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| Application No. | Application Title | Issue Date |
| 20120129775 | ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE Methods of inhibiting undesired angiogenesis are provided, which methods include administering to a subject a therapeutically effective amount of at least one of the compounds described herein, or a pharmaceutically acceptable salt thereof.... | 05/24/2012 |
| 20120129798 | STEALTH POLYMERIC PARTICLES FOR DELIVERY OF BIOACTIVE OR DIAGNOSTIC AGENTS The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent.... | 05/24/2012 |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120029087 | USE OF RASAGILINE FOR THE TREATMENT OF OLFACTORY DYSFUNCTION Disclosed are methods of treating olfactory dysfunction by periodically administering a therapeutically effective amount of rasagiline or a pharmaceutically acceptable salt of rasagiline to a subject.... | 02/02/2012 |
| 20120022070 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and conditions, such as inflammation and neurodegenerative disorders. Methods of tr... | 01/26/2012 |
| 20120003310 | DELAYED RELEASE RASAGILINE FORMULATION Disclosed are formulations of rasagiline base which are designed to delay release of rasagiline while maintaining specific pharmacokinetic properties. Also, disclosed are rasagiline citrate salt and the use and process of manufacture thereof.... | 01/05/2012 |
| 20110319446 | BICYCLO[2.2.1]HEPT-7-YLAMINE DERIVATIVES AND THEIR USES Compounds of formula (I) have muscarinic M3 receptor modulating activity; wherein A is an oxygen atom or group —N(R12)—;
| 12/29/2011 |
| 20110313050 | SOLID COMPOSITION CONTAINING THE INGREDIENT RASAGILINE The present invention relates to a solid composition containing at least one pharmaceutically compatible auxiliary ingredient and rasagiline or a pharmaceutically compatible salt thereof as an active ingredient. The invention further relates to a method for producing sa... | 12/22/2011 |
| 20110301099 | Method for enhancing penetration of lipid insoluble medicaments through cell membranes using small S-Allyl-containing molecules with phospholipid permeability as carrier molecules A method and composition that allows for the penetration of lipid insoluble medicaments through cell membranes using small S-Allyl-containing molecules with phospholipid permeable molecules as carrier molecules. S-Allyl-containing compounds can include alliin, allicin, ... | 12/08/2011 |
| 20110294830 | NITROGEN-CONTAINING COMPOUNDS AND HARMFUL ORGANISM CONTROL AGENTS The present invention provides a nitrogen-containing compound represented by formula (I1) (in formula (I1), R0 represents a nitro group or the like, Z represents an optionally substituted aryl group or the like, R3 represents ... | 12/01/2011 |
| 20110294863 | FUNGICIDE N-CYCLOALKYL-N-BICYCLIMETHYLENE-CARBOXAMIDE DERIVATIVES The present invention relates N-cycloalkyl-N-bicyclicmethylene-carboxamide, thiocarboxamide or N-substituted carboximidamide derivatives of formula (I) wherein A represents a carbo-linked, 5-membered heterocyclyl group, T represents O or S, Z1 represents a C<... | 12/01/2011 |
| 20110281953 | PROCESS FOR PREPARING AND DRYING SOLID RASAGILINE BASE Disclosed is crystalline R(+)-N-propargyl-1-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also disclosed is a process for the pre... | 11/17/2011 |
| 20110281954 | METHODS OF SYNTHESIZING CINACALCET AND SALTS THEREOF Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared ... | 11/17/2011 |
| 20110281850 | INTRACELLULAR KINASE INHIBITORS Intracellular kinase inhibitors and their therapeutic uses for patients with T cell malignancies, B cell malignancies, autoimmune disorders, and transplanted organs.... | 11/17/2011 |
| 20110268785 | Propynylaminoindan Transdermal Compositions Propynylaminoindan (e.g., Rasagiline) transdermal compositions are provided. Aspects of the transdermal compositions include a matrix of the propynylaminoindan in a pressure sensitive adhesive comprising a carboxylated polymer. In some instances, the matrix further incl... | 11/03/2011 |
| 20110263719 | POLYMORPHIC FORM OF RASAGILINE MESYLATE The present invention relates to a novel crystalline form of rasagiline mesylate and a pure form of rasagiline mesylate and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said forms and use of said compositions ... | 10/27/2011 |
| 20110251288 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE AMINES The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline. ... | 10/13/2011 |
| 20110245235 | Systems, Methods, and Devices for Rehabilitation of Auditory System Disorders Using Pharmaceutical Agents and Auditory Devices The present inventions provide combination therapies, kits, and methods for providing relief and/or for improving one or more symptoms associated with an auditory system disorder in a subject diagnosed with the auditory system disorder, comprising an effective amount of... | 10/06/2011 |
| 20110230513 | PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSONS DISEASE Pharmaceutical compositions are provided for treatment of Parkinson's disease comprising a pharmaceutically acceptable carrier and a fixed dose combination of two active agents selected from compounds having either neuroprotective or symptomatic effects, or both, in Par... | 09/22/2011 |
| 20110224256 | THERAPEUTIC IMPRINTING FOR THE TREATMENT OF PSYCHIATRIC DISORDERS The invention features methods, kits, and compositions for the treatment of psychiatric disorders using therapeutic imprinting in pre-pubescent subjects.... | 09/15/2011 |
| 20110218158 | DNA CYTOSINE DEAMINASE INHIBITORS Cytosine deaminase inhibitors and methods for identifying inhibitors of the anti-retroviral activity of APOBEC3G are described.... | 09/08/2011 |
| 20110207730 | ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF Ion channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment o... | 08/25/2011 |
| 20110195936 | BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.... | 08/11/2011 |
| 20110184071 | PROCESS FOR THE PREPARATION OF AMINES The present invention relates to an improved process for the preparation of rasagiline (1) and its pharmaceutically acceptable salts. In particular it relates to a process for preparing rasagiline (1) and its salts substantially free from impurities. | 07/28/2011 |
| 20110152381 | 3-KETO-N-PROPARGYL-1-AMINOINDAN The subject invention provides a pharmaceutical composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of 3-keto-N-propargyl-1-aminoindan or a salt thereof.... | 06/23/2011 |
| 20110130466 | USE OF RASAGILINE FOR THE TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY A method for the treatment of Progressive Supranuclear Palsy. Such method includes administering to a subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof.... | 06/02/2011 |
| 20110117200 | RASAGILINE MESYLATE PARTICLES AND PROCESS FOR THE PREPARATION THEREOF Provided herein is rasagiline mesylate having a 90 volume-percent of the particles (D90) with a size of about 600 microns to about 1500 microns, and a process for the preparation thereof. Provided also herein are pharmaceutical compositions comprising rasagil... | 05/19/2011 |
| 20110118307 | Compositions and methods for the treatment of infectious diseases Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods... | 05/19/2011 |
| 20110110871 | SUBSTITUTED 3-(PHENOXYMETHYL) BENZYL AMINES AND PERSONAL CARE COMPOSITIONS Certain novel substituted 3-(phenoxymethyl) benzyl amines and personal care compositions comprising such, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.... | 05/12/2011 |
| 20110105622 | PHARMACEUTICAL COMPOSITION CONTAINING GLUR2-LACKING AMPAR ANTAGONIST FOR PREVENTING OR TREATING PSYCHIATRIC ILLNESSES A pharmaceutical composition, comprising a GluR2-lacking AMPAR antagonist as an active ingredient, is effective for preventing or treating mental diseases selected from the group consisting of posttraumatic stress disorder (PTSD), drug addiction, and phobia.... | 05/05/2011 |
| 20110053980 | INDANE-AMINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS The present invention relates to indane-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the preparation of a medicament for the treatment of humans or animals.... | 03/03/2011 |
| 20110046139 | BENZOCYCLOHEPTANE AND BENZOXEPINE DERIVATIVES The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof,... | 02/24/2011 |
| 20110028564 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES The invention features compositions, methods, and kits useful for the treatment of filovirus-mediated diseases, e.g., hemorrhagic fever caused by Ebola virus, in an animal.... | 02/03/2011 |
| 20110021502 | USE OF CHOLINESTERASE INHIBITORS FOR TREATING VASCULAR DEPRESSION The invention discloses the use of cholinesterase inhibitors in treating vascular depression.... | 01/27/2011 |
| 20110015274 | FORM OF AN AMINOINDAN MESYLATE DERIVATIVE The present disclosure relates generally to rasagiline mesylate with improved flowability and with advantageously reduced stickiness, to processes for the preparation thereof, and to the use thereof for milling and for preparing pharmaceutical formulations. Methods for ... | 01/20/2011 |
| 20100310599 | Orally Bioavailable Lipid-Based Constructs The present invention is embodied by a composition capable inducing weight loss in a patient in need thereof.... | 12/09/2010 |
| 20100285139 | PHARMACEUTICAL COMPOSITION FOR THE PROPHYLAXIS AND/OR SYMPTOMATIC TREATMENT OF CYSTIC FIBROSIS A pharmaceutical composition for prophylaxis and/or treatment of infections and/or infectious diseases occurring in cystic fibrosis includes at least one antidepressant; at least one dispersant; and at least one pharmaceutically tolerable carrier material.... | 11/11/2010 |
| 20100239666 | Process for producing mouldings from (meth) acrylate copolymers by means of injection moulding The invention relates to a process for producing mouldings by injection moulding the steps in the process being a) melting and mixing of a (meth)acrylate copolymer composed of from 85 to 98% by weight of C1-C4-alkyl (meth)acrylates capable of free-radical polymerization... | 09/23/2010 |
| 20100234411 | New Combination for the Treatment of Respiratory Diseases The present invention relates to novel pharmaceutical compositions based on telmisartan 1 and anticholinergics 2 processes for preparing them and their use for the treatment of respiratory diseases.... | 09/16/2010 |
| 20100227865 | Oligomer-Beta Blocker Conjugates The invention provides Beta-blocker drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate... | 09/09/2010 |
