009 |
| 20090036357 | Azapeptide derivatives This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention al... | 02/05/2009 |
| 20090023633 | REGULATION OF MINERAL AND SKELETAL METABOLISM A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulati... | 01/22/2009 |
| 20090023634 | REGULATION OF MINERAL AND SKELETAL METABOLISM A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulati... | 01/22/2009 |
| 20080269111 | METHOD OF TREATING DYSLIPIDEMIC DISORDER The invention provides methods of treating or preventing a condition or disorder associated with dyslipidemia with compositions comprising apolipoprotein-sphingomyelin complexes. The methods of the invention permit reduction, by 4- to 20-fold, of the amount of apolipopr... | 10/30/2008 |
| 20080241133 | Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors... | 10/02/2008 |
| 20080194463 | Antibacterial antisense oligonucleotide and method A method for enhancing, by at least 10 fold, the antibacterial activity of an antisense oligonucleotide composed of morpholino subunits linked by phosphorus-containing intersubunit linkages. The method includes one or both of: conjugating an arginine-rich carrier to a 3... | 08/14/2008 |
| 20080166428 | Sensitization to another anticancer therapy and/or amelioration of a side effect of another anticancer therapy by treatment with a GST-activated anticancer compound A method of sensitizing a mammal, especially a human, to another anticancer therapy by administering a sensitizing effective amount of a GST-activated anticancer compound. A method of ameliorating a side effect of another anticancer therapy in a mammal, especially a hum... | 07/10/2008 |
| 20080161415 | Compounds and methods for reducing undesired toxicity of chemotherapeutic agents Novel compositions and formulations are disclosed that have use as toxicity-reducing agents for various chemotherapeutic agents and as treatment for certain diseases and conditions. The compositions of matter are amino acid and peptide heteroconjugated disulfides of 2-m... | 07/03/2008 |
| 20080139456 | Macrocyclic Sh2 Domain Binding Inhibitors Disclosed are compounds for inhibiting the binding of an SH2 domain-containing protein, for example, a compound of formula (I): FORMULA (I) wherein R1 is a lipophile; R2, in combination with the phenyl ring, is a phenylphosphate mimic group or a protected phenylphosphat... | 06/12/2008 |
